Jeffrey Robert Petrella | Scholars@Duke

Jeffrey Robert Petrella
Professor of Radiology

- Quantitating and modeling physiologic processes in normal and diseased states in the central nervous system through the use of imaging
- Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques
- Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease
- Development of functional imaging biomarkers for early diagnosis and monitoring of dementia
- Functional MRI as an aid to preoperative planning in patients with potentially resectable brain lesions

Current Appointments & Affiliations

Professor of Radiology, Radiology, Neuroradiology, Radiology 2014
Member of the Center for Brain Imaging and Analysis, Duke-UNC Center for Brain Imaging and Analysis, Institutes and Centers 2004

Contact Information

1527 Hosp North, Durham, NC 27710
Box 3808 Med Ctr, Durham, NC 27710
jeffrey.petrella@duke.edu (919) 684-7218

Background
Education, Training, & Certifications
- M.D., Rutgers University 1987
Duke Appointment History
- Associate Professor of Radiology, Radiology, Neuroradiology, Radiology 2006 - 2014
- Associate Professor of Radiology, Radiology, Neuroradiology, Radiology 2005 - 2006
- Assistant Professor of Radiology, Radiology, Neuroradiology, Radiology 1997 - 2005
- Instructor, Temporary in the Department of Radiology, Radiology, Neuroradiology, Radiology 1997
Research
Selected Grants
- High Resolution Intracortical DTI for Early Detection of Alzheimer¿s Disease awarded by Neuroradiology Education and Reserach Foundation (formerly Foundation of the ASNR) 2016 - 2019
- Cognitive training and neuroplasticity in Mild Cognitive Impairment awarded by Columbia University 2017 - 2019
- Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
- Motion-immune neuro and body MRI for challenging patient populations awarded by National Institutes of Health 2014 - 2018
- Imaging of Intrinsic Connectivity Networks awarded by National Institutes of Health 2011 - 2018
- Prognostic Performance in MCI of Two Commercially Available Hippocampal Volumetry Tools awarded by Radiological Society of North America 2015 - 2017
- Susceptibility MRI as a marker for diagnosis and clinical disability in MS awarded by National Institutes of Health 2014 - 2017
- A Linux Cluster Computational Facility for Neuroimaging Research awarded by National Institutes of Health 2009 - 2010
- fMRI Studies in Early Alzheimer's Disease awarded by National Institutes of Health 2001 - 2008
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Huang, SY, Hsu, JL, Lin, KJ, Liu, HL, Wey, SP, Hsiao, IT, Weiner, M, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Saykin, AJ, Morris, J, Shaw, LM, Liu, E, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, DeCarli, C, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Householder, E, Reinwald, LT, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, SG, Shen, L, Kelley, F, Kim, S, Nho, K, Kachaturian, Z, Frank, R, Snyder, PJ, Molchan, S, Kaye, J, Quinn, J, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Meyer, JV, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Carroll, M, Leon, S, and Mintun, MA. "Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease." Scientific Reports 8, no. 1 (December 1, 2018). Full Text
  - Mahjoub, I, Mahjoub, MA, and Rekik, I. "Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states." Scientific Reports 8, no. 1 (December 2018). Full Text
  - Motter, JN, Pelton, GH, D'Antonio, K, Rushia, SN, Pimontel, MA, Petrella, JR, Garcon, E, Ciovacco, MW, Sneed, JR, Doraiswamy, PM, and Devanand, DP. "Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder." International Journal of Geriatric Psychiatry 33, no. 12 (December 2018): 1604-1612. Full Text
  - Gong, N-J, Kuzminski, S, Clark, M, Fraser, M, Sundman, M, Guskiewicz, K, Petrella, JR, and Liu, C. "Microstructural alterations of cortical and deep gray matter over a season of high school football revealed by diffusion kurtosis imaging." Neurobiology of Disease 119 (November 2018): 79-87. Full Text
  - Young, AL, Marinescu, RV, Oxtoby, NP, Bocchetta, M, Yong, K, Firth, NC, Cash, DM, Thomas, DL, Dick, KM, Cardoso, J, van Swieten, J, Borroni, B, Galimberti, D, Masellis, M, Tartaglia, MC, Rowe, JB, Graff, C, Tagliavini, F, Frisoni, GB, Laforce, R, Finger, E, de Mendonça, A, Sorbi, S, Warren, JD, Crutch, S, Fox, NC, Ourselin, S, Schott, JM, Rohrer, JD, Alexander, DC, Genetic FTD Initiative (GENFI), , and Alzheimer’s Disease Neuroimaging Initiative (ADNI), . "Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference." Nature Communications 9, no. 1 (October 15, 2018): 4273-null. Full Text
  - Devanand, DP, Pelton, GH, D'Antonio, K, Ciarleglio, A, Scodes, J, Andrews, H, Lunsford, J, Beyer, JL, Petrella, JR, Sneed, J, Ciovacco, M, and Doraiswamy, PM. "Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 26, no. 10 (October 2018): 1050-1060. Full Text
  - Sohn, D, Shpanskaya, K, Lucas, JE, Petrella, JR, Saykin, AJ, Tanzi, RE, Samatova, NF, and Doraiswamy, PM. "Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease." Scientific Reports 8, no. 1 (May 10, 2018): 7490-null. Full Text
  - Kuzminski, SJ, Clark, MD, Fraser, MA, Haswell, CC, Morey, RA, Liu, C, Choudhury, KR, Guskiewicz, KM, and Petrella, JR. "White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football." Ajnr. American Journal of Neuroradiology 39, no. 2 (February 2018): 245-251. Full Text Open Access Copy
  - Schilling, LP, Pascoal, TA, Zimmer, ER, Mathotaarachchi, S, Shin, M, de Mello Rieder, CR, Gauthier, S, Palmini, A, Rosa-Neto, P, Weiner, MW, Aisen, P, Petersen, R, Jack, RCR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Saykin, AJ, Morris, J, Shaw, LM, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Morris, JC, Carroll, M, Creech, ML, Franklin, E, Mintun, MA, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Love, MN, Grossman, H, Mitsis, E, Shah, RC, de Shah Toledo-Morrell, L, Duara, R, Varon, D, Greig, MT, Roberts, P, Albert, M, Onyike, C, D’Agostino, D, Kielb, S, Galvin, JE, Cerbone, B, Michel, CA, Pogorelec, DM, Rusinek, H, de Leon, MJ, Glodzik, L, De Santi, S, Doraiswamy, PM, Petrella, JR, Borges-Neto, S, Wong, TZ, Coleman, E, and Smith, CD. "Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer’s Dementia(Accepted)." Molecular Neurobiology (January 1, 2018). Full Text
  - Du, L, Liu, K, Yao, X, Yan, J, Risacher, SL, Han, J, Guo, L, Saykin, AJ, Shen, L, Weiner, MW, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Morris, J, Shaw, LM, Khachaturian, Z, Sorensen, G, Carrillo, M, Kuller, L, Raichle, M, Paul, S, Davies, P, Fillit, H, Hefti, F, Holtzman, D, Mesulam, MM, Potter, W, Snyder, P, Schwartz, A, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Balasubramanian, AB, Mason, J, Sim, I, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, Decarli, C, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Franklin, E, Taylor-Reinwald, L, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, S, Faber, K, Kim, S, Nho, K, Thal, L, Buckholtz, N, Albert, M, Frank, R, Hsiao, J, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, and Knopman, D. "Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty." Scientific Reports 7, no. 1 (December 1, 2017). Full Text
  - Singanamalli, A, Wang, H, Madabhushi, A, Weiner, M, Aisen, P, Petersen, R, Jack, C, Jagust, W, Trojanowki, J, Toga, A, Beckett, L, Green, R, Saykin, A, Morris, J, Shaw, L, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, L, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, B, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, J, Lord, J, Mason, S, Albers, C, Knopman, D, Johnson, K, Doody, R, Villanueva-Meyer, J, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, L, Bell, K, Ances, B, Carroll, M, Creech, M, Franklin, E, Mintun, M, Schneider, S, Oliver, A, Marson, D, Griffith, R, Clark, D, Geldmacher, D, Brockington, J, Roberson, E, Natelson Love, M, Grossman, H, Mitsis, E, Shah, R, Detoledo-Morrell, L, Duara, R, Varon, D, Greig, M, Roberts, P, Albert, M, Onyike, C, D'Agostino, D, Kielb, S, Galvin, J, Cerbone, B, Michel, C, Pogorelec, D, Rusinek, H, De Leon, M, Glodzik, L, De Santi, S, Doraiswamy, P, Petrella, J, Borges-Neto, S, Wong, T, Coleman, E, Smith, C, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Porsteinsson, A, Goldstein, B, Martin, K, Makino, K, Ismail, M, Brand, C, Mulnard, R, Thai, G, Mc-Adams-Ortiz, C, Womack, K, and Mathews, D. "Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features." Scientific Reports 7, no. 1 (December 1, 2017). Full Text
  - Black, DF, Vachha, B, Mian, A, Faro, SH, Maheshwari, M, Sair, HI, Petrella, JR, Pillai, JJ, and Welker, K. "American Society of Functional Neuroradiology-Recommended fMRI Paradigm Algorithms for Presurgical Language Assessment." AJNR. American journal of neuroradiology 38, no. 10 (October 2017): E65-E73. Full Text
  - Farber, SH, Han, JL, Petraglia Iii, FW, Gramer, R, Yang, S, Pagadala, P, Parente, B, Xie, J, Petrella, JR, and Lad, SP. "Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation." Pain Physician 20, no. 6 (September 2017): E969-E977.
  - Padmanabhan, K, Nudelman, K, Harenberg, S, Bello, G, Sohn, D, Shpanskaya, K, Dikshit, PT, Yerramsetty, PS, Tanzi, RE, Saykin, AJ, Petrella, JR, Doraiswamy, PM, and Samatova, NF. "Characterizing gene and protein crosstalks in subjects at risk of developing Alzheimer's disease: A new computational approach." Processes 5, no. 3 (September 1, 2017). Full Text
  - Mattsson, N, Andreasson, U, Zetterberg, H, Blennow, K, and Alzheimer’s Disease Neuroimaging Initiative, . "Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease." Jama Neurology 74, no. 5 (May 2017): 557-566. Full Text
  - Tanpitukpongse, TP, Mazurowski, MA, Ikhena, J, Petrella, JR, and Alzheimer's Disease Neuroimaging Initiative, . "Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?." Ajnr. American Journal of Neuroradiology 38, no. 3 (March 2017): 546-552. Full Text
  - Huang, M, Yang, W, Feng, Q, Chen, W, and Alzheimer’s Disease Neuroimaging Initiative, . "Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease." Scientific Reports 7 (January 12, 2017): 39880-null. Full Text
  - Iturria-Medina, Y, Sotero, RC, Toussaint, PJ, Mateos-Pérez, JM, Evans, AC, and Alzheimer’s Disease Neuroimaging Initiative, . "Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis." Nature Communications 7 (June 21, 2016): 11934-null. Full Text
  - Risacher, SL, McDonald, BC, Tallman, EF, West, JD, Farlow, MR, Unverzagt, FW, Gao, S, Boustani, M, Crane, PK, Petersen, RC, Jack, CR, Jagust, WJ, Aisen, PS, Weiner, MW, Saykin, AJ, and Alzheimer’s Disease Neuroimaging Initiative, . "Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults." Jama Neurology 73, no. 6 (June 2016): 721-732. Full Text
  - Prescott, JW, Guidon, A, Doraiswamy, PM, Choudhury, KR, Liu, C, and Petrella, JR. "Erratum: The Alzheimer Structural Connectome: Changes in Cortical Network Topology with Increased Amyloid Plaque Burden (Radiology (2014) 273:1 (175-184) DOI: 10.1148/radiol.14132593)." Radiology 279, no. 1 (April 1, 2016): 328-null. Full Text
  - Frey, KA, Lodge, MA, Meltzer, CC, Peller, PJ, Wong, TZ, Hess, CP, Petrella, JR, Sair, HI, and Subramaniam, RM. "ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia." Clinical nuclear medicine 41, no. 2 (February 2016): 118-125. Full Text
  - Lin, KA, Choudhury, KR, Rathakrishnan, BG, Marks, DM, Petrella, JR, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Marked gender differences in progression of mild cognitive impairment over 8 years." Alzheimer'S & Dementia (New York, N. Y.) 1, no. 2 (September 2015): 103-110. Full Text
  - Ayton, S, Faux, NG, Bush, AI, and Alzheimer's Disease Neuroimaging Initiative, . "Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE." Nature Communications 6 (May 19, 2015): 6760-null. Full Text
  - Shpanskaya, KS, Choudhury, KR, Hostage, C, Murphy, KR, Petrella, JR, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort." Journal of neuroradiology. Journal de neuroradiologie 41, no. 5 (December 2014): 350-357. Full Text
  - Shpanskaya, KS, Choudhury, KR, Hostage, C, Murphy, KR, Petrella, JR, and Doraiswamy, PM. "Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort." Journal of Neuroradiology 41, no. 5 (December 1, 2014): 350-357. Full Text
  - Prescott, JW, Guidon, A, Doraiswamy, PM, Roy Choudhury, K, Liu, C, Petrella, JR, and Alzheimer’s Disease Neuroimaging Initiative, . "The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden." Radiology 273, no. 1 (October 2014): 175-184. Full Text
  - Zannas, AS, Doraiswamy, PM, Shpanskaya, KS, Murphy, KR, Petrella, JR, Burke, JR, and Wong, TZ. "Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making." Neurocase 20, no. 4 (August 2014): 466-473. Full Text Link to Item
  - Hostage, CA, Choudhury, KR, Murali Doraiswamy, P, Petrella, JR, and Alzheimer's Disease Neuroimaging Initiative, . "Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network." Radiology 271, no. 1 (April 2014): 211-219. Full Text
  - Pelton, GH, Andrews, H, Roose, SP, Marcus, SM, D'Antonio, K, Husn, H, Petrella, JR, Zannas, AS, Doraiswamy, PM, and Devanand, DP. "Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design." Contemporary Clinical Trials 37, no. 2 (March 2014): 200-208. Full Text
  - Rathakrishnan, BG, Doraiswamy, PM, and Petrella, JR. "Science to practice: translating automated brain MRI volumetry in Alzheimer's disease from research to routine diagnostic use in the work-up of dementia." Frontiers in Neurology 4 (January 9, 2014): 216-null. (Review) Full Text
  - Lampert, EJ, Roy Choudhury, K, Hostage, CA, Rathakrishnan, B, Weiner, M, Petrella, JR, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Brain atrophy rates in first degree relatives at risk for Alzheimer's." Neuroimage. Clinical 6 (January 2014): 340-346. Full Text
  - Zannas, AS, Doraiswamy, PM, Shpanskaya, KS, Murphy, KR, Petrella, JR, Burke, JR, and Wong, TZ. "Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making." Neurocase 20, no. 4 (January 1, 2014): 466-473. Full Text
  - Petrella, JR. "Neuroimaging and the search for a cure for Alzheimer disease." Radiology 269, no. 3 (December 2013): 671-691. (Review) Full Text
  - Murphy, KR, Landau, SM, Choudhury, KR, Hostage, CA, Shpanskaya, KS, Sair, HI, Petrella, JR, Wong, TZ, Doraiswamy, PM, and Alzheimer's Disease Neuroimaging Initiative, . "Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth." Neuroimage 78 (September 2013): 474-480. Full Text Link to Item
  - Atluri, G, Padmanabhan, K, Fang, G, Steinbach, M, Petrella, JR, Lim, K, Macdonald, A, Samatova, NF, Doraiswamy, PM, and Kumar, V. "Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack." Neuroimage. Clinical 3 (August 7, 2013): 123-131. (Review) Full Text
  - Browndyke, JN, Giovanello, K, Petrella, J, Hayden, K, Chiba-Falek, O, Tucker, KA, Burke, JR, and Welsh-Bohmer, KA. "Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease." Alzheimers Dement 9, no. 3 (May 2013): 284-294. Full Text Open Access Copy Link to Item
  - Petrella, JR, and Doraiswamy, PM. "From the bridges of Konigsberg to the fields of Alzheimer: connecting the dots." Neurology 80, no. 15 (April 9, 2013): 1360-1362. Full Text Link to Item
  - Shaffer, JL, Petrella, JR, Sheldon, FC, Choudhury, KR, Calhoun, VD, Coleman, RE, Doraiswamy, PM, and Alzheimer’s Disease Neuroimaging Initiative, . "Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers." Radiology 266, no. 2 (February 2013): 583-591. Full Text
  - Browndyke, JN, Giovanello, K, Petrella, J, Hayden, K, Chiba-Falek, O, Tucker, KA, Burke, JR, and Welsh-Bohmer, KA. "Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease." Alzheimer's and Dementia 9, no. 3 (2013): 284-294. Full Text
  - Hostage, CA, Roy Choudhury, K, Doraiswamy, PM, Petrella, JR, and Alzheimer’s Disease Neuroimaging Initiative, . "Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease." PLoS One 8, no. 2 (2013): e54483-. Full Text Link to Item
  - Lampert, EJ, Roy Choudhury, K, Hostage, CA, Petrella, JR, Doraiswamy, PM, and Alzheimer’s Disease Neuroimaging Initiative, . "Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives." Plos One 8, no. 4 (January 2013): e60747-null. Full Text
  - Chou, Y-H, Panych, LP, Dickey, CC, Petrella, JR, and Chen, N-K. "Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study." Ajnr Am J Neuroradiol 33, no. 5 (May 2012): 833-838. Full Text Link to Item
  - Petrella, JR. "Use of graph theory to evaluate brain networks: a clinical tool for a small world?." Radiology 259, no. 2 (May 2011): 317-320. Full Text
  - Petrella, JR, Sheldon, FC, Prince, SE, Calhoun, VD, and Doraiswamy, PM. "Default mode network connectivity in stable vs progressive mild cognitive impairment." Neurology 76, no. 6 (February 2011): 511-517. Full Text
  - Karikari, IO, Grant, G, Cummings, TJ, Petrella, J, and Fuchs, HE. "Endodermal cyst of the oculomotor nerve." Pediatr Neurosurg 46, no. 2 (August 2010): 155-156. Full Text Link to Item
  - Lungren, MP, Petrella, JR, Cummings, TJ, and Grant, GA. "Isolated intracranial Rosai-Dorfman disease in a child." AJNR Am J Neuroradiol 30, no. 10 (November 2009): E148-E149. (Letter) Full Text Link to Item
  - Voyvodic, JT, Petrella, JR, and Friedman, AH. "fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment." J Magn Reson Imaging 29, no. 4 (April 2009): 751-759. Full Text Link to Item
  - Petrella, JR, Prince, SE, Krishnan, S, Husn, H, Kelley, L, and Doraiswamy, PM. "Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging." Ajnr. American Journal of Neuroradiology 30, no. 2 (February 2009): 411-416. Full Text
  - Woo, SL, Prince, SE, Petrella, JR, Hellegers, C, and Doraiswamy, PM. "Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 17, no. 1 (January 2009): 24-29. Full Text
  - Woo, SL, Prince, SE, Hellegers, C, Petrella, JR, and Doraiswamy, PM. "Modulation of Human Memory Circuit by Minor Depression in Late Life: An fMRI Study." AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 16, no. 3 (March 2008): A98-A98. Link to Item
  - Prince, SE, Woo, S, Doraiswamy, PM, and Petrella, JR. "Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus?." Expert Rev Neurother 8, no. 2 (February 2008): 169-175. Full Text Link to Item
  - Petrella, JR, Mattay, VS, and Doraiswamy, PM. "Imaging genetics of brain longevity and mental wellness: the next frontier?." Radiology 246, no. 1 (January 2008): 20-32. (Review) Full Text
  - Petrella, JR, Prince, SE, Wang, L, Hellegers, C, and Doraiswamy, PM. "Prognostic value of posteromedial cortex deactivation in mild cognitive impairment. (Published online)" PLoS One 2, no. 10 (October 31, 2007): e1104-. Full Text Link to Item
  - Petrella, JR, Wang, L, Krishnan, S, Slavin, MJ, Prince, SE, Tran, T-TT, and Doraiswamy, PM. "Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging." Radiology 245, no. 1 (October 2007): 224-235. Full Text
  - Slavin, MJ, Sandstrom, CK, Tran, T-TT, Doraiswamy, PM, and Petrella, JR. "Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment." AJR Am J Roentgenol 188, no. 5 (May 2007): 1404-1410. Full Text Link to Item
  - Petrella, JR, Shah, LM, Harris, KM, Friedman, AH, George, TM, Sampson, JH, Pekala, JS, and Voyvodic, JT. "Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors." Radiology 240, no. 3 (September 2006): 793-802. Full Text
  - Sandstrom, CK, Krishnan, S, Slavin, MJ, Tran, T-TT, Doraiswamy, PM, and Petrella, JR. "Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment." AJNR Am J Neuroradiol 27, no. 8 (September 2006): 1622-1627. Link to Item
  - Petrella, JR, Krishnan, S, Slavin, MJ, Tran, T-TT, Murty, L, and Doraiswamy, PM. "Mild cognitive impairment: evaluation with 4-T functional MR imaging." Radiology 240, no. 1 (July 2006): 177-186. Full Text
  - Krishnan, S, Slavin, MJ, Tran, T-TT, Doraiswamy, PM, and Petrella, JR. "Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders." Neuroimage 31, no. 2 (June 2006): 560-571. Full Text Link to Item
  - Krishnan, S, Talley, BD, Slavin, MJ, Doraiswamy, PM, and Petrella, JR. "Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research." Neuroimaging Clin N Am 15, no. 4 (November 2005): 853-xi. (Review) Full Text Link to Item
  - Petrella, JR, and Doraiswamy, PM. "Alzheimer's disease: 100 Years of progress." Neuroimaging Clinics of North America 15, no. 4 (November 1, 2005). Full Text
  - York, G, Barboriak, D, Petrella, J, DeLong, D, and Provenzale, JM. "Association of internal carotid artery injury with carotid canal fractures in patients with head trauma." AJR Am J Roentgenol 184, no. 5 (May 2005): 1672-1678. Full Text Link to Item
  - Benson, AD, Slavin, MJ, Tran, T-T, Petrella, JR, and Doraiswamy, PM. "Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?." Prim Care Companion J Clin Psychiatry 7, no. 2 (2005): 62-69. Link to Item
  - Petrella, JR, Townsend, BA, Jha, AP, Ziajko, LA, Slavin, MJ, Lustig, C, Hart, SJ, and Doraiswamy, PM. "Increasing memory load modulates regional brain activity in older adults as measured by fMRI." J Neuropsychiatry Clin Neurosci 17, no. 1 (2005): 75-83. Full Text Link to Item
  - Holmes, TM, Petrella, JR, and Provenzale, JM. "Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI." AJR Am J Roentgenol 183, no. 5 (November 2004): 1247-1252. Full Text Link to Item
  - Holmes, TM, Petrella, JR, and Provenzale, JM. "Original report. Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI." AMERICAN JOURNAL OF ROENTGENOLOGY 183, no. 5 (November 2004): 1247-1252. Full Text Link to Item
  - Sair, HI, Doraiswamy, PM, and Petrella, JR. "In vivo amyloid imaging in Alzheimer's disease." Neuroradiology 46, no. 2 (February 2004): 93-104. (Review) Full Text Link to Item
  - Gaillard, WD, Sachs, BC, Whitnah, JR, Ahmad, Z, Balsamo, LM, Petrella, JR, Braniecki, SH, McKinney, CM, Hunter, K, Xu, B, and Grandin, CB. "Developmental aspects of language processing: fMRI of verbal fluency in children and adults." Human Brain Mapping 18, no. 3 (March 2003): 176-185. Full Text
  - Petrella, JR, Coleman, RE, and Doraiswamy, PM. "Neuroimaging and early diagnosis of Alzheimer disease: a look to the future." Radiology 226, no. 2 (February 2003): 315-336. (Review) Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, DeLong, DM, and Alberts, MJ. "Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke." Cerebrovasc Dis 15, no. 3 (2003): 188-191. Full Text Link to Item
  - Balsamo, LM, Xu, B, Grandin, CB, Petrella, JR, Braniecki, SH, Elliott, TK, and Gaillard, WD. "A functional magnetic resonance imaging study of left hemisphere language dominance in children." Arch Neurol 59, no. 7 (July 2002): 1168-1174. Link to Item
  - Provenzale, JM, Wang, GR, Brenner, T, Petrella, JR, and Sorensen, AG. "Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging." Ajr. American Journal of Roentgenology 178, no. 3 (March 2002): 711-716. Full Text
  - Eastwood, JD, Alexander, MJ, Petrella, JR, and Provenzale, JM. "Dynamic CT perfusion imaging with acetazolamide challenge for the preprocedural evaluation of a patient with symptomatic middle cerebral artery occlusive disease." AJNR Am J Neuroradiol 23, no. 2 (February 2002): 285-287. Link to Item
  - Petrella, JR, Lustig, C, Bucher, LA, Jha, AP, and Doraiswamy, PM. "Prefrontal activation patterns in subjects at risk for Alzheimer disease." Am J Geriatr Psychiatry 10, no. 1 (January 2002): 112-113. (Letter) Link to Item
  - Townsend, BA, Petrella, JR, and Doraiswamy, PM. "The role of neuroimaging in geriatric psychiatry." Current Opinion in Psychiatry 15, no. 4 (January 1, 2002): 427-432. (Review) Full Text
  - Provenzale, JM, Petrella, JR, Cruz, LC, Wong, JC, Engelter, S, and Barboriak, DP. "Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome." AJNR Am J Neuroradiol 22, no. 8 (September 2001): 1455-1461. Link to Item
  - Gaillard, WD, Pugliese, M, Grandin, CB, Braniecki, SH, Kondapaneni, P, Hunter, K, Xu, B, Petrella, JR, Balsamo, L, and Basso, G. "Cortical localization of reading in normal children: an fMRI language study." Neurology 57, no. 1 (July 10, 2001): 47-54. Link to Item
  - Guo, AC, Provenzale, JM, Cruz, LC, and Petrella, JR. "Cerebral abscesses: investigation using apparent diffusion coefficient maps." Neuroradiology 43, no. 5 (May 2001): 370-374. Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, Alberts, MJ, DeLong, DM, and MacFall, JR. "Use of exponential diffusion imaging to determine the age of ischemic infarcts." J Neuroimaging 11, no. 2 (April 2001): 141-147. Link to Item
  - Guo, AC, Petrella, JR, Kurtzberg, J, and Provenzale, JM. "Evaluation of white matter anisotropy in Krabbe disease with diffusion tensor MR imaging: initial experience." Radiology 218, no. 3 (March 2001): 809-815. Full Text
  - Petrella, JR, Bucher, L, Jha, A, Doraiswamy, PM, and McCarthy, G. "Event-related functional MRI for the early diagnosis of Alzheimer disease: A pilot study in normal volunteers and patients with mild cognitive impairment." NEUROBIOLOGY OF AGING 22, no. 2 (2001): 338-338. Link to Item
  - Engelter, ST, Provenzale, JM, and Petrella, JR. "Assessment of vasogenic edema in eclampsia using diffusion imaging." Neuroradiology 42, no. 11 (November 2000): 818-820. Link to Item
  - Engelter, ST, Provenzale, JM, Petrella, JR, DeLong, DM, and MacFall, JR. "The effect of aging on the apparent diffusion coefficient of normal-appearing white matter." AJR Am J Roentgenol 175, no. 2 (August 2000): 425-430. Full Text Link to Item
  - van Gelderen, P, Grandin, C, Petrella, JR, and Moonen, CT. "Rapid three-dimensional MR imaging method for tracking a bolus of contrast agent through the brain." Radiology 216, no. 2 (August 2000): 603-608. Full Text
  - Petrella, JR, and Provenzale, JM. "MR perfusion imaging of the brain: techniques and applications." Ajr. American Journal of Roentgenology 175, no. 1 (July 2000): 207-219. (Review) Full Text
  - Kassem-Moussa, H, Provenzale, JM, Petrella, JR, and Lewis, DV. "Early diffusion-weighted MR imaging abnormalities in sustained seizure activity." AJR Am J Roentgenol 174, no. 5 (May 2000): 1304-1306. Full Text Link to Item
  - Wong, JC, Provenzale, JM, and Petrella, JR. "Perfusion MR imaging of brain neoplasms." AJR Am J Roentgenol 174, no. 4 (April 2000): 1147-1157. Full Text Link to Item
  - Wong, JC, Provenzale, JM, and Petrella, JR. "Pictorial essay. Perfusion MR imaging of brain neoplasms." American Journal of Roentgenology 174, no. 4 (January 1, 2000): 1147-1157. Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, Alberts, MJ, Kidwell, CS, Alger, JR, Di Salle, F, Starkman, S, Villablanca, P, Bentson, J, and Saver, JL. "Diffusion MR imaging and transient ischemic attacks [4] (multiple letters)." Stroke 30, no. 12 (December 10, 1999): 2762-2763. (Letter)
  - Engelter, ST, Petrella, JR, Alberts, MJ, and Provenzale, JM. "Assessment of cerebral microcirculation in a patient with hypertensive encephalopathy using MR perfusion imaging." AJR Am J Roentgenol 173, no. 6 (December 1999): 1491-1493. Full Text Link to Item
  - Engelter, ST, Provenzale, JM, Petrella, JR, and Alberts, MJ. "Diffusion MR imaging and transient ischemic attacks." Stroke 30, no. 12 (December 1999): 2762-2763. (Letter) Link to Item
  - Provenzale, JM, Engelter, ST, Petrella, JR, Smith, JS, and MacFall, JR. "Use of MR exponential diffusion-weighted images to eradicate T2 "shine-through" effect." Ajr. American Journal of Roentgenology 172, no. 2 (February 1999): 537-539. Full Text
  - Engelter, ST, Provenzale, JM, Petrella, JR, Hoffmann, KL, Delong, DM, and Alberts, MJ. "Signal intensity of exponential diffusion weighted images correlates with infarct age." STROKE 30, no. 1 (January 1999): 260-260. Link to Item
  - Grandin, CB, Gaillard, WD, Whitnah, JR, Petrella, JR, Braniecki, SH, Hunter, KE, and Theodore, WH. "Gender related differences in activated brain areas for language processing: An fMRI study." Neuroimage 7, no. 4 PART II (December 1, 1998).
  - Grandin, CB, Gaillard, WD, Hunter, KE, Petrella, JR, Braniecki, SH, Whitnah, JR, and Theodore, WH. "Comparison of phonemic and semantic verbal fluency tasks: An fMRI study." NeuroImage 7, no. 4 PART II (1998): S133-.
  - Petrella, JR, DeCarli, C, Dagli, M, Grandin, CB, Duyn, JH, Frank, JA, Hoffman, EA, and Theodore, WH. "Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study." AJNR Am J Neuroradiol 19, no. 1 (January 1998): 39-44. Link to Item
  - Petrella, JR, DeCarli, C, Dagli, M, Duyn, JH, Grandin, CB, Frank, JA, Hoffman, EA, and Theodore, WH. "Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst." AJNR Am J Neuroradiol 18, no. 6 (June 1997): 1153-1161. Link to Item
  - Petrella, JR, Grossman, RI, McGowan, JC, Campbell, G, and Cohen, JA. "Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect." AJNR Am J Neuroradiol 17, no. 6 (June 1996): 1041-1049. Link to Item
  - Frank, JA, Bash, C, Stone, L, Petrella, J, Maloni, H, and McFarland, H. "Evaluation of magnetic resonance imaging sensitivity in patients with relapsing remitting multiple sclerosis: baseline versus Betaseron treatment trials." Academic radiology 3 Suppl 2 (1996): S173-S175.
  - Fortin, DF, Cusma, JT, Spero, LA, and Bashore, TM. "Reply." The American Journal of Cardiology 69, no. 16 (1992): 1378--.
- Conference Papers
  - Krishnan, S, Slavin, MJ, Tran, T-T, Murty, L, Finefrock, AE, Doraiswamy, PM, and Petrella, JR. "P2-189 Comparison of FMRI activation patterns in mild cognitive impairment (MCI) subjects and elderly controls at ultra-high field strength." : Elsevier BV, July 2004. Full Text
Teaching & Mentoring
Recent Courses
- NEUROSCI 493: Research Independent Study 1 2017

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