Overview
- Quantitating and modeling physiologic processes in normal and diseased states in the central nervous system through the use of imaging
- Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques
- Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease
- Development of functional imaging biomarkers for early diagnosis and monitoring of dementia
- Functional MRI as an aid to preoperative planning in patients with potentially resectable brain lesions
- Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques
- Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease
- Development of functional imaging biomarkers for early diagnosis and monitoring of dementia
- Functional MRI as an aid to preoperative planning in patients with potentially resectable brain lesions
Current Appointments & Affiliations
Professor of Radiology
·
2014 - Present
Radiology, Neuroradiology,
Radiology
Director of Alzheimer's Disease Imaging Research Laboratory
·
2008 - Present
Radiology,
Clinical Science Departments
Member of the Center for Brain Imaging and Analysis
·
2004 - Present
Duke-UNC Brain Imaging and Analysis Center,
Institutes and Centers
Recent Publications
Harnessing artificial intelligence to transform Alzheimer's disease research.
Journal Article Nat Med · May 2025 Full text Link to item CiteErratum for: MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum.
Journal Article Radiology · May 2025 Full text Link to item CiteCorrection: Polygenic effects on the risk of Alzheimer's disease in the Japanese population.
Journal Article Alzheimers Res Ther · July 10, 2024 Full text Link to item CiteRecent Grants
Functional Networks of White Matter in Alzheimer's Disease and their Associations with Cognitive Decline
ResearchCo Investigator · Awarded by New Jersey Institute of Technology · 2024 - 2029Collaborative Research: Personalized modeling of Alzheimer's disease
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2021 - 2025High Resolution Intracortical DTI for Early Detection of Alzheimer¿s Disease
ResearchPrincipal Investigator · Awarded by Neuroradiology Education and Reserach Foundation (formerly Foundation of the ASNR) · 2016 - 2020View All Grants
Education, Training & Certifications
Rutgers University ·
1987
M.D.
Georgetown University ·
1983
B.S.