Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Neurology, Medicine, Duke University 1989 - 1991
  • Resident in Neurology, Medicine, Duke University 1986 - 1989
  • Intern, Medicine, Staten Island University Hospital 1985 - 1986
  • M.D., State University of New York, Brooklyn 1985
  • Ph.D., University of Tennessee Knoxville 1981
• 

  Previous Appointments & Affiliations

  • Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2012 - 2021
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2010 - 2012
  • Associate Professor of Medicine, Neurology, Clinical Science Departments 2003 - 2011
  • Associate Professor of Medicine, Neurology, Clinical Science Departments 2001 - 2003
  • Assistant Professor of Medicine, Neurology, Clinical Science Departments 1993 - 2001
  • Associate in the Department of Medicine, Medicine, Clinical Science Departments 1990 - 1993
• Recognition
• 

  In the News

  • MAY 7, 2015

    Durham Herald-Sun

    War on Alzheimer's: Durham firms lead push in treatment R&D
• Research
• 

  Selected Grants

  • Retinal Light Scattering Measurements as a Clinical Biomarker of Alzheimer's Disease awarded by National Institutes of Health 2022 - 2027
  • Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health 2020 - 2024
  • Improving the lives of persons living with dementia and their families through person-centered measurement of home time awarded by National Institutes of Health 2021 - 2024
  • Combination anti-amyloid therapy for preclinical Alzheimer's disease awarded by University of Southern California 2019 - 2024
  • Pesticides, Olfaction, and Prodromal Neurodegeneration Among US Farmers awarded by Michigan State University 2019 - 2024
  • Open-Label Extension of Studies ATH-1017-0201 and ATH-1017-0202 in Subjects with Mild to Moderate Alzheimer¿s Disease awarded by Athira Pharma, Inc. 2021 - 2023
  • A Randomized, Placebo-Controlled, Double-Blind Study of ATH-1017 Treatment in Subjects with Mild to Moderate Alzheimer's Disease awarded by Athira Pharma, Inc. 2021 - 2023
  • A 72-Week, Multicenter, Randomized, Double-Blind, Placebo- Controlled Study in Subjects with Mild Cognitive Impairment due to Alzheimer's Disease (AD) (Stage 3 AD) to Evaluate the Effect on Cognitive and Functional Impairment, Safety, and Tolerabilit awarded by Neuraly 2021 - 2023
  • The A3 Study: Ante-Amyloid Prevention of Alzheimer's disease awarded by University of Southern California 2019 - 2023
  • Cognitive Training to Reduce Cognitive Impairment: The PACT Trial awarded by University of South Florida 2021 - 2023
  • AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subjects With Preclinical Alzheimer's Disease and Elevated Amyloid (A45 Trial) and in Subjects W awarded by Eisai, Inc. 2020 - 2022
  • An Extension Study of ABBV-8E12 in Early Alzheimer's Disease awarded by AbbVie Inc. 2019 - 2022
  • A Phase 2 Multiple Dose, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Subjects with Early Alzheimer's Disease awarded by AbbVie Inc. 2016 - 2021
  • A randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of CNP520 in participants at risk for the onset of clinical symptoms of Alzheimer's Disease (AD) awarded by Novartis Pharmaceuticals Corporation 2017 - 2021
  • Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study awarded by National Institutes of Health 2014 - 2021
  • A randomized, double-blind, placebo-controlled, two cohort parallel group study to evaluate the efficacy of CAD106 and CNP520 in participants at risk for the onset of clinical symptoms of Alzheimer's disease awarded by Novartis Pharmaceuticals Corporation 2016 - 2020
  • Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals awarded by Brigham and Women's Hospital 2015 - 2020
  • A Blinded Longterm Ext Study to Eval the Safety and Efficacy of Pioglitazone (AD-4833 Sust Release 0.8 mg daily) to Slow the Progress of Cog Decline in Subj Who Have completed the AD4833/TOMM40_301 Study w/ Diag of Mild Cog Impair due to Alz Disease. awarded by Takeda Pharmaceuticals North America Inc. 2015 - 2019
  • A Phase III Clinical Trial to Study the Efficacy & Safety of MK-8931 (SCH900931) in subjects with Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease (Prodromal AD) awarded by Merck Sharp & Dohme 2016 - 2019
  • A DB, Randomized, Placebo Controlled, Parallel Group Study to Qualify a Biomarker Algorithm for Risk of Developing MCI due to AD and to Test the S&E of Pioglitazone (AD-4833 SR 0.8 mg QD) Delay Onset of MCI due AD in Cognitively Normal Subjects. awarded by Takeda Pharmaceuticals North America Inc. 2013 - 2019
  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Efficacy and Safety of Lemborexant in Subjects with Irregular Sleep-Wake Rhythm Disorder and Mild to Moderate Alzheimer's Disease Dementia awarded by Eisai, Inc. 2017 - 2018
  • Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health 2011 - 2018
  • Caregivers' Reactions and Experience: Imaging Dementia - Evidence for Amyloid Scanning - CARE IDEAS awarded by Brown University 2016 - 2017
  • Novel Retinal Biomarkers for Early Detection of Alzheimer's Disease awarded by Alzheimer's Association 2013 - 2016
  • IPA - John F Ervin awarded by Durham Veterans Affairs Medical Center 2013 - 2014
  • Metabolic Signatures for Alzheimer's Disease awarded by National Institutes of Health 2007 - 2011
  • Epidemiology of Dementia in Cache County, Utah awarded by National Institutes of Health 1994 - 2011
  • NIH State of the Science Conference on Preventing Alzheimer's Disease and Cognitive Decline awarded by Agency for Healthcare Research and Quality 2008 - 2010
  • Same awarded by National Institutes of Health 1989 - 2008
  • Admin Suppl - Novel therapeutics in Parkinson's disease: Identification of alpha-synuclein binding peptides by screening awarded by National Institutes of Health 2000 - 2003
  • Manipulation of polyglutamine-protein interactions awarded by National Institutes of Health 2000 - 2003
  • NINDS Administrative supplement for FDA-approved compound screens for neurodegeneration awarded by National Institutes of Health 2000 - 2003
  • Genetic Epidemiolgy Of Alzheimer Disease In Twins awarded by National Institutes of Health 1996 - 1998
  • Arly Genes And Kindling Development awarded by National Institutes of Health 1993 - 1996
  • Early Gene And Kindling Development awarded by National Institutes of Health 1992 - 1996
  • Early Genes And Kindling Development awarded by National Institutes of Health 1991 - 1996
  • Early Genes And Kindling Development - Cida awarded by National Institutes of Health 1991 - 1996
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Bélanger, Emmanuelle, Eric Jutkowitz, Peter Shewmaker, Courtney H. Van Houtven, James R. Burke, Brenda L. Plassman, Megan Shepherd-Banigan, Elyse Couch, Caroline Mills, and Terrie T. Wetle. “Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment.” J Affect Disord 334 (August 1, 2023): 293–96. https://doi.org/10.1016/j.jad.2023.04.115.
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    • Nicholson, Jody S., Elizabeth M. Hudak, Christine B. Phillips, Marianne Chanti-Ketterl, Jennifer L. O’Brien, Lesley A. Ross, Jennifer J. Lister, et al. “The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.” Contemp Clin Trials 123 (December 2022): 106978. https://doi.org/10.1016/j.cct.2022.106978.
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    • Heath, Laura, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, et al. “Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.” Scientific Reports 12, no. 1 (April 2022): 6117. https://doi.org/10.1038/s41598-022-09825-2.
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    • Liu, Andy J., Jay B. Lusk, John Ervin, James Burke, Richard O’Brien, and Shih-Hsiu J. Wang. “Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.” Acta Neuropathol Commun 10, no. 1 (March 3, 2022): 27. https://doi.org/10.1186/s40478-022-01330-x.
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    • Wisely, C Ellis, Dong Wang, Ricardo Henao, Dilraj S. Grewal, Atalie C. Thompson, Cason B. Robbins, Stephen P. Yoon, et al. “Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging.” Br J Ophthalmol 106, no. 3 (March 2022): 388–95. https://doi.org/10.1136/bjophthalmol-2020-317659.
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    • Shepherd-Banigan, Megan E., Cassie B. Ford, Valerie A. Smith, Emmanuelle Belanger, Terrie T. Wetle, Brenda L. Plassman, James R. Burke, et al. “Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time.” J Alzheimers Dis 90, no. 2 (2022): 775–82. https://doi.org/10.3233/JAD-220611.
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    • Burns, Daniel K., Robert C. Alexander, Kathleen A. Welsh-Bohmer, Meredith Culp, Carl Chiang, Janet O’Neil, Rebecca M. Evans, et al. “Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.” Lancet Neurol 20, no. 7 (July 2021): 537–47. https://doi.org/10.1016/S1474-4422(21)00043-0.
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    • Robbins, Cason B., Dilraj S. Grewal, Sandra S. Stinnett, Srinath Soundararajan, Stephen P. Yoon, Bryce W. Polascik, Andy J. Liu, James R. Burke, and Sharon Fekrat. “Assessing the Retinal Microvasculature in Individuals With Early and Late-Onset Alzheimer's Disease.” Ophthalmic Surg Lasers Imaging Retina 52, no. 6 (June 2021): 336–44. https://doi.org/10.3928/23258160-20210528-06.
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    • Polascik, Bryce W., Atalie C. Thompson, Stephen P. Yoon, James H. Powers, James R. Burke, Dilraj S. Grewal, and Sharon Fekrat. “Association of OCT Angiography Parameters With Age in Cognitively Healthy Older Adults.” Ophthalmic Surg Lasers Imaging Retina 51, no. 12 (December 1, 2020): 706–14. https://doi.org/10.3928/23258160-20201202-05.
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    • Van Houtven, Courtney H., Steven J. Lippmann, Emmanuelle Bélanger, Valerie A. Smith, Hailey J. James, Megan Shepherd-Banigan, Eric Jutkowitz, et al. “Measurement Properties of the CAPACITY Instrument to Assess Perceived Communication With the Health Care Team Among Care Partners of Patients With Cognitive Impairment.” Med Care 58, no. 9 (September 2020): 842–49. https://doi.org/10.1097/MLR.0000000000001363.
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    • Cocroft, Shelytia, Kathleen A. Welsh-Bohmer, Brenda L. Plassman, Marianne Chanti-Ketterl, Henry Edmonds, Lisa Gwyther, Michelle McCart, Heather MacDonald, Guy Potter, and James R. Burke. “Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies.” Alzheimers Dement 16, no. 8 (August 2020): 1107–14. https://doi.org/10.1002/alz.12048.
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    • Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, P Murali Doraiswamy, et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc 68, no. 3 (March 2020): 559–68. https://doi.org/10.1111/jgs.16252.
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    • Reiman, Eric M., Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Matthew J. Huentelman, Thomas G. Beach, Richard J. Caselli, Yinghua Chen, et al. “Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.” Nat Commun 11, no. 1 (February 3, 2020): 667. https://doi.org/10.1038/s41467-019-14279-8.
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    • James, Hailey J., Courtney Harold Van Houtven, Steven Lippmann, James R. Burke, Megan Shepherd-Banigan, Emmanuelle Belanger, Terrie Fox Wetle, and Brenda L. Plassman. “How Accurately Do Patients and Their Care Partners Report Results of Amyloid-β PET Scans for Alzheimer's Disease Assessment?” J Alzheimers Dis 74, no. 2 (2020): 625–36. https://doi.org/10.3233/JAD-190922.
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    • Smith, Patrick J., Stephanie M. Mabe, Andrew Sherwood, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, James R. Burke, William E. Kraus, et al. “Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.” J Alzheimers Dis 77, no. 4 (2020): 1793–1803. https://doi.org/10.3233/JAD-200374.
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    • Yoon, Stephen P., Atalie C. Thompson, Bryce W. Polascik, Christopher Calixte, James R. Burke, Jeffrey R. Petrella, Dilraj S. Grewal, and Sharon Fekrat. “Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease.” Ophthalmic Surg Lasers Imaging Retina 50, no. 11 (November 1, 2019): 709–18. https://doi.org/10.3928/23258160-20191031-06.
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    • Kunkle, Brian W., Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, et al. “Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.” Nat Genet 51, no. 9 (September 2019): 1423–24. https://doi.org/10.1038/s41588-019-0495-7.
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    • Ma, Yiyi, Gyungah R. Jun, Xiaoling Zhang, Jaeyoon Chung, Adam C. Naj, Yuning Chen, Celine Bellenguez, et al. “Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.” Jama Neurol 76, no. 9 (September 1, 2019): 1099–1108. https://doi.org/10.1001/jamaneurol.2019.1456.
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    • Ma, Yiyi, Gyungah R. Jun, Jaeyoon Chung, Xiaoling Zhang, Brian W. Kunkle, Adam C. Naj, Charles C. White, et al. “CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.” Aging Cell 18, no. 4 (August 2019): e12964. https://doi.org/10.1111/acel.12964.
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    • Zheng, Naiyu, Ian M. Catlett, Kristin Taylor, Huidong Gu, Mark A. Pattoli, Robert J. Neely, Wenying Li, et al. “Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS.” Anal Chem 91, no. 13 (July 2, 2019): 8443–52. https://doi.org/10.1021/acs.analchem.9b01462.
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    • Yoon, Stephen P., Dilraj S. Grewal, Atalie C. Thompson, Bryce W. Polascik, Cynthia Dunn, James R. Burke, and Sharon Fekrat. “Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants.” Ophthalmology. Retina 3, no. 6 (June 2019): 489–99. https://doi.org/10.1016/j.oret.2019.02.002.
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    • Hu, Yiming, Mo Li, Qiongshi Lu, Haoyi Weng, Jiawei Wang, Seyedeh M. Zekavat, Zhaolong Yu, et al. “A statistical framework for cross-tissue transcriptome-wide association analysis.” Nat Genet 51, no. 3 (March 2019): 568–76. https://doi.org/10.1038/s41588-019-0345-7.
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    • Kunkle, Brian W., Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, et al. “Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.” Nat Genet 51, no. 3 (March 2019): 414–30. https://doi.org/10.1038/s41588-019-0358-2.
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    • Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Pao-Hwa Lin, Lawrence Liao, Kathleen A. Welsh-Bohmer, et al. “Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.” Neurology 92, no. 3 (January 15, 2019): e212–23. https://doi.org/10.1212/WNL.0000000000006784.
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    • Knodt, Annchen R., James R. Burke, Kathleen A. Welsh-Bohmer, Brenda L. Plassman, Daniel K. Burns, Stephen K. Brannan, Michael Kukulka, Jingtao Wu, and Ahmad R. Hariri. “Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults.” Alzheimers Dement (N Y) 5 (2019): 254–63. https://doi.org/10.1016/j.trci.2019.05.004.
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    • Smith, Patrick J., Stephanie Mabe, Andrew Sherwood, Michael A. Babyak, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, William Kraus, James Burke, Alan Hinderliter, and James A. Blumenthal. “Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.” J Alzheimers Dis 71, no. 3 (2019): 921–29. https://doi.org/10.3233/JAD-190569.
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    • Deming, Yuetiva, Logan Dumitrescu, Lisa L. Barnes, Madhav Thambisetty, Brian Kunkle, Katherine A. Gifford, William S. Bush, et al. “Sex-specific genetic predictors of Alzheimer's disease biomarkers.” Acta Neuropathol 136, no. 6 (December 2018): 857–72. https://doi.org/10.1007/s00401-018-1881-4.
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    • Hohman, Timothy J., Logan Dumitrescu, Lisa L. Barnes, Madhav Thambisetty, Gary Beecham, Brian Kunkle, Katherine A. Gifford, et al. “Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.” Jama Neurol 75, no. 8 (August 1, 2018): 989–98. https://doi.org/10.1001/jamaneurol.2018.0821.
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    • Rafii, Michael S., Mark H. Tuszynski, Ronald G. Thomas, David Barba, James B. Brewer, Robert A. Rissman, Joao Siffert, Paul S. Aisen, and Paul S. AAV2-NGF Study Team. “Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial.” Jama Neurol 75, no. 7 (July 1, 2018): 834–41. https://doi.org/10.1001/jamaneurol.2018.0233.
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    • Lad, Eleonora M., Dibyendu Mukherjee, Sandra S. Stinnett, Scott W. Cousins, Guy G. Potter, James R. Burke, Sina Farsiu, and Heather E. Whitson. “Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.” Plos One 13, no. 2 (2018): e0192646. https://doi.org/10.1371/journal.pone.0192646.
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    • Peloso, G. M., S. J. van der Lee, R. Sims, A. C. Naj, C. Bellenguez, N. Badarinarayan, J. Jakobsdottir, et al. “Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.” Alzheimer’S and Dementia: Diagnosis, Assessment and Disease Monitoring 10 (January 1, 2018): 595–98. https://doi.org/10.1016/j.dadm.2018.08.008.
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    • Sims, Rebecca, Sven J. van der Lee, Adam C. Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W. Kunkle, et al. “Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.” Nat Genet 49, no. 9 (September 2017): 1373–84. https://doi.org/10.1038/ng.3916.
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    • Jun, Gyungah R., Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W. Beecham, David A. Bennett, Joseph D. Buxbaum, et al. “Transethnic genome-wide scan identifies novel Alzheimer's disease loci.” Alzheimers Dement 13, no. 7 (July 2017): 727–38. https://doi.org/10.1016/j.jalz.2016.12.012.
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    • Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, Pao-Hwa Lin, et al. “Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.” Psychosom Med 79, no. 6 (2017): 719–27. https://doi.org/10.1097/PSY.0000000000000474.
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    • Mo, Yi, Julie Stromswold, Kimberly Wilson, Daniel Holder, Cyrille Sur, Omar Laterza, Mary J. Savage, et al. “A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging.” Alzheimers Dement (Amst) 6 (2017): 201–9. https://doi.org/10.1016/j.dadm.2017.02.004.
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    • Watterson, Scott H., George V. De Lucca, Qing Shi, Charles M. Langevine, Qingjie Liu, Douglas G. Batt, Myra Beaudoin Bertrand, et al. “Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.” J Med Chem 59, no. 19 (October 13, 2016): 9173–9200. https://doi.org/10.1021/acs.jmedchem.6b01088.
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    • De Lucca, George V., Qing Shi, Qingjie Liu, Douglas G. Batt, Myra Beaudoin Bertrand, Rick Rampulla, Arvind Mathur, et al. “Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).” J Med Chem 59, no. 17 (September 8, 2016): 7915–35. https://doi.org/10.1021/acs.jmedchem.6b00722.
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    • Ridge, Perry G., Kaitlyn B. Hoyt, Kevin Boehme, Shubhabrata Mukherjee, Paul K. Crane, Jonathan L. Haines, Richard Mayeux, et al. “Assessment of the genetic variance of late-onset Alzheimer's disease.” Neurobiol Aging 41 (May 2016): 200.e13-200.e20. https://doi.org/10.1016/j.neurobiolaging.2016.02.024.
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    • Oh, Gabriel, Sasha Ebrahimi, Sun-Chong Wang, Rene Cortese, Zachary A. Kaminsky, Irving I. Gottesman, James R. Burke, Brenda L. Plassman, and Art Petronis. “Epigenetic assimilation in the aging human brain.” Genome Biol 17 (April 28, 2016): 76. https://doi.org/10.1186/s13059-016-0946-8.
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    • Foster, Chris M., Donna Rose Addis, Jaclyn H. Ford, Daniel I. Kaufer, James R. Burke, Jeffrey N. Browndyke, Kathleen A. Welsh-Bohmer, and Kelly S. Giovanello. “Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.” Neuroimage Clin 11 (2016): 158–66. https://doi.org/10.1016/j.nicl.2016.01.008.
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    • Jun, G., C. A. Ibrahim-Verbaas, M. Vronskaya, J. -. C. Lambert, J. Chung, A. C. Naj, B. W. Kunkle, et al. “A novel Alzheimer disease locus located near the gene encoding tau protein.” Mol Psychiatry 21, no. 1 (January 2016): 108–17. https://doi.org/10.1038/mp.2015.23.
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    • Karch, Celeste M., Lubov A. Ezerskiy, Sarah Bertelsen, Sarah Alzheimer’s Disease Genetics Consortium (ADGC), and Alison M. Goate. “Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.” Plos One 11, no. 2 (2016): e0148717. https://doi.org/10.1371/journal.pone.0148717.
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    • Lutz, Michael W., Scott S. Sundseth, Daniel K. Burns, Ann M. Saunders, Kathleen M. Hayden, James R. Burke, Kathleen A. Welsh-Bohmer, and Allen D. Roses. “A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease.” Alzheimers Dement (N Y) 2, no. 1 (January 1, 2016): 30–44. https://doi.org/10.1016/j.trci.2015.12.002.
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    • Mukherjee, Shubhabrata, Stefan Walter, John S. K. Kauwe, Andrew J. Saykin, David A. Bennett, Eric B. Larson, Paul K. Crane, et al. “Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.” Alzheimers Dement 11, no. 12 (December 2015): 1439–51. https://doi.org/10.1016/j.jalz.2015.05.015.
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    • Ghani, Mahdi, Christiane Reitz, Rong Cheng, Badri Narayan Vardarajan, Gyungah Jun, Christine Sato, Adam Naj, et al. “Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.” Jama Neurol 72, no. 11 (November 2015): 1313–23. https://doi.org/10.1001/jamaneurol.2015.1700.
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    • Uzarski, Diane, James Burke, Barbara Turner, James Vroom, and Nancy Short. “A Plan for Academic Biobank Solvency-Leveraging Resources and Applying Business Processes to Improve Sustainability.” Clin Transl Sci 8, no. 5 (October 2015): 553–57. https://doi.org/10.1111/cts.12287.
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    • Holsinger, Tracey, Brenda L. Plassman, Karen M. Stechuchak, James R. Burke, Cynthia J. Coffman, and John W. Williams. “Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.” J Am Geriatr Soc 63, no. 6 (June 2015): 1105–11. https://doi.org/10.1111/jgs.13455.
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    • Østergaard, Søren D., Shubhabrata Mukherjee, Stephen J. Sharp, Petroula Proitsi, Luca A. Lotta, Felix Day, John R. B. Perry, et al. “Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study.” Plos Med 12, no. 6 (June 2015): e1001841. https://doi.org/10.1371/journal.pmed.1001841.
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    • Wang, Li-San, Adam C. Naj, Robert R. Graham, Paul K. Crane, Brian W. Kunkle, Carlos Cruchaga, Josue D Gonzalez Murcia, et al. “Rarity of the Alzheimer disease-protective APP A673T variant in the United States.” Jama Neurol 72, no. 2 (February 2015): 209–16. https://doi.org/10.1001/jamaneurol.2014.2157.
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    • Kotagal, Vikas, Kenneth M. Langa, Brenda L. Plassman, Gwenith G. Fisher, Bruno J. Giordani, Robert B. Wallace, James R. Burke, et al. “Factors associated with cognitive evaluations in the United States.” Neurology 84, no. 1 (January 6, 2015): 64–71. https://doi.org/10.1212/WNL.0000000000001096.
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    • Berger, Miles, James Burke, Roderick Eckenhoff, and Joseph Mathew. “Alzheimer's disease, anesthesia, and surgery: a clinically focused review.” J Cardiothorac Vasc Anesth 28, no. 6 (December 2014): 1609–23. https://doi.org/10.1053/j.jvca.2014.04.014.
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    • Chuang, Yi-Fang, John C. S. Breitner, Yen-Ling Chiu, Ara Khachaturian, Kathleen Hayden, Chris Corcoran, JoAnn Tschanz, et al. “Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.” Neurobiol Aging 35, no. 11 (November 2014): 2429–35. https://doi.org/10.1016/j.neurobiolaging.2014.05.002.
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    • Hayden, Kathleen M., Maragatha Kuchibhatla, Heather R. Romero, Brenda L. Plassman, James R. Burke, Jeffrey N. Browndyke, and Kathleen A. Welsh-Bohmer. “Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.” Am J Geriatr Psychiatry 22, no. 11 (November 2014): 1364–74. https://doi.org/10.1016/j.jagp.2013.07.008.
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    • Naj, Adam C., Gyungah Jun, Christiane Reitz, Brian W. Kunkle, William Perry, Yo Son Park, Gary W. Beecham, et al. “Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.” Jama Neurol 71, no. 11 (November 2014): 1394–1404. https://doi.org/10.1001/jamaneurol.2014.1491.
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    • Linnertz, Colton, Lauren Anderson, William Gottschalk, Donna Crenshaw, Michael W. Lutz, Jawara Allen, Sunita Saith, et al. “The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes.” Alzheimers Dement 10, no. 5 (September 2014): 541–51. https://doi.org/10.1016/j.jalz.2013.08.280.
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    • Zannas, Anthony S., P Murali Doraiswamy, Katie S. Shpanskaya, Kelly R. Murphy, Jeffrey R. Petrella, James R. Burke, and Terence Z. Wong. “Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.” Neurocase 20, no. 4 (August 2014): 466–73. https://doi.org/10.1080/13554794.2013.791867.
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    • Popiel, H Akiko, Toshihide Takeuchi, James R. Burke, Warren J. Strittmatter, Tatsushi Toda, Keiji Wada, and Yoshitaka Nagai. “Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases.” Neurotherapeutics 10, no. 3 (July 2013): 440–46. https://doi.org/10.1007/s13311-013-0184-7.
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    • Browndyke, Jeffrey N., Kelly Giovanello, Jeffrey Petrella, Kathleen Hayden, Ornit Chiba-Falek, Karen A. Tucker, James R. Burke, and Kathleen A. Welsh-Bohmer. “Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.” Alzheimers Dement 9, no. 3 (May 2013): 284–94. https://doi.org/10.1016/j.jalz.2011.12.006.
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    • Potter, Guy G., H Ryan Wagner, James R. Burke, Brenda L. Plassman, Kathleen A. Welsh-Bohmer, and David C. Steffens. “Neuropsychological predictors of dementia in late-life major depressive disorder.” Am J Geriatr Psychiatry 21, no. 3 (March 2013): 297–306. https://doi.org/10.1016/j.jagp.2012.12.009.
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    • Crenshaw, D. G., W. K. Gottschalk, M. W. Lutz, I. Grossman, A. M. Saunders, J. R. Burke, K. A. Welsh-Bohmer, S. K. Brannan, D. K. Burns, and A. D. Roses. “Using genetics to enable studies on the prevention of Alzheimer's disease.” Clin Pharmacol Ther 93, no. 2 (February 2013): 177–85. https://doi.org/10.1038/clpt.2012.222.
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    • Blumenthal, James A., Patrick J. Smith, Kathleen Welsh-Bohmer, Michael A. Babyak, Jeffrey Browndyke, Pao-Hwa Lin, P Murali Doraiswamy, et al. “Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.” Contemp Clin Trials 34, no. 1 (January 2013): 60–69. https://doi.org/10.1016/j.cct.2012.09.004.
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    • Whitcomb, David C., Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, et al. “Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.” Nat Genet 44, no. 12 (December 2012): 1349–54. https://doi.org/10.1038/ng.2466.
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    • Giovanello, Kelly S., Felipe De Brigard, Jaclyn Hennessey Ford, Daniel I. Kaufer, James R. Burke, Jeffrey N. Browndyke, and Kathleen A. Welsh-Bohmer. “Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment.” J Int Neuropsychol Soc 18, no. 5 (September 2012): 886–97. https://doi.org/10.1017/S1355617712000689.
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    • Coppola, Giovanni, Subashchandrabose Chinnathambi, Jason JiYong Lee, Beth A. Dombroski, Matt C. Baker, Alexandra I. Soto-Ortolaza, Suzee E. Lee, et al. “Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.” Hum Mol Genet 21, no. 15 (August 1, 2012): 3500–3512. https://doi.org/10.1093/hmg/dds161.
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    • McCarthy, Jeanette J., Sunita Saith, Colton Linnertz, James R. Burke, Christine M. Hulette, Kathleen A. Welsh-Bohmer, and Ornit Chiba-Falek. “The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.” Neurobiol Aging 33, no. 7 (July 2012): 1485.e1-1485.e8. https://doi.org/10.1016/j.neurobiolaging.2010.10.004.
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    • Holsinger, Tracey, Brenda L. Plassman, Karen M. Stechuchak, James R. Burke, Cynthia J. Coffman, and John W. Williams. “Screening for cognitive impairment: comparing the performance of four instruments in primary care.” J Am Geriatr Soc 60, no. 6 (June 2012): 1027–36. https://doi.org/10.1111/j.1532-5415.2012.03967.x.
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    • Mehlenbacher, Adam, Bruce Capehart, Dale Bass, and James R. Burke. “Sound induced vertigo: superior canal dehiscence resulting from blast exposure.” Arch Phys Med Rehabil 93, no. 4 (April 2012): 723–24. https://doi.org/10.1016/j.apmr.2011.09.020.
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    • Potter, G. G., H. R. Wagner, J. R. Burke, B. L. Plassman, K. A. Welsh-Bohmer, and D. C. Steffens. “Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.” Am J Geriatr Psychiatry, March 11, 2012. https://doi.org/10.1097/JGP.0b013e318248764e.
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    • Ritchie, C. W., D. Ames, J. R. Burke, J. Bustin, P. Connelly, J. Laczo, and F. Portet. “Erratum: An international perspective on advanced neuroimaging: Cometh the hour or ivory tower? (International Psychogeriatrics (2011) 23 (S58-S64) DOI: 10.1017/S1041610211001566).” International Psychogeriatrics 24, no. 1 (January 1, 2012): 170. https://doi.org/10.1017/S1041610211002316.
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    • Daviglus, Martha L., Brenda L. Plassman, Amber Pirzada, Carl C. Bell, Phyllis E. Bowen, James R. Burke, E Sander Connolly, et al. “Risk factors and preventive interventions for Alzheimer disease: state of the science.” Arch Neurol 68, no. 9 (September 2011): 1185–90. https://doi.org/10.1001/archneurol.2011.100.
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    • Plassman, Brenda L., Kenneth M. Langa, Ryan J. McCammon, Gwenith G. Fisher, Guy G. Potter, James R. Burke, David C. Steffens, et al. “Incidence of dementia and cognitive impairment, not dementia in the United States.” Ann Neurol 70, no. 3 (September 2011): 418–26. https://doi.org/10.1002/ana.22362.
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    • Ritchie, Craig W., David Ames, James R. Burke, Julian Bustin, Peter Connelly, Jan Laczo, and Florence Portet. “An international perspective on advanced neuroimaging: cometh the hour or ivory tower?” Int Psychogeriatr 23 Suppl 2 (September 2011): S58–64. https://doi.org/10.1017/S1041610211000901.
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    • Kaddurah-Daouk, Rima, Steve Rozen, Wayne Matson, Xianlin Han, Christine M. Hulette, James R. Burke, P Murali Doraiswamy, and Kathleen A. Welsh-Bohmer. “Metabolomic changes in autopsy-confirmed Alzheimer's disease.” Alzheimers Dement 7, no. 3 (May 2011): 309–17. https://doi.org/10.1016/j.jalz.2010.06.001.
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    • Naj, Adam C., Gyungah Jun, Gary W. Beecham, Li-San Wang, Badri Narayan Vardarajan, Jacqueline Buros, Paul J. Gallins, et al. “Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.” Nat Genet 43, no. 5 (May 2011): 436–41. https://doi.org/10.1038/ng.801.
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    • Womack, Kyle B., Ramon Diaz-Arrastia, Howard J. Aizenstein, Steven E. Arnold, Nancy R. Barbas, Bradley F. Boeve, Christopher M. Clark, et al. “Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors.” Arch Neurol 68, no. 3 (March 2011): 329–37. https://doi.org/10.1001/archneurol.2010.295.
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    • McCarthy, Jeanette J., Colton Linnertz, Laura Saucier, James R. Burke, Christine M. Hulette, Kathleen A. Welsh-Bohmer, and Ornit Chiba-Falek. “The effect of SNCA 3' region on the levels of SNCA-112 splicing variant.” Neurogenetics 12, no. 1 (February 2011): 59–64. https://doi.org/10.1007/s10048-010-0263-4.
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    • Dyckman, Alaric J., Charles M. Langevine, Claude Quesnelle, James Kempson, Junqing Guo, Patrice Gill, Steven H. Spergel, et al. “Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.” Bioorg Med Chem Lett 21, no. 1 (January 1, 2011): 383–86. https://doi.org/10.1016/j.bmcl.2010.10.133.
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    • Han, Xianlin, Steve Rozen, Stephen H. Boyle, Caroline Hellegers, Hua Cheng, James R. Burke, Kathleen A. Welsh-Bohmer, P Murali Doraiswamy, and Rima Kaddurah-Daouk. “Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.” Plos One 6, no. 7 (2011): e21643. https://doi.org/10.1371/journal.pone.0021643.
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    • Popiel, H Akiko, James R. Burke, Warren J. Strittmatter, Shinya Oishi, Nobutaka Fujii, Toshihide Takeuchi, Tatsushi Toda, Keiji Wada, and Yoshitaka Nagai. “The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases.” J Amino Acids 2011 (2011): 265084. https://doi.org/10.4061/2011/265084.
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    • Gabel, Matthew J., Norman L. Foster, Judith L. Heidebrink, Roger Higdon, Howard J. Aizenstein, Steven E. Arnold, Nancy R. Barbas, et al. “Validation of consensus panel diagnosis in dementia.” Arch Neurol 67, no. 12 (December 2010): 1506–12. https://doi.org/10.1001/archneurol.2010.301.
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    • Plassman, Brenda L., John W. Williams, James R. Burke, Tracey Holsinger, and Sophiya Benjamin. “Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.” Ann Intern Med 153, no. 3 (August 3, 2010): 182–93. https://doi.org/10.7326/0003-4819-153-3-201008030-00258.
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    • Dennis, Nancy A., Jeffrey N. Browndyke, Jared Stokes, Anna Need, James R. Burke, Kathleen A. Welsh-Bohmer, and Roberto Cabeza. “Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.” Alzheimers Dement 6, no. 4 (July 2010): 303–11. https://doi.org/10.1016/j.jalz.2009.07.003.
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    • Williams, John W., B. L. Plassman, J. Burke, and S. Benjamin. “Preventing Alzheimer's disease and cognitive decline.” Evid Rep Technol Assess (Full Rep), no. 193 (April 2010): 1–727.
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    • Heinzen, Erin L., Anna C. Need, Kathleen M. Hayden, Ornit Chiba-Falek, Allen D. Roses, Warren J. Strittmatter, James R. Burke, Christine M. Hulette, Kathleen A. Welsh-Bohmer, and David B. Goldstein. “Genome-wide scan of copy number variation in late-onset Alzheimer's disease.” J Alzheimers Dis 19, no. 1 (2010): 69–77. https://doi.org/10.3233/JAD-2010-1212.
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    • Romero, H. R., J. N. Browndyke, J. R. Burke, K. M. Hayden, and K. A. Welsh-Bohmer. “Executive Measures are Related to Functional Ability in an Ethnically Diverse Cohort.” Clinical Neuropsychologist 24, no. 4 (January 1, 2010): 599–600.
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    • Potter, Guy G., Brenda L. Plassman, James R. Burke, Mohammed U. Kabeto, Kenneth M. Langa, David J. Llewellyn, Mary A. M. Rogers, and David C. Steffens. “Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.” Alzheimers Dement 5, no. 6 (November 2009): 445–53. https://doi.org/10.1016/j.jalz.2009.04.1234.
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    • Linnertz, Colton, Laura Saucier, Dongliang Ge, Kenneth D. Cronin, James R. Burke, Jeffrey N. Browndyke, Christine M. Hulette, Kathleen A. Welsh-Bohmer, and Ornit Chiba-Falek. “Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.” Plos One 4, no. 10 (October 16, 2009): e7480. https://doi.org/10.1371/journal.pone.0007480.
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    • Mathias, J. L., and J. Burke. “Cognitive functioning in Alzheimer's and vascular dementia: a meta-analysis.” Neuropsychology 23, no. 4 (July 2009): 411–23. https://doi.org/10.1037/a0015384.
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    • Kempson, James, Junqing Guo, Jagabandhu Das, Robert V. Moquin, Steven H. Spergel, Scott H. Watterson, Charles M. Langevine, et al. “Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.” Bioorg Med Chem Lett 19, no. 10 (May 15, 2009): 2646–49. https://doi.org/10.1016/j.bmcl.2009.03.159.
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    • Wang, C Sheei-Meei, J. R. Burke, D. C. Steffens, C. M. Hulette, J. C. S. Breitner, and B. L. Plassman. “Twin pairs discordant for neuropathologically confirmed Lewy body dementia.” J Neurol Neurosurg Psychiatry 80, no. 5 (May 2009): 562–65. https://doi.org/10.1136/jnnp.2008.151654.
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    • Hulette, Christine M., John F. Ervin, Yvette Edmonds, Samantha Antoine, Nicolas Stewart, Mari H. Szymanski, Kathleen M. Hayden, Carl F. Pieper, James R. Burke, and Kathleen A. Welsh-Bohmer. “Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease.” J Neuropathol Exp Neurol 68, no. 4 (April 2009): 417–24. https://doi.org/10.1097/NEN.0b013e31819e6334.
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    • Lai, Thung-S, Yusha Liu, Tim Tucker, Kurt R. Daniel, David C. Sane, Eric Toone, James R. Burke, Warren J. Strittmatter, and Charles S. Greenberg. “Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.” Chem Biol 15, no. 9 (September 22, 2008): 969–78. https://doi.org/10.1016/j.chembiol.2008.07.015.
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    • Carlson, Michelle C., Michael J. Helms, David C. Steffens, James R. Burke, Guy G. Potter, and Brenda L. Plassman. “Midlife activity predicts risk of dementia in older male twin pairs.” Alzheimers Dement 4, no. 5 (September 2008): 324–31. https://doi.org/10.1016/j.jalz.2008.07.002.
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    • Browndyke, Jeffrey N., James Paskavitz, Lawrence H. Sweet, Ronald A. Cohen, Karen A. Tucker, Kathleen A. Welsh-Bohmer, James R. Burke, and Donald E. Schmechel. “Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task.” Brain Inj 22, no. 6 (June 2008): 481–89. https://doi.org/10.1080/02699050802084894.
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    • Gambetti, Pierluigi, Zhiqian Dong, Jue Yuan, Xiangzhu Xiao, Mengjie Zheng, Amer Alshekhlee, Rudy Castellani, et al. “A novel human disease with abnormal prion protein sensitive to protease.” Ann Neurol 63, no. 6 (June 2008): 697–708. https://doi.org/10.1002/ana.21420.
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    • Plassman, Brenda L., Kenneth M. Langa, Gwenith G. Fisher, Steven G. Heeringa, David R. Weir, Mary Beth Ofstedal, James R. Burke, et al. “Prevalence of cognitive impairment without dementia in the United States.” Ann Intern Med 148, no. 6 (March 18, 2008): 427–34. https://doi.org/10.7326/0003-4819-148-6-200803180-00005.
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    • Steinberg, Martin, Huibo Shao, Peter Zandi, Constantine G. Lyketsos, Kathleen A. Welsh-Bohmer, Maria C. Norton, John C. S. Breitner, David C. Steffens, Joann T. Tschanz, and Joann T. Cache County Investigators. “Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.” Int J Geriatr Psychiatry 23, no. 2 (February 2008): 170–77. https://doi.org/10.1002/gps.1858.
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    • Ervin, John F., Erin L. Heinzen, Kenneth D. Cronin, David Goldstein, Mari H. Szymanski, James R. Burke, Kathleen A. Welsh-Bohmer, and Christine M. Hulette. “Postmortem delay has minimal effect on brain RNA integrity.” J Neuropathol Exp Neurol 66, no. 12 (December 2007): 1093–99. https://doi.org/10.1097/nen.0b013e31815c196a.
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    • Hamuro, Lora, Guangtao Zhang, Timothy J. Tucker, Christopher Self, Warren J. Strittmatter, and James R. Burke. “Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.” Assay Drug Dev Technol 5, no. 5 (October 2007): 629–36. https://doi.org/10.1089/adt.2007.083.
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    • Steffens, David C., Guy G. Potter, Douglas R. McQuoid, James R. MacFall, Martha E. Payne, James R. Burke, Brenda L. Plassman, and Kathleen A. Welsh-Bohmer. “Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.” Am J Geriatr Psychiatry 15, no. 10 (October 2007): 839–49. https://doi.org/10.1097/JGP.0b013e318048a1a0.
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    • Fearing, Michael A., Erin D. Bigler, Maria Norton, Jo Ann Tschanz, Christine Hulette, Carol Leslie, Kathleen Welsh-Bohmer, and Kathleen Cache County Investigators. “Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.” J Clin Exp Neuropsychol 29, no. 5 (July 2007): 553–60. https://doi.org/10.1080/13803390600826579.
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    • Potter, Guy G., Michael J. Helms, James R. Burke, David C. Steffens, and Brenda L. Plassman. “Job demands and dementia risk among male twin pairs.” Alzheimers Dement 3, no. 3 (July 2007): 192–99. https://doi.org/10.1016/j.jalz.2007.04.377.
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    • Heinzen, Erin L., Woohyun Yoon, Michael E. Weale, Arjune Sen, Nicholas W. Wood, James R. Burke, Kathleen A. Welsh-Bohmer, Christine M. Hulette, Sanjay M. Sisodiya, and David B. Goldstein. “Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease.” Genome Biol 8, no. 3 (2007): R32. https://doi.org/10.1186/gb-2007-8-3-r32.
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    • Plassman, B. L., K. M. Langa, G. G. Fisher, S. G. Heeringa, D. R. Weir, M. B. Ofstedal, J. R. Burke, et al. “Prevalence of dementia in the United States: the aging, demographics, and memory study.” Neuroepidemiology 29, no. 1–2 (2007): 125–32. https://doi.org/10.1159/000109998.
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    • Plassman, Brenda L., David C. Steffens, James R. Burke, Kathleen A. Welsh-Bohmer, Tiffany N. Newman, Deborah Drosdick, Michael J. Helms, Guy G. Potter, and John C. S. Breitner. “Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.” Twin Res Hum Genet 9, no. 6 (December 2006): 950–57. https://doi.org/10.1375/183242706779462381.
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    • Lyketsos, Constantine G., Leslie Toone, Joann Tschanz, Christopher Corcoran, Maria Norton, Peter Zandi, Ron Munger, John C. S. Breitner, Kathleen Welsh-Bohmer, and Kathleen Cache County Study Group. “A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study.” Int J Geriatr Psychiatry 21, no. 6 (June 2006): 509–18. https://doi.org/10.1002/gps.1502.
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    • Puranam, Kasturi L., Guanghong Wu, Warren J. Strittmatter, and James R. Burke. “Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria.” Biochem Biophys Res Commun 341, no. 2 (March 10, 2006): 607–13. https://doi.org/10.1016/j.bbrc.2006.01.007.
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    • Kenan, Daniel J., Warren J. Strittmatter, and James R. Burke. “Phage display screening for peptides that inhibit polyglutamine aggregation.” Methods Enzymol 413 (2006): 253–73. https://doi.org/10.1016/S0076-6879(06)13014-1.
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    • Plassman, Brenda L., Ara S. Khachaturian, Jeannette J. Townsend, Melvyn J. Ball, David C. Steffens, Carol E. Leslie, JoAnn T. Tschanz, et al. “Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.” Alzheimers Dement 2, no. 1 (January 2006): 2–11. https://doi.org/10.1016/j.jalz.2005.11.001.
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    • LaBar, Kevin S., Dana C. Torpey, Craig A. Cook, Stephanie R. Johnson, Lauren H. Warren, James R. Burke, and Kathleen A. Welsh-Bohmer. “Emotional enhancement of perceptual priming is preserved in aging and early-stage Alzheimer's disease.” Neuropsychologia 43, no. 12 (2005): 1824–37. https://doi.org/10.1016/j.neuropsychologia.2005.01.018.
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    • Langa, Kenneth M., Brenda L. Plassman, Robert B. Wallace, A Regula Herzog, Steven G. Heeringa, Mary Beth Ofstedal, James R. Burke, et al. “The Aging, Demographics, and Memory Study: study design and methods.” Neuroepidemiology 25, no. 4 (2005): 181–91. https://doi.org/10.1159/000087448.
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    • Tschanz, Joann T., Katherine Treiber, Maria C. Norton, Kathleen A. Welsh-Bohmer, Leslie Toone, Peter P. Zandi, Christine A. Szekely, Constantine Lyketsos, John C. S. Breitner, and John C. S. Cache County Study Group. “A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.” Care Manag J 6, no. 2 (2005): 107–14. https://doi.org/10.1891/cmaj.6.2.107.
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    • Steffens, David C., Kathleen A. Welsh-Bohmer, James R. Burke, Brenda L. Plassman, John L. Beyer, Kenneth R. Gersing, and Guy G. Potter. “Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.” J Geriatr Psychiatry Neurol 17, no. 4 (December 2004): 202–11. https://doi.org/10.1177/0891988704269819.
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    • Colton, C. A., Q. Xu, J. R. Burke, S. Y. Bae, J. K. Wakefield, A. Nair, W. J. Strittmatter, and M. P. Vitek. “Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death.” J Neurosci 24, no. 32 (August 11, 2004): 7118–27. https://doi.org/10.1523/JNEUROSCI.1233-04.2004.
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    • Popiel, Helena A., Yoshitaka Nagai, Osamu Onodera, Takashi Inui, Nobuhiro Fujikake, Yoshihiro Urade, Warren J. Strittmatter, James R. Burke, Atsushi Ichikawa, and Tatsushi Toda. “Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity.” Biochem Biophys Res Commun 317, no. 4 (May 14, 2004): 1200–1206. https://doi.org/10.1016/j.bbrc.2004.03.161.
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    • Lai, T. -. S., T. Tucker, J. R. Burke, W. J. Strittmatter, and C. S. Greenberg. “Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.” J Neurochem 88, no. 5 (March 2004): 1253–60. https://doi.org/10.1046/j.1471-4159.2003.02249.x.
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    • Colton, Carol A., Leila K. Needham, Candice Brown, Danielle Cook, Karima Rasheed, James R. Burke, Warren J. Strittmatter, Donald E. Schmechel, and Michael P. Vitek. “APOE genotype-specific differences in human and mouse macrophage nitric oxide production.” J Neuroimmunol 147, no. 1–2 (February 2004): 62–67. https://doi.org/10.1016/j.jneuroim.2003.10.015.
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    • Nagai, Yoshitaka, Nobuhiro Fujikake, Katsuhito Ohno, Hiroyuki Higashiyama, Helena A. Popiel, Julia Rahadian, Masamitsu Yamaguchi, Warren J. Strittmatter, James R. Burke, and Tatsushi Toda. “Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila.” Hum Mol Genet 12, no. 11 (June 1, 2003): 1253–59. https://doi.org/10.1093/hmg/ddg144.
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    • Steffens, D. C., M. C. Norton, A. D. Hart, I. Skoog, C. Corcoran, J. C. S. Breitner, and J. C. S. Cache County Study Group. “Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study.” Psychol Med 33, no. 3 (April 2003): 541–47. https://doi.org/10.1017/s0033291702007201.
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    • Panov, Alexander V., James R. Burke, Warren J. Strittmatter, and J Timothy Greenamyre. “In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.” Arch Biochem Biophys 410, no. 1 (February 1, 2003): 1–6. https://doi.org/10.1016/s0003-9861(02)00585-4.
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    • Panov, Alexander V., Claire-Anne Gutekunst, Blair R. Leavitt, Michael R. Hayden, James R. Burke, Warren J. Strittmatter, and J Timothy Greenamyre. “Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.” Nat Neurosci 5, no. 8 (August 2002): 731–36. https://doi.org/10.1038/nn884.
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    • Shimohata, Takayoshi, Aki Sato, James R. Burke, Warren J. Strittmatter, Shoji Tsuji, and Osamu Onodera. “Expanded polyglutamine stretches form an 'aggresome'.” Neurosci Lett 323, no. 3 (May 3, 2002): 215–18. https://doi.org/10.1016/s0304-3940(02)00162-3.
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    • Tschanz, JoAnn T., Kathleen A. Welsh-Bohmer, Brenda L. Plassman, Maria C. Norton, Bonita W. Wyse, John C. S. Breitner, and John C. S. Cache County Study Group. “An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study.” Neuropsychiatry Neuropsychol Behav Neurol 15, no. 1 (March 2002): 28–38.
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    • Ren, H., Y. Nagai, T. Tucker, W. J. Strittmatter, and J. R. Burke. “Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death.” Biochem Biophys Res Commun 288, no. 3 (November 2, 2001): 703–10. https://doi.org/10.1006/bbrc.2001.5783.
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    • Nagai, Y., H. Ren, J. R. Burke, W. J. Strittmatter, N. Fujikake, H. Higashiyama, M. Yamaguchi, and T. Toda. “Polyglutamine Binding Peptide 1 (QBP1) inhibits polyglutamine aggregation and cytotoxicity in vitro and in an in vivo disease model.” American Journal of Human Genetics 69, no. 4 (October 1, 2001): 211–211.
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    • Magboo, M. C., B. L. Plassman, R. J. Havlik, D. C. Steffens, M. J. Helms, J. R. Burke, L. J. Launer, C. Phillips, J. M. Guralnik, and J. C. Breitner. “Documented head injury in early adulthood and risk of stroke in late life.” Journal of the American Geriatrics Society 49, no. 4 (April 1, 2001): S22–S22.
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    • Plassman, B. L., R. J. Havlik, D. C. Steffens, M. J. Helms, T. N. Newman, D. Drosdick, C. Phillips, et al. “Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias.” Neurology 55, no. 8 (October 24, 2000): 1158–66. https://doi.org/10.1212/wnl.55.8.1158.
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    • Nagai, Y., T. Tucker, H. Ren, D. J. Kenan, B. S. Henderson, J. D. Keene, W. J. Strittmatter, and J. R. Burke. “Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.” J Biol Chem 275, no. 14 (April 7, 2000): 10437–42. https://doi.org/10.1074/jbc.275.14.10437.
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    • Burke, J. R., and J. C. Morgenlander. “Update on Alzheimer's disease. Promising advances in detection and treatment.” Postgrad Med 106, no. 5 (October 15, 1999): 85–86. https://doi.org/10.3810/pgm.1999.10.15.746.
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    • Burke, J. R., and J. C. Morgenlander. “Managing common behavioral problems in dementia. How to improve quality of life for patients and families.” Postgrad Med 106, no. 5 (October 15, 1999): 131–40. https://doi.org/10.3810/pgm.1999.10.15.748.
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    • Nagai, Y., T. J. Tucker, D. J. Kenan, B. S. Henderson, J. D. Keene, W. J. Strittmatter, and J. R. Burke. “Identification of QBP1, a synthetic peptide that preferentially binds expanded polyglutamine domain by phage display technique.” American Journal of Human Genetics 65, no. 4 (October 1, 1999): A463–A463.
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    • Cooper, A. J., K. F. Sheu, J. R. Burke, W. J. Strittmatter, V. Gentile, G. Peluso, and J. P. Blass. “Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability.” J Neurochem 72, no. 3 (March 1999): 889–99. https://doi.org/10.1046/j.1471-4159.1999.0720889.x.
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    • Nagai, Y., O. Onodera, J. Chun, W. J. Strittmatter, and J. R. Burke. “Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network.” Exp Neurol 155, no. 2 (February 1999): 195–203. https://doi.org/10.1006/exnr.1998.6991.
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    • Moulder, K. L., O. Onodera, J. R. Burke, W. J. Strittmatter, and E. M. Johnson. “Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length.” J Neurosci 19, no. 2 (January 15, 1999): 705–15. https://doi.org/10.1523/JNEUROSCI.19-02-00705.1999.
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    • Nagai, Y., O. Onodera, W. J. Strittmatter, and J. R. Burke. “Polyglutamine domain proteins with expanded repeats bind neurofilament, altering the neurofilament network.” Ann N Y Acad Sci 893 (1999): 192–202. https://doi.org/10.1111/j.1749-6632.1999.tb07826.x.
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    • Burke, J. R., K. R. Gregor, R. Padmanabha, J. Banville, M. R. Witmer, L. B. Davern, S. P. Manly, and K. M. Tramposch. “A beta-lactam inhibitor of cytosolic phospholipase A2 which acts in a competitive, reversible manner at the lipid/water interface.” J Enzyme Inhib 13, no. 3 (June 1998): 195–206. https://doi.org/10.3109/14756369809028340.
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    • Burke, J. R., K. R. Miller, M. K. Wood, and C. A. Meyers. “The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha.” J Biol Chem 273, no. 20 (May 15, 1998): 12041–46. https://doi.org/10.1074/jbc.273.20.12041.
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    • Cooper, A. J., K. F. Sheu, J. R. Burke, O. Onodera, W. J. Strittmatter, A. D. Roses, and J. P. Blass. “Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions?” Age (Omaha) 21, no. 1 (January 1998): 25–30. https://doi.org/10.1007/s11357-998-0004-x.
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    • Cooper, A. J., K. F. Sheu, J. R. Burke, W. J. Strittmatter, and J. P. Blass. “Glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntington disease fibroblasts.” Dev Neurosci 20, no. 4–5 (1998): 462–68. https://doi.org/10.1159/000017344.
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    • Cooper, A. J., K. R. Sheu, J. R. Burke, O. Onodera, W. J. Strittmatter, A. D. Roses, and J. P. Blass. “Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length.” Proc Natl Acad Sci U S A 94, no. 23 (November 11, 1997): 12604–9. https://doi.org/10.1073/pnas.94.23.12604.
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    • Onodera, O., J. R. Burke, S. E. Miller, S. Hester, S. Tsuji, A. D. Roses, and W. J. Strittmatter. “Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells.” Biochem Biophys Res Commun 238, no. 2 (September 18, 1997): 599–605. https://doi.org/10.1006/bbrc.1997.7337.
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    • Cooper, A. J., K. F. Sheu, J. R. Burke, O. Onodera, W. J. Strittmatter, A. D. Roses, and J. P. Blass. “Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases?” J Neurochem 69, no. 1 (July 1997): 431–34. https://doi.org/10.1046/j.1471-4159.1997.69010431.x.
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    • Cooper, A. J. L., K. F. R. Sheu, J. R. Burke, O. Onodera, W. J. Strittmatter, A. D. Roses, and J. P. Blass. “Poly Q domains are substrates of transglutaminase: Implications for expanded CAG/poly Q repeat disorders.” Journal of Neurochemistry 69 (January 1, 1997): S267–S267.
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    • Onodera, O., A. D. Roses, S. Tsuji, J. M. Vance, W. J. Strittmatter, and J. R. Burke. “Toxicity of expanded polyglutamine-domain proteins in Escherichia coli.” Febs Lett 399, no. 1–2 (December 9, 1996): 135–39. https://doi.org/10.1016/s0014-5793(96)01301-4.
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    • Davem, L. B., K. R. Gregor, J. R. Burke, D. Lee, and K. M. Tramposch. “Fmlp stimulates arachidonic acid release in dibutyryl cyclic amp treated u937 cells.” Faseb Journal 10, no. 3 (December 1, 1996).
    • Greoor, K. R., L. B. Davem, D. Lee, and J. R. Burke. “Characterizationof dibutyryl cyclic amp treated u937 cells: role of phosphorylation in cpla2 activation.” Faseb Journal 10, no. 3 (December 1, 1996).
    • Burke, J. R., and J. M. Vance. “Hot papers - Human genetics - The Haw River syndrome: Dentatorubropallidoluysian atrophy (DRPLA) in an African-American family by J.R. Burke, M.S. Wingfield, K.E. Lewis, A.D. Roses, J.E. Lee, C. Hulette, M.A. Pericak-Vance, J.M. Vance - Comments.” Scientist 10, no. 15 (July 22, 1996): 13–13.
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    • Saunders, A. M., O. Hulette, K. A. Welsh-Bohmer, D. E. Schmechel, B. Crain, J. R. Burke, M. J. Alberts, W. J. Strittmatter, J. C. Breitner, and C. Rosenberg. “Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease.” Lancet 348, no. 9020 (July 13, 1996): 90–93. https://doi.org/10.1016/s0140-6736(96)01251-2.
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    • Chuang, D. M., and R. Ishitani. “A role for GAPDH in apoptosis and neurodegeneration.” Nat Med 2, no. 6 (June 1996): 609–10. https://doi.org/10.1038/nm0696-609.
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    • Roses, Allen D., James R. Burke, Jeffery M. Vance, and Warren J. Strittmatter. “Reply to “A role for GAPDH in apoptosis and neurodegeneration”.” Nature Medicine 2, no. 6 (June 1996): 610–610. https://doi.org/10.1038/nm0696-610a.
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    • Steffens, D. C., K. A. Welsh, J. R. Burke, M. J. Helms, M. F. Folstein, J. Brandt, W. M. McDonald, and J. C. S. Breitner. “Diagnosis of Alzheimer's disease in epidemiologic studies by staged review of clinical data.” Neuropsychiatry, Neuropsychology and Behavioral Neurology 9, no. 2 (April 1, 1996): 107–13.
    • Burke, J. R., J. J. Enghild, M. E. Martin, Y. S. Jou, R. M. Myers, A. D. Roses, J. M. Vance, and W. J. Strittmatter. “Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.” Nat Med 2, no. 3 (March 1996): 347–50. https://doi.org/10.1038/nm0396-347.
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    • Lautenschlager, N. T., L. A. Cupples, V. S. Rao, S. A. Auerbach, R. Becker, J. Burke, H. Chui, et al. “Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?” Neurology 46, no. 3 (March 1996): 641–50. https://doi.org/10.1212/wnl.46.3.641.
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    • Strittmatter, W. J., J. R. Burke, V. S. DeSerrano, D. Y. Huang, W. Matthew, A. M. Saunders, B. L. Scott, J. M. Vance, K. H. Weisgraber, and A. D. Roses. “Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases.” Cold Spring Harb Symp Quant Biol 61 (1996): 597–605.
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    • Burke, J. R., T. Ikeuchi, R. Koide, S. Tsuji, M. Yamada, M. A. Pericak-Vance, and J. M. Vance. “Dentatorubral-pallidoluysian atrophy and Haw River syndrome.” Lancet 344, no. 8938 (December 17, 1994): 1711–12. https://doi.org/10.1016/s0140-6736(94)90497-9.
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    • Burke, J., R. G. Knight, and F. M. Partridge. “Priming deficits in patients with dementia of the Alzheimer type.” Psychol Med 24, no. 4 (November 1994): 987–93. https://doi.org/10.1017/s003329170002907x.
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    • Burke, J. R., M. S. Wingfield, K. E. Lewis, A. D. Roses, J. E. Lee, C. Hulette, M. A. Pericak-Vance, and J. M. Vance. “The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family.” Nat Genet 7, no. 4 (August 1994): 521–24. https://doi.org/10.1038/ng0894-521.
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    • Farrer, L. A., L. A. Cupples, S. Blackburn, D. K. Kiely, S. Auerbach, J. H. Growdon, L. Connor-Lacke, H. Karlinsky, A. Thibert, and J. R. Burke. “Interrater agreement for diagnosis of Alzheimer's disease: the MIRAGE study.” Neurology 44, no. 4 (April 1994): 652–56. https://doi.org/10.1212/wnl.44.4.652.
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    • Burke, J. R., and A. D. Roses. “Genetics of Alzheimer's disease.” Int J Neurol 25–26 (1991): 41–51.
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    • “Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group.” Ann Neurol 27, no. 6 (June 1990): 591–605. https://doi.org/10.1002/ana.410270603.
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    • Waters, L. C., J. R. Burke, and M. P. Stulberg. “Studies on the function of the non-primer tRNAs associated with the 70 S RNA of avian myeloblastosis virus.” Biochim Biophys Acta 696, no. 2 (February 26, 1982): 201–7. https://doi.org/10.1016/0167-4781(82)90029-x.
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  • Book Sections

    • Xu, Hanzhang, Matthew Dupre, and James Burke. “Subjective Cognitive Decline.” In Encyclopedia of Gerontology and Population Aging, edited by Danan Gu and Matthew Dupre. Springer Nature, 2020. https://doi.org/10.1007/978-3-319-69892-2_1136-1.
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  • Conference Papers

    • Pead, Emma Jean Roberta, Dilraj S. Grewal, Stephen P. Yoon, Bryce Polascik, Atalie Thompson, James R. Burke, Cynthia Dunn, Emmanuel Trucco, Tom MacGillivray, and Sharon Fekrat. “Ultra-widefield imaging of the retinal vasculature in mild cognitive impairment and Alzheimer's disease: A pilot study.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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    • Wisely, Clayton Ellis, Dong Wang, Ricardo Henao, Dilraj S. Grewal, Stephen Paul Yoon, Bryce Polascik, Atalie C. Thompson, James R. Burke, Lawrence Carin, and Sharon Fekrat. “Deep learning algorithm for diagnosis of Alzheimer's disease using multimodal retinal imaging.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.
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    • Yoon, Stephen Paul, Dilraj Singh Grewal, Bryce W. Polascik, Cynthia Dunn, Kim Johnson, James Burke, and Sharon Fekrat. “Comparison of Retinal Microvasculature and Neurodegenerative Changes among Alzheimer's disease, Mild Cognitive Impairment, and Controls.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.
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    • Whitson, Heather, Sina Farsiu, Sandra S. Stinnett, Leon Kwark, Guy Potter, James Burke, Scott W. Cousins, and Eleonora M. Lad. “Retinal Biomarkers of Alzheimer's Disease.” In Investigative Ophthalmology & Visual Science, Vol. 57. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016.
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    • Whitson, Heather E., Sina Farsiu, Sandra Stinnett, Sung Lee, Leon Kwark, Guy Potter, James Burke, Scott W. Cousins, and Eleonora Lad. “Retinal imaging biomarkers for early diagnosis of Alzheimer's disease.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.
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    • Foster, Chris, Donna Addis, Jaclyn Ford, Daniel Kaufer, Jeffrey Browndyke, Kathleen Welsh-Bohmer, and Kelly Giovanello. “PREFRONTAL CONTRIBUTIONS TO RELATIONAL ENCODING IN HEALTHY AGING AND MILD COGNITIVE IMPAIRMENT.” In Journal of Cognitive Neuroscience, 197–197. MIT PRESS, 2013.
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    • Gambetti, Pierluigi, Amer Alshekhlee, Rudy Castellani, Mark Cohen, James A. Mastrianni, Qingzhong Kong, and Wen-Quan Zou. “A novel human disease with abnormal prion protein sensitive to protease.” In Journal of Neuropathology and Experimental Neurology, 67:498–99, 2008.
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    • Hulette, Christine Marie, John F. Ervin, Emily Steed, Mari Szymanski, James Burke, and Kathleen Welsh-Bohmer. “Arteriolar ApoE expression is increased Alzheimer disease cortex.” In Journal of Neuropathology and Experimental Neurology, 66:433–433. Oxford University Press (OUP), 2007. https://doi.org/10.1097/01.jnen.0000268866.50903.81.
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    • Ervin, John F., Erin L. Heinzen, David Goldstein, Mari H. Szymanski, James R. Burke, Kathleen A. Welsh-Bohmer, and Christine M. Hulette. “Human brain tissue may be retrieved up to 30 hours post-mortem with little effect on RNA or protein integrity.” In Brain Pathology, 16:S125–S125. BLACKWELL PUBLISHING, 2006.
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    • Gambetti, Pierluigi, Zhiqian Dong, Jue Yuan, Xiangzhu Xiao, Mengjie Zheng, Amer Alsheklee, Rudy Castellan, et al. “A human prion disease with protease-sensitive prion.” In Brain Pathology, 16:S10–S10. BLACKWELL PUBLISHING, 2006.
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    • Plassman, Brenda L., David C. Steffens, James R. Burke, Kathleen A. Welsh-Bohmer, Michael J. Helms, and John C. Breitner. “P4-137 Alzheimer's disease in the NAS-NRC twin registry of WWII veterans.” In Neurobiology of Aging, 25:S514–S514. Elsevier BV, 2004. https://doi.org/10.1016/s0197-4580(04)81695-6.
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    • Nagal, Y., N. Fujikake, K. Ohno, H. Higashiyama, T. Inui, H. A. Popiel, Y. Urade, et al. “Polyglutamine Binding Peptide 1 (QBP1) inhibits polyglutamine aggregation and rescues neurological phenotypes in Drosophila polyglutarnine disease models.” In American Journal of Human Genetics, 71:470–470. UNIV CHICAGO PRESS, 2002.
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    • Ogrocki, P. K., K. A. Welsh-Bohmer, D. C. Koltai, and J. R. Burke. “Heterogeneity in the atypical variants of Alzheimer's disease: A case study of isolated bilateral sensorimotor impairment.” In Archives of Clinical Neuropsychology, 12:377–78. Oxford University Press (OUP), 1997. https://doi.org/10.1093/arclin/12.4.377a.
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    • Roses, A. D., A. M. Saunders, C. Hulette, K. A. Welsh, B. Crain, J. R. Burke, M. J. Alberts, et al. “Predictive value of ApoE genotyping in a consecutive series of autopsied sporadic probable Alzheimer disease patients.” In Neurology, 47:294–294. LITTLE BROWN CO, 1996.
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