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P. Murali Doraiswamy

Professor of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt Street North Pavil, 6th Floor, Room 6032, Durham, NC 27710
2400 Pratt Street North Pavil, Box 102505, Durham, NC 27710

Selected Publications


Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index

Journal Article Journal of Alzheimer's Disease Reports · May 14, 2024 Background: There is a need for integration and comprehensive characterization of environmental determinants of Alzheimer's disease. The Environmental Justice Index (EJI) is a new measure that consolidates multiple environmental health hazards. Objective: ... Full text Cite

The influence of economic policies on social environments and mental health.

Journal Article Bull World Health Organ · May 1, 2024 Despite increased advocacy and investments in mental health systems globally, there has been limited progress in reducing mental disorder prevalence. In this paper, we argue that meaningful advancements in population mental health necessitate addressing th ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

Deep learning-aided decision support for diagnosis of skin disease across skin tones.

Journal Article Nat Med · February 2024 Although advances in deep learning systems for image-based medical diagnosis demonstrate their potential to augment clinical decision-making, the effectiveness of physician-machine partnerships remains an open question, in part because physicians and algor ... Full text Link to item Cite

Expectancy Does Not Predict 18-month Treatment Outcomes with Cognitive Training in Mild Cognitive Impairment.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Computerized cognitive training (CCT) has emerged as a potential treatment option for mild cognitive impairment (MCI). It remains unclear whether CCT's effect is driven in part by expectancy of improvement. OBJECTIVES: This study aimed to deter ... Full text Link to item Cite

Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear. METHODS: We used data from a two-site, 78-week randomized trial of MCI comparin ... Full text Link to item Cite

Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Mathematical models of complex diseases, such as Alzheimer's disease, have the potential to play a significant role in personalized medicine. Specifically, models can be personalized by fitting parameters with individual data for the purpose of ... Full text Link to item Cite

Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham Heart Study.

Journal Article Alzheimers Dement (Amst) · 2024 The relationship between sex-specific blood biomarkers and memory changes in middle-aged adults remains unclear. We aimed to investigate this relationship using the data from the Framingham Heart Study (FHS). We conducted association analysis, partial corr ... Full text Link to item Cite

Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease.

Journal Article JAMA Neurol · December 1, 2023 IMPORTANCE: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH al ... Full text Link to item Cite

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Journal Article EBioMedicine · November 2023 BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. T ... Full text Link to item Cite

Independent Care Navigators for the Mental Health Maze.

Journal Article NEJM Catalyst Innovations in Care Delivery · October 18, 2023 Summary The nonprofit organization INclude - the Mental Health Initiative has developed and deployed an independent, data-backed navigation service in North Carolina and provides insights and lessons learned from its first year of operation as a pilot. The ... Full text Cite

MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum.

Journal Article Radiology · October 2023 Background PET can be used for amyloid-tau-neurodegeneration (ATN) classification in Alzheimer disease, but incurs considerable cost and exposure to ionizing radiation. MRI currently has limited use in characterizing ATN status. Deep learning techniques ca ... Full text Link to item Cite

Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.

Journal Article BMC Geriatr · July 31, 2023 BACKGROUND: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however furt ... Full text Link to item Cite

Enhancing social connectedness with companion robots using AI.

Journal Article Sci Robot · July 12, 2023 Companion robots with AI may usher a new science of social connectedness that requires the development of ethical frameworks. ... Full text Link to item Cite

Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Mild cognitive impairment (MCI) represents a high risk group for Alzheimer's disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive netwo ... Full text Link to item Cite

Expanding the scope of health disparities research in Alzheimer's disease and related dementias: Recommendations from the "Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias" Workshop Series.

Journal Article Alzheimers Dement (Amst) · 2023 Topics discussed at the "Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias" workshop, held by Duke University and the Alzheimer's Association with support from the N ... Full text Link to item Cite

Reproductive Markers in Alzheimer's Disease Progression: The Framingham Heart Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: Reproductive status, such as the age of menarche or menopause, may be linked to cognitive abilities and risk for incident Alzheimer's disease (AD) but the evidence is conflicting. It is also not fully known if these factors interact with cortic ... Full text Link to item Cite

Cerebral venous biomarkers and veno-arterial gradients: untapped resources in Alzheimer's disease.

Journal Article Front Neurol · 2023 Blood based biomarkers (BBB) derived from forearm veins for estimating brain changes is becoming ubiquitous in Alzheimer's Disease (AD) research and could soon become standard in routine clinical diagnosis. However, there are many peripheral sources of con ... Full text Link to item Cite

Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index

Journal Article Journal of Alzheimer's Disease Reports · May 14, 2024 Background: There is a need for integration and comprehensive characterization of environmental determinants of Alzheimer's disease. The Environmental Justice Index (EJI) is a new measure that consolidates multiple environmental health hazards. Objective: ... Full text Cite

The influence of economic policies on social environments and mental health.

Journal Article Bull World Health Organ · May 1, 2024 Despite increased advocacy and investments in mental health systems globally, there has been limited progress in reducing mental disorder prevalence. In this paper, we argue that meaningful advancements in population mental health necessitate addressing th ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

Deep learning-aided decision support for diagnosis of skin disease across skin tones.

Journal Article Nat Med · February 2024 Although advances in deep learning systems for image-based medical diagnosis demonstrate their potential to augment clinical decision-making, the effectiveness of physician-machine partnerships remains an open question, in part because physicians and algor ... Full text Link to item Cite

Expectancy Does Not Predict 18-month Treatment Outcomes with Cognitive Training in Mild Cognitive Impairment.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Computerized cognitive training (CCT) has emerged as a potential treatment option for mild cognitive impairment (MCI). It remains unclear whether CCT's effect is driven in part by expectancy of improvement. OBJECTIVES: This study aimed to deter ... Full text Link to item Cite

Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear. METHODS: We used data from a two-site, 78-week randomized trial of MCI comparin ... Full text Link to item Cite

Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Mathematical models of complex diseases, such as Alzheimer's disease, have the potential to play a significant role in personalized medicine. Specifically, models can be personalized by fitting parameters with individual data for the purpose of ... Full text Link to item Cite

Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham Heart Study.

Journal Article Alzheimers Dement (Amst) · 2024 The relationship between sex-specific blood biomarkers and memory changes in middle-aged adults remains unclear. We aimed to investigate this relationship using the data from the Framingham Heart Study (FHS). We conducted association analysis, partial corr ... Full text Link to item Cite

Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease.

Journal Article JAMA Neurol · December 1, 2023 IMPORTANCE: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH al ... Full text Link to item Cite

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Journal Article EBioMedicine · November 2023 BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. T ... Full text Link to item Cite

Independent Care Navigators for the Mental Health Maze.

Journal Article NEJM Catalyst Innovations in Care Delivery · October 18, 2023 Summary The nonprofit organization INclude - the Mental Health Initiative has developed and deployed an independent, data-backed navigation service in North Carolina and provides insights and lessons learned from its first year of operation as a pilot. The ... Full text Cite

MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum.

Journal Article Radiology · October 2023 Background PET can be used for amyloid-tau-neurodegeneration (ATN) classification in Alzheimer disease, but incurs considerable cost and exposure to ionizing radiation. MRI currently has limited use in characterizing ATN status. Deep learning techniques ca ... Full text Link to item Cite

Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.

Journal Article BMC Geriatr · July 31, 2023 BACKGROUND: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however furt ... Full text Link to item Cite

Enhancing social connectedness with companion robots using AI.

Journal Article Sci Robot · July 12, 2023 Companion robots with AI may usher a new science of social connectedness that requires the development of ethical frameworks. ... Full text Link to item Cite

Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Mild cognitive impairment (MCI) represents a high risk group for Alzheimer's disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive netwo ... Full text Link to item Cite

Expanding the scope of health disparities research in Alzheimer's disease and related dementias: Recommendations from the "Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias" Workshop Series.

Journal Article Alzheimers Dement (Amst) · 2023 Topics discussed at the "Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer's Disease and Related Dementias" workshop, held by Duke University and the Alzheimer's Association with support from the N ... Full text Link to item Cite

Reproductive Markers in Alzheimer's Disease Progression: The Framingham Heart Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: Reproductive status, such as the age of menarche or menopause, may be linked to cognitive abilities and risk for incident Alzheimer's disease (AD) but the evidence is conflicting. It is also not fully known if these factors interact with cortic ... Full text Link to item Cite

Cerebral venous biomarkers and veno-arterial gradients: untapped resources in Alzheimer's disease.

Journal Article Front Neurol · 2023 Blood based biomarkers (BBB) derived from forearm veins for estimating brain changes is becoming ubiquitous in Alzheimer's Disease (AD) research and could soon become standard in routine clinical diagnosis. However, there are many peripheral sources of con ... Full text Link to item Cite

Pre-exposure cognitive performance variability is associated with severity of respiratory infection.

Journal Article Sci Rep · December 30, 2022 Using data from a longitudinal viral challenge study, we find that the post-exposure viral shedding and symptom severity are associated with a novel measure of pre-exposure cognitive performance variability (CPV), defined before viral exposure occurs. Each ... Full text Link to item Cite

General Anxiety Disorder-7 Questionnaire as a marker of low socioeconomic status and inequity.

Journal Article J Affect Disord · November 15, 2022 BACKGROUND: The General Anxiety Disorder-7 (GAD-7) questionnaire is a standard tool used for screening and follow-up of patients with Generalized Anxiety Disorder (GAD). Although it is generally accepted that anxiety correlates with clinical and psychosoci ... Full text Link to item Cite

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.

Journal Article Commun Biol · October 8, 2022 Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzhe ... Full text Link to item Cite

Data-driven causal model discovery and personalized prediction in Alzheimer's disease.

Journal Article NPJ Digit Med · September 8, 2022 With the explosive growth of biomarker data in Alzheimer's disease (AD) clinical trials, numerous mathematical models have been developed to characterize disease-relevant biomarker trajectories over time. While some of these models are purely empiric, othe ... Full text Link to item Cite

Importance of Social Determinants in Screening for Depression.

Journal Article J Gen Intern Med · August 2022 IMPORTANCE: The most common screening tool for depression is the Patient Health Questionnaire-9 (PHQ-9). Despite extensive research on the clinical and behavioral implications of the PHQ-9, data are limited on the relationship between PHQ-9 scores and soci ... Full text Link to item Cite

Research to Clinical Practice-Youth seeking mental health information online and its impact on the first steps in the patient journey.

Journal Article Acta Psychiatr Scand · March 2022 BACKGROUND: Online searches about anxiety and depression are recorded every 3-5 s. As such, information and communication technologies (ICT) have enormous potential to enable or impair help-seeking and patient-professional interactions. Youth studies indic ... Full text Link to item Cite

Biological and clinical correlates of the patient health questionnaire-9: exploratory cross-sectional analyses of the baseline health study.

Journal Article BMJ Open · January 4, 2022 OBJECTIVES: We assessed the relationship between the Patient Health Questionnaire-9 (PHQ-9) at intake and other measurements intended to assess biological factors, markers of disease and health status. DESIGN, SETTING AND PARTICIPANTS: We performed a cross ... Full text Link to item Cite

Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort.

Journal Article Radiology · January 2022 Background Pathologic evidence of Alzheimer disease (AD) is detectable years before onset of clinical symptoms. Imaging-based identification of structural changes of the brain in people at genetic risk for early-onset AD may provide insights into how genes ... Full text Link to item Cite

Probing gut-brain links in Alzheimer's disease with rifaximin.

Journal Article Alzheimers Dement (N Y) · 2022 Gut-microbiome-inflammation interactions have been linked to neurodegeneration in Alzheimer's disease (AD) and other disorders. We hypothesized that treatment with rifaximin, a minimally absorbed gut-specific antibiotic, may modify the neurodegenerative pr ... Full text Link to item Cite

Validity of the Web-Based, Self-Directed, NeuroCognitive Performance Test in Mild Cognitive Impairment.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Digital cognitive tests offer several potential advantages over established paper-pencil tests but have not yet been fully evaluated for the clinical evaluation of mild cognitive impairment. OBJECTIVE: The NeuroCognitive Performance Test (NCPT) ... Full text Link to item Cite

Measuring, Modeling, and Forecasting the Mental Wealth of Nations.

Journal Article Front Public Health · 2022 The COVID-19 pandemic has exposed the deep links and fragility of economic, health and social systems. Discussions of reconstruction include renewed interest in moving beyond GDP and recognizing "human capital", "brain capital", "mental capital", and "well ... Full text Link to item Cite

Sex-specific biomarkers in Alzheimer's disease progression: Framingham Heart Study.

Journal Article Alzheimers Dement (Amst) · 2022 BACKGROUND: Sex differences in Alzheimer's disease (AD) are not well understood. METHODS: We performed sex-specific analyses of AD and annualized cognitive decline with clinical and blood biomarker data in participants 60+ years old in the community-based ... Full text Link to item Cite

Models of depressive pseudoamnestic disorder.

Journal Article Alzheimer's & dementia (New York, N. Y.) · January 2022 ObjectiveLittle effort has been made in the past to validate depressive pseudodementia based on hypothesis-driven approaches. We extended this concept to individuals with amnestic Mild Cognitive Impairment and Major Depression, that is, pseudodepr ... Full text Cite

Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.

Journal Article J Affect Disord · December 1, 2021 BACKGROUND: Depression (DEP) and cognitive impairment (CI) share etiological risk factors, anatomical underpinnings, and interact to produce deleterious treatment outcomes. Both DEP and CI exhibit altered patterns of cortical thickness which may impact the ... Full text Link to item Cite

Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.

Journal Article Alzheimers Res Ther · October 20, 2021 BACKGROUND: Interactions between the gut microbiota, microglia, and aging may modulate Alzheimer's disease (AD) pathogenesis but the precise nature of such interactions is not known. METHODS: We developed an integrated multi-dimensional, knowledge-driven, ... Full text Link to item Cite

Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.

Journal Article JAMA Netw Open · September 1, 2021 IMPORTANCE: Currently, there are no presymptomatic screening methods to identify individuals infected with a respiratory virus to prevent disease spread and to predict their trajectory for resource allocation. OBJECTIVE: To evaluate the feasibility of usin ... Full text Open Access Link to item Cite

Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.

Journal Article Clin Nucl Med · July 1, 2021 Early, accurate diagnosis of Alzheimer disease (AD) is essential but remains challenging. Neuropathological hallmarks of AD are β-amyloid neuritic plaques and tau protein neurofibrillary tangles. 18F-Florbetapir is one of several available PET tracers for ... Full text Open Access Link to item Cite

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.

Journal Article Nat Commun · June 28, 2021 Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins ... Full text Link to item Cite

Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review.

Journal Article Neurol Ther · June 2021 In mild cognitive impairment (MCI) due to Alzheimer disease (AD), also known as prodromal AD, there is evidence for a pathologic shortage of uridine, choline, and docosahexaenoic acid [DHA]), which are key nutrients needed by the brain. Preclinical and cli ... Full text Link to item Cite

Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results From 2 Phase III Clinical Trials.

Journal Article JAMA Neurol · April 1, 2021 IMPORTANCE: Flortaucipir positron emission tomography (PET) scans, rated with a novel, US Food and Drug Administration-approved, clinically applicable visual interpretation method, provide valuable information regarding near-term clinical progression of pa ... Full text Link to item Cite

Are we ready for COVID-19’s golden passport? Insights from a global physician survey

Journal Article Journal of Health and Social Sciences · March 1, 2021 Introduction: COVID-19 immunity passports could protect the right to free movement, but critics worry about insufficient evidence, privacy, fraud, and discrimination. We aimed to characterize the global physician community’s opinion regarding immunity pass ... Cite

The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.

Journal Article Depress Anxiety · February 2021 OBJECTIVES: To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treatin ... Full text Link to item Cite

Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression.

Journal Article Brain Commun · 2021 Metabolomics in the Alzheimer's Disease Neuroimaging Initiative cohort provides a powerful tool for mapping biochemical changes in Alzheimer's disease, and a unique opportunity to learn about the association between circulating blood metabolites and brain ... Full text Link to item Cite

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.

Journal Article Cell Rep Med · November 17, 2020 Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes and identify genes in the alternative bile ... Full text Link to item Cite

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.

Journal Article Mol Neurodegener · October 8, 2020 BACKGROUND: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a centr ... Full text Link to item Cite

Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers.

Journal Article Neurology · May 19, 2020 OBJECTIVE: To investigate the association of triglyceride (TG) principal component scores with Alzheimer disease (AD) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (A/T/N/V) biomarkers for AD. METHODS: Serum levels of 84 TG species w ... Full text Link to item Cite

Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.

Journal Article Nat Commun · March 2, 2020 Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group- ... Full text Link to item Cite

Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.

Journal Article J Am Geriatr Soc · March 2020 OBJECTIVES: To evaluate the longer term changes in executive functioning among participants with cardiovascular disease (CVD) risk factors and cognitive impairments with no dementia (CIND) randomized to a diet and exercise intervention. DESIGN: A 2 (Exerci ... Full text Link to item Cite

Artificial intelligence and the future of psychiatry: Insights from a global physician survey.

Journal Article Artif Intell Med · January 2020 BACKGROUND: Futurists have predicted that new autonomous technologies, embedded with artificial intelligence (AI) and machine learning (ML), will lead to substantial job losses in many sectors disrupting many aspects of healthcare. Mental health appears ri ... Full text Link to item Cite

Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting.

Journal Article J Prev Alzheimers Dis · 2020 Emerging digital tools have the potential to enable a new generation of qualitative and quantitative assessment of cognitive performance. Moreover, the ubiquity of consumer electronics, such as smartphones and tablets, can be harnessed to support large-sca ... Full text Link to item Cite

Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies.

Journal Article J Prev Alzheimers Dis · 2020 Disease-modifying pharmacotherapies for Alzheimer's Disease (AD) are currently in late-stage clinical development; once approved, new healthcare infrastructures and services, including primary healthcare, will be necessary to accommodate a huge demand for ... Full text Link to item Cite

Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Previous studies have demonstrated that aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet can improve neurocognition. However, the mechanisms by which lifestyle improves neurocognition have not been widely studie ... Full text Link to item Cite

Computerized Cognitive Training by Healthy Older and Younger Adults: Age Comparisons of Overall Efficacy and Selective Effects on Cognition.

Journal Article Front Neurol · 2020 Among the non-pharmacological methods under development for maintaining cognitive function across the lifespan is computerized cognitive training (CCT). There has been considerable interest in using CCT to slow or remediate age-related cognitive decline, b ... Full text Link to item Cite

Digital Medicine

Journal Article SCIENTIFIC AMERICAN · 2020 Cite

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.

Journal Article Sci Rep · October 10, 2019 Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set e ... Full text Link to item Cite

Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers.

Journal Article JAMA Netw Open · July 3, 2019 IMPORTANCE: Increasing evidence suggests an important role of liver function in the pathophysiology of Alzheimer disease (AD). The liver is a major metabolic hub; therefore, investigating the association of liver function with AD, cognition, neuroimaging, ... Full text Open Access Link to item Cite

Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Journal Article J Neurol · July 2019 Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in ... Full text Link to item Cite

Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.

Journal Article Mol Neurobiol · July 2019 We investigated the association between amyloid-β deposition and white matter (WM) integrity as a determinant of brain glucose hypometabolism across the Alzheimer's disease (AD) spectrum. We assessed ninety-six subjects (27 cognitively normal, 49 mild cogn ... Full text Link to item Cite

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia.

Journal Article Brain · June 1, 2019 The advent of tau-targeted PET tracers such as flortaucipir (18F) (flortaucipir, also known as 18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of development of tau in relationship to age, amyloid-β, and to the development of cog ... Full text Link to item Cite

A blood-based signature of cerebrospinal fluid Aβ1-42 status.

Journal Article Sci Rep · March 11, 2019 It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of ... Full text Link to item Cite

Type 2 diabetes mellitus, brain atrophy, and cognitive decline.

Journal Article Neurology · February 19, 2019 OBJECTIVE: To study longitudinal relationships between type 2 diabetes mellitus (T2DM), cortical thickness, and cognitive function in older people with normal cognition, mild cognitive impairment, and Alzheimer disease (AD). METHODS: The sample was derived ... Full text Link to item Cite

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Journal Article Alzheimers Dement · February 2019 INTRODUCTION: Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests gut microbiota influence pathological features of Alzheimer's disease (AD) including neuroinflammatio ... Full text Link to item Cite

Differential food intake and food choice by depression and body mass index levels following a mood manipulation in a buffet-style setting.

Journal Article J Health Psychol · February 2019 While eating in response to emotional cues is associated with intake of unhealthy foods, less is known about the extent to which obesity and depression may differentially influence food intake in a buffet-style setting where low- and high-calorie foods are ... Full text Link to item Cite

Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.

Journal Article Neurology · January 15, 2019 OBJECTIVE: To determine the independent and additive effects of aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet on executive functioning in adults with cognitive impairments with no dementia (CIND) and risk factors for car ... Full text Link to item Cite

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.

Journal Article Alzheimers Dement · January 2019 INTRODUCTION: Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism and clearance, are produced i ... Full text Open Access Link to item Cite

Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease.

Journal Article Comput Math Methods Med · 2019 BACKGROUND: Alzheimer's disease (AD) is a major public health concern, and there is an urgent need to better understand its complex biology and develop effective therapies. AD progression can be tracked in patients through validated imaging and spinal flui ... Full text Link to item Cite

Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.

Journal Article J Alzheimers Dis · 2019 BACKGROUND: Greater body weight has been associated impairments in neurocognition and greater dementia risk, although the mechanisms linking weight and neurocognition have yet to be adequately delineated. OBJECTIVE: To examine metabolic mechanisms underlyi ... Full text Link to item Cite

Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.

Journal Article PLoS One · 2019 INTRODUCTION: Previous studies evaluating the association between clinically diagnosed Alzheimer's disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is highe ... Full text Link to item Cite

Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition.

Journal Article J Prev Alzheimers Dis · 2019 BACKGROUND: There is a need to more fully characterize financial capacity losses in the preclinical and prodromal stages of Alzheimer's disease (AD) and their pathological substrates. OBJECTIVES: To test the association between financial skills and cortica ... Full text Link to item Cite

Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.

Journal Article Int J Geriatr Psychiatry · December 2018 OBJECTIVE: The classification of mild cognitive impairment (MCI) continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Older adults presenting with both a depressive disorder (DEP) and cognitive impairmen ... Full text Link to item Cite

Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial.

Journal Article Am J Geriatr Psychiatry · October 2018 OBJECTIVE: Depression and cognitive impairment are often comorbid in older adults, but optimal treatment strategies remain unclear. In a two-site study, the efficacy and safety of add-on donepezil versus placebo were compared in depressed patients with cog ... Full text Link to item Cite

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.

Journal Article Sci Rep · May 10, 2018 Sex differences in Alzheimer's disease (AD) biology and progression are not yet fully characterized. The goal of this study is to examine the effect of sex on cognitive progression in subjects with high likelihood of mild cognitive impairment (MCI) due to ... Full text Link to item Cite

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images.

Journal Article Sci Rep · April 9, 2018 Alzheimer's Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism image ... Full text Link to item Cite

Change in Sense of Nondual Awareness and Spiritual Awakening in Response to a Multidimensional Well-Being Program.

Journal Article J Altern Complement Med · April 2018 OBJECTIVE: This study examined the effects of a comprehensive mind-body program on sense of nondual awareness and spiritual awakening. DESIGN AND INTERVENTION: The study compared the effects of participation in an intensive 6-day Ayurveda-based mind-body p ... Full text Link to item Cite

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Journal Article Anesthesiology · April 2018 BackgroundAmyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in thos ... Full text Cite

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states.

Journal Article Sci Rep · March 7, 2018 Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the sha ... Full text Link to item Cite

No calorie comfort: Viewing and drawing "comfort foods" similarly augment positive mood for those with depression.

Journal Article J Health Psychol · March 2018 Based on behavioral and neurobiological data, we tested the hypothesis that viewing/drawing visual images of comfort foods in the absence of eating will increase positive mood and that this effect is augmented for those with clinical symptoms of depression ... Full text Link to item Cite

Therapeutic Strategies in Depression with Cognitive Impairment

Conference The American Journal of Geriatric Psychiatry · March 2018 Full text Cite

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.

Journal Article PLoS Med · January 2018 BACKGROUND: The metabolic basis of Alzheimer disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD pathogenesis are unclear. Understanding how global perturbations in metabolism are related to severity ... Full text Link to item Cite

Mobile and pervasive computing technologies and the future of Alzheimer's clinical trials.

Journal Article NPJ Digit Med · 2018 The rapid growth of mobile phones, automated speech recognizing personal assistants, and internet access among the elderly provides new opportunities for incorporating such technologies into clinical research and personalized medical care. Alzheimer's dise ... Full text Link to item Cite

Detecting neurodegenerative disorders from web search signals.

Journal Article NPJ Digit Med · 2018 Neurodegenerative disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD), are important public health problems warranting early detection. We trained machine-learned classifiers on the longitudinal search logs of 31,321,773 search engine ... Full text Link to item Cite

Metabolic network failures in Alzheimer's disease: A biochemical road map.

Journal Article Alzheimers Dement · September 2017 INTRODUCTION: The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, and nonprofit organizations to develop new research directions to transform our understanding of Alzheimer's disease (AD) and propel the d ... Full text Link to item Cite

Characterizing gene and protein crosstalks in subjects at risk of developing Alzheimer's disease: A new computational approach

Journal Article Processes · September 1, 2017 Alzheimer's disease (AD) is a major public health threat; however, despite decades of research, the disease mechanisms are not completely understood, and there is a significant dearth of predictive biomarkers. The availability of systems biology approaches ... Full text Cite

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features.

Journal Article Sci Rep · August 15, 2017 The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, pr ... Full text Link to item Cite

Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease.

Journal Article Sci Rep · July 28, 2017 The heterogeneity of Alzheimer's disease contributes to the high failure rate of prior clinical trials. We analyzed 5-year longitudinal outcomes and biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (ADNI) usin ... Full text Link to item Cite

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.

Journal Article JAMA Neurol · May 1, 2017 IMPORTANCE: Existing cerebrospinal fluid (CSF) or imaging (tau positron emission tomography) biomarkers for Alzheimer disease (AD) are invasive or expensive. Biomarkers based on standard blood test results would be useful in research, drug development, and ... Full text Link to item Cite

Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment.

Journal Article J Alzheimers Dis · 2017 BACKGROUND: Prior studies have noted gender differences in cognition, imaging, and pathological markers in mild cognitive impairment (MCI) subjects. Sex hormone-binding globulin (SHBG), a major controlling factor in the proportion of bioavailable versus bo ... Full text Link to item Cite

Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.

Journal Article Psychosom Med · 2017 OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 ... Full text Link to item Cite

Single-nucleotide polymorphisms are associated with cognitive decline at Alzheimer's disease conversion within mild cognitive impairment patients.

Journal Article Alzheimers Dement (Amst) · 2017 INTRODUCTION: The growing public threat of Alzheimer's disease (AD) has raised the urgency to quantify the degree of cognitive decline during the conversion process of mild cognitive impairment (MCI) to AD and its underlying genetic pathway. The aim of thi ... Full text Link to item Cite

Effectiveness of Florbetapir PET Imaging in Changing Patient Management.

Journal Article Dement Geriatr Cogn Disord · 2017 AIMS: To evaluate the impact of amyloid PET imaging on diagnosis and patient management in a multicenter, randomized, controlled study. METHODS: Physicians identified patients seeking a diagnosis for mild cognitive impairment or dementia, possibly due to A ... Full text Link to item Cite

Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).

Journal Article Sci Rep · September 9, 2016 The effects of integrative medicine practices such as meditation and Ayurveda on human physiology are not fully understood. The aim of this study was to identify altered metabolomic profiles following an Ayurveda-based intervention. In the experimental gro ... Full text Link to item Cite

The Self-Directed Biological Transformation Initiative and Well-Being.

Journal Article J Altern Complement Med · August 2016 OBJECTIVE: To examine the effects of a comprehensive residential mind-body program on well-being. DESIGN: The Self-Directed Biological Transformation Initiative was a quasi-randomized trial comparing the effects of participation in a 6-day Ayurvedic system ... Full text Link to item Cite

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.

Journal Article Nat Commun · June 21, 2016 Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structura ... Full text Link to item Cite

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

Journal Article JAMA Neurol · June 1, 2016 IMPORTANCE: The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of br ... Full text Link to item Cite

Accelerating stem cell trials for Alzheimer's disease.

Journal Article Lancet Neurol · February 2016 At present, no effective cure or prophylaxis exists for Alzheimer's disease. Symptomatic treatments are modestly effective and offer only temporary benefit. Advances in induced pluripotent stem cell (iPSC) technology have the potential to enable developmen ... Full text Open Access Link to item Cite

Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.

Journal Article J Alzheimers Dis · 2016 Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer's disease (AD) and o ... Full text Link to item Cite

Computerized cognitive training and functional recovery in major depressive disorder: A meta-analysis.

Journal Article J Affect Disord · January 1, 2016 OBJECTIVE: Depression is common, frequently resistant to antidepressant treatment, and associated with impairments in cognition and everyday functioning. Computerized cognitive training (CCT) paradigms offer potential to improve cognition, mood and everyda ... Full text Link to item Cite

Knowledge-guided maximal clique enumeration

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2016 Maximal clique enumeration is a long-standing problem in graph mining and knowledge discovery. Numerous classic algorithms exist for solving this problem. However, these algorithms focus on enumerating all maximal cliques, which may be computationally impr ... Full text Cite

A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings.

Journal Article Alzheimers Dement (Amst) · December 2015 INTRODUCTION: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (A ... Full text Link to item Cite

Marked gender differences in progression of mild cognitive impairment over 8 years.

Journal Article Alzheimers Dement (N Y) · September 1, 2015 INTRODUCTION: This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. METHODS: We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Al ... Full text Link to item Cite

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.

Journal Article Nat Commun · May 19, 2015 Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal ... Full text Link to item Cite

Eat now or later: self-control as an overlapping cognitive mechanism of depression and obesity.

Journal Article PLoS One · 2015 While overlapping neurobiological mechanisms are known, relatively little is known about how "self-control" and cognitive affective processing of rewards may also influence the bi-directional risk between obesity and depression. The objective of this study ... Full text Link to item Cite

Predicting Alzheimer's Disease Using Combined Imaging-Whole Genome SNP Data.

Journal Article J Alzheimers Dis · 2015 The growing public threat of Alzheimer's disease (AD) has raised the urgency to discover and validate prognostic biomarkers in order to predicting time to onset of AD. It is anticipated that both whole genome single nucleotide polymorphism (SNP) data and h ... Full text Link to item Cite

Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE.

Journal Article Front Neurosci · 2015 Traumatic brain injury (TBI) has been increasingly accepted as a major external risk factor for neurodegenerative morbidity and mortality. Recent evidence indicates that the resultant chronic neurobiological sequelae following head trauma may, at least in ... Full text Open Access Link to item Cite

Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort.

Journal Article J Neuroradiol · December 2014 INTRODUCTION: Subjects with higher cognitive reserve (CR) may be at a lower risk for Alzheimer's disease (AD), but the neural mechanisms underlying this are not known. Hippocampal volume loss is an early event in AD that triggers cognitive decline. MATERIA ... Full text Link to item Cite

Exercise to combat depression.

Journal Article JAMA · November 26, 2014 Full text Link to item Cite

The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.

Journal Article Radiology · October 2014 PURPOSE: To evaluate differences in the structural connectome among patients with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer disease (AD) and to determine associations between the structural connectome and cortical amyloid deposi ... Full text Link to item Cite

Comparison of brain structural variables, neuropsychological factors, and treatment outcome in early-onset versus late-onset late-life depression.

Journal Article Am J Geriatr Psychiatry · October 2014 OBJECTIVE: To compare differences in gray matter volumes, white matter and subcortical gray matter hyperintensities, neuropsychological factors, and treatment outcome between early- and late-onset late-life depressed (LLD) subjects. METHODS: We conducted a ... Full text Link to item Cite

Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study.

Journal Article Mol Psychiatry · September 2014 This study was designed to evaluate whether subjects with amyloid beta (Aβ) pathology, detected using florbetapir positron emission tomorgraphy (PET), demonstrated greater cognitive decline than subjects without Aβ pathology. Sixty-nine cognitively normal ... Full text Link to item Cite

Cognitive effects of pharmacotherapy for major depressive disorder: a systematic review.

Journal Article J Clin Psychiatry · August 2014 OBJECTIVE: Cognitive impairment frequently accompanies major depressive disorder (MDD) and can persist during remission. This review examined pharmacotherapy effects on cognitive function in MDD. DATA SOURCES: PubMed and EMBASE searches were conducted on J ... Full text Link to item Cite

Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.

Journal Article Neurocase · August 2014 ¹⁸F-florbetapir positron emission tomography (PET) imaging of the brain is now approved by the Food and Drug Administration (FDA) approved for estimation of β -amyloid neuritic plaque density when evaluating patients with cognitive impairment. However, its ... Full text Link to item Cite

Preimplantation genetic diagnosis for inherited neurological disorders.

Journal Article Nat Rev Neurol · July 2014 Preimplantation genetic diagnosis (PGD) is an option for couples at risk of having offspring with an inherited debilitating or fatal neurological disorder who wish to conceive a healthy child. PGD has been carried out for conditions with various modes of i ... Full text Link to item Cite

Comparative mortality risks of antipsychotic medications in community-dwelling older adults.

Journal Article Br J Psychiatry · July 2014 BACKGROUND: All antipsychotic medications carry warnings of increased mortality for older adults, but little is known about comparative mortality risks between individual agents. AIMS: To estimate the comparative mortality risks of commonly prescribed anti ... Full text Link to item Cite

Preimplantation genetic diagnosis (PGD) for genetic prion disorder due to F198S mutation in the PRNP gene.

Journal Article JAMA Neurol · April 2014 IMPORTANCE: To describe the first case of preimplantation genetic diagnosis (PGD) and in vitro fertilization (IVF) performed for the prevention of genetic prion disease in the children of a 27-year-old asymptomatic woman with a family history of Gerstmann- ... Full text Link to item Cite

Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.

Journal Article Radiology · April 2014 PURPOSE: To determine the effect of the apolipoprotein E (APOE) genotype on atrophy rates of specific brain gray matter regions hypothesized to be key components of cognitive networks disrupted in Alzheimer disease. MATERIALS AND METHODS: The Alzheimer's D ... Full text Link to item Cite

Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.

Journal Article Contemp Clin Trials · March 2014 Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depre ... Full text Link to item Cite

Cholinesterase inhibitors and Pisa syndrome: a pharmacovigilance study.

Journal Article Pharmacotherapy · March 2014 STUDY OBJECTIVES: Case reports suggest a relationship between cholinesterase inhibitors (ChEIs) and Pisa syndrome (PS), also known as pleurothotonus, a form of dystonia, but this relationship has not been systematically examined. Our objective was to estim ... Full text Link to item Cite

Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates.

Journal Article J Neuropathol Exp Neurol · January 2014 Neuropathologic heterogeneity is often present among Alzheimer disease (AD) patients. We sought to determine whether amyloid imaging measures of AD are affected by concurrent pathologies. Thirty-eight clinically and pathologically defined AD and 17 nondeme ... Full text Link to item Cite

Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.

Journal Article J Neuropathol Exp Neurol · January 2014 Tauopathies are degenerative diseases characterized by the accumulation of phosphorylated tau in neurons and glial cells. With some exceptions, tau deposits in neurons are mainly manifested as pretangles and tangles unrelated to the tauopathy. It is though ... Full text Link to item Cite

Brain atrophy rates in first degree relatives at risk for Alzheimer's.

Journal Article Neuroimage Clin · 2014 A positive family history (FH) raises the risk for late-onset Alzheimer's disease though, other than the known risk conferred by apolipoprotein ε4 (ApoE4), much of the genetic variance remains unexplained. We examined the effect of family history on longit ... Full text Link to item Cite

Social cognition in major depressive disorder: A new paradigm?

Journal Article Translational Neuroscience · December 1, 2013 Social cognition refers to the brain mechanisms by which we process social information about other humans and ourselves. Alterations in interpersonal and social functioning are common in major depressive disorder, though only poorly addressed by current ph ... Full text Cite

Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging.

Journal Article Alzheimers Dement · October 2013 OBJECTIVE: To evaluate the performance characteristics of florbetapir F18 positron emission tomography (PET) in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy control subjects (HCs). METHODS: Florbetapir PET was acquir ... Full text Link to item Cite

Cortical β-amyloid levels and neurocognitive performance after cardiac surgery.

Journal Article BMJ Open · September 20, 2013 INTRODUCTION: Neurological and neurocognitive dysfunction occurs frequently in the large number of increasingly elderly patients undergoing cardiac surgery every year. Perioperative cognitive deficits have been shown to persist after discharge and up to se ... Full text Open Access Link to item Cite

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth.

Journal Article Neuroimage · September 2013 BACKGROUND: Although it is well known that many clinical and genetic factors have been associated with beta-amyloid deposition, few studies have examined the interactions of such factors across different stages of Alzheimer's pathogenesis. METHODS: We used ... Full text Link to item Cite

Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack.

Journal Article Neuroimage Clin · August 7, 2013 Neuropsychiatric disorders such as schizophrenia, bipolar disorder and Alzheimer's disease are major public health problems. However, despite decades of research, we currently have no validated prognostic or diagnostic tests that can be applied at an indiv ... Full text Link to item Cite

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging.

Journal Article Acta Neuropathol Commun · June 27, 2013 BACKGROUND: A critical and as-yet unmet need in Alzheimer disease (AD) research is the development of novel markers that can identify individuals at risk for cognitive decline due to AD. This would aid intervention trials designed to slow the progression o ... Full text Link to item Cite

The largest human cognitive performance dataset reveals insights into the effects of lifestyle factors and aging

Journal Article Frontiers in Human Neuroscience · June 3, 2013 Making new breakthroughs in understanding the processes underlying human cognition may depend on the availability of very large datasets that have not historically existed in psychology and neuroscience. Lumosity is a web-based cognitive training platform ... Full text Cite

Alterations in metabolic pathways and networks in Alzheimer's disease.

Journal Article Transl Psychiatry · April 9, 2013 The pathogenic mechanisms of Alzheimer's disease (AD) remain largely unknown and clinical trials have not demonstrated significant benefit. Biochemical characterization of AD and its prodromal phase may provide new diagnostic and therapeutic insights. We u ... Full text Link to item Cite

Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.

Journal Article Neurobiol Aging · March 2013 The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 ((18)F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assesse ... Full text Link to item Cite

Alzheimer's disease: the importance of early diagnosis and appropriate management.

Journal Article J Clin Psychiatry · March 2013 Alzheimer's disease is a progressive neurodegenerative disorder that causes severe cognitive decline, functional disability, and eventually death. Although there is no cure for this illness, early diagnosis and treatment can reduce or delay cognitive and f ... Full text Link to item Cite

Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers.

Journal Article Radiology · February 2013 PURPOSE: To assess the extent to which multiple Alzheimer disease (AD) biomarkers improve the ability to predict future decline in subjects with mild cognitive impairment (MCI) compared with predictions based on clinical parameters alone. MATERIALS AND MET ... Full text Link to item Cite

A multidisciplinary approach to mind and consciousness

Journal Article NeuroQuantology · January 1, 2013 In the last 400 years physics has achieved great success, in theory and experimentation, determining the structure of matter and energy. The next great step in the evolution of science will be exploring the role of mind and consciousness in the universe, e ... Full text Cite

An empirical study on symptoms of heavier Internet usage among young adults

Journal Article 2013 IEEE International Conference on Advanced Networks and Telecommunications Systems, ANTS 2013 · January 1, 2013 Understanding negative consequences of heavy Internet use on mental health is a topic that is gaining significant traction recently. A number of studies have investigated heavy Internet usage, especially among young adults in relation to online games, soci ... Full text Cite

Dementia Clinical Research in India

Journal Article · January 1, 2013 There is considerable interest, both nationally and internationally, in conducting dementia research in India. Motivated by a rapid increase in the aging population and a desire for indigenous, self-sufficient healthcare and medical research, dementia rese ... Full text Cite

Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.

Journal Article Contemp Clin Trials · January 2013 BACKGROUND: Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. ... Full text Link to item Cite

What is the role of pharmacogenetics in clinical psychiatry?

Journal Article Expert Opin Drug Metab Toxicol · January 2013 Psychiatric disorders are a leading cause of disability worldwide and despite significant pharmacologic advances, often remain difficult to diagnose correctly and treat fully. Factors which contribute to these difficulties include imprecise understanding o ... Full text Link to item Cite

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease.

Journal Article Neurobiol Aging · January 2013 OBJECTIVES: Investigate apolipoprotein E ε4 (APOE4) gene and aging effects on florbetapir F18 positron emission tomography (PET) in normal aging and Alzheimer's disease (AD). METHODS: Florbetapir F18 PET images were analyzed from 245 participants, 18-92 ye ... Full text Link to item Cite

Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline.

Journal Article Alzheimer Dis Assoc Disord · 2013 Florbetapir F18 has been approved by the Food and Drug Administration for in vivo assessment of amyloid pathology in patients undergoing evaluation for Alzheimer disease (AD). The aim of this study was to determine the impact of amyloid imaging on the diag ... Full text Link to item Cite

Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

Journal Article PLoS One · 2013 OBJECTIVE: To investigate whether there is a specific dose-dependent effect of the Apolipoprotein E (APOE) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to Alzheimer's Disease (AD). MATERIALS AND METHODS: We anal ... Full text Link to item Cite

Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives.

Journal Article PLoS One · 2013 OBJECTIVE: A positive family history (FH) is a risk factor for late-onset Alzheimer's disease (AD). Our aim was to examine the effects of FH on pathological and neuronal loss biomarkers across the cognitive spectrum. DESIGN: Cross-sectional analyses of dat ... Full text Link to item Cite

The largest human cognitive performance dataset reveals insights into the effects of lifestyle factors and aging.

Journal Article Front Hum Neurosci · 2013 Making new breakthroughs in understanding the processes underlying human cognition may depend on the availability of very large datasets that have not historically existed in psychology and neuroscience. Lumosity is a web-based cognitive training platform ... Full text Link to item Cite

Treatment course with antidepressant therapy in late-life depression.

Journal Article Am J Psychiatry · November 2012 OBJECTIVE: In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Åsberg Depre ... Full text Link to item Cite

Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study.

Journal Article Neurology · October 16, 2012 OBJECTIVES: Florbetapir F 18 PET can image amyloid-β (Aβ) aggregates in the brains of living subjects. We prospectively evaluated the prognostic utility of detecting Aβ pathology using florbetapir PET in subjects at risk for progressive cognitive decline. ... Full text Link to item Cite

Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study.

Journal Article J Am Coll Cardiol · September 18, 2012 OBJECTIVES: The aim of this study was to assess the efficacy of exercise and antidepressant medication in reducing depressive symptoms and improving cardiovascular biomarkers in depressed patients with coronary heart disease. BACKGROUND: Although there is ... Full text Link to item Cite

Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: To test the hypothesis that the degree of vascular burden and/or age of onset may influence the degree to which cognition can improve during the course of treatment in late-life depression. DESIGN: Measurement of cognition both before and follo ... Full text Link to item Cite

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study.

Journal Article Lancet Neurol · August 2012 BACKGROUND: Results of previous studies have shown associations between PET imaging of amyloid plaques and amyloid-β pathology measured at autopsy. However, these studies were small and not designed to prospectively measure sensitivity or specificity of am ... Full text Link to item Cite

Is the idle mind a Devil's workshop?

Journal Article Biol Psychiatry · May 1, 2012 Full text Link to item Cite

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Journal Article Proc Natl Acad Sci U S A · March 6, 2012 Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors con ... Full text Link to item Cite

The ADNI Publication Policy: commensurate recognition of critical contributors who are not authors.

Journal Article Neuroimage · February 15, 2012 An efficient approach to certain types of biomedical research requires a scale that precludes involvement of all critical contributors in all aspects of experimental design, execution, and as well as writing of most, if not all, derived works. Guarantors o ... Full text Link to item Cite

Yoga on our minds: a systematic review of yoga for neuropsychiatric disorders.

Journal Article Front Psychiatry · 2012 BACKGROUND: The demand for clinically efficacious, safe, patient acceptable, and cost-effective forms of treatment for mental illness is growing. Several studies have demonstrated benefit from yoga in specific psychiatric symptoms and a general sense of we ... Full text Link to item Cite

How much is a picture worth? Putting amyloid imaging to the test.

Journal Article Dement Geriatr Cogn Dis Extra · January 2012 Full text Link to item Cite

Molecular PET imaging in multicenter Alzheimer's therapeutic trials: current trends and implementation strategies.

Journal Article Expert Rev Neurother · December 2011 Current therapeutic approaches for Alzheimer's disease (AD) have evolved to target specific molecular biological, metabolic and neuropathologic hallmarks of the disease. Since these approaches are hypothesized to be most effective at the earliest stages of ... Full text Link to item Cite

Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease.

Journal Article Arch Neurol · November 2011 OBJECTIVES: To characterize quantitative florbetapir F 18 (hereafter referred to as simply florbetapir) positron emission tomographic (PET) measurements of fibrillar β-amyloid (Aβ) burden in a large clinical cohort of participants with probable Alzheimer d ... Full text Link to item Cite

Delivering happiness: translating positive psychology intervention research for treating major and minor depressive disorders.

Journal Article J Altern Complement Med · August 2011 Despite the availability of many treatment options, depressive disorders remain a global public health problem. Even in affluent nations, 70% of reported cases either do not receive the recommended level of treatment or do not get treated at all, and this ... Full text Link to item Cite

Review of the use of mirtazapine in the treatment of depression.

Journal Article Expert Opin Pharmacother · July 2011 INTRODUCTION: Depression is a heterogeneous illness affecting large numbers of patients with far reaching effects on both psychiatric and medical outcomes as well as quality of life. Knowledge about the different treatment modalities used to treat depressi ... Full text Link to item Cite

Metabolomic changes in autopsy-confirmed Alzheimer's disease.

Journal Article Alzheimers Dement · May 2011 BACKGROUND: Metabolomics, the global science of biochemistry, provides powerful tools to map perturbations in the metabolic network and enables simultaneous quantification of several metabolites to identify metabolic perturbances that might provide insight ... Full text Link to item Cite

Default mode network connectivity in stable vs progressive mild cognitive impairment.

Journal Article Neurology · February 8, 2011 OBJECTIVE: Dysfunction of the default mode network (DMN) has been identified in prior cross-sectional fMRI studies of Alzheimer disease (AD) and mild cognitive impairment (MCI); however, no studies have examined its utility in predicting future cognitive d ... Full text Link to item Cite

Use of florbetapir-PET for imaging beta-amyloid pathology.

Journal Article JAMA · January 19, 2011 CONTEXT: The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease. OBJECTIVE: To determine if florbetapir F 18 positron emission tomographic (PET) imaging performed during life accurately ... Full text Link to item Cite

One-year change in anterior cingulate cortex white matter microstructure: relationship with late-life depression outcomes.

Journal Article Am J Geriatr Psychiatry · January 2011 OBJECTIVE: differences in white matter structure measured with diffusion tensor imaging (DTI) are associated with late-life depression, but results examining how these differences relate to antidepressant remission are mixed. To better describe these relat ... Full text Link to item Cite

Exercise and pharmacotherapy in patients with major depression: one-year follow-up of the SMILE study.

Journal Article Psychosom Med · 2011 OBJECTIVE: To examine a 1-year follow-up of a 4-month, controlled clinical trial of exercise and antidepressant medication in patients with major depressive disorder (MDD). METHODS: In the original study, 202 sedentary adults with MDD were randomized to: a ... Full text Link to item Cite

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.

Journal Article PLoS One · 2011 BACKGROUND: The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and ... Full text Link to item Cite

The effect of vascular risk factors on the efficacy of rivastigmine patch and capsule treatment in Alzheimer's disease.

Journal Article Dement Geriatr Cogn Dis Extra · January 2011 BACKGROUND: Vascular risk factors (VRF) may influence response to rivastigmine in Alzheimer's disease (AD). METHODS: AD patients who participated in a randomized, double-blind, placebo-controlled trial of rivastigmine patch and capsule treatment were strat ... Full text Link to item Cite

e-Interview

Journal Article Psychiatrist · December 1, 2010 Full text Cite

Cerebrovascular risk factors and cerebral hyperintensities among middle-aged and older adults with major depression.

Journal Article Am J Geriatr Psychiatry · September 2010 OBJECTIVES: To examine the association between cerebral hyperintensities and cerebrovascular risk factors (CVRF) among middle-aged and older adults with major depressive disorder (MDD). METHODS: Thirty patients (aged 55-77 years) with MDD and no history of ... Full text Link to item Cite

Diagnostic utility of the Quick Inventory of Depressive Symptomatology (QIDS-C16 and QIDS-SR16) in the elderly.

Journal Article Acta Psychiatr Scand · September 2010 OBJECTIVE: To evaluate psychometric properties and comparability ability of the Montgomery-Asberg Depression Rating Scale (MADRS) vs. the Quick Inventory of Depressive Symptomatology-Clinician-rated (QIDS-C(16)) and Self-report (QIDS-SR(16)) scales to dete ... Full text Link to item Cite

Disruption of Functional Brain Connections in Alzheimer's Disease

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2010 Link to item Cite

Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

Journal Article Arch Gen Psychiatry · March 2010 CONTEXT: Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity. OBJECTIVE: To evaluate the relationship of neuropsychological performance and white matt ... Full text Link to item Cite

Cardiovascular disease risk, vascular health and erectile dysfunction among middle-aged, clinically depressed men.

Journal Article Int J Impot Res · 2010 Erectile dysfunction (ED) is especially common in men with major depressive disorder (MDD). This study examined the extent to which risk factors for cardiovascular disease (CVD) and vascular endothelial dysfunction were associated with ED severity in MDD p ... Full text Link to item Cite

Are we using relevant models of dementia?

Journal Article EUROPEAN JOURNAL OF NEUROLOGY · October 1, 2009 Link to item Cite

Effects of aerobic exercise on sexual functioning in depressed adults

Journal Article Mental Health and Physical Activity · June 1, 2009 Objective: Exercise appears to be generally comparable to antidepressant medication in reducing depressive symptoms. The current study examines the effects of aerobic exercise, compared to antidepressant medication and placebo pill, on sexual function amon ... Full text Cite

Intima-media thickness and age of first depressive episode.

Journal Article Biol Psychol · March 2009 BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ... Full text Link to item Cite

Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging.

Journal Article AJNR Am J Neuroradiol · February 2009 BACKGROUND AND PURPOSE: Cholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine t ... Full text Link to item Cite

Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study.

Journal Article Am J Geriatr Psychiatry · January 2009 OBJECTIVE: Functional deactivation of the posteromedial cortex (PMC) seems to be a physiologic process underlying normal memory. The authors examined whether older subjects with subsyndromal depressive symptoms show impaired PMC deactivation. DESIGN: Subje ... Full text Link to item Cite

Atypical antipsychotic drugs and diabetes mellitus in the US Food and Drug Administration Adverse Event database: a systematic Bayesian signal detection analysis.

Journal Article Psychopharmacol Bull · 2009 BACKGROUND: Prior literature suggests that the risk of diabetes-related adverse events (DRAEs) differs between atypical antipsychotics. The present study evaluated the potential association between atypical antipsychotics or haloperidol and diabetes using ... Link to item Cite

Frontal white matter anisotropy and antidepressant remission in late-life depression.

Journal Article PLoS One · September 24, 2008 INTRODUCTION: Neuroanatomic features associated with antidepressant treatment outcomes in older depressed individuals are not well established. This study used diffusion tensor imaging to examine frontal white matter structure in depressed subjects undergo ... Full text Link to item Cite

Exercise fails to improve neurocognition in depressed middle-aged and older adults.

Journal Article Med Sci Sports Exerc · July 2008 PURPOSE: Although cross-sectional studies have demonstrated an association between higher levels of aerobic fitness and improved neurocognitive function, there have been relatively few interventional studies investigating this relationship, and results hav ... Full text Link to item Cite

Modulation of Human Memory Circuit by Minor Depression in Late Life: An fMRI Study

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

Response to letters to the editor [3]

Journal Article Psychosomatic Medicine · February 1, 2008 Full text Cite

Imaging genetics of brain longevity and mental wellness: the next frontier?

Journal Article Radiology · January 2008 The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great inte ... Full text Link to item Cite

Prolactin-related and metabolic adverse effects of atypical antipsychotic agents.

Journal Article J Clin Psychiatry · 2008 While there are many effective antipsychotics available to clinicians for treating schizophrenia or bipolar mania, the onset of antipsychotic-associated prolactin-related and metabolic adverse effects can diminish the effectiveness of treatment. Increased ... Link to item Cite

Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve.

Journal Article Neurobiol Aging · November 2007 Major predictors of Alzheimer's disease (AD) include apolipoprotein E (APOE)-epsilon4, hippocampal atrophy on magnetic resonance imaging (MRI), and memory dysfunction prior to diagnosis. We examined 159 normal elderly subjects with MRI and the California V ... Full text Link to item Cite

Prognostic value of posteromedial cortex deactivation in mild cognitive impairment.

Journal Article PLoS One · October 31, 2007 BACKGROUND: Normal subjects deactivate specific brain regions, notably the posteromedial cortex (PMC), during many tasks. Recent cross-sectional functional magnetic resonance imaging (fMRI) data suggests that deactivation during memory tasks is impaired in ... Full text Link to item Cite

Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.

Journal Article Radiology · October 2007 PURPOSE: To prospectively identify brain regions in which task-related changes in activation during a memory encoding task, measured with functional magnetic resonance (MR) imaging, correlate with degree of memory impairment across Alzheimer disease (AD), ... Full text Link to item Cite

Metabolomic mapping of atypical antipsychotic effects in schizophrenia.

Journal Article Mol Psychiatry · October 2007 Schizophrenia is associated with impairments in neurotransmitter systems and changes in neuronal membrane phospholipids. Several atypical antipsychotic drugs induce weight gain and hypertriglyceridemia. To date, there has not been a comprehensive evaluatio ... Full text Link to item Cite

Does Meditation Enhance Cognition and Brain Longevity?

Journal Article Ann N Y Acad Sci · September 28, 2007 Meditation practices have various health benefits including the possibility of preserving cognition and preventing dementia. While the mechanisms remain investigational, studies show that meditation may affect multiple pathways that could play a role in br ... Full text Link to item Cite

Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment.

Journal Article AJR Am J Roentgenol · May 2007 OBJECTIVE: The purpose of this study was to examine the diagnostic efficacy of hippocampal volumetry and the Mini-Mental State Examination (MMSE) in differentiating amnestic mild cognitive impairment from the normal changes of aging. SUBJECTS AND METHODS: ... Full text Link to item Cite

PET scanning in mild cognitive impairment.

Journal Article N Engl J Med · March 15, 2007 Full text Link to item Cite

Effect of bupropion extended release on negative emotion processing in major depressive disorder: a pilot functional magnetic resonance imaging study.

Journal Article J Clin Psychiatry · February 2007 BACKGROUND: Prior imaging studies suggest that patients with major depressive disorder have abnormalities in frontal and limbic neural circuitry including the amygdala, which is relatively more activated at rest and in response to negative emotional stimul ... Full text Link to item Cite

Exercise and pharmacotherapy in the treatment of major depressive disorder.

Journal Article Psychosom Med · 2007 OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in dep ... Full text Link to item Cite

Understanding prognostic benefits of exercise and antidepressant therapy for persons with depression and heart disease: the UPBEAT study--rationale, design, and methodological issues.

Journal Article Clin Trials · 2007 BACKGROUND: Depression is relatively common in patients with coronary heart disease (CHD) and is associated with worse prognosis. Recently there has been interest in evaluating the impact of treating depression on clinical outcomes. Anti-depressant medicat ... Full text Link to item Cite

Cerebrovascular risk factors, vascular disease, and neuropsychological outcomes in adults with major depression.

Journal Article Psychosom Med · 2007 OBJECTIVE: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depre ... Full text Link to item Cite

Effect of mirtazapine orally disintegrating tablets on health-related quality of life in elderly depressed patients with comorbid medical disorders: a pilot study.

Journal Article Psychopharmacol Bull · 2007 BACKGROUND: There is a need for additional studies on the quality of life (QOL) of elderly depressed subjects with medical comorbidity. METHOD: We conducted a 10-week, open trial of mirtazapine orally disintegrating tablets in 16 elderly subjects with majo ... Link to item Cite

Atypical antipsychotics and pituitary neoplasms in the WHO database.

Journal Article Psychopharmacol Bull · 2007 Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia. Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice. To investi ... Link to item Cite

Coenzyme Q10: a review of its promise as a neuroprotectant.

Journal Article CNS Spectr · January 2007 Coenzyme Q10 (CoQ10) is a powerful antioxidant that buffers the potential adverse consequences of free radicals produced during oxidative phosphorylation in the inner mitochondrial membrane. Oxidative stress, resulting in glutathione loss and oxidative DNA ... Full text Link to item Cite

Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study.

Journal Article J Child Adolesc Psychopharmacol · December 2006 Individuals with Down syndrome (DS) exhibit a cholinergic deficiency similar to that found in Alzheimer's disease. Cholinesterase inhibitors, used to treat Alzheimer's disease, may improve cognitive function in individuals with DS. This is the first invest ... Full text Link to item Cite

Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.

Journal Article AJNR Am J Neuroradiol · September 2006 BACKGROUND AND PURPOSE: Functional MR imaging has been used to study patterns of hippocampal activation that distinguish pathologic from normal memory loss in the elderly population. Our objective was to assess whether hippocampal atrophy confounds measure ... Link to item Cite

Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.

Journal Article Neurobiol Aging · August 2006 We previously reported a linkage region on chromosome 10q for age-at-onset (AAO) of Alzheimer (AD) and Parkinson (PD) diseases. Glutathione S-transferase, omega-1 (GSTO1) and the adjacent gene GSTO2, located in this linkage region, were then reported to as ... Full text Link to item Cite

Mild cognitive impairment: evaluation with 4-T functional MR imaging.

Journal Article Radiology · July 2006 PURPOSE: To prospectively assess abnormalities in brain activation patterns during encoding and retrieval in subjects with mild cognitive impairment by using 4-T functional magnetic resonance (MR) imaging. MATERIALS AND METHODS: The institutional review bo ... Full text Link to item Cite

Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis.

Journal Article Neurogenetics · July 2006 Previous linkage studies have suggested that chromosome 12 may harbor susceptibility genes for late-onset Alzheimer disease (LOAD). No risk genes on chromosome 12 have been conclusively identified yet. We have reported that the linkage evidence for LOAD in ... Full text Link to item Cite

Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed.

Journal Article Biol Psychiatry · July 1, 2006 BACKGROUND: A number of studies have examined clinical factors linked to worse neuropsychological performance in late life depression (LLD). To understand the influence of LLD on cognition, it is important to determine if deficits in a number of cognitive ... Full text Link to item Cite

Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders.

Journal Article Neuroimage · June 2006 Functional magnetic resonance imaging (fMRI) studies in memory impairment have detected functional alterations in medial temporal lobe (MTL) structures, notably the hippocampus. Many of these studies employ spatial normalization to place subjects in a stan ... Full text Link to item Cite

Atypical antipsychotics and pituitary tumors: a pharmacovigilance study.

Journal Article Pharmacotherapy · June 2006 STUDY OBJECTIVE: To analyze the disproportionality of reporting of hyperprolactinemia, galactorrhea, and pituitary tumors with seven widely used antipsychotic drugs. DESIGN: Retrospective pharmacovigilance study. DATA SOURCE: United States Food and Drug Ad ... Full text Link to item Cite

Lack of association between UBQLN1 and Alzheimer disease.

Journal Article Am J Med Genet B Neuropsychiatr Genet · April 5, 2006 Alzheimer disease (AD) is heterogeneous and complex with a strong genetic diathesis. It is the most common cause of dementia affecting the elderly. Linkage studies [Kehoe et al., 1999; Hum Mol Genet 8: 237-245]; [Pericak-Vance et al., 2000; Exp Gerontol 35 ... Full text Link to item Cite

Elevation in plasma Abeta42 in geriatric depression: a pilot study.

Journal Article Neurochem Res · March 2006 Elevated plasma amyloid beta 1-42 (Abeta42) level has been linked to increased risk for incident AD in cognitively-intact elderly. However, plasma Abeta levels in individuals with late-life depression (LLMD), especially those with a late age of onset of fi ... Full text Link to item Cite

A randomized controlled trial of paroxetine for noncardiac chest pain.

Journal Article Psychopharmacol Bull · 2006 Noncardiac chest pain occurs frequently in medical practice and is often difficult to treat. We conducted a randomized double-blind, placebo-controlled, 8-week trial of paroxetine in 50 patients with noncardiac chest pain. None of the patients met criteria ... Link to item Cite

What constitutes clinical evidence for neuroprotection in Alzheimer disease: support for the cholinesterase inhibitors?

Journal Article Alzheimer Dis Assoc Disord · 2006 The progression of Alzheimer disease (AD) corresponds to a prolonged course of neuronal loss in the cerebral cortex. Strategies aimed at reducing the rates of neuronal loss are therefore particularly important. The clinical measures to evaluate the disease ... Full text Link to item Cite

Increased pituitary volume in ...psychosis study.

Journal Article Neuropsychopharmacology · January 2006 Full text Link to item Cite

Pharmacological strategies for the prevention of Alzheimer's disease.

Journal Article Expert Opin Pharmacother · January 2006 This review examines key pharmacological strategies that have been clinically studied for the primary or secondary prevention of Alzheimer's disease. Much information (neuropsychological, genetic and imaging) is already available to characterise an individ ... Full text Link to item Cite

Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research.

Journal Article Neuroimaging Clin N Am · November 2005 Advanced MR techniques, such as functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging, offer the capability of detecting early functional, hemodynamic, and microstructural alterations in Alzheimer's disease before gross anatomic a ... Full text Link to item Cite

A review of 1H MR spectroscopy findings in Alzheimer's disease.

Journal Article Neuroimaging Clin N Am · November 2005 Hydrogen-1 MR spectroscopy (MRS) studies demonstrate metabolic differences between patients who have Alzheimer's disease (AD) and cognitive normal age-matched controls. Clinical MRS also shows regional variations in metabolites between patients who have AD ... Full text Link to item Cite

Alzheimer's disease: 100 Years of progress

Journal Article Neuroimaging Clinics of North America · November 1, 2005 Full text Cite

Statins and cognition: what can we learn from existing randomized trials?

Journal Article CNS Spectr · November 2005 BACKGROUND: Statins are being developed as treatments for Alzheimer's dementia based on evidence from preclinical and observational studies. However, cholesterol plays an integral role in cell membrane signal transduction and suboptimal cholesterol level c ... Full text Link to item Cite

Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not?

Journal Article Geriatrics · June 2005 Although FDA-approved Alzheimer's disease (AD) treatment strategies (cholinesterase inhibitors and memantine) offer proven benefits, providers recognize unmet needs beyond what is currently available. Consequently there is a significant use of anecdotal ye ... Link to item Cite

Elevated plasma A beta(1-42) in geriatric depression

Conference BIOLOGICAL PSYCHIATRY · April 15, 2005 Link to item Cite

Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?

Journal Article Prim Care Companion J Clin Psychiatry · 2005 Background: The objective of this study was to compare the performance of the Mini-Mental State Examination (MMSE) total score as well as item scores in separating 4 groups of elderly (55-85 years of age) subjects-normal controls, subjects with mild cognit ... Full text Link to item Cite

Increasing memory load modulates regional brain activity in older adults as measured by fMRI.

Journal Article J Neuropsychiatry Clin Neurosci · 2005 Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and ne ... Full text Link to item Cite

Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly.

Journal Article Neurochem Res · December 2004 The GABA system is an active target for drugs to treat a variety of disorders and the availability of an indirect measure of central GABA activity would not only enhance psychiatric research, but also permit assessment of the pharmacodynamic effects of dru ... Full text Link to item Cite

A systematic review of antidepressant placebo-controlled trials for geriatric depression: limitations of current data and directions for the future.

Journal Article Neuropsychopharmacology · December 2004 Depression in the elderly is a major public health problem as untreated depression adversely impacts comorbid illnesses. It is important to develop safe and effective antidepressant therapies for older individuals. We performed a systematic review of all p ... Full text Link to item Cite

Plasma amyloid beta 1-42 levels in geriatric depression: A pilot study

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2004 Link to item Cite

Cognitive deficits following coronary artery bypass grafting: prevalence, prognosis, and therapeutic strategies.

Journal Article CNS Spectr · October 2004 There is increasing recognition that coronary artery bypass grafting (CABG) may be a risk factor for subtle cognitive decline although the presence and pattern of such decline has varied across studies. Cognitive deficits may present as short-term memory l ... Full text Link to item Cite

Pharmacovigilance in the 21st century: new systematic tools for an old problem.

Journal Article Pharmacotherapy · September 2004 The large number of adverse-event reports generated by marketed drugs and devices argues for the application of validated computerized algorithms to supplement traditional methods of detecting adverse-event signals. Difficulties in accurately estimating pa ... Full text Link to item Cite

Analysis of European mitochondrial haplogroups with Alzheimer disease risk.

Journal Article Neurosci Lett · July 15, 2004 We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs). Logistic regression analyses were used to as ... Full text Link to item Cite

Marked increase in Alzheimer's disease identified in medicare claims records between 1991 and 1999.

Journal Article J Gerontol A Biol Sci Med Sci · July 2004 BACKGROUND: Epidemiologic evidence suggests that African Americans have higher rates of Alzheimer's disease (AD) than do whites. Examining longitudinal trends in the number of persons who are identified as having AD in administrative databases may provide ... Full text Link to item Cite

Metals in our minds: therapeutic implications for neurodegenerative disorders.

Journal Article Lancet Neurol · July 2004 BACKGROUND: Abnormal interactions of copper or iron in the brain with metal-binding proteins (such as amyloid-beta peptide [Abeta] or neuromelanin) that lead to oxidative stress have emerged as important potential mechanisms in brain ageing and neurodegene ... Full text Link to item Cite

A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus.

Journal Article J Clin Psychiatry · June 2004 OBJECTIVE: To explore the clinical characteristics of hyperglycemia in patients treated with quetiapine. METHOD: A pharmacovigilance survey of spontaneously reported adverse events in quetiapine-treated patients was conducted using reports from the U.S. Fo ... Full text Link to item Cite

In vivo amyloid imaging in Alzheimer's disease.

Journal Article Neuroradiology · February 2004 Targeted approaches to therapy for Alzheimer's disease have evolved based on detailed understanding of the genetic, molecular biologic, and neuropathologic basis of the disease. Given the potential for greater treatment efficacy in the earlier stages of th ... Full text Link to item Cite

Efficacy, safety, and tolerability of sertraline in patients with late-life depression and comorbid medical illness.

Journal Article J Am Geriatr Soc · January 2004 OBJECTIVES: To report on the efficacy, safety, and tolerability of sertraline in the treatment of elderly depres-sed patients with and without comorbid medical illness. SETTING: Multicenter. DESIGN: Randomized, double-blind, placebo-controlled study. PARTI ... Full text Link to item Cite

Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: a pilot observational study.

Journal Article Am J Alzheimers Dis Other Demen · 2004 Statins are investigational therapies for preventing or treating Alzheimer's disease (AD) and mild cognitive impairment (MCI). Hippocampal atrophy is a characteristic feature of MCI and AD. This study analyzed cross-sectional data from 246 nondemented elde ... Full text Link to item Cite

Does antidepressant therapy improve cognition in elderly depressed patients?

Journal Article J Gerontol A Biol Sci Med Sci · December 2003 OBJECTIVES: To analyze the effects of antidepressants on cognitive functioning in elderly depression. METHODS: Data were pooled for elderly participants with major depression from two double-blind 12-week studies (n = 444) comparing sertraline to fluoxetin ... Full text Link to item Cite

Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.

Journal Article Am J Psychiatry · November 2003 OBJECTIVE: The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer's disease. METHOD: In this randomized, double-blind, placebo-controlled pilot study, 67 patients with ... Full text Link to item Cite

The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential.

Journal Article Curr Neurol Neurosci Rep · September 2003 Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an unknown etiology. Pathologic processes implicated in AD include b-amyloid-induced synaptic failure; tau hyperphosphorylation; inflammation; oxidative stress; abnormal neurotransmi ... Full text Link to item Cite

Pancreatitis associated with atypical antipsychotics: from the Food and Drug Administration's MedWatch surveillance system and published reports.

Journal Article Pharmacotherapy · September 2003 STUDY OBJECTIVE: To investigate the relative numbers and clinical characteristics of pancreatitis in patients treated with the atypical antipsychotic agents, clozapine, olanzapine, and risperidone, versus the conventional neuroleptic, haloperidol. DESIGN: ... Full text Link to item Cite

The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease.

Journal Article Neurosci Lett · August 28, 2003 Previous studies have reported conflicting results regarding the association of the Q7R polymorphism in the Saitohin gene with late-onset Alzheimer disease (AD). Given that AD is a tauopathy but no mutations or polymorphisms in Tau have been consistently a ... Full text Link to item Cite

Current status of metals as therapeutic targets in Alzheimer's disease.

Journal Article J Am Geriatr Soc · August 2003 There is accumulating evidence that interactions between beta-amyloid and copper, iron, and zinc are associated with the pathophysiology of Alzheimer's disease (AD). A significant dyshomeostasis of copper, iron, and zinc has been detected, and the mismanag ... Full text Link to item Cite

Statin-associated memory loss: analysis of 60 case reports and review of the literature.

Journal Article Pharmacotherapy · July 2003 OBJECTIVE: To review case reports of statin-associated memory loss as well as the available published evidence for and against such a link. METHODS: We searched the MedWatch drug surveillance system of the Food and Drug Administration (FDA) from November 1 ... Full text Link to item Cite

Risperidone-associated diabetes mellitus: a pharmacovigilance study.

Journal Article Pharmacotherapy · June 2003 STUDY OBJECTIVE: To explore the clinical characteristics of hyperglycemia in patients treated with risperidone. DESIGN: Pharmacovigilance survey of spontaneously reported adverse events in risperidone-treated patients, with reports of haloperidol-associate ... Full text Link to item Cite

Does increased platelet release of Abeta peptide contribute to brain abnormalities in individuals with depression?

Journal Article Med Hypotheses · May 2003 Increased platelet activation with release of procoagulant factors from their alpha granules has been demonstrated in individuals with major depression. Platelet activation has also been shown to be associated with release of beta-amyloid peptides, which h ... Full text Link to item Cite

Ginkgo and memory.

Journal Article JAMA · February 5, 2003 Full text Link to item Cite

Ginkgo and memory.

Journal Article JAMA · February 5, 2003 Full text Link to item Cite

Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.

Journal Article Radiology · February 2003 Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Current consensus statements have emphasized the need for early recognition and the fact that a diagnosis of AD can be made with high acc ... Full text Link to item Cite

Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial.

Journal Article Am J Med Genet A · January 15, 2003 At present, there is no proven pharmacologic treatment for cognitive or language impairments in Down syndrome (DS). Cholinergic deficits have been documented in DS and linked to cognitive deficits. This study is a 24-week open-label clinical trial of donep ... Full text Link to item Cite

Therapeutic implications of HPA axis abnormalities in Alzheimer's disease: review and update.

Journal Article Psychopharmacol Bull · 2003 The adaptive and maladaptive roles of the hypothalamic-pituitary-adrenal (HPA) axis in stressful conditions and in disorders such as major depression, posttraumatic stress disorder, and Cushing's syndrome, have been the subject of substantial, ongoing stud ... Link to item Cite

Alzheimer's disease and the glutamate NMDA receptor.

Journal Article Psychopharmacol Bull · 2003 Current treatment of Alzheimer's disease (AD) has focused on the use of cholinesterase inhibitors. This review emphasizes emerging therapies for the treatment and/or prevention of AD with a focus on glutamatergic excitotoxicity in dementia and the therapeu ... Link to item Cite

Hippocampal volume and magnetic resonance imaging markers in clinical trials

Journal Article INTERNATIONAL PSYCHOGERIATRICS · January 1, 2003 Link to item Cite

Comparing treatment data in medically comorbid patients

Journal Article INTERNATIONAL PSYCHOGERIATRICS · January 1, 2003 Link to item Cite

Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure.

Journal Article Health Psychol · November 2002 Psychosocial factors predicting treatment dropout or failure to benefit from treatment were identified in a randomized trial of exercise therapy and pharmacotherapy for major depression. One hundred fifty-six men and women over age 50 diagnosed with major ... Link to item Cite

Olanzapine-associated diabetes mellitus.

Journal Article Pharmacotherapy · July 2002 STUDY OBJECTIVE: To explore the clinical characteristics of hyperglycemia in patients treated with olanzapine. DESIGN: Retrospective, epidemiologic survey of spontaneously reported adverse events related to olanzapine therapy SETTING: Government-affiliated ... Full text Link to item Cite

Mifepristone (RU 486) for Alzheimer's disease - A pilot study

Journal Article NEUROBIOLOGY OF AGING · July 1, 2002 Link to item Cite

Mood disorders and chronic obstructive pulmonary disease: current research and future needs.

Journal Article Curr Psychiatry Rep · June 2002 The following review examines the interrelationships between chronic obstructive pulmonary disease (COPD), psychiatric illness, and tobacco use. The influence that these three entities have is very unclear, and this article attempts to address the current ... Full text Link to item Cite

Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 2002 Goals of the study included evaluating the long-term efficacy of rivastigmine in Alzheimer's disease (AD) patient categories stratified by baseline dementia severity, and post hoc investigation of particular benefits of early initiation of rivastigmine tre ... Full text Link to item Cite

Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.

Journal Article JAMA · April 10, 2002 CONTEXT: Extracts of Hypericum perforatum (St John's wort) are widely used for the treatment of depression of varying severity. Their efficacy in major depressive disorder, however, has not been conclusively demonstrated. OBJECTIVE: To test the efficacy an ... Full text Link to item Cite

Working memory load dissociates transient and delay activity in normal aging

Journal Article JOURNAL OF COGNITIVE NEUROSCIENCE · April 1, 2002 Link to item Cite

Prevalence and impact of medical comorbidity in Alzheimer's disease.

Journal Article J Gerontol A Biol Sci Med Sci · March 2002 BACKGROUND: We examined the prevalence of comorbid medical illnesses in Alzheimer's disease (AD) patients at different severity levels. We also examined the effect of cumulative medical comorbidity on cognition and function. METHODS: Analyses of data from ... Full text Link to item Cite

Does apolipoprotein E modulate human brain aging?

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2002 Link to item Cite

Science with a human face: Lessons from the Nun Study and Alzheimer's research.

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2002 Link to item Cite

Sleep in Alzheimer's disease: Do cholinergic drugs help or hurt?

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2002 Link to item Cite

Cardiac disease and depression: A double hit on cerebral perfusion?

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2002 Link to item Cite

The spectrum of quality-of-life impairments in recurrent geriatric depression.

Journal Article J Gerontol A Biol Sci Med Sci · February 2002 BACKGROUND: Although recurrent major depression in elderly individuals is a disabling condition, only a few studies have systematically examined the magnitude and specificity of quality-of-life (QOL) impairments in such patients in comparison with matched ... Full text Link to item Cite

Health perception, pain, and disability as correlates of anxiety and depression symptoms in primary care patients.

Journal Article J Am Board Fam Pract · 2002 BACKGROUND: Anxiety and depression occur frequently, and recognition of their symptoms can be difficult because of comorbid medical conditions. The purpose of this study was to analyze the relations among symptoms, diagnoses, and severity of illness as ind ... Link to item Cite

Treatment of social anxiety disorder with citalopram.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · January 2002 Selective serotonin reuptake inhibitors (SSRIs) are used as treatment for generalized and specific social phobias (social anxiety disorders). The efficacy of citalopram, an SSRI, for the treatment of social anxiety disorders has not yet been fully evaluate ... Full text Link to item Cite

Non-cholinergic strategies for treating and preventing Alzheimer's disease.

Journal Article CNS Drugs · 2002 The pathophysiology of Alzheimer's disease is complex and involves several different biochemical pathways. These include defective beta-amyloid (Abeta) protein metabolism, abnormalities of glutamatergic, adrenergic, serotonergic and dopaminergic neurotrans ... Full text Link to item Cite

Learning and recall in subjects at genetic risk for Alzheimer's disease.

Journal Article J Neuropsychiatry Clin Neurosci · 2002 Deficits in delayed recall of learned information may be an early marker of Alzheimer's disease (AD). The apolipoprotein E E4 allele and a positive family history (FH) are both genetic risk factors for AD. The authors cross-sectionally compared performance ... Full text Link to item Cite

The role of neuroimaging in geriatric psychiatry

Journal Article Current Opinion in Psychiatry · January 1, 2002 Purpose of review: This article reviews some of the key neuroimaging advances that have occurred over the past year, of relevance to Alzheimer's disease and late-life depression. As the number of elderly in the population continues to grow, the prevalence ... Full text Cite

Erratum: (Alzheimer Disease and Associated Disorders (October/December 2001) (174))

Journal Article Alzheimer Disease and Associated Disorders · January 1, 2002 Full text Cite

Atypical antipsychotic drugs and hyperglycemia in adolescents [4] (multiple letters)

Journal Article Journal of the American Medical Association · November 28, 2001 Full text Cite

Olanzapine-associated severe hyperglycemia, ketonuria, and acidosis: case report and review of literature.

Journal Article Pharmacotherapy · November 2001 Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain-2 years after starting o ... Full text Link to item Cite

Bupropion SR in the naturalistic treatment of elderly patients with major depression.

Journal Article Int J Geriatr Psychiatry · September 2001 INTRODUCTION: Bupropion immediate release (IR) and bupropion sustained release (SR) are frequently used to treat geriatric depression, as they have few cardiovascular, gastrointestinal and sexual adverse effects. We sought to examine the efficacy and dosin ... Full text Link to item Cite

How should we teach psychopharmacology to residents? Results of the initial experience with the ASCP model curriculum

Journal Article Academic Psychiatry · June 1, 2001 There is now more information to assimilate in clinical psychopharmacology and newer ways to acquire this information. Educational materials should be designed for and targeted to meet the diverse needs of such groups as medical students, psychiatry reside ... Full text Cite

Brain 1H-MR spectroscopy in subjects at risk for Alzheimer's disease

Journal Article NEUROBIOLOGY OF AGING · March 1, 2001 Link to item Cite

Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · February 2001 1. The safety and efficacy of sertraline in the treatment of moderate-to-severe major depression in elderly outpatients, aged 60 years and older, with comorbid vascular disease was evaluated. 2. An analysis of the pooled results for the sertraline treatmen ... Full text Link to item Cite

Contemporary management of comorbid anxiety and depression in geriatric patients.

Journal Article J Clin Psychiatry · 2001 Anxiety and depression in elderly people are major public health problems in the United States. Recognition and treatment of these conditions will likely gain more attention in the next 30 to 50 years because of the projected growth of the geriatric popula ... Link to item Cite

The Alzheimer's Disease Assessment Scale: evaluation of psychometric properties and patterns of cognitive decline in multicenter clinical trials of mild to moderate Alzheimer's disease.

Journal Article Alzheimer Dis Assoc Disord · 2001 PURPOSE: To evaluate the psychometric properties and patterns of decline on the total score and item scores of the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) in patients with Alzheimer Disease (AD). METHODS: We analyzed data ... Full text Link to item Cite

Quality of life in geriatric depression: a comparison of remitters, partial responders, and nonresponders.

Journal Article Am J Geriatr Psychiatry · 2001 The authors examined patterns of improvement in quality of life (QOL) in elderly patients with recurrent major depression (MDD) after acute treatment. One hundred elderly (age 60-88 years) patients with recurrent MDD were randomized to receive either bupro ... Link to item Cite

Effects of exercise training on cognitive functioning among depressed older men and women

Journal Article Journal of Aging and Physical Activity · January 1, 2001 The effects of a structured exercise program on the cognitive functioning of 84 clinically depressed middle-aged and older adults (mean age = 57 years) were examined. Participants were randomized to either 4 months of aerobic exercise (n = 42) or antidepre ... Full text Cite

Informant-rated cognitive symptoms in normal aging, mild cognitive impairment, and dementia. Initial development of an informant-rated screen (Brief Cognitive Scale) for mild cognitive impairment and dementia.

Journal Article Psychopharmacol Bull · 2001 An informant-rated cognitive screen may have the potential to reliably help detect early dementia. A valuable scale should have good interitem associations and strong reliability when tested in groups with and without cognitive impairment. Our scale, the B ... Link to item Cite

Donepezil for Down's syndrome.

Journal Article Am J Psychiatry · January 2001 Full text Link to item Cite

Efficacy and safety of St. John's wort for the treatment of major depression.

Journal Article Public Health Nutr · December 2000 OBJECTIVE: Extracts of St. John's wort have been widely used in the treatment of depression. Our aim was to review information related to the efficacy and safety of St. John's wort as an antidepressant. DATA SOURCES: Primary and review articles were identi ... Full text Link to item Cite

A double-blind comparison of sertraline and fluoxetine in depressed elderly patients

Journal Article Primary Care Companion to the Journal of Clinical Psychiatry · December 1, 2000 Background: There has been a paucity of well-designed studies comparing selective serotonin reuptake inhibitor (SSRI) medications in the treatment of depression in the elderly. This multicenter study was designed to examine the efficacy and safety of sertr ... Cite

Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression.

Journal Article Ann Pharmacother · November 2000 OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and tolerability of reboxetine in the treatment of major depressive illness. DATA SOURCES: A MEDLINE search restricted to English-language literature was conducted (1966 to July 1999). Abst ... Full text Link to item Cite

A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients.

Journal Article J Clin Psychiatry · August 2000 BACKGROUND: There has been a paucity of well-designed studies comparing selective serotonin reuptake inhibitor (SSRI) medications in the treatment of depression in the elderly. This multicenter study was designed to examine the efficacy and safety of sertr ... Full text Link to item Cite

Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.

Journal Article Neurology · June 13, 2000 Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased ... Full text Link to item Cite

Current and future treatments for cognitive deficits in dementia.

Journal Article Curr Psychiatry Rep · February 2000 In this article, we primarily focus on the treatment approaches currently marketed and in advanced stages of development for Alzheimer's disease (AD). Amyloid plaques and neurofibrillary tangles remain the pathologic hallmarks of AD, and much progress has ... Full text Link to item Cite

Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate.

Journal Article Acta Neurol Scand Suppl · 2000 This paper reviews published post-mortem brain and in-vivo proton magnetic resonance spectroscopy (1H-MRS) studies in Alzheimer's disease (AD) and focuses on the emerging role of N-acetylaspartate (NAA) as a prognostic marker of neuronal function. Post-mor ... Full text Link to item Cite

Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months.

Journal Article Psychosom Med · 2000 OBJECTIVE: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy ... Full text Link to item Cite

Brain magnetic resonance spectroscopy: Role in assessing outcomes in Alzheimer's disease

Journal Article CNS Drugs · January 1, 2000 Contemporary 1H-magnetic resonance spectroscopy (MRS) techniques can estimate the levels of brain metabolites with a high reproducibility and add only 10 minutes to a routine or volumetric magnetic resonance imaging scan. In patients with Alzheimer's disea ... Full text Cite

Health-related quality-of-life and service utilization in Alzheimer's disease: A cross-sectional study

Journal Article American Journal of Alzheimer's Disease and Other Dementias · January 1, 2000 The objective of this study was to explore the relationships between the severity of Alzheimer's disease (AD) in different care settings, health-related quality-of-life (HQoL), service utilization, and caregiver time and burden. Data were from a 1996 cross ... Full text Cite

Effect of Bupropion SR on the Quality of Life of Elderly Depressed Patients With Comorbid Medical Disorders.

Journal Article Prim Care Companion J Clin Psychiatry · December 1999 BACKGROUND: There is a need for additional studies of the quality of life (QOL) of elderly depressed subjects with medical comorbidity. METHOD: We conducted an 8-week, open trial of bupropion sustained release (SR) in 18 elderly (60-81 years) subjects with ... Full text Link to item Cite

Effects of exercise training on older patients with major depression.

Journal Article Arch Intern Med · October 25, 1999 BACKGROUND: Previous observational and interventional studies have suggested that regular physical exercise may be associated with reduced symptoms of depression. However, the extent to which exercise training may reduce depressive symptoms in older patien ... Full text Link to item Cite

Magnetic resonance assessment of cerebral perfusion in depressed cardiac patients: preliminary findings.

Journal Article Am J Psychiatry · October 1999 OBJECTIVE: The authors investigated the links between depression, cardiac disease, and microcirculatory cerebral blood flow (CBF). METHOD: A magnetic resonance imaging technique based on arterial spin tagging was used to estimate microcirculatory CBF in de ... Full text Link to item Cite

Cholinergic therapy for Down's syndrome.

Journal Article Lancet · March 27, 1999 Full text Link to item Cite

Defining meaningful change in Alzheimer's disease trials: the donepezil experience.

Journal Article J Geriatr Psychiatry Neurol · 1999 Regulatory guidelines in the US and Europe generally require that a drug specifically indicated for treating Alzheimer's disease (AD) must demonstrate an effect upon the core manifestations of dementia. Progressive cognitive and functional losses are the c ... Full text Link to item Cite

EXERCISE TRAINING AND MAJOR DEPRESSION

Journal Article Psychosomatic Medicine · 1999 Full text Cite

Current status of antioxidant therapy for Alzheimer's Disease.

Journal Article J Am Geriatr Soc · December 1998 Accumulating evidence from preclinical and clinical studies supports the hypothesis that oxidative stress may be associated with the onset and progression of Alzheimer's Disease (AD). Antioxidant therapies are being promoted in the lay press to enhance men ... Full text Link to item Cite

Focus on citalopram: A selective reuptake inhibitor for the treatment of depression

Journal Article Formulary · December 1, 1998 Citalopram is a selective serotonin reuptake inhibitor (SSRI) approved by the FDA for the treatment of major depression. Pharmacologically, it has higher serotonin selectivity than other marketed SSRIs. Clinical trials in a variety of practice settings and ... Cite

Combination therapy for early Alzheimer's disease: what are we waiting for?

Journal Article J Am Geriatr Soc · October 1998 The practical pharmacological approaches currently available to palliate the cognitive and functional losses in early Alzheimer's disease (AD) include cholinesterase inhibitors (ChEI), antioxidants (e.g., vitamin E), anti-inflammatory agents, estrogen, sel ... Full text Link to item Cite

Early recognition of Alzheimer's disease: what is consensual? What is controversial? What is practical?

Journal Article J Clin Psychiatry · 1998 Alzheimer's disease is often unrecognized or misdiagnosed in its early stages. Despite the lack of curative treatments, there are compelling reasons why early recognition of Alzheimer's disease may offer substantial benefits. Early evaluation and diagnosis ... Link to item Cite

Vascular dementia: The end stage of cerebral vascular disease

Journal Article Current Opinion in Psychiatry · January 1, 1998 Recent research on vascular dementia has focused on improving diagnostic criteria, classification, etiology risk factors modification, and interaction with Alzheimer's dementia. ... Full text Cite

Gender, concurrent estrogen use and cognition in Alzheimer's disease

Journal Article International Journal of Geriatric Psychopharmacology · December 1, 1997 We analyzed baseline data from 444 Alzheimer's disease (AD) subjects selected for a multicenter clinical trial to determine whether there are gender differences in cognitive measures in AD, and whether concurrent estrogen use in women with AD is associated ... Cite

The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials.

Journal Article Neurology · June 1997 The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is used as an efficacy measure in clinical drug trials of Alzheimer's disease (AD). We used data from 1,648 AD participants in two identical 26-week multicenter drug trials to ex ... Full text Link to item Cite

Memory, language, and praxis in Alzheimer's disease: norms for outpatient clinical trial populations.

Journal Article Psychopharmacol Bull · 1997 The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is designed specifically to assess memory, language, and praxis dysfunctions characteristic of Alzheimer's disease (AD). In this report, we use data from 1,648 AD participants in ... Link to item Cite

Neurobiology of chronic fatigue syndrome.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · July 1996 1. Chronic fatigue syndrome (CFS) is characterized by a new onset of significant fatigue for a period of six months or longer usually following an infection, injury or period of high stress. 2. The exact etiology of CFS is not known and a diagnostic test i ... Full text Link to item Cite

Cognitive performance on the Alzheimer's Disease Assessment Scale: effect of education.

Journal Article Neurology · November 1995 The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is used to monitor disease progression and treatment efficacy in clinical trials of Alzheimer's disease (AD). Using data from a 12-week drug trial, we retrospectively studied the ... Full text Link to item Cite

Psychosis in Parkinson's disease: diagnosis and treatment.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · September 1995 1. This article reviews the prevalence, diagnosis, pathophysiology and management of psychosis in Parkinson's disease. 2. Psychosis in Parkinson's disease has been associated with all antiparkinsonian medications. The most common symptoms are vivid disturb ... Full text Link to item Cite

Neuroleptic treatment and caudate plasticity.

Journal Article Lancet · March 18, 1995 Link to item Cite

POSSIBLE SEASONAL-CHANGES IN PITUITARY SIZE - COMMENT

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · January 1, 1995 Link to item Cite

Emergency department patterns in psychiatric visits during the holiday season.

Journal Article Ann Emerg Med · November 1994 STUDY OBJECTIVE: To determine the prevalence of psychopathology during the holiday season and which subpopulations are at greatest risk for holiday decompensation. DESIGN: A retrospective analysis of emergency department records. SETTING: ED of a universit ... Full text Link to item Cite

Proton spectroscopy of human brain: effects of age and sex.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · October 1994 1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic i ... Full text Link to item Cite

Magnetic resonance imaging in social phobia.

Journal Article Psychiatry Res · April 1994 Recent studies have implicated dopamine and the basal ganglia circuits in the pathophysiology of social phobia. Twenty-two patients who met DSM-III-R criteria for social phobia and 22 age- and sex-matched control subjects underwent magnetic resonance imagi ... Full text Link to item Cite

Wernicke-Korsakoff syndrome caused by psychogenic food refusal: MR findings.

Journal Article AJNR Am J Neuroradiol · March 1994 A 37-year-old woman developed Wernicke encephalopathy after prolonged psychogenic food refusal. MR revealed characteristic signal abnormalities in the midbrain and dorsal thalamus. Follow-up scans showed atrophy and third ventricular enlargement. Wernicke ... Link to item Cite

Bicaudate index on magnetic resonance imaging: effects of normal aging.

Journal Article J Geriatr Psychiatry Neurol · 1994 The bicaudate and bifrontal indices have been used in prior computed tomographic studies to investigate atrophy of the caudate nuclei in patients with Huntington's chorea and cerebral atrophy. However, the relationship between these indices and caudate vol ... Link to item Cite

Changes in pituitary gland signal intensity and morphology as evaluated by magnetic resonance imaging in aging, depression, and by gender

Journal Article Depression · January 1, 1994 Magnetic resonance images (MRI) were used to measure anterior (A) and posterior (P) pituitary lobe signal intensity changes with age and by gender in 35 normal controls and 19 depressed patients. Females in the control group had a significant increase in b ... Full text Cite

Vitamin E treatment of tardive dyskinesia.

Journal Article American Journal of Psychiatry · June 1, 1993 Cite

Vitamin E treatment of tardive dyskinesia.

Journal Article Am J Psychiatry · June 1993 Link to item Cite

Hypercortisolemia and hippocampal changes in depression.

Journal Article Psychiatry Res · May 1993 Hypercortisolemia is a frequently observed abnormality in patients with major depression. It has been hypothesized that the hippocampus, as a major feedback site for glucocorticoids, is involved in the pathophysiology of hypercortisolemia. Some have in fac ... Full text Link to item Cite

Reduction of cerebellar volume in major depression: A controlled MRI study

Journal Article Depression · January 1, 1993 A systematic sampling stereological method of serially acquired axial intermediate T2‐weighted Spin echo magnetic resonance imaging (MRI) of the brain was used to measure cerebellar volume in 30 patients who fulfilled DSM III criteria for major depression ... Full text Cite

MRI detection of abnormality in the corpus callosum and late‐onset depression

Journal Article Depression · January 1, 1993 A Case of a 75‐year‐old female with late‐onset depression and MRI finding of a T2 signal hyperintensity in the anterior corpus callosum is presented. This case furthers the clinical anatomical association between late‐onset mood disorders and frontal subco ... Full text Cite

Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging.

Journal Article J Neural Transm Suppl · 1993 Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nu ... Link to item Cite

Neuroanatomical substrates of depression in the elderly.

Journal Article Eur Arch Psychiatry Clin Neurosci · 1993 The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to ... Full text Link to item Cite

Interuncal distance measurements in healthy volunteers and in patients with Alzheimer disease.

Journal Article AJNR Am J Neuroradiol · 1993 PURPOSE: To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy. METHODS: The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the ... Link to item Cite

Interuncal distance as a measure of hippocampal atrophy: normative data on axial MR imaging.

Journal Article AJNR Am J Neuroradiol · 1993 PURPOSE: To assess the effects of age and gender on the interuncal distance measured from MR images. METHODS: High-field strength MR images (axial) of 75 volunteers, 21-82 years old and free of neurologic disorders, were used to measure the interuncal dist ... Link to item Cite

In vivo assessment of pituitary volume with magnetic resonance imaging and systematic stereology: relationship to dexamethasone suppression test results in patients.

Journal Article Psychiatry Res · October 1992 The relationship between dexamethasone suppression test (DST) results and in vivo pituitary volume was studied in 24 psychiatric inpatients. The principles of systematic stereology were used to measure pituitary volume from 3-mm contiguous sagittal spin-ec ... Full text Link to item Cite

Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations.

Journal Article Arch Gen Psychiatry · July 1992 A role of the caudate nucleus in depression has been suggested from relevant clinical conditions, such as patients with Huntington's disease or caudate infarcts, as well as animal studies. Correlations of caudate nucleus disease with depressive symptoms ha ... Full text Link to item Cite

Posterior fossa abnormalities in major depression: a controlled magnetic resonance imaging study.

Journal Article Acta Psychiatr Scand · June 1992 High-field magnetic resonance (MR) images were used to study posterior fossa morphology in 27 patients with major depression and 36 normal control subjects. Depressed patients demonstrated smaller brain stem and cerebellar vermis than controls. These diffe ... Full text Link to item Cite

Subcortical brain anatomy in anorexia and bulimia.

Journal Article Biol Psychiatry · April 1, 1992 Full text Link to item Cite

Morphometric changes of the human midbrain with normal aging: MR and stereologic findings.

Journal Article AJNR Am J Neuroradiol · 1992 PURPOSE: To determine the effects of age on estimated midbrain volume. PATIENTS AND METHODS: T2-weighted MR imaging and an unbiased stereologic method were used in 75 volunteers; the subjects ranged in age from 21 to 82 years and were without any significa ... Link to item Cite

Simultaneous major depression and panic disorder: treatment with electroconvulsive therapy.

Journal Article J Clin Psychiatry · January 1992 BACKGROUND: Major depression and panic disorder commonly occur together. Patients with simultaneous depression and panic disorder may have a higher lifetime rate of suicide attempts and an overall worse prognosis than patients with either depression or pan ... Link to item Cite

MR assessment of pituitary gland morphology in healthy volunteers: age- and gender-related differences.

Journal Article AJNR Am J Neuroradiol · 1992 PURPOSE AND METHODS: High-field MR images at 1.5 T were used to characterize the effects of age and gender on pituitary size and shape in a sample of 71 adult volunteers (40 females), aged 21 to 82 years. FINDINGS: For all subjects, age was inversely corre ... Link to item Cite

The treatment of late age onset psychoses with electroconvulsive therapy

Journal Article International Journal of Geriatric Psychiatry · January 1, 1992 The authors describe the clinical course and the brain imaging findings of six patients with late age onset psychoses who were treated with electroconvulsive therapy (ECT). In all five patients who failed to respond to ECT, one or more structural brain cha ... Full text Cite

Occurrence of subcortical hyperintensities in elderly subjects with mania.

Journal Article Psychiatry Res · December 1991 In a retrospective study, brain magnetic resonance images of 12 patients with the onset of manic symptoms after the age of 50 years were compared to age- and sex-matched control subjects for the incidence, size, and location of subcortical hyperintensities ... Full text Link to item Cite

A magnetic resonance imaging study of putamen nuclei in major depression

Journal Article Psychiatry Research · December 1, 1991 The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depress ... Full text Cite

Levels of urinary free cortisol in social phobia.

Journal Article J Clin Psychiatry · November 1991 Levels of urinary free cortisol were measured in 10 patients with social phobias and in 15 age- and sex-matched normal controls. No differences were found either in cortisol levels or in the ratio of free cortisol to creatinine. These nonsignificant differ ... Link to item Cite

A magnetic resonance imaging study of putamen nuclei in major depression.

Journal Article Psychiatry Res · October 1991 The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depress ... Full text Link to item Cite

MRI quantification.

Journal Article Neurology · June 1991 Full text Link to item Cite

MRI quantification.

Journal Article Neurology · June 1, 1991 Cite

Magnetic resonance findings in patients with early-onset Alzheimer's disease.

Journal Article Biol Psychiatry · April 15, 1991 The magnetic resonance scans of 22 patients with early-onset Alzheimer's disease (AD) were compared to 16 age-matched neurologically normal controls for the presence of white matter subcortical hyperintensities (SCH) and periventricular hyperintensities (P ... Full text Link to item Cite

Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.

Journal Article Biol Psychiatry · April 1, 1991 We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free pla ... Full text Link to item Cite

Pituitary size in depression.

Journal Article J Clin Endocrinol Metab · February 1991 Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age- and sex-matched controls. Depressed patients had significantly greater pituitary cross-secti ... Full text Link to item Cite

A magnetic resonance image study of age-related changes in human putamen nuclei.

Journal Article Neuroreport · January 1991 Putamen nuclei were assessed in 36 normal volunteers using magnetic resonance imaging and a systematic sampling method. There was a significant decrease in the volume of the putamen nuclei with advancing age (r = -0.74, p less than 0.0001), and an associat ... Full text Link to item Cite

Caudate hyperintensities in elderly depressed patients with neuroleptic-induced parkinsonism.

Journal Article J Geriatr Psychiatry Neurol · 1991 Elderly patients are particularly sensitive to the neurologic side effects of psychotropic medications. This increased sensitivity may be related to brain structural changes associated with aging. In this pilot study, the authors report on the occurrence o ... Full text Link to item Cite

Hippocampal abnormalities in depression.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 A quantitative magnetic resonance imaging study of regional brain T1 spin-lattice relaxation times in 29 normal volunteers and in 20 patients with major depression revealed significantly shortened T1 relaxation times for the hippocampus in depressed patien ... Full text Link to item Cite

In vivo stereological assessment of human cerebellar volume: effects of gender and age.

Journal Article AJNR Am J Neuroradiol · 1991 Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebella ... Link to item Cite

Magnetic resonance imaging in biological psychiatry.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1991 1. Although clinicians have been quick to adopt magnetic resonance imaging (MRI) in the search for brain pathology in psychiatric disorders, the clinical utility of MRI is only now being well defined. 2. Numerous past computerized tomography or post-mortem ... Full text Link to item Cite

Pituitary abnormalities in eating disorders: further evidence from MRI studies.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · 1991 1. The frequent occurrence of hypothalamo-pituitary dysfunction in patients with eating disorders as well as prior reports that nutritional and endocrine status influence pituitary morphology, led us to hypothesize that pituitary size and shape may be alte ... Full text Link to item Cite

Assessment of posterior fossa structures with midsagittal MRI: the effects of age.

Journal Article Neurobiol Aging · 1991 Midsagittal magnetic resonance (MR) images of 36 normal volunteers, ranging in age from 26 to 79 years, were used to evaluate the effects of age on the size of posterior fossa structures (cerebellar vermis, midbrain, pons, medulla and fourth ventricle). Ou ... Full text Link to item Cite

Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late age onset and early onset elderly depressed subjects.

Journal Article Neurobiol Aging · 1991 Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes ... Full text Link to item Cite

Aging of the human corpus callosum: magnetic resonance imaging in normal volunteers.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 A brain magnetic resonance imaging (MRI) study of the corpus callosum in 36 normal volunteers, ages 26-79 years, revealed that age was positively correlated with the T1 spin-lattice relaxation time of the corpus callosum and was negatively correlated with ... Full text Link to item Cite

ECT-induced delirium in depressed patients with Parkinson's disease.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 In this pilot study, a prolonged (interictal) delirium was induced by electroconvulsive therapy (ECT) in seven out of seven depressed patients with Parkinson's disease. This occurrence of delirium appears much higher than what has been reported in other pa ... Full text Link to item Cite

Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects.

Journal Article J Neuropsychiatry Clin Neurosci · 1991 Bipolar disorder has been reported to occur frequently in a number of subcortical diseases. This suggests that subcortical structures may be involved in the etiology of bipolar disorder in some patients. With the advent of brain magnetic resonance imaging ... Full text Link to item Cite

PITUITARY CHANGES IN DEPRESSION

Conference BIOLOGICAL PSYCHIATRY, VOL 1 · January 1, 1991 Link to item Cite

In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age.

Journal Article J Clin Endocrinol Metab · August 1990 We used sagittal and coronal T1 weighted magnetic resonance images, at 1.5 Tesla, to measure the height, width, length, and cross-sectional area and to generate two estimates of pituitary gland volume in 35 normal volunteers aged 26-79 yr (19 females and 1 ... Full text Link to item Cite

A brain magnetic resonance imaging study of pituitary gland morphology in anorexia nervosa and bulimia.

Journal Article Biol Psychiatry · July 15, 1990 Magnetic resonance imaging (MRI) of the brain was used to examine the morphology and dimensions of the pituitary gland in 18 patients with eating disorders (8 anorectics and 10 bulimics), in comparison with 13 healthy volunteers. None of the 18 patients wi ... Full text Link to item Cite

Subcortical structural changes in ECT-induced delirium.

Journal Article J Geriatr Psychiatry Neurol · 1990 A prolonged (interictal) delirium was induced by electroconvulsive therapy (ECT) in 6/36 (17%) elderly depressed patients. Brain magnetic resonance imaging or brain computerized axial tomography revealed structural changes in the basal ganglia and white ma ... Full text Link to item Cite

In vivo stereological assessment of caudate volume in man: effect of normal aging.

Journal Article Life Sci · 1990 Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p less than 0.000 ... Full text Link to item Cite

Brain magnetic resonance imaging findings in ECT-induced delirium.

Journal Article J Neuropsychiatry Clin Neurosci · 1990 A prolonged (interictal) but reversible delirium was induced by electroconvulsive therapy (ECT) in 10 of 87 (11%) elderly depressed patients. Brain magnetic resonance imaging (MRI) revealed several structural abnormalities, particularly basal ganglia and m ... Full text Link to item Cite