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James Robert Burke

Professor of Neurology
Neurology, Behavioral Neurology
Duke Box 3333, Room 201 B Bryan Research Bldg, Durham, NC 27710
932 Morreene Rd, Box 2900, Durham, NC 27710

Overview


My research focuses on the characterization of cognitive change with age.  I am specifically interested in delineating the change between normal and pathologic changes associated with aging and developing therapies to delay decline.  

My area of expertise is neurodegenerative diseases and dementia with an emphasis on Alzheimer's disease.

Keywords: Alzheimer's disease.

Current Appointments & Affiliations


Professor of Neurology · 2012 - Present Neurology, Behavioral Neurology, Neurology
Professor in Psychiatry and Behavioral Sciences · 2021 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences

In the News


Published May 7, 2015
War on Alzheimer's: Durham firms lead push in treatment R&D

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Recent Publications


Beta amyloid PET scans for dementia diagnoses: Practice and research implications from CARE-IDEAS.

Journal Article J Am Geriatr Soc · October 2024 Beta amyloid PET scans are a minimally invasive biomarker that may inform Alzheimer's disease (AD) diagnosis. The Caregiver's Reactions and Experience (CARE) study, an IDEAS supplement, aimed to understand experiences of PET scan recipients and their care ... Full text Link to item Cite

Association between results of an amyloid PET scan and healthcare utilization in individuals with cognitive impairment.

Journal Article J Am Geriatr Soc · March 2024 BACKGROUND: The Imaging Dementia Evidence for Amyloid Scanning (IDEAS) study reports that amyloid PET scans help providers diagnose and manage Alzheimer's disease and related dementias (ADRD). Using CARE-IDEAS, an IDEAS supplemental study, we examined the ... Full text Link to item Cite

Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI ... Full text Link to item Cite
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Recent Grants


Improving the lives of persons living with dementia and their families through person-centered measurement of home time

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

Cognitive Training to Reduce Cognitive Impairment: The PACT Trial

ResearchPhysician · Awarded by University of South Florida · 2021 - 2026

Open-Label Extension of Studies ATH-1017-0201 and ATH-1017-0202 in Subjects with Mild to Moderate Alzheimer¿s Disease

Clinical TrialPrincipal Investigator · Awarded by Athira Pharma, Inc. · 2021 - 2026

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Education, Training & Certifications


State University of New York, Brooklyn · 1985 M.D.
University of Tennessee, Knoxville · 1981 Ph.D.