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Metabolomic changes in autopsy-confirmed Alzheimer's disease.

Publication ,  Journal Article
Kaddurah-Daouk, R; Rozen, S; Matson, W; Han, X; Hulette, CM; Burke, JR; Doraiswamy, PM; Welsh-Bohmer, KA
Published in: Alzheimers Dement
May 2011

BACKGROUND: Metabolomics, the global science of biochemistry, provides powerful tools to map perturbations in the metabolic network and enables simultaneous quantification of several metabolites to identify metabolic perturbances that might provide insights into disease. METHODS: In this pilot study, we took a targeted electrochemistry-based metabolomics approach where liquid chromatography followed by coulometric array detection enables quantification of over 30 metabolites within key neurotransmitter pathways (dopamine and serotonin) and pathways involved in oxidative stress. RESULTS: Using samples from postmortem ventricular cerebrospinal fluid (15 Alzheimer's disease [AD] and 15 nondemented subjects with autopsy-confirmed diagnoses) and by using regression models, correlations, Wilcoxon rank-sum tests, and t-tests we identified alterations in tyrosine, tryptophan, purine, and tocopherol pathways in patients with AD. Reductions in norepinephrine and its related metabolites were also seen, consistent with previously published data. CONCLUSIONS: These data support further investigation of metabolomics in larger samples of clinical AD as well as in those with preclinical disease for use as biomarkers.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

May 2011

Volume

7

Issue

3

Start / End Page

309 / 317

Location

United States

Related Subject Headings

  • Tocopherols
  • Purines
  • Predictive Value of Tests
  • Pilot Projects
  • Oxidative Stress
  • Metabolomics
  • Male
  • Humans
  • Geriatrics
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Kaddurah-Daouk, R., Rozen, S., Matson, W., Han, X., Hulette, C. M., Burke, J. R., … Welsh-Bohmer, K. A. (2011). Metabolomic changes in autopsy-confirmed Alzheimer's disease. Alzheimers Dement, 7(3), 309–317. https://doi.org/10.1016/j.jalz.2010.06.001
Kaddurah-Daouk, Rima, Steve Rozen, Wayne Matson, Xianlin Han, Christine M. Hulette, James R. Burke, P Murali Doraiswamy, and Kathleen A. Welsh-Bohmer. “Metabolomic changes in autopsy-confirmed Alzheimer's disease.Alzheimers Dement 7, no. 3 (May 2011): 309–17. https://doi.org/10.1016/j.jalz.2010.06.001.
Kaddurah-Daouk R, Rozen S, Matson W, Han X, Hulette CM, Burke JR, et al. Metabolomic changes in autopsy-confirmed Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):309–17.
Kaddurah-Daouk, Rima, et al. “Metabolomic changes in autopsy-confirmed Alzheimer's disease.Alzheimers Dement, vol. 7, no. 3, May 2011, pp. 309–17. Pubmed, doi:10.1016/j.jalz.2010.06.001.
Kaddurah-Daouk R, Rozen S, Matson W, Han X, Hulette CM, Burke JR, Doraiswamy PM, Welsh-Bohmer KA. Metabolomic changes in autopsy-confirmed Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):309–317.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

May 2011

Volume

7

Issue

3

Start / End Page

309 / 317

Location

United States

Related Subject Headings

  • Tocopherols
  • Purines
  • Predictive Value of Tests
  • Pilot Projects
  • Oxidative Stress
  • Metabolomics
  • Male
  • Humans
  • Geriatrics
  • Female