Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Rutgers University 1987
• 

  Duke Appointment History

  • Associate Professor of Radiology, Radiology, Neuroradiology, Radiology 2006 - 2014
  • Associate Professor of Radiology, Radiology, Neuroradiology, Radiology 2005 - 2006
  • Assistant Professor of Radiology, Radiology, Neuroradiology, Radiology 1997 - 2005
  • Instructor, Temporary in the Department of Radiology, Radiology, Neuroradiology, Radiology 1997
• 

  Leadership & Clinical Positions at Duke

  • Director, Alzheimer Imaging Research Laboratory
• Research
• 

  Selected Grants

  • Cognitive training and neuroplasticity in Mild Cognitive Impairment awarded by Columbia University 2017 - 2021
  • High Resolution Intracortical DTI for Early Detection of Alzheimer¿s Disease awarded by Neuroradiology Education and Reserach Foundation (formerly Foundation of the ASNR) 2016 - 2020
  • Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
  • Motion-immune neuro and body MRI for challenging patient populations awarded by National Institutes of Health 2014 - 2018
  • Imaging of Intrinsic Connectivity Networks awarded by National Institutes of Health 2011 - 2018
  • Prognostic Performance in Mild Cognitive Impairment (MCI) of Two Commercially Available Hippocampal Volumetry Tools awarded by Radiological Society of North America 2015 - 2017
  • Susceptibility MRI as a marker for diagnosis and clinical disability in MS awarded by National Institutes of Health 2014 - 2017
  • A Linux Cluster Computational Facility for Neuroimaging Research awarded by National Institutes of Health 2009 - 2010
  • fMRI Studies in Early Alzheimer's Disease awarded by National Institutes of Health 2001 - 2008
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ghusayni, Ryan, Jordan P. Richardson, Julie Uchitel, Elie Abdelnour, Melissa McLean, Lyndsey Prange, Tavis Abrahamsen, Allen Song, Jeffrey R. Petrella, and Mohamad A. Mikati. “Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study.” Eur J Paediatr Neurol 26 (May 2020): 15–19. https://doi.org/10.1016/j.ejpn.2020.02.001.
       Full Text  Link to Item
    • Yoon, Stephen P., Atalie C. Thompson, Bryce W. Polascik, Christopher Calixte, James R. Burke, Jeffrey R. Petrella, Dilraj S. Grewal, and Sharon Fekrat. “Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease.” Ophthalmic Surg Lasers Imaging Retina 50, no. 11 (November 1, 2019): 709–18. https://doi.org/10.3928/23258160-20191031-06.
       Full Text  Link to Item
    • Horgusluoglu-Moloch, Emrin, Shannon L. Risacher, Paul K. Crane, Derrek Hibar, Paul M. Thompson, Andrew J. Saykin, Kwangsik Nho, and Kwangsik Alzheimer’s Disease Neuroimaging Initiative (ADNI). “Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.” Scientific Reports 9, no. 1 (October 10, 2019): 14498. https://doi.org/10.1038/s41598-019-50507-3.
       Full Text
    • D’Antonio, Jessica, Laura Simon-Pearson, Terry Goldberg, Joel R. Sneed, Sara Rushia, Nancy Kerner, Howard Andrews, et al. “Cognitive training and neuroplasticity in mild cognitive impairment (COG-IT): protocol for a two-site, blinded, randomised, controlled treatment trial.” Bmj Open 9, no. 8 (August 30, 2019): e028536. https://doi.org/10.1136/bmjopen-2018-028536.
       Full Text  Link to Item
    • Schilling, Lucas Porcello, Tharick A. Pascoal, Eduardo R. Zimmer, Sulantha Mathotaarachchi, Monica Shin, Carlos Roberto de Mello Rieder, Serge Gauthier, André Palmini, Pedro Rosa-Neto, and Pedro Alzheimer’s Disease Neuroimaging Initiative. “Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.” Mol Neurobiol 56, no. 7 (July 2019): 4916–24. https://doi.org/10.1007/s12035-018-1405-1.
       Full Text  Link to Item
    • Goudey, Benjamin, Bowen J. Fung, Christine Schieber, Noel G. Faux, Noel G. Alzheimer’s Disease Metabolomics Consortium, and Noel G. Alzheimer’s Disease Neuroimaging Initiative. “A blood-based signature of cerebrospinal fluid Aβ1-42 status.” Sci Rep 9, no. 1 (March 11, 2019): 4163. https://doi.org/10.1038/s41598-018-37149-7.
       Full Text  Link to Item
    • Moran, Chris, Richard Beare, Wei Wang, Michele Callisaya, Velandai Srikanth, and Velandai Alzheimer’s Disease Neuroimaging Initiative (ADNI). “Type 2 diabetes mellitus, brain atrophy, and cognitive decline.” Neurology 92, no. 8 (February 19, 2019): e823–30. https://doi.org/10.1212/WNL.0000000000006955.
       Full Text  Link to Item
    • Petrella, Jeffrey R., Wenrui Hao, Adithi Rao, and P Murali Doraiswamy. “Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease.” Comput Math Methods Med 2019 (2019): 6216530. https://doi.org/10.1155/2019/6216530.
       Full Text  Link to Item
    • Tolbert, S., Y. Liu, C. Hellegers, J. R. Petrella, M. W. Weiner, T. Z. Wong, and P. Murali Doraiswamy. “Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition.” J Prev Alzheimers Dis 6, no. 4 (2019): 274–82. https://doi.org/10.14283/jpad.2019.26.
       Full Text  Link to Item
    • Motter, Jeffrey N., Gregory H. Pelton, Kristina D’Antonio, Sara N. Rushia, Monique A. Pimontel, Jeffrey R. Petrella, Ernst Garcon, et al. “Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.” Int J Geriatr Psychiatry 33, no. 12 (December 2018): 1604–12. https://doi.org/10.1002/gps.4955.
       Full Text  Link to Item
    • Gong, Nan-Jie, Samuel Kuzminski, Michael Clark, Melissa Fraser, Mark Sundman, Kevin Guskiewicz, Jeffrey R. Petrella, and Chunlei Liu. “Microstructural alterations of cortical and deep gray matter over a season of high school football revealed by diffusion kurtosis imaging.” Neurobiol Dis 119 (November 2018): 79–87. https://doi.org/10.1016/j.nbd.2018.07.020.
       Full Text  Link to Item
    • Young, Alexandra L., Razvan V. Marinescu, Neil P. Oxtoby, Martina Bocchetta, Keir Yong, Nicholas C. Firth, David M. Cash, et al. “Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.” Nat Commun 9, no. 1 (October 15, 2018): 4273. https://doi.org/10.1038/s41467-018-05892-0.
       Full Text  Link to Item
    • Devanand, Davangere P., Gregory H. Pelton, Kristina D’Antonio, Adam Ciarleglio, Jennifer Scodes, Howard Andrews, Julia Lunsford, et al. “Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial.” Am J Geriatr Psychiatry 26, no. 10 (October 2018): 1050–60. https://doi.org/10.1016/j.jagp.2018.05.008.
       Full Text  Link to Item
    • Huang, Sheng-Yao, Jung-Lung Hsu, Kun-Ju Lin, Ho-Ling Liu, Shiaw-Pying Wey, Ing-Tsung Hsiao, and Ing-Tsung Alzheimer’s Disease Neuroimaging Initiative. “Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer's disease.” Sci Rep 8, no. 1 (September 14, 2018): 13807. https://doi.org/10.1038/s41598-018-31794-8.
       Full Text  Link to Item
    • Sohn, Dongwha, Katie Shpanskaya, Joseph E. Lucas, Jeffrey R. Petrella, Andrew J. Saykin, Rudolph E. Tanzi, Nagiza F. Samatova, and P Murali Doraiswamy. “Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.” Sci Rep 8, no. 1 (May 10, 2018): 7490. https://doi.org/10.1038/s41598-018-25377-w.
       Full Text  Link to Item
    • Lu, Donghuan, Karteek Popuri, Gavin Weiguang Ding, Rakesh Balachandar, Mirza Faisal Beg, and Mirza Faisal Alzheimer’s Disease Neuroimaging Initiative. “Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images.” Sci Rep 8, no. 1 (April 9, 2018): 5697. https://doi.org/10.1038/s41598-018-22871-z.
       Full Text  Link to Item
    • Mahjoub, Ines, Mohamed Ali Mahjoub, Islem Rekik, and Islem Alzheimer’s Disease Neuroimaging Initiative. “Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states.” Scientific Reports 8, no. 1 (March 7, 2018): 4103. https://doi.org/10.1038/s41598-018-21568-7.
       Full Text
    • Kuzminski, S. J., M. D. Clark, M. A. Fraser, C. C. Haswell, R. A. Morey, C. Liu, K. R. Choudhury, K. M. Guskiewicz, and J. R. Petrella. “White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.” Ajnr Am J Neuroradiol 39, no. 2 (February 2018): 245–51. https://doi.org/10.3174/ajnr.A5489.
       Full Text  Open Access Copy  Link to Item
    • Du, Lei, Kefei Liu, Xiaohui Yao, Jingwen Yan, Shannon L. Risacher, Junwei Han, Lei Guo, Andrew J. Saykin, Li Shen, and Li Alzheimer’s Disease Neuroimaging Initiative. “Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.” Scientific Reports 7, no. 1 (October 25, 2017): 14052. https://doi.org/10.1038/s41598-017-13930-y.
       Full Text
    • Black, D. F., B. Vachha, A. Mian, S. H. Faro, M. Maheshwari, H. I. Sair, J. R. Petrella, J. J. Pillai, and K. Welker. “American Society of Functional Neuroradiology-Recommended fMRI Paradigm Algorithms for Presurgical Language Assessment.” Ajnr Am J Neuroradiol 38, no. 10 (October 2017): E65–73. https://doi.org/10.3174/ajnr.A5345.
       Full Text  Link to Item
    • Farber, S Harrison, Jing L. Han, Frank W. Petraglia Iii, Robert Gramer, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Jeffrey R. Petrella, and Shivanand P. Lad. “Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation.” Pain Physician 20, no. 6 (September 2017): E969–77.
       Link to Item
    • Farber, S Harrison, Jing L. Han, Frank W. Petraglia, Robert Gramer, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Jeffrey R. Petrella, and Shivanand P. Lad. “Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation.” Pain Physician 20, no. 6 (September 1, 2017): E968–76.
       Link to Item
    • Padmanabhan, K., K. Nudelman, S. Harenberg, G. Bello, D. Sohn, K. Shpanskaya, P. T. Dikshit, et al. “Characterizing gene and protein crosstalks in subjects at risk of developing Alzheimer's disease: A new computational approach.” Processes 5, no. 3 (September 1, 2017). https://doi.org/10.3390/pr5030047.
       Full Text
    • Tanpitukpongse, T. P., and J. R. Petrella. “Reply.” Ajnr Am J Neuroradiol 38, no. 9 (September 2017): E62. https://doi.org/10.3174/ajnr.A5259.
       Full Text  Link to Item
    • Singanamalli, Asha, Haibo Wang, Anant Madabhushi, and Anant Alzheimer’s Disease Neuroimaging Initiative. “Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features.” Sci Rep 7, no. 1 (August 15, 2017): 8137. https://doi.org/10.1038/s41598-017-03925-0.
       Full Text  Link to Item
    • Mattsson, Niklas, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, and Kaj Alzheimer’s Disease Neuroimaging Initiative. “Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.” Jama Neurology 74, no. 5 (May 2017): 557–66. https://doi.org/10.1001/jamaneurol.2016.6117.
       Full Text
    • Tanpitukpongse, T. P., M. A. Mazurowski, J. Ikhena, J. R. Petrella, and J. R. Alzheimer’s Disease Neuroimaging Initiative. “Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?” Ajnr Am J Neuroradiol 38, no. 3 (March 2017): 546–52. https://doi.org/10.3174/ajnr.A5061.
       Full Text  Link to Item
    • Huang, Meiyan, Wei Yang, Qianjin Feng, Wufan Chen, and Wufan Alzheimer’s Disease Neuroimaging Initiative. “Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease.” Sci Rep 7 (January 12, 2017): 39880. https://doi.org/10.1038/srep39880.
       Full Text  Link to Item
    • Iturria-Medina, Y., R. C. Sotero, P. J. Toussaint, J. M. Mateos-Pérez, A. C. Evans, and A. C. Alzheimer’s Disease Neuroimaging Initiative. “Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.” Nat Commun 7 (June 21, 2016): 11934. https://doi.org/10.1038/ncomms11934.
       Full Text  Link to Item
    • Risacher, Shannon L., Brenna C. McDonald, Eileen F. Tallman, John D. West, Martin R. Farlow, Fredrick W. Unverzagt, Sujuan Gao, et al. “Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.” Jama Neurol 73, no. 6 (June 1, 2016): 721–32. https://doi.org/10.1001/jamaneurol.2016.0580.
       Full Text  Link to Item
    • Frey, Kirk A., Martin A. Lodge, Carolyn Cidis Meltzer, Patrick J. Peller, Terence Z. Wong, Christopher P. Hess, Jeffrey R. Petrella, Haris I. Sair, and Rathan M. Subramaniam. “ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia.” Clin Nucl Med 41, no. 2 (February 2016): 118–25. https://doi.org/10.1097/RLU.0000000000001037.
       Full Text  Link to Item
    • Lin, Katherine A., Kingshuk Roy Choudhury, Bharath G. Rathakrishnan, David M. Marks, Jeffrey R. Petrella, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Marked gender differences in progression of mild cognitive impairment over 8 years.” Alzheimers Dement (N Y) 1, no. 2 (September 1, 2015): 103–10. https://doi.org/10.1016/j.trci.2015.07.001.
       Full Text  Link to Item
    • Ayton, Scott, Noel G. Faux, Ashley I. Bush, and Ashley I. Alzheimer’s Disease Neuroimaging Initiative. “Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.” Nat Commun 6 (May 19, 2015): 6760. https://doi.org/10.1038/ncomms7760.
       Full Text  Link to Item
    • Shpanskaya, Katie S., Kingshuk Roy Choudhury, Christopher Hostage, Kelly R. Murphy, Jeffrey R. Petrella, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort.” J Neuroradiol 41, no. 5 (December 2014): 350–57. https://doi.org/10.1016/j.neurad.2013.11.004.
       Full Text  Link to Item
    • Prescott, Jeffrey W., Arnaud Guidon, P Murali Doraiswamy, Kingshuk Roy Choudhury, Chunlei Liu, Jeffrey R. Petrella, and Jeffrey R. Alzheimer’s Disease Neuroimaging Initiative. “The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.” Radiology 273, no. 1 (October 2014): 175–84. https://doi.org/10.1148/radiol.14132593.
       Full Text  Link to Item
    • Zannas, Anthony S., P Murali Doraiswamy, Katie S. Shpanskaya, Kelly R. Murphy, Jeffrey R. Petrella, James R. Burke, and Terence Z. Wong. “Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.” Neurocase 20, no. 4 (August 2014): 466–73. https://doi.org/10.1080/13554794.2013.791867.
       Full Text  Link to Item
    • Hostage, Christopher A., Kingshuk Roy Choudhury, P. Murali Doraiswamy, Jeffrey R. Petrella, and Jeffrey R. Alzheimer’s Disease Neuroimaging Initiative. “Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.” Radiology 271, no. 1 (April 2014): 211–19. https://doi.org/10.1148/radiol.13131041.
       Full Text  Link to Item
    • Pelton, Gregory H., Howard Andrews, Steven P. Roose, Sue M. Marcus, Kristina D’Antonio, Hala Husn, Jeffrey R. Petrella, Anthony S. Zannas, P Murali Doraiswamy, and D. P. Devanand. “Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.” Contemp Clin Trials 37, no. 2 (March 2014): 200–208. https://doi.org/10.1016/j.cct.2013.11.015.
       Full Text  Link to Item
    • Rathakrishnan, Bharath Gopal, P Murali Doraiswamy, and Jeffrey R. Petrella. “Science to practice: translating automated brain MRI volumetry in Alzheimer's disease from research to routine diagnostic use in the work-up of dementia.” Front Neurol 4 (January 9, 2014): 216. https://doi.org/10.3389/fneur.2013.00216.
       Full Text  Link to Item
    • Lampert, Erika J., Kingshuk Roy Choudhury, Christopher A. Hostage, Bharath Rathakrishnan, Michael Weiner, Jeffrey R. Petrella, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Brain atrophy rates in first degree relatives at risk for Alzheimer's.” Neuroimage Clin 6 (2014): 340–46. https://doi.org/10.1016/j.nicl.2014.08.024.
       Full Text  Link to Item
    • Petrella, Jeffrey R. “Neuroimaging and the search for a cure for Alzheimer disease.” Radiology 269, no. 3 (December 2013): 671–91. https://doi.org/10.1148/radiol.13122503.
       Full Text  Link to Item
    • Murphy, Kelly R., Susan M. Landau, Kingshuk Roy Choudhury, Christopher A. Hostage, Katie S. Shpanskaya, Haris I. Sair, Jeffrey R. Petrella, Terence Z. Wong, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth.” Neuroimage 78 (September 2013): 474–80. https://doi.org/10.1016/j.neuroimage.2013.04.048.
       Full Text  Link to Item
    • Atluri, Gowtham, Kanchana Padmanabhan, Gang Fang, Michael Steinbach, Jeffrey R. Petrella, Kelvin Lim, Angus Macdonald, Nagiza F. Samatova, P Murali Doraiswamy, and Vipin Kumar. “Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack.” Neuroimage Clin 3 (August 7, 2013): 123–31. https://doi.org/10.1016/j.nicl.2013.07.004.
       Full Text  Link to Item
    • Browndyke, Jeffrey N., Kelly Giovanello, Jeffrey Petrella, Kathleen Hayden, Ornit Chiba-Falek, Karen A. Tucker, James R. Burke, and Kathleen A. Welsh-Bohmer. “Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.” Alzheimers Dement 9, no. 3 (May 2013): 284–94. https://doi.org/10.1016/j.jalz.2011.12.006.
       Full Text  Open Access Copy  Link to Item
    • Petrella, Jeffrey R., and P Murali Doraiswamy. “From the bridges of Konigsberg to the fields of Alzheimer: connecting the dots.” Neurology 80, no. 15 (April 9, 2013): 1360–62. https://doi.org/10.1212/WNL.0b013e31828c3062.
       Full Text  Link to Item
    • Shaffer, Jennifer L., Jeffrey R. Petrella, Forrest C. Sheldon, Kingshuk Roy Choudhury, Vince D. Calhoun, R Edward Coleman, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers.” Radiology 266, no. 2 (February 2013): 583–91. https://doi.org/10.1148/radiol.12120010.
       Full Text  Link to Item
    • Hostage, Christopher A., Kingshuk Roy Choudhury, Pudugramam Murali Doraiswamy, Jeffrey R. Petrella, and Jeffrey R. Alzheimer’s Disease Neuroimaging Initiative. “Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.” Plos One 8, no. 2 (2013): e54483. https://doi.org/10.1371/journal.pone.0054483.
       Full Text  Link to Item
    • Lampert, Erika J., Kingshuk Roy Choudhury, Christopher A. Hostage, Jeffrey R. Petrella, P Murali Doraiswamy, and P Murali Alzheimer’s Disease Neuroimaging Initiative. “Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives.” Plos One 8, no. 4 (2013): e60747. https://doi.org/10.1371/journal.pone.0060747.
       Full Text  Link to Item
    • Chou, Y. -. H., L. P. Panych, C. C. Dickey, J. R. Petrella, and N. -. K. Chen. “Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study.” Ajnr Am J Neuroradiol 33, no. 5 (May 2012): 833–38. https://doi.org/10.3174/ajnr.A2894.
       Full Text  Link to Item
    • Petrella, Jeffrey R. “Use of graph theory to evaluate brain networks: a clinical tool for a small world?” Radiology 259, no. 2 (May 2011): 317–20. https://doi.org/10.1148/radiol.11110380.
       Full Text  Link to Item
    • Petrella, J. R., F. C. Sheldon, S. E. Prince, V. D. Calhoun, and P. M. Doraiswamy. “Default mode network connectivity in stable vs progressive mild cognitive impairment.” Neurology 76, no. 6 (February 8, 2011): 511–17. https://doi.org/10.1212/WNL.0b013e31820af94e.
       Full Text  Link to Item
    • Karikari, Isaac O., Gerald Grant, Thomas J. Cummings, Jeffrey Petrella, and Herbert E. Fuchs. “Endodermal cyst of the oculomotor nerve.” Pediatr Neurosurg 46, no. 2 (August 2010): 155–56. https://doi.org/10.1159/000319562.
       Full Text  Link to Item
    • Lungren, M. P., J. R. Petrella, T. J. Cummings, and G. A. Grant. “Isolated intracranial Rosai-Dorfman disease in a child.” Ajnr Am J Neuroradiol 30, no. 10 (November 2009): E148–49. https://doi.org/10.3174/ajnr.A1812.
       Full Text  Link to Item
    • Voyvodic, James T., Jeffrey R. Petrella, and Allan H. Friedman. “fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.” J Magn Reson Imaging 29, no. 4 (April 2009): 751–59. https://doi.org/10.1002/jmri.21716.
       Full Text  Link to Item
    • Petrella, J. R., S. E. Prince, S. Krishnan, H. Husn, L. Kelley, and P. M. Doraiswamy. “Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging.” Ajnr Am J Neuroradiol 30, no. 2 (February 2009): 411–16. https://doi.org/10.3174/ajnr.A1359.
       Full Text  Link to Item
    • Woo, Shoshana L., Steven E. Prince, Jeffrey R. Petrella, Caroline Hellegers, and P Murali Doraiswamy. “Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study.” Am J Geriatr Psychiatry 17, no. 1 (January 2009): 24–29. https://doi.org/10.1097/JGP.0b013e318180056a.
       Full Text  Link to Item
    • Woo, Shoshana L., Steven E. Prince, Caroline Hellegers, Jeffrey R. Petrella, and P Murali Doraiswamy. “Modulation of Human Memory Circuit by Minor Depression in Late Life: An fMRI Study.” American Journal of Geriatric Psychiatry 16, no. 3 (March 1, 2008): A98–A98.
       Link to Item
    • Prince, Steven E., Shoshana Woo, P Murali Doraiswamy, and Jeffrey R. Petrella. “Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus?” Expert Rev Neurother 8, no. 2 (February 2008): 169–75. https://doi.org/10.1586/14737175.8.2.169.
       Full Text  Link to Item
    • Petrella, Jeffrey R., Venkata S. Mattay, and P Murali Doraiswamy. “Imaging genetics of brain longevity and mental wellness: the next frontier?” Radiology 246, no. 1 (January 2008): 20–32. https://doi.org/10.1148/radiol.2461061994.
       Full Text  Link to Item
    • Petrella, Jeffrey R., Steven E. Prince, Lihong Wang, Caroline Hellegers, and P Murali Doraiswamy. “Prognostic value of posteromedial cortex deactivation in mild cognitive impairment.” Plos One 2, no. 10 (October 31, 2007): e1104. https://doi.org/10.1371/journal.pone.0001104.
       Full Text  Link to Item
    • Petrella, Jeffrey R., Lihong Wang, Sriyesh Krishnan, Melissa J. Slavin, Steven E. Prince, Thanh-Thu T. Tran, and P Murali Doraiswamy. “Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.” Radiology 245, no. 1 (October 2007): 224–35. https://doi.org/10.1148/radiol.2451061847.
       Full Text  Link to Item
    • Slavin, Melissa J., Claire K. Sandstrom, Thanh-Thu T. Tran, P Murali Doraiswamy, and Jeffrey R. Petrella. “Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment.” Ajr Am J Roentgenol 188, no. 5 (May 2007): 1404–10. https://doi.org/10.2214/AJR.06.1052.
       Full Text  Link to Item
    • Petrella, Jeffrey R., Lubdha M. Shah, Katy M. Harris, Allen H. Friedman, Timothy M. George, John H. Sampson, Joseph S. Pekala, and James T. Voyvodic. “Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors.” Radiology 240, no. 3 (September 2006): 793–802. https://doi.org/10.1148/radiol.2403051153.
       Full Text  Link to Item
    • Sandstrom, C. K., S. Krishnan, M. J. Slavin, T. -. T. T. Tran, P. M. Doraiswamy, and J. R. Petrella. “Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.” Ajnr Am J Neuroradiol 27, no. 8 (September 2006): 1622–27.
       Link to Item
    • Petrella, Jeffrey R., Sriyesh Krishnan, Melissa J. Slavin, Thanh-Thu T. Tran, Lakshmi Murty, and P Murali Doraiswamy. “Mild cognitive impairment: evaluation with 4-T functional MR imaging.” Radiology 240, no. 1 (July 2006): 177–86. https://doi.org/10.1148/radiol.2401050739.
       Full Text  Link to Item
    • Krishnan, Sriyesh, Melissa J. Slavin, Thanh-Thu T. Tran, P Murali Doraiswamy, and Jeffrey R. Petrella. “Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders.” Neuroimage 31, no. 2 (June 2006): 560–71. https://doi.org/10.1016/j.neuroimage.2005.12.061.
       Full Text  Link to Item
    • Krishnan, Sriyesh, Brad D. Talley, Melissa J. Slavin, P Murali Doraiswamy, and Jeffrey R. Petrella. “Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research.” Neuroimaging Clin N Am 15, no. 4 (November 2005): 853–xi. https://doi.org/10.1016/j.nic.2005.09.011.
       Full Text  Link to Item
    • Petrella, J. R., and P. M. Doraiswamy. “Alzheimer's disease: 100 Years of progress.” Neuroimaging Clinics of North America 15, no. 4 (November 1, 2005). https://doi.org/10.1016/j.nic.2005.10.001.
       Full Text
    • York, Gerald, Daniel Barboriak, Jeffrey Petrella, David DeLong, and James M. Provenzale. “Association of internal carotid artery injury with carotid canal fractures in patients with head trauma.” Ajr Am J Roentgenol 184, no. 5 (May 2005): 1672–78. https://doi.org/10.2214/ajr.184.5.01841672.
       Full Text  Link to Item
    • Benson, Aaron D., Melissa J. Slavin, Thanh-Thu Tran, Jeffrey R. Petrella, and P Murali Doraiswamy. “Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?” Prim Care Companion J Clin Psychiatry 7, no. 2 (2005): 62–69. https://doi.org/10.4088/pcc.v07n0204.
       Full Text  Link to Item
    • Petrella, Jeffrey R., Brent A. Townsend, Amishi P. Jha, Lauretta A. Ziajko, Melissa J. Slavin, Cindy Lustig, Sarah J. Hart, and P Murali Doraiswamy. “Increasing memory load modulates regional brain activity in older adults as measured by fMRI.” J Neuropsychiatry Clin Neurosci 17, no. 1 (2005): 75–83. https://doi.org/10.1176/jnp.17.1.75.
       Full Text  Link to Item
    • Holmes, Thomas M., Jeffrey R. Petrella, and James M. Provenzale. “Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI.” Ajr Am J Roentgenol 183, no. 5 (November 2004): 1247–52. https://doi.org/10.2214/ajr.183.5.1831247.
       Full Text  Link to Item
    • Sair, H. I., P. M. Doraiswamy, and J. R. Petrella. “In vivo amyloid imaging in Alzheimer's disease.” Neuroradiology 46, no. 2 (February 2004): 93–104. https://doi.org/10.1007/s00234-003-1034-9.
       Full Text  Link to Item
    • Gaillard, William D., Bonnie C. Sachs, Joseph R. Whitnah, Zaaira Ahmad, Lyn M. Balsamo, Jeffrey R. Petrella, Suzanne H. Braniecki, et al. “Developmental aspects of language processing: fMRI of verbal fluency in children and adults.” Hum Brain Mapp 18, no. 3 (March 2003): 176–85. https://doi.org/10.1002/hbm.10091.
       Full Text  Link to Item
    • Petrella, Jeffrey R., R Edward Coleman, and P Murali Doraiswamy. “Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.” Radiology 226, no. 2 (February 2003): 315–36. https://doi.org/10.1148/radiol.2262011600.
       Full Text  Link to Item
    • Engelter, Stefan T., James M. Provenzale, Jeffrey R. Petrella, David M. DeLong, and Mark J. Alberts. “Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke.” Cerebrovasc Dis 15, no. 3 (2003): 188–91. https://doi.org/10.1159/000068826.
       Full Text  Link to Item
    • Balsamo, Lyn M., Benjamin Xu, Cecile B. Grandin, Jeffrey R. Petrella, Suzanne H. Braniecki, Teresa K. Elliott, and William D. Gaillard. “A functional magnetic resonance imaging study of left hemisphere language dominance in children.” Archives of Neurology 59, no. 7 (July 2002): 1168–74. https://doi.org/10.1001/archneur.59.7.1168.
       Full Text
    • Provenzale, James M., Gin R. Wang, Thomas Brenner, Jeffrey R. Petrella, and A Gregory Sorensen. “Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging.” Ajr Am J Roentgenol 178, no. 3 (March 2002): 711–16. https://doi.org/10.2214/ajr.178.3.1780711.
       Full Text  Link to Item
    • Eastwood, James D., Michael J. Alexander, Jeffrey R. Petrella, and James M. Provenzale. “Dynamic CT perfusion imaging with acetazolamide challenge for the preprocedural evaluation of a patient with symptomatic middle cerebral artery occlusive disease.” Ajnr Am J Neuroradiol 23, no. 2 (February 2002): 285–87.
       Link to Item
    • Petrella, Jeffrey R., Cindy Lustig, Lauretta A. Bucher, Amishi P. Jha, and P Murali Doraiswamy. “Prefrontal activation patterns in subjects at risk for Alzheimer disease.” Am J Geriatr Psychiatry 10, no. 1 (January 2002): 112–13.
       Link to Item
    • Townsend, B. A., J. R. Petrella, and P. M. Doraiswamy. “The role of neuroimaging in geriatric psychiatry.” Current Opinion in Psychiatry 15, no. 4 (January 1, 2002): 427–32. https://doi.org/10.1097/00001504-200207000-00014.
       Full Text
    • Petrella, J. R., C. Lustig, L. A. Bucher, A. P. Jha, and P. M. Doraiswamy. “Brain activation in patients at genetic risk for Alzheimer's disease: A pilot study using a functional MRI stress test.” Radiology 221 (November 1, 2001): 614–614.
       Link to Item
    • Provenzale, J. M., J. R. Petrella, L. C. Cruz, J. C. Wong, S. Engelter, and D. P. Barboriak. “Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome.” Ajnr Am J Neuroradiol 22, no. 8 (September 2001): 1455–61.
       Link to Item
    • Gaillard, W. D., M. Pugliese, C. B. Grandin, S. H. Braniecki, P. Kondapaneni, K. Hunter, B. Xu, J. R. Petrella, L. Balsamo, and G. Basso. “Cortical localization of reading in normal children: an fMRI language study.” Neurology 57, no. 1 (July 10, 2001): 47–54. https://doi.org/10.1212/wnl.57.1.47.
       Full Text  Link to Item
    • Guo, A. C., J. M. Provenzale, L. C. Cruz, and J. R. Petrella. “Cerebral abscesses: investigation using apparent diffusion coefficient maps.” Neuroradiology 43, no. 5 (May 2001): 370–74. https://doi.org/10.1007/s002340000519.
       Full Text  Link to Item
    • Engelter, S. T., J. M. Provenzale, J. R. Petrella, M. J. Alberts, D. M. DeLong, and J. R. MacFall. “Use of exponential diffusion imaging to determine the age of ischemic infarcts.” J Neuroimaging 11, no. 2 (April 2001): 141–47. https://doi.org/10.1111/j.1552-6569.2001.tb00024.x.
       Full Text  Link to Item
    • Guo, A. C., J. R. Petrella, J. Kurtzberg, and J. M. Provenzale. “Evaluation of white matter anisotropy in Krabbe disease with diffusion tensor MR imaging: initial experience.” Radiology 218, no. 3 (March 2001): 809–15. https://doi.org/10.1148/radiology.218.3.r01mr14809.
       Full Text  Link to Item
    • Petrella, J. R., L. Bucher, A. Jha, P. M. Doraiswamy, and G. McCarthy. “Event-related functional MRI for the early diagnosis of Alzheimer disease: A pilot study in normal volunteers and patients with mild cognitive impairment.” Neurobiology of Aging 22, no. 2 (March 1, 2001): 338–338.
       Link to Item
    • Engelter, S. T., J. M. Provenzale, and J. R. Petrella. “Assessment of vasogenic edema in eclampsia using diffusion imaging.” Neuroradiology 42, no. 11 (November 2000): 818–20. https://doi.org/10.1007/s002340000439.
       Full Text  Link to Item
    • Petrella, J. R., L. A. Bucher, P. M. Doraiswamy, A. P. Jha, J. M. Provenzale, and G. McCarthy. “Cortical activation differences between patients with mild cognitive impairment and older normal subjects during a working memory task: An event-related fMRI study.” Radiology 217 (November 1, 2000): 552–552.
       Link to Item
    • Engelter, S. T., J. M. Provenzale, J. R. Petrella, D. M. DeLong, and J. R. MacFall. “The effect of aging on the apparent diffusion coefficient of normal-appearing white matter.” Ajr Am J Roentgenol 175, no. 2 (August 2000): 425–30. https://doi.org/10.2214/ajr.175.2.1750425.
       Full Text  Link to Item
    • Gelderen, P. van, C. Grandin, J. R. Petrella, and C. T. Moonen. “Rapid three-dimensional MR imaging method for tracking a bolus of contrast agent through the brain.” Radiology 216, no. 2 (August 2000): 603–8. https://doi.org/10.1148/radiology.216.2.r00au27603.
       Full Text  Link to Item
    • Petrella, J. R., and J. M. Provenzale. “MR perfusion imaging of the brain: techniques and applications.” Ajr Am J Roentgenol 175, no. 1 (July 2000): 207–19. https://doi.org/10.2214/ajr.175.1.1750207.
       Full Text  Link to Item
    • Kassem-Moussa, H., J. M. Provenzale, J. R. Petrella, and D. V. Lewis. “Early diffusion-weighted MR imaging abnormalities in sustained seizure activity.” Ajr Am J Roentgenol 174, no. 5 (May 2000): 1304–6. https://doi.org/10.2214/ajr.174.5.1741304.
       Full Text  Link to Item
    • Wong, J. C., J. M. Provenzale, and J. R. Petrella. “Perfusion MR imaging of brain neoplasms.” Ajr Am J Roentgenol 174, no. 4 (April 2000): 1147–57. https://doi.org/10.2214/ajr.174.4.1741147.
       Full Text  Link to Item
    • Engelter, S. T., J. M. Provenzale, J. R. Petrella, M. J. Alberts, C. S. Kidwell, J. R. Alger, F. Di Salle, et al. “Diffusion MR imaging and transient ischemic attacks [4] (multiple letters).” Stroke 30, no. 12 (December 10, 1999): 2762–63.
    • Engelter, S. T., J. M. Provenzale, J. R. Petrella, and M. J. Alberts. “Diffusion MR imaging and transient ischemic attacks.” Stroke 30, no. 12 (December 1999): 2762–63. https://doi.org/10.1161/01.str.30.12.2759-c.
       Full Text  Link to Item
    • Engelter, S. T., J. R. Petrella, M. J. Alberts, and J. M. Provenzale. “Assessment of cerebral microcirculation in a patient with hypertensive encephalopathy using MR perfusion imaging.” Ajr Am J Roentgenol 173, no. 6 (December 1999): 1491–93. https://doi.org/10.2214/ajr.173.6.10584788.
       Full Text  Link to Item
    • Barboriak, D. P., J. R. Petrella, J. Wong, K. C. Ott, J. M. Provenzale, and J. R. MacFall. “Measurement of apparent diffusion coefficients in human brain: Comparison of three-direction isotropic and six-direction tensor methods.” Radiology 213P (November 1, 1999): 274–274.
       Link to Item
    • Provenzale, J. M., S. T. Engelter, D. M. Delong, J. R. Petrella, J. Smith, and J. R. MacFall. “Neuroradiology keynote speaker: Time course of MR diffusion abnormalities in stroke.” Radiology 213P (November 1, 1999): 441–441.
       Link to Item
    • Provenzale, J. M., S. T. Engelter, J. R. Petrella, J. S. Smith, and J. R. MacFall. “Use of MR exponential diffusion-weighted images to eradicate T2 "shine-through" effect.” Ajr Am J Roentgenol 172, no. 2 (February 1999): 537–39. https://doi.org/10.2214/ajr.172.2.9930819.
       Full Text  Link to Item
    • Engelter, S. T., J. M. Provenzale, J. R. Petrella, K. L. Hoffmann, D. M. Delong, and M. J. Alberts. “Signal intensity of exponential diffusion weighted images correlates with infarct age.” Stroke 30, no. 1 (January 1, 1999): 260–260.
       Link to Item
    • Engelter, S. T., J. M. Provenzale, M. K. Farrelly, J. R. Petrella, and J. R. MacFall. “Patient age correlates with increasing apparent diffusion coefficient of white matter on diffusion-weighted MR imaging.” Radiology 209P (November 1, 1998): 200–201.
       Link to Item
    • Petrella, J. R., S. T. Engelter, J. M. Provenzale, S. S. Goldwag, and J. R. MacFall. “Optimization of interscanner reproducibility of apparent diffusion coefficient measurements in the human brain using a phantom derived scaling factor.” Radiology 209P (November 1, 1998): 469–469.
       Link to Item
    • Grandin, C. B., W. D. Gaillard, J. R. Whitnah, J. R. Petrella, S. H. Braniecki, K. E. Hunter, and W. H. Theodore. “Gender related differences in activated brain areas for language processing: An fMRI study.” Neuroimage 7, no. 4 PART II (January 1, 1998). https://doi.org/10.1016/s1053-8119(18)30992-3.
       Full Text
    • Grandin, C. B., W. D. Gaillard, K. E. Hunter, J. R. Petrella, S. H. Braniecki, J. R. Whitnah, and W. H. Theodore. “Comparison of phonemic and semantic verbal fluency tasks: An fMRI study.” Neuroimage 7, no. 4 PART II (January 1, 1998). https://doi.org/10.1016/s1053-8119(18)30966-2.
       Full Text
    • Petrella, J. R., C. DeCarli, M. Dagli, C. B. Grandin, J. H. Duyn, J. A. Frank, E. A. Hoffman, and W. H. Theodore. “Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study.” Ajnr Am J Neuroradiol 19, no. 1 (January 1998): 39–44.
       Link to Item
    • Petrella, J. R., C. DeCarli, M. Dagli, J. H. Duyn, C. B. Grandin, J. A. Frank, E. A. Hoffman, and W. H. Theodore. “Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst.” Ajnr Am J Neuroradiol 18, no. 6 (June 1997): 1153–61.
       Link to Item
    • Frank, J. A., C. Bash, L. Stone, J. Petrella, H. Maloni, and H. McFarland. “Evaluation of magnetic resonance imaging sensitivity in patients with relapsing remitting multiple sclerosis: baseline versus Betaseron treatment trials.” Academic Radiology 3 Suppl 2 (August 1996): S173–75. https://doi.org/10.1016/s1076-6332(96)80525-3.
       Full Text
    • Petrella, J. R., R. I. Grossman, J. C. McGowan, G. Campbell, and J. A. Cohen. “Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect.” Ajnr Am J Neuroradiol 17, no. 6 (June 1996): 1041–49.
       Link to Item

  • Conference Papers

    • Doraiswamy, P Murali, R Edward Coleman, Jeffrey R. Petrella, Forrest Sheldon, Michael J. Pontecorvo, Franz Hefti, Alan Carpenter, Daniel M. Skovronsky, and Christopher M. Clark. “In Cognitively Healthy and Mildly Impaired Individuals Florbetapir F 18 PET Measures of Amyloid Deposition Correlate with the Degree of Functional Impairment Assessed Six Months Later.” In Neurology, 74:A338–A338. LIPPINCOTT WILLIAMS & WILKINS, 2010.
       Link to Item
    • Krishnan, Sriyesh, Melissa J. Slavin, Thanh-Thu Tran, Lakshmi Murty, Anne E. Finefrock, P. M. Doraiswamy, and Jeffrey R. Petrella. “P2-189 Comparison of FMRI activation patterns in mild cognitive impairment (MCI) subjects and elderly controls at ultra-high field strength.” In Neurobiology of Aging, 25:S281–82. Elsevier BV, 2004. https://doi.org/10.1016/s0197-4580(04)80935-7.
       Full Text
    • Petrella, J. R., M. S. Dagli, J. H. Duyn, C. B. Grandin, J. A. Frank, and C. S. DeCarli. “Method of quantifying fractional cerebral blood volume for inter- and intrasubject comparisons with whole-brain dynamic contrast-enhanced susceptibility MR imaging.” In Radiology, 201:1534–1534, 1996.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.