Jeffrey Robert Petrella | Scholars@Duke

Jeffrey Robert Petrella
Professor of Radiology

- Quantitating and modeling physiologic processes in normal and diseased states in the central nervous system through the use of imaging
- Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques
- Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease
- Development of functional imaging biomarkers for early diagnosis and monitoring of dementia
- Functional MRI as an aid to preoperative planning in patients with potentially resectable brain lesions

Current Appointments & Affiliations

Professor of Radiology, Radiology, Neuroradiology, Radiology 2014
Member of the Center for Brain Imaging and Analysis, Duke-UNC Center for Brain Imaging and Analysis, Institutes and Centers 2004

Contact Information

1527 Hosp North, Durham, NC 27710
Box 3808 Med Ctr, Durham, NC 27710
jeffrey.petrella@duke.edu (919) 684-7218

Background
Education, Training, & Certifications
- M.D., Rutgers University 1987
Duke Appointment History
- Associate Professor of Radiology, Radiology, Neuroradiology, Radiology 2006 - 2014
- Associate Professor of Radiology, Radiology, Neuroradiology, Radiology 2005 - 2006
- Assistant Professor of Radiology, Radiology, Neuroradiology, Radiology 1997 - 2005
- Instructor, Temporary in the Department of Radiology, Radiology, Neuroradiology, Radiology 1997
Research
Selected Grants
- Cognitive training and neuroplasticity in Mild Cognitive Impairment awarded by Columbia University 2017 - 2022
- Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
- High Resolution Intracortical DTI for Early Detection of Alzheimer¿s Disease awarded by Neuroradiology Education and Reserach Foundation (formerly Foundation of the ASNR) 2016 - 2018
- Motion-immune neuro and body MRI for challenging patient populations awarded by National Institutes of Health 2014 - 2018
- Imaging of Intrinsic Connectivity Networks awarded by National Institutes of Health 2011 - 2018
- Prognostic Performance in MCI of Two Commercially Available Hippocampal Volumetry Tools awarded by Radiological Society of North America 2015 - 2017
- Susceptibility MRI as a marker for diagnosis and clinical disability in MS awarded by National Institutes of Health 2014 - 2017
- A Linux Cluster Computational Facility for Neuroimaging Research awarded by National Institutes of Health 2009 - 2010
- fMRI Studies in Early Alzheimer's Disease awarded by National Institutes of Health 2001 - 2008
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Krishnan, S, Slavin, MJ, Tran, TT, Murty, L, Finefrock, AE, Doraiswamy, PM, and Petrella, JR. "Comparison of FMRI activation patterns in mild cognitive impairment (MCI) subjects and elderly controls at ultra-high field strength." July 2004. Full Text Link to Item
- Journal Articles
  - Huang, SY, Hsu, JL, Lin, KJ, Liu, HL, Wey, SP, Hsiao, IT, Weiner, M, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Saykin, AJ, Morris, J, Shaw, LM, Liu, E, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, DeCarli, C, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Householder, E, Reinwald, LT, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, SG, Shen, L, Kelley, F, Kim, S, Nho, K, Kachaturian, Z, Frank, R, Snyder, PJ, Molchan, S, Kaye, J, Quinn, J, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Meyer, JV, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Carroll, M, Leon, S, and Mintun, MA. "Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease(Accepted)." Scientific Reports 8, no. 1 (December 1, 2018). Full Text
  - Mahjoub, I, Mahjoub, MA, and Rekik, I. "Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states(Published online)." Scientific Reports 8, no. 1 (December 2018). Full Text
  - Gong, N-J, Kuzminski, S, Clark, M, Fraser, M, Sundman, M, Guskiewicz, K, Petrella, JR, and Liu, C. "Microstructural alterations of cortical and deep gray matter over a season of high school football revealed by diffusion kurtosis imaging.(Accepted)" Neurobiology of Disease 119 (November 2018): 79-87. Full Text
  - Motter, JN, Pelton, GH, D'Antonio, K, Rushia, SN, Pimontel, MA, Petrella, JR, Garcon, E, Ciovacco, MW, Sneed, JR, Doraiswamy, PM, and Devanand, DP. "Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder." International Journal of Geriatric Psychiatry (July 23, 2018). Full Text
  - Devanand, DP, Pelton, GH, D'Antonio, K, Ciarleglio, A, Scodes, J, Andrews, H, Lunsford, J, Beyer, JL, Petrella, JR, Sneed, J, Ciovacco, M, and Doraiswamy, PM. "Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry (June 28, 2018). Full Text
  - Sohn, D, Shpanskaya, K, Lucas, JE, Petrella, JR, Saykin, AJ, Tanzi, RE, Samatova, NF, and Doraiswamy, PM. "Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease." Scientific Reports 8, no. 1 (May 10, 2018): 7490-null. Full Text
  - Kuzminski, SJ, Clark, MD, Fraser, MA, Haswell, CC, Morey, RA, Liu, C, Choudhury, KR, Guskiewicz, KM, and Petrella, JR. "White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football." Ajnr. American Journal of Neuroradiology 39, no. 2 (February 2018): 245-251. Full Text Open Access Copy
  - Du, L, Liu, K, Yao, X, Yan, J, Risacher, SL, Han, J, Guo, L, Saykin, AJ, and Shen, L. "Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty." Scientific Reports 7, no. 1 (December 2017). Full Text
  - Huang, M, Yang, W, Feng, Q, and Chen, W. "Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease." Scientific Reports 7, no. 1 (December 2017). Full Text
  - Singanamalli, A, Wang, H, and Madabhushi, A. "Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features." Scientific Reports 7, no. 1 (December 2017). Full Text
  - Black, DF, Vachha, B, Mian, A, Faro, SH, Maheshwari, M, Sair, HI, Petrella, JR, Pillai, JJ, and Welker, K. "American Society of Functional Neuroradiology-Recommended fMRI Paradigm Algorithms for Presurgical Language Assessment." AJNR. American journal of neuroradiology 38, no. 10 (October 2017): E65-E73. Full Text
  - Farber, SH, Han, JL, Petraglia Iii, FW, Gramer, R, Yang, S, Pagadala, P, Parente, B, Xie, J, Petrella, JR, and Lad, SP. "Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation." Pain Physician 20, no. 6 (September 2017): E969-E977.
  - Padmanabhan, K, Nudelman, K, Harenberg, S, Bello, G, Sohn, D, Shpanskaya, K, Tiwari Dikshit, P, Yerramsetty, P, Tanzi, R, Saykin, A, Petrella, J, Doraiswamy, P, Samatova, N, and Alzheimer’s Disease Neuroimaging Initiative, . "Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach." Processes 5, no. 3 (September 2017): 47-47. Full Text
  - Mattsson, N, Andreasson, U, Zetterberg, H, Blennow, K, and Alzheimer’s Disease Neuroimaging Initiative, . "Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease." Jama Neurology 74, no. 5 (May 2017): 557-566. Full Text
  - Tanpitukpongse, TP, Mazurowski, MA, Ikhena, J, Petrella, JR, and Alzheimer's Disease Neuroimaging Initiative, . "Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?." Ajnr. American Journal of Neuroradiology 38, no. 3 (March 2017): 546-552. Full Text
  - Iturria-Medina, Y, Sotero, RC, Toussaint, PJ, Mateos-Pérez, JM, Evans, AC, and Alzheimer’s Disease Neuroimaging Initiative, . "Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis." Nature Communications 7 (June 21, 2016): 11934-null. Full Text
  - Risacher, SL, McDonald, BC, Tallman, EF, West, JD, Farlow, MR, Unverzagt, FW, Gao, S, Boustani, M, Crane, PK, Petersen, RC, Jack, CR, Jagust, WJ, Aisen, PS, Weiner, MW, Saykin, AJ, and Alzheimer’s Disease Neuroimaging Initiative, . "Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults." Jama Neurology 73, no. 6 (June 2016): 721-732. Full Text
  - Prescott, JW, Guidon, A, Doraiswamy, PM, Choudhury, KR, Liu, C, and Petrella, JR. "Erratum: The Alzheimer Structural Connectome: Changes in Cortical Network Topology with Increased Amyloid Plaque Burden (Radiology (2014) 273:1 (175-184) DOI: 10.1148/radiol.14132593)." Radiology 279, no. 1 (April 1, 2016): 328-. Full Text
  - Frey, KA, Lodge, MA, Meltzer, CC, Peller, PJ, Wong, TZ, Hess, CP, Petrella, JR, Sair, HI, and Subramaniam, RM. "ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia." Clinical nuclear medicine 41, no. 2 (February 2016): 118-125. Full Text
  - Lin, KA, Choudhury, KR, Rathakrishnan, BG, Marks, DM, Petrella, JR, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Marked gender differences in progression of mild cognitive impairment over 8 years." Alzheimer'S & Dementia (New York, N. Y.) 1, no. 2 (September 2015): 103-110. Full Text
  - Ayton, S, Faux, NG, Bush, AI, and Alzheimer's Disease Neuroimaging Initiative, . "Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE." Nature Communications 6 (May 19, 2015): 6760-null. Full Text
  - Shpanskaya, KS, Choudhury, KR, Hostage, C, Murphy, KR, Petrella, JR, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort." Journal of neuroradiology. Journal de neuroradiologie 41, no. 5 (December 2014): 350-357. Full Text
  - Shpanskaya, KS, Choudhury, KR, Hostage, C, Murphy, KR, Petrella, JR, and Doraiswamy, PM. "Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort." Journal of Neuroradiology 41, no. 5 (December 1, 2014): 350-357. Full Text
  - Prescott, JW, Guidon, A, Doraiswamy, PM, Roy Choudhury, K, Liu, C, Petrella, JR, and Alzheimer’s Disease Neuroimaging Initiative, . "The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden." Radiology 273, no. 1 (October 2014): 175-184. Full Text
  - Zannas, AS, Doraiswamy, PM, Shpanskaya, KS, Murphy, KR, Petrella, JR, Burke, JR, and Wong, TZ. "Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making." Neurocase 20, no. 4 (August 2014): 466-473. Full Text Link to Item
  - Hostage, CA, Choudhury, KR, Murali Doraiswamy, P, Petrella, JR, and Alzheimer's Disease Neuroimaging Initiative, . "Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network." Radiology 271, no. 1 (April 2014): 211-219. Full Text
  - Pelton, GH, Andrews, H, Roose, SP, Marcus, SM, D'Antonio, K, Husn, H, Petrella, JR, Zannas, AS, Doraiswamy, PM, and Devanand, DP. "Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design." Contemp Clin Trials 37, no. 2 (March 2014): 200-208. Full Text Link to Item
  - Rathakrishnan, BG, Doraiswamy, PM, and Petrella, JR. "Science to practice: translating automated brain MRI volumetry in Alzheimer's disease from research to routine diagnostic use in the work-up of dementia." Frontiers in Neurology 4 (January 9, 2014): 216-null. (Review) Full Text
  - Lampert, EJ, Roy Choudhury, K, Hostage, CA, Rathakrishnan, B, Weiner, M, Petrella, JR, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Brain atrophy rates in first degree relatives at risk for Alzheimer's." Neuroimage. Clinical 6 (January 2014): 340-346. Full Text
  - Zannas, AS, Doraiswamy, PM, Shpanskaya, KS, Murphy, KR, Petrella, JR, Burke, JR, and Wong, TZ. "Impact of 18F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making." Neurocase 20, no. 4 (January 1, 2014): 466-473. Full Text
  - Petrella, JR. "Neuroimaging and the search for a cure for Alzheimer disease." Radiology 269, no. 3 (December 2013): 671-691. (Review) Full Text
  - Murphy, KR, Landau, SM, Choudhury, KR, Hostage, CA, Shpanskaya, KS, Sair, HI, Petrella, JR, Wong, TZ, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth." Neuroimage 78 (September 2013): 474-480. Full Text Link to Item
  - Atluri, G, Padmanabhan, K, Fang, G, Steinbach, M, Petrella, JR, Lim, K, Macdonald, A, Samatova, NF, Doraiswamy, PM, and Kumar, V. "Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack." Neuroimage. Clinical 3 (August 7, 2013): 123-131. (Review) Full Text
  - Browndyke, JN, Giovanello, K, Petrella, J, Hayden, K, Chiba-Falek, O, Tucker, KA, Burke, JR, and Welsh-Bohmer, KA. "Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease." Alzheimers Dement 9, no. 3 (May 2013): 284-294. Full Text Open Access Copy Link to Item
  - Petrella, JR, and Doraiswamy, PM. "From the bridges of Konigsberg to the fields of Alzheimer: connecting the dots." Neurology 80, no. 15 (April 9, 2013): 1360-1362. Full Text Link to Item
  - Shaffer, JL, Petrella, JR, Sheldon, FC, Choudhury, KR, Calhoun, VD, Coleman, RE, Doraiswamy, PM, and Alzheimer’s Disease Neuroimaging Initiative, . "Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers." Radiology 266, no. 2 (February 2013): 583-591. Full Text
  - Browndyke, JN, Giovanello, K, Petrella, J, Hayden, K, Chiba-Falek, O, Tucker, KA, Burke, JR, and Welsh-Bohmer, KA. "Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease." Alzheimer's and Dementia 9, no. 3 (2013): 284-294. Full Text
  - Hostage, CA, Roy Choudhury, K, Doraiswamy, PM, Petrella, JR, and Alzheimer’s Disease Neuroimaging Initiative, . "Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease." PLoS One 8, no. 2 (2013): e54483-. Full Text Link to Item
  - Lampert, EJ, Roy Choudhury, K, Hostage, CA, Petrella, JR, Doraiswamy, PM, and Alzheimer’s Disease Neuroimaging Initiative, . "Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives." Plos One 8, no. 4 (January 2013): e60747-null. Full Text
  - Chou, Y-H, Panych, LP, Dickey, CC, Petrella, JR, and Chen, N-K. "Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study." Ajnr. American Journal of Neuroradiology 33, no. 5 (May 2012): 833-838. Full Text
  - Petrella, JR. "Use of graph theory to evaluate brain networks: a clinical tool for a small world?." Radiology 259, no. 2 (May 2011): 317-320. Full Text
  - Petrella, JR, Sheldon, FC, Prince, SE, Calhoun, VD, and Doraiswamy, PM. "Default mode network connectivity in stable vs progressive mild cognitive impairment." Neurology 76, no. 6 (February 2011): 511-517. Full Text
  - Karikari, IO, Grant, G, Cummings, TJ, Petrella, J, and Fuchs, HE. "Endodermal cyst of the oculomotor nerve." Pediatr Neurosurg 46, no. 2 (August 2010): 155-156. Full Text Link to Item
  - Lungren, MP, Petrella, JR, Cummings, TJ, and Grant, GA. "Isolated intracranial Rosai-Dorfman disease in a child." AJNR Am J Neuroradiol 30, no. 10 (November 2009): E148-E149. (Letter) Full Text Link to Item
  - Voyvodic, JT, Petrella, JR, and Friedman, AH. "fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment." J Magn Reson Imaging 29, no. 4 (April 2009): 751-759. Full Text Link to Item
  - Petrella, JR, Prince, SE, Krishnan, S, Husn, H, Kelley, L, and Doraiswamy, PM. "Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging." AJNR Am J Neuroradiol 30, no. 2 (February 2009): 411-416. Full Text Link to Item
  - Woo, SL, Prince, SE, Petrella, JR, Hellegers, C, and Doraiswamy, PM. "Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 17, no. 1 (January 2009): 24-29. Full Text
  - Woo, SL, Prince, SE, Hellegers, C, Petrella, JR, and Doraiswamy, PM. "Modulation of Human Memory Circuit by Minor Depression in Late Life: An fMRI Study." AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 16, no. 3 (March 2008): A98-A98. Link to Item
  - Prince, SE, Woo, S, Doraiswamy, PM, and Petrella, JR. "Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus?." Expert Rev Neurother 8, no. 2 (February 2008): 169-175. Full Text Link to Item
  - Petrella, JR, Mattay, VS, and Doraiswamy, PM. "Imaging genetics of brain longevity and mental wellness: the next frontier?." Radiology 246, no. 1 (January 2008): 20-32. (Review) Full Text
  - Petrella, JR, Prince, SE, Wang, L, Hellegers, C, and Doraiswamy, PM. "Prognostic value of posteromedial cortex deactivation in mild cognitive impairment. (Published online)" PLoS One 2, no. 10 (October 31, 2007): e1104-. Full Text Link to Item
  - Petrella, JR, Wang, L, Krishnan, S, Slavin, MJ, Prince, SE, Tran, T-TT, and Doraiswamy, PM. "Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging." Radiology 245, no. 1 (October 2007): 224-235. Full Text
  - Slavin, MJ, Sandstrom, CK, Tran, T-TT, Doraiswamy, PM, and Petrella, JR. "Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment." AJR Am J Roentgenol 188, no. 5 (May 2007): 1404-1410. Full Text Link to Item
  - Petrella, JR, Shah, LM, Harris, KM, Friedman, AH, George, TM, Sampson, JH, Pekala, JS, and Voyvodic, JT. "Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors." Radiology 240, no. 3 (September 2006): 793-802. Full Text
  - Sandstrom, CK, Krishnan, S, Slavin, MJ, Tran, T-TT, Doraiswamy, PM, and Petrella, JR. "Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment." AJNR Am J Neuroradiol 27, no. 8 (September 2006): 1622-1627. Link to Item
  - Petrella, JR, Krishnan, S, Slavin, MJ, Tran, T-TT, Murty, L, and Doraiswamy, PM. "Mild cognitive impairment: evaluation with 4-T functional MR imaging." Radiology 240, no. 1 (July 2006): 177-186. Full Text
  - Krishnan, S, Slavin, MJ, Tran, T-TT, Doraiswamy, PM, and Petrella, JR. "Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders." Neuroimage 31, no. 2 (June 2006): 560-571. Full Text Link to Item
  - Krishnan, S, Talley, BD, Slavin, MJ, Doraiswamy, PM, and Petrella, JR. "Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research." Neuroimaging Clin N Am 15, no. 4 (November 2005): 853-xi. (Review) Full Text Link to Item
  - York, G, Barboriak, D, Petrella, J, DeLong, D, and Provenzale, JM. "Association of internal carotid artery injury with carotid canal fractures in patients with head trauma." AJR Am J Roentgenol 184, no. 5 (May 2005): 1672-1678. Full Text Link to Item
  - Benson, AD, Slavin, MJ, Tran, T-T, Petrella, JR, and Doraiswamy, PM. "Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?." Prim Care Companion J Clin Psychiatry 7, no. 2 (2005): 62-69. Link to Item
  - Petrella, JR, Townsend, BA, Jha, AP, Ziajko, LA, Slavin, MJ, Lustig, C, Hart, SJ, and Doraiswamy, PM. "Increasing memory load modulates regional brain activity in older adults as measured by fMRI." J Neuropsychiatry Clin Neurosci 17, no. 1 (2005): 75-83. Full Text Link to Item
  - Petrella, JR, and Doraiswamy, PM. "Alzheimer's disease: 100 Years of progress." Neuroimaging Clinics of North America 15, no. 4 (2005): xiii-xiv. Full Text
  - Holmes, TM, Petrella, JR, and Provenzale, JM. "Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI." AJR Am J Roentgenol 183, no. 5 (November 2004): 1247-1252. Full Text Link to Item
  - Holmes, TM, Petrella, JR, and Provenzale, JM. "Original report. Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI." AMERICAN JOURNAL OF ROENTGENOLOGY 183, no. 5 (November 2004): 1247-1252. Full Text Link to Item
  - Sair, HI, Doraiswamy, PM, and Petrella, JR. "In vivo amyloid imaging in Alzheimer's disease." Neuroradiology 46, no. 2 (February 2004): 93-104. (Review) Full Text Link to Item
  - Gaillard, WD, Sachs, BC, Whitnah, JR, Ahmad, Z, Balsamo, LM, Petrella, JR, Braniecki, SH, McKinney, CM, Hunter, K, Xu, B, and Grandin, CB. "Developmental aspects of language processing: fMRI of verbal fluency in children and adults." Human Brain Mapping 18, no. 3 (March 2003): 176-185. Full Text
  - Petrella, JR, Coleman, RE, and Doraiswamy, PM. "Neuroimaging and early diagnosis of Alzheimer disease: a look to the future." Radiology 226, no. 2 (February 2003): 315-336. (Review) Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, DeLong, DM, and Alberts, MJ. "Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke." Cerebrovasc Dis 15, no. 3 (2003): 188-191. Full Text Link to Item
  - Balsamo, LM, Xu, B, Grandin, CB, Petrella, JR, Braniecki, SH, Elliott, TK, and Gaillard, WD. "A functional magnetic resonance imaging study of left hemisphere language dominance in children." Arch Neurol 59, no. 7 (July 2002): 1168-1174. Link to Item
  - Provenzale, JM, Wang, GR, Brenner, T, Petrella, JR, and Sorensen, AG. "Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging." Ajr. American Journal of Roentgenology 178, no. 3 (March 2002): 711-716. Full Text
  - Eastwood, JD, Alexander, MJ, Petrella, JR, and Provenzale, JM. "Dynamic CT perfusion imaging with acetazolamide challenge for the preprocedural evaluation of a patient with symptomatic middle cerebral artery occlusive disease." AJNR Am J Neuroradiol 23, no. 2 (February 2002): 285-287. Link to Item
  - Petrella, JR, Lustig, C, Bucher, LA, Jha, AP, and Doraiswamy, PM. "Prefrontal activation patterns in subjects at risk for Alzheimer disease." Am J Geriatr Psychiatry 10, no. 1 (January 2002): 112-113. (Letter) Link to Item
  - Townsend, BA, Petrella, JR, and Doraiswamy, PM. "The role of neuroimaging in geriatric psychiatry." Current Opinion in Psychiatry 15, no. 4 (2002): 427-432. Full Text
  - Provenzale, JM, Petrella, JR, Cruz, LC, Wong, JC, Engelter, S, and Barboriak, DP. "Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome." AJNR Am J Neuroradiol 22, no. 8 (September 2001): 1455-1461. Link to Item
  - Gaillard, WD, Pugliese, M, Grandin, CB, Braniecki, SH, Kondapaneni, P, Hunter, K, Xu, B, Petrella, JR, Balsamo, L, and Basso, G. "Cortical localization of reading in normal children: an fMRI language study." Neurology 57, no. 1 (July 10, 2001): 47-54. Link to Item
  - Guo, AC, Provenzale, JM, Cruz, LC, and Petrella, JR. "Cerebral abscesses: investigation using apparent diffusion coefficient maps." Neuroradiology 43, no. 5 (May 2001): 370-374. Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, Alberts, MJ, DeLong, DM, and MacFall, JR. "Use of exponential diffusion imaging to determine the age of ischemic infarcts." J Neuroimaging 11, no. 2 (April 2001): 141-147. Link to Item
  - Guo, AC, Petrella, JR, Kurtzberg, J, and Provenzale, JM. "Evaluation of white matter anisotropy in Krabbe disease with diffusion tensor MR imaging: initial experience." Radiology 218, no. 3 (March 2001): 809-815. Full Text
  - Petrella, JR, Bucher, L, Jha, A, Doraiswamy, PM, and McCarthy, G. "Event-related functional MRI for the early diagnosis of Alzheimer disease: A pilot study in normal volunteers and patients with mild cognitive impairment." NEUROBIOLOGY OF AGING 22, no. 2 (2001): 338-338. Link to Item
  - Engelter, ST, Provenzale, JM, and Petrella, JR. "Assessment of vasogenic edema in eclampsia using diffusion imaging." Neuroradiology 42, no. 11 (November 2000): 818-820. Link to Item
  - Engelter, ST, Provenzale, JM, Petrella, JR, DeLong, DM, and MacFall, JR. "The effect of aging on the apparent diffusion coefficient of normal-appearing white matter." AJR Am J Roentgenol 175, no. 2 (August 2000): 425-430. Full Text Link to Item
  - van Gelderen, P, Grandin, C, Petrella, JR, and Moonen, CT. "Rapid three-dimensional MR imaging method for tracking a bolus of contrast agent through the brain." Radiology 216, no. 2 (August 2000): 603-608. Full Text
  - Petrella, JR, and Provenzale, JM. "MR perfusion imaging of the brain: techniques and applications." Ajr. American Journal of Roentgenology 175, no. 1 (July 2000): 207-219. (Review) Full Text
  - Kassem-Moussa, H, Provenzale, JM, Petrella, JR, and Lewis, DV. "Early diffusion-weighted MR imaging abnormalities in sustained seizure activity." AJR Am J Roentgenol 174, no. 5 (May 2000): 1304-1306. Full Text Link to Item
  - Wong, JC, Provenzale, JM, and Petrella, JR. "Perfusion MR imaging of brain neoplasms." AJR Am J Roentgenol 174, no. 4 (April 2000): 1147-1157. Full Text Link to Item
  - Wong, JC, Provenzale, JM, and Petrella, JR. "Pictorial essay. Perfusion MR imaging of brain neoplasms." American Journal of Roentgenology 174, no. 4 (2000): 1147-1157.
  - Engelter, ST, Petrella, JR, Alberts, MJ, and Provenzale, JM. "Assessment of cerebral microcirculation in a patient with hypertensive encephalopathy using MR perfusion imaging." AJR Am J Roentgenol 173, no. 6 (December 1999): 1491-1493. Full Text Link to Item
  - Engelter, ST, Provenzale, JM, Petrella, JR, and Alberts, MJ. "Diffusion MR imaging and transient ischemic attacks." Stroke 30, no. 12 (December 1999): 2762-2763. (Letter) Link to Item
  - Provenzale, JM, Engelter, ST, Petrella, JR, Smith, JS, and MacFall, JR. "Use of MR exponential diffusion-weighted images to eradicate T2 "shine-through" effect." Ajr. American Journal of Roentgenology 172, no. 2 (February 1999): 537-539. Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, Alberts, MJ, Kidwell, CS, Alger, JR, Salle, FD, Starkman, S, Villablanca, P, Bentson, J, and Saver, JL. "Diffusion MR imaging and transient ischemic attacks [4] (multiple letters)." Stroke 30, no. 12 (1999): 2762-2763.
  - Engelter, ST, Provenzale, JM, Petrella, JR, Hoffmann, KL, Delong, DM, and Alberts, MJ. "Signal intensity of exponential diffusion weighted images correlates with infarct age." STROKE 30, no. 1 (January 1999): 260-260. Link to Item
  - Grandin, CB, Gaillard, WD, Hunter, KE, Petrella, JR, Braniecki, SH, Whitnah, JR, and Theodore, WH. "Comparison of phonemic and semantic verbal fluency tasks: An fMRI study." NeuroImage 7, no. 4 PART II (1998): S133-.
  - Grandin, CB, Gaillard, WD, Whitnah, JR, Petrella, JR, Braniecki, SH, Hunter, KE, and Theodore, WH. "Gender related differences in activated brain areas for language processing: An fMRI study." NeuroImage 7, no. 4 PART II (1998): S159-.
  - Petrella, JR, DeCarli, C, Dagli, M, Grandin, CB, Duyn, JH, Frank, JA, Hoffman, EA, and Theodore, WH. "Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study." AJNR Am J Neuroradiol 19, no. 1 (January 1998): 39-44. Link to Item
  - Petrella, JR, DeCarli, C, Dagli, M, Duyn, JH, Grandin, CB, Frank, JA, Hoffman, EA, and Theodore, WH. "Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst." AJNR Am J Neuroradiol 18, no. 6 (June 1997): 1153-1161. Link to Item
  - Petrella, JR, Grossman, RI, McGowan, JC, Campbell, G, and Cohen, JA. "Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect." AJNR Am J Neuroradiol 17, no. 6 (June 1996): 1041-1049. Link to Item
  - Frank, JA, Bash, C, Stone, L, Petrella, J, Maloni, H, and McFarland, H. "Evaluation of magnetic resonance imaging sensitivity in patients with relapsing remitting multiple sclerosis: baseline versus Betaseron treatment trials." Academic radiology 3 Suppl 2 (1996): S173-S175.
  - Fortin, DF, Cusma, JT, Spero, LA, and Bashore, TM. "Reply." The American Journal of Cardiology 69, no. 16 (1992): 1378--.
Teaching & Mentoring
Recent Courses
- NEUROSCI 493: Research Independent Study 1 2017

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