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Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.

Publication ,  Journal Article
Nwosu, A; Qian, M; Phillips, J; Hellegers, CA; Rushia, S; Sneed, J; Petrella, JR; Goldberg, TE; Devanand, DP; Doraiswamy, PM
Published in: J Prev Alzheimers Dis
2024

BACKGROUND: African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear. METHODS: We used data from a two-site, 78-week randomized trial of MCI comparing intensive, home-based, computerized training with Web-based cognitive games or Web-based crossword puzzles to examine the effect of race on outcomes. The study outcomes were changes from baseline in cognitive and functional scales as well as MRI-measured changes in hippocampal volume and cortical thickness. Analyses used linear models adjusted for baseline scores. This was an exploratory study. RESULTS: A total of 105 subjects were included comprising 81 whites (77.1%) and 24 African Americans (22.8%). The effect of race on the change from baseline in ADAS-Cog-11 was not significant. The effect of race on change from baseline to week 78 in the Functional Activities Questionnaire (FAQ) was significant with African American participants' FAQ scores showing greater improvements at weeks 52 and 78 (P = 0.009, P = 0.0002, respectively) than white subjects. Within the CCT cohort, FAQ scores for African American participants showed greater improvement between baseline and week 78, compared to white participants randomized to CCT (P = 0.006). There was no effect of race on the UPSA. There was no effect of race on hippocampal or cortical thickness outcomes. CONCLUSIONS: Our preliminary findings suggest that web-based cognitive training programs may benefit African Americans with MCI at least as much as Caucasians, and highlight the need to further study underrepresented minorities in AD prevention trials. (Supported by the National Institutes of Health, National Institute on Aging; ClinicalTrials.gov number, NCT03205709.).

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Published In

J Prev Alzheimers Dis

DOI

EISSN

2426-0266

Publication Date

2024

Volume

11

Issue

1

Start / End Page

149 / 154

Location

Switzerland

Related Subject Headings

  • White
  • Surveys and Questionnaires
  • Humans
  • Cognitive Training
  • Cognitive Dysfunction
  • Black or African American
  • Alzheimer Disease
  • 5204 Cognitive and computational psychology
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
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Nwosu, A., Qian, M., Phillips, J., Hellegers, C. A., Rushia, S., Sneed, J., … Doraiswamy, P. M. (2024). Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians. J Prev Alzheimers Dis, 11(1), 149–154. https://doi.org/10.14283/jpad.2023.80
Nwosu, A., M. Qian, J. Phillips, C. A. Hellegers, S. Rushia, J. Sneed, J. R. Petrella, T. E. Goldberg, D. P. Devanand, and P. M. Doraiswamy. “Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.J Prev Alzheimers Dis 11, no. 1 (2024): 149–54. https://doi.org/10.14283/jpad.2023.80.
Nwosu A, Qian M, Phillips J, Hellegers CA, Rushia S, Sneed J, et al. Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians. J Prev Alzheimers Dis. 2024;11(1):149–54.
Nwosu, A., et al. “Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.J Prev Alzheimers Dis, vol. 11, no. 1, 2024, pp. 149–54. Pubmed, doi:10.14283/jpad.2023.80.
Nwosu A, Qian M, Phillips J, Hellegers CA, Rushia S, Sneed J, Petrella JR, Goldberg TE, Devanand DP, Doraiswamy PM. Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians. J Prev Alzheimers Dis. 2024;11(1):149–154.

Published In

J Prev Alzheimers Dis

DOI

EISSN

2426-0266

Publication Date

2024

Volume

11

Issue

1

Start / End Page

149 / 154

Location

Switzerland

Related Subject Headings

  • White
  • Surveys and Questionnaires
  • Humans
  • Cognitive Training
  • Cognitive Dysfunction
  • Black or African American
  • Alzheimer Disease
  • 5204 Cognitive and computational psychology
  • 5202 Biological psychology
  • 3209 Neurosciences