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Jeffrey Robert Petrella

Professor of Radiology
Radiology, Neuroradiology
Box 3808 Med Ctr, Durham, NC 27710
1527 Hosp North, Durham, NC 27710

Selected Publications


Correction to: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population (Alzheimer's Research & Therapy, (2024), 16, 1, (45), 10.1186/s13195-024-01414-x)

Journal Article Alzheimer's Research and Therapy · December 1, 2024 Following publication of the original article [1], the authors corrected an error in Fig. 2. (Figure presented.) The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (A, C) and pTau/Aβ42 (B, D) ratios by decile of PRS ... Full text Cite

Expectancy Does Not Predict 18-month Treatment Outcomes with Cognitive Training in Mild Cognitive Impairment.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Computerized cognitive training (CCT) has emerged as a potential treatment option for mild cognitive impairment (MCI). It remains unclear whether CCT's effect is driven in part by expectancy of improvement. OBJECTIVES: This study aimed to deter ... Full text Link to item Cite

Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear. METHODS: We used data from a two-site, 78-week randomized trial of MCI comparin ... Full text Link to item Cite

Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Mathematical models of complex diseases, such as Alzheimer's disease, have the potential to play a significant role in personalized medicine. Specifically, models can be personalized by fitting parameters with individual data for the purpose of ... Full text Link to item Cite

MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum.

Journal Article Radiology · October 2023 Background PET can be used for amyloid-tau-neurodegeneration (ATN) classification in Alzheimer disease, but incurs considerable cost and exposure to ionizing radiation. MRI currently has limited use in characterizing ATN status. Deep learning techniques ca ... Full text Link to item Cite

Column-based cortical depth analysis of the diffusion anisotropy and radiality in submillimeter whole-brain diffusion tensor imaging of the human cortical gray matter in vivo.

Journal Article Neuroimage · April 15, 2023 High-resolution diffusion tensor imaging (DTI) can noninvasively probe the microstructure of cortical gray matter in vivo. In this study, 0.9-mm isotropic whole-brain DTI data were acquired in healthy subjects with an efficient multi-band multi-shot echo-p ... Full text Link to item Cite

Changes in resting state networks in high school football athletes across a single season.

Journal Article Br J Radiol · March 1, 2023 OBJECTIVE: The aim of this pilot cohort study was to examine changes in the organization of resting-state brain networks in high school football athletes and its relationship to exposure to on-field head impacts over the course of a single season. METHODS: ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal Article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Mild cognitive impairment (MCI) represents a high risk group for Alzheimer's disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive netwo ... Full text Link to item Cite

Computerized Games versus Crosswords Training in Mild Cognitive Impairment.

Journal Article NEJM Evid · December 2022 BACKGROUND: Mild cognitive impairment (MCI) increases the risk of dementia. The efficacy of cognitive training in patients with MCI is unclear. METHODS: In a two-site, single-blinded, 78-week trial, participants with MCI - stratified by age, severity (earl ... Full text Link to item Cite

Data-driven causal model discovery and personalized prediction in Alzheimer's disease.

Journal Article NPJ Digit Med · September 8, 2022 With the explosive growth of biomarker data in Alzheimer's disease (AD) clinical trials, numerous mathematical models have been developed to characterize disease-relevant biomarker trajectories over time. While some of these models are purely empiric, othe ... Full text Link to item Cite

Optimal anti-amyloid-beta therapy for Alzheimer's disease via a personalized mathematical model.

Journal Article PLoS Comput Biol · September 2022 With the recent approval by the FDA of the first disease-modifying drug for Alzheimer's Disease (AD), personalized medicine will be increasingly important for appropriate management and counseling of patients with AD and those at risk. The growing availabi ... Full text Link to item Cite

Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort.

Journal Article Radiology · January 2022 Background Pathologic evidence of Alzheimer disease (AD) is detectable years before onset of clinical symptoms. Imaging-based identification of structural changes of the brain in people at genetic risk for early-onset AD may provide insights into how genes ... Full text Link to item Cite

Validity of the Web-Based, Self-Directed, NeuroCognitive Performance Test in Mild Cognitive Impairment.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Digital cognitive tests offer several potential advantages over established paper-pencil tests but have not yet been fully evaluated for the clinical evaluation of mild cognitive impairment. OBJECTIVE: The NeuroCognitive Performance Test (NCPT) ... Full text Link to item Cite

Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.

Journal Article J Affect Disord · December 1, 2021 BACKGROUND: Depression (DEP) and cognitive impairment (CI) share etiological risk factors, anatomical underpinnings, and interact to produce deleterious treatment outcomes. Both DEP and CI exhibit altered patterns of cortical thickness which may impact the ... Full text Link to item Cite

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.

Journal Article Nat Commun · June 28, 2021 Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins ... Full text Link to item Cite

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.

Journal Article Mol Neurodegener · October 8, 2020 BACKGROUND: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a centr ... Full text Link to item Cite

Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study.

Journal Article Eur J Paediatr Neurol · May 2020 Quantitative MRI is increasingly being used as a biomarker in neurological disorders. Cerebellar atrophy occurs in some Alternating Hemiplegia of Childhood (AHC) patients. However, it is not known if cerebellar atrophy can be a potential biomarker in AHC o ... Full text Link to item Cite

Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease.

Journal Article Ophthalmic Surg Lasers Imaging Retina · November 1, 2019 BACKGROUD AND OBJECTIVE: To evaluate the relationship between retinal microvascular parameters on optical coherence tomography angiography (OCTA) and neurodegenerative changes assessed by measurement of brain volume on volumetric magnetic resonance imaging ... Full text Link to item Cite

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.

Journal Article Sci Rep · October 10, 2019 Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set e ... Full text Link to item Cite

Correction to: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population (Alzheimer's Research & Therapy, (2024), 16, 1, (45), 10.1186/s13195-024-01414-x)

Journal Article Alzheimer's Research and Therapy · December 1, 2024 Following publication of the original article [1], the authors corrected an error in Fig. 2. (Figure presented.) The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (A, C) and pTau/Aβ42 (B, D) ratios by decile of PRS ... Full text Cite

Expectancy Does Not Predict 18-month Treatment Outcomes with Cognitive Training in Mild Cognitive Impairment.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Computerized cognitive training (CCT) has emerged as a potential treatment option for mild cognitive impairment (MCI). It remains unclear whether CCT's effect is driven in part by expectancy of improvement. OBJECTIVES: This study aimed to deter ... Full text Link to item Cite

Computerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear. METHODS: We used data from a two-site, 78-week randomized trial of MCI comparin ... Full text Link to item Cite

Personalized Computational Causal Modeling of the Alzheimer Disease Biomarker Cascade.

Journal Article J Prev Alzheimers Dis · 2024 BACKGROUND: Mathematical models of complex diseases, such as Alzheimer's disease, have the potential to play a significant role in personalized medicine. Specifically, models can be personalized by fitting parameters with individual data for the purpose of ... Full text Link to item Cite

MRI-based Deep Learning Assessment of Amyloid, Tau, and Neurodegeneration Biomarker Status across the Alzheimer Disease Spectrum.

Journal Article Radiology · October 2023 Background PET can be used for amyloid-tau-neurodegeneration (ATN) classification in Alzheimer disease, but incurs considerable cost and exposure to ionizing radiation. MRI currently has limited use in characterizing ATN status. Deep learning techniques ca ... Full text Link to item Cite

Column-based cortical depth analysis of the diffusion anisotropy and radiality in submillimeter whole-brain diffusion tensor imaging of the human cortical gray matter in vivo.

Journal Article Neuroimage · April 15, 2023 High-resolution diffusion tensor imaging (DTI) can noninvasively probe the microstructure of cortical gray matter in vivo. In this study, 0.9-mm isotropic whole-brain DTI data were acquired in healthy subjects with an efficient multi-band multi-shot echo-p ... Full text Link to item Cite

Changes in resting state networks in high school football athletes across a single season.

Journal Article Br J Radiol · March 1, 2023 OBJECTIVE: The aim of this pilot cohort study was to examine changes in the organization of resting-state brain networks in high school football athletes and its relationship to exposure to on-field head impacts over the course of a single season. METHODS: ... Full text Link to item Cite

Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.

Journal Article NMR Biomed · February 2023 The United States is experiencing a dramatic increase in maternal opioid misuse and, consequently, the number of individuals exposed to opioids in utero. Prenatal opioid exposure has both acute and long-lasting effects on health and wellbeing. Effects on t ... Full text Link to item Cite

Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Mild cognitive impairment (MCI) represents a high risk group for Alzheimer's disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive netwo ... Full text Link to item Cite

Computerized Games versus Crosswords Training in Mild Cognitive Impairment.

Journal Article NEJM Evid · December 2022 BACKGROUND: Mild cognitive impairment (MCI) increases the risk of dementia. The efficacy of cognitive training in patients with MCI is unclear. METHODS: In a two-site, single-blinded, 78-week trial, participants with MCI - stratified by age, severity (earl ... Full text Link to item Cite

Data-driven causal model discovery and personalized prediction in Alzheimer's disease.

Journal Article NPJ Digit Med · September 8, 2022 With the explosive growth of biomarker data in Alzheimer's disease (AD) clinical trials, numerous mathematical models have been developed to characterize disease-relevant biomarker trajectories over time. While some of these models are purely empiric, othe ... Full text Link to item Cite

Optimal anti-amyloid-beta therapy for Alzheimer's disease via a personalized mathematical model.

Journal Article PLoS Comput Biol · September 2022 With the recent approval by the FDA of the first disease-modifying drug for Alzheimer's Disease (AD), personalized medicine will be increasingly important for appropriate management and counseling of patients with AD and those at risk. The growing availabi ... Full text Link to item Cite

Diffusion Tensor MRI Structural Connectivity and PET Amyloid Burden in Preclinical Autosomal Dominant Alzheimer Disease: The DIAN Cohort.

Journal Article Radiology · January 2022 Background Pathologic evidence of Alzheimer disease (AD) is detectable years before onset of clinical symptoms. Imaging-based identification of structural changes of the brain in people at genetic risk for early-onset AD may provide insights into how genes ... Full text Link to item Cite

Validity of the Web-Based, Self-Directed, NeuroCognitive Performance Test in Mild Cognitive Impairment.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Digital cognitive tests offer several potential advantages over established paper-pencil tests but have not yet been fully evaluated for the clinical evaluation of mild cognitive impairment. OBJECTIVE: The NeuroCognitive Performance Test (NCPT) ... Full text Link to item Cite

Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.

Journal Article J Affect Disord · December 1, 2021 BACKGROUND: Depression (DEP) and cognitive impairment (CI) share etiological risk factors, anatomical underpinnings, and interact to produce deleterious treatment outcomes. Both DEP and CI exhibit altered patterns of cortical thickness which may impact the ... Full text Link to item Cite

Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.

Journal Article Nat Commun · June 28, 2021 Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins ... Full text Link to item Cite

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration.

Journal Article Mol Neurodegener · October 8, 2020 BACKGROUND: The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain that plays a centr ... Full text Link to item Cite

Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study.

Journal Article Eur J Paediatr Neurol · May 2020 Quantitative MRI is increasingly being used as a biomarker in neurological disorders. Cerebellar atrophy occurs in some Alternating Hemiplegia of Childhood (AHC) patients. However, it is not known if cerebellar atrophy can be a potential biomarker in AHC o ... Full text Link to item Cite

Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease.

Journal Article Ophthalmic Surg Lasers Imaging Retina · November 1, 2019 BACKGROUD AND OBJECTIVE: To evaluate the relationship between retinal microvascular parameters on optical coherence tomography angiography (OCTA) and neurodegenerative changes assessed by measurement of brain volume on volumetric magnetic resonance imaging ... Full text Link to item Cite

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.

Journal Article Sci Rep · October 10, 2019 Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set e ... Full text Link to item Cite

Cognitive training and neuroplasticity in mild cognitive impairment (COG-IT): protocol for a two-site, blinded, randomised, controlled treatment trial.

Journal Article BMJ Open · August 30, 2019 INTRODUCTION: Mild cognitive impairment (MCI) is common in older adults and represents a high-risk group for progression to Alzheimer's disease (AD). Medication trials in MCI have generally failed, but new discoveries with brain plasticity in ageing have l ... Full text Link to item Cite

Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.

Journal Article Mol Neurobiol · July 2019 We investigated the association between amyloid-β deposition and white matter (WM) integrity as a determinant of brain glucose hypometabolism across the Alzheimer's disease (AD) spectrum. We assessed ninety-six subjects (27 cognitively normal, 49 mild cogn ... Full text Link to item Cite

Neurodegenerative disorders

Chapter · April 23, 2019 Cite

A blood-based signature of cerebrospinal fluid Aβ1-42 status.

Journal Article Sci Rep · March 11, 2019 It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of ... Full text Link to item Cite

Type 2 diabetes mellitus, brain atrophy, and cognitive decline.

Journal Article Neurology · February 19, 2019 OBJECTIVE: To study longitudinal relationships between type 2 diabetes mellitus (T2DM), cortical thickness, and cognitive function in older people with normal cognition, mild cognitive impairment, and Alzheimer disease (AD). METHODS: The sample was derived ... Full text Link to item Cite

Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer's Disease.

Journal Article Comput Math Methods Med · 2019 BACKGROUND: Alzheimer's disease (AD) is a major public health concern, and there is an urgent need to better understand its complex biology and develop effective therapies. AD progression can be tracked in patients through validated imaging and spinal flui ... Full text Link to item Cite

Financial Management Skills in Aging, MCI and Dementia: Cross Sectional Relationship to 18F-Florbetapir PET Cortical β-amyloid Deposition.

Journal Article J Prev Alzheimers Dis · 2019 BACKGROUND: There is a need to more fully characterize financial capacity losses in the preclinical and prodromal stages of Alzheimer's disease (AD) and their pathological substrates. OBJECTIVES: To test the association between financial skills and cortica ... Full text Link to item Cite

Clinical and radiological characteristics of early versus late mild cognitive impairment in patients with comorbid depressive disorder.

Journal Article Int J Geriatr Psychiatry · December 2018 OBJECTIVE: The classification of mild cognitive impairment (MCI) continues to be debated though it has recently been subtyped into late (LMCI) versus early (EMCI) stages. Older adults presenting with both a depressive disorder (DEP) and cognitive impairmen ... Full text Link to item Cite

Microstructural alterations of cortical and deep gray matter over a season of high school football revealed by diffusion kurtosis imaging.

Journal Article Neurobiol Dis · November 2018 OBJECTIVES: To probe microstructural changes that are associated with subconcussive head impact exposure in deep and cortical gray matter of high school football players over a single season. METHODS: Players underwent diffusion kurtosis imaging (DKI) and ... Full text Link to item Cite

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.

Journal Article Nat Commun · October 15, 2018 The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique-Su ... Full text Link to item Cite

Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial.

Journal Article Am J Geriatr Psychiatry · October 2018 OBJECTIVE: Depression and cognitive impairment are often comorbid in older adults, but optimal treatment strategies remain unclear. In a two-site study, the efficacy and safety of add-on donepezil versus placebo were compared in depressed patients with cog ... Full text Link to item Cite

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer's disease.

Journal Article Sci Rep · September 14, 2018 The change in hypometabolism affects the regional links in the brain network. Here, to understand the underlying brain metabolic network deficits during the early stage and disease evolution of AD (Alzheimer disease), we applied correlation analysis to ide ... Full text Link to item Cite

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.

Journal Article Sci Rep · May 10, 2018 Sex differences in Alzheimer's disease (AD) biology and progression are not yet fully characterized. The goal of this study is to examine the effect of sex on cognitive progression in subjects with high likelihood of mild cognitive impairment (MCI) due to ... Full text Link to item Cite

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images.

Journal Article Sci Rep · April 9, 2018 Alzheimer's Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism image ... Full text Link to item Cite

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states.

Journal Article Sci Rep · March 7, 2018 Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the sha ... Full text Link to item Cite

White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.

Journal Article AJNR Am J Neuroradiol · February 2018 BACKGROUND AND PURPOSE: The effect of exposing the developing brain of a high school football player to subconcussive impacts during a single season is unknown. The purpose of this pilot study was to use diffusion tensor imaging to assess white matter chan ... Full text Open Access Link to item Cite

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.

Journal Article Sci Rep · October 25, 2017 Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popula ... Full text Link to item Cite

American Society of Functional Neuroradiology-Recommended fMRI Paradigm Algorithms for Presurgical Language Assessment.

Journal Article AJNR Am J Neuroradiol · October 2017 INTRODUCTION: Functional MR imaging is increasingly being used for presurgical language assessment in the treatment of patients with brain tumors, epilepsy, vascular malformations, and other conditions. The inherent complexity of fMRI, which includes numer ... Full text Link to item Cite

Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation.

Journal Article Pain Physician · September 2017 BACKGROUND: Failed back surgery syndrome (FBSS) has a high incidence following spinal surgery, is notoriously refractory to treatment, and results in high health care utilization. Spinal cord stimulation (SCS) is a well-accepted modality for pain relief in ... Link to item Cite

Characterizing gene and protein crosstalks in subjects at risk of developing Alzheimer's disease: A new computational approach

Journal Article Processes · September 1, 2017 Alzheimer's disease (AD) is a major public health threat; however, despite decades of research, the disease mechanisms are not completely understood, and there is a significant dearth of predictive biomarkers. The availability of systems biology approaches ... Full text Cite

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Journal Article AJNR Am J Neuroradiol · September 2017 Full text Link to item Cite

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features.

Journal Article Sci Rep · August 15, 2017 The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, pr ... Full text Link to item Cite

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.

Journal Article JAMA Neurol · May 1, 2017 IMPORTANCE: Existing cerebrospinal fluid (CSF) or imaging (tau positron emission tomography) biomarkers for Alzheimer disease (AD) are invasive or expensive. Biomarkers based on standard blood test results would be useful in research, drug development, and ... Full text Link to item Cite

Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?

Journal Article AJNR Am J Neuroradiol · March 2017 BACKGROUND AND PURPOSE: Alzheimer disease is a prevalent neurodegenerative disease. Computer assessment of brain atrophy patterns can help predict conversion to Alzheimer disease. Our aim was to assess the prognostic efficacy of individual-versus-combined ... Full text Link to item Cite

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease.

Journal Article Sci Rep · January 12, 2017 Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should b ... Full text Link to item Cite

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.

Journal Article Nat Commun · June 21, 2016 Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structura ... Full text Link to item Cite

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

Journal Article JAMA Neurol · June 1, 2016 IMPORTANCE: The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of br ... Full text Link to item Cite

ACR-ASNR Practice Parameter for Brain PET/CT Imaging Dementia.

Journal Article Clin Nucl Med · February 2016 This practice parameter is for both FDG and amyloid brain PET or PET/computed tomography (CT) for patients with cognitive decline, and has been developed collaboratively by the American College of Radiology (ACR) and the American Society for Neuroradiology ... Full text Link to item Cite

Marked gender differences in progression of mild cognitive impairment over 8 years.

Journal Article Alzheimers Dement (N Y) · September 1, 2015 INTRODUCTION: This study examined whether, among subjects with mild cognitive impairment (MCI), women progressed at faster rates than men. METHODS: We examine longitudinal rates of change from baseline in 398 MCI subjects (141 Females, 257 Males) in the Al ... Full text Link to item Cite

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.

Journal Article Nat Commun · May 19, 2015 Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal ... Full text Link to item Cite

Educational attainment and hippocampal atrophy in the Alzheimer's disease neuroimaging initiative cohort.

Journal Article J Neuroradiol · December 2014 INTRODUCTION: Subjects with higher cognitive reserve (CR) may be at a lower risk for Alzheimer's disease (AD), but the neural mechanisms underlying this are not known. Hippocampal volume loss is an early event in AD that triggers cognitive decline. MATERIA ... Full text Link to item Cite

The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.

Journal Article Radiology · October 2014 PURPOSE: To evaluate differences in the structural connectome among patients with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer disease (AD) and to determine associations between the structural connectome and cortical amyloid deposi ... Full text Link to item Cite

Impact of ¹⁸F-florbetapir PET imaging of β-amyloid neuritic plaque density on clinical decision-making.

Journal Article Neurocase · August 2014 ¹⁸F-florbetapir positron emission tomography (PET) imaging of the brain is now approved by the Food and Drug Administration (FDA) approved for estimation of β -amyloid neuritic plaque density when evaluating patients with cognitive impairment. However, its ... Full text Link to item Cite

Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.

Journal Article Radiology · April 2014 PURPOSE: To determine the effect of the apolipoprotein E (APOE) genotype on atrophy rates of specific brain gray matter regions hypothesized to be key components of cognitive networks disrupted in Alzheimer disease. MATERIALS AND METHODS: The Alzheimer's D ... Full text Link to item Cite

Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.

Journal Article Contemp Clin Trials · March 2014 Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depre ... Full text Link to item Cite

Brain atrophy rates in first degree relatives at risk for Alzheimer's.

Journal Article Neuroimage Clin · 2014 A positive family history (FH) raises the risk for late-onset Alzheimer's disease though, other than the known risk conferred by apolipoprotein ε4 (ApoE4), much of the genetic variance remains unexplained. We examined the effect of family history on longit ... Full text Link to item Cite

Neuroimaging and the search for a cure for Alzheimer disease.

Journal Article Radiology · December 2013 As radiologists, our role in the workup of the dementia patient has long been limited by the sensitivity of our imaging tools and lack of effective treatment options. Over the past 30 years, we have made tremendous strides in understanding the genetic, mol ... Full text Link to item Cite

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth.

Journal Article Neuroimage · September 2013 BACKGROUND: Although it is well known that many clinical and genetic factors have been associated with beta-amyloid deposition, few studies have examined the interactions of such factors across different stages of Alzheimer's pathogenesis. METHODS: We used ... Full text Link to item Cite

Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack.

Journal Article Neuroimage Clin · August 7, 2013 Neuropsychiatric disorders such as schizophrenia, bipolar disorder and Alzheimer's disease are major public health problems. However, despite decades of research, we currently have no validated prognostic or diagnostic tests that can be applied at an indiv ... Full text Link to item Cite

Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.

Journal Article Alzheimers Dement · May 2013 BACKGROUND: Reliable blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggreg ... Full text Open Access Link to item Cite

Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers.

Journal Article Radiology · February 2013 PURPOSE: To assess the extent to which multiple Alzheimer disease (AD) biomarkers improve the ability to predict future decline in subjects with mild cognitive impairment (MCI) compared with predictions based on clinical parameters alone. MATERIALS AND MET ... Full text Link to item Cite

Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.

Journal Article PLoS One · 2013 OBJECTIVE: To investigate whether there is a specific dose-dependent effect of the Apolipoprotein E (APOE) ε4 and ε2 alleles on hippocampal volume, across the cognitive spectrum, from normal aging to Alzheimer's Disease (AD). MATERIALS AND METHODS: We anal ... Full text Link to item Cite

Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives.

Journal Article PLoS One · 2013 OBJECTIVE: A positive family history (FH) is a risk factor for late-onset Alzheimer's disease (AD). Our aim was to examine the effects of FH on pathological and neuronal loss biomarkers across the cognitive spectrum. DESIGN: Cross-sectional analyses of dat ... Full text Link to item Cite

Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study.

Journal Article AJNR Am J Neuroradiol · May 2012 BACKGROUND AND PURPOSE: Connectivity mapping based on resting-state fMRI is rapidly developing, and this methodology has great potential for clinical applications. However, before resting-state fMRI can be applied for diagnosis, prognosis, and monitoring t ... Full text Link to item Cite

Default mode network connectivity in stable vs progressive mild cognitive impairment.

Journal Article Neurology · February 8, 2011 OBJECTIVE: Dysfunction of the default mode network (DMN) has been identified in prior cross-sectional fMRI studies of Alzheimer disease (AD) and mild cognitive impairment (MCI); however, no studies have examined its utility in predicting future cognitive d ... Full text Link to item Cite

Endodermal cyst of the oculomotor nerve.

Journal Article Pediatr Neurosurg · August 2010 Full text Link to item Cite

Isolated intracranial Rosai-Dorfman disease in a child.

Journal Article AJNR Am J Neuroradiol · November 2009 Full text Link to item Cite

fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.

Journal Article J Magn Reson Imaging · April 2009 PURPOSE: To evaluate the performance of a relative activation amplitude algorithm, versus standard t-value thresholding, for reliably establishing the location, amplitude, and spatial extent of functional magnetic resonance imaging (fMRI) brain activation ... Full text Link to item Cite

Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging.

Journal Article AJNR Am J Neuroradiol · February 2009 Featured Publication BACKGROUND AND PURPOSE: Cholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine t ... Full text Link to item Cite

Modulation of a human memory circuit by subsyndromal depression in late life: a functional magnetic resonance imaging study.

Journal Article Am J Geriatr Psychiatry · January 2009 OBJECTIVE: Functional deactivation of the posteromedial cortex (PMC) seems to be a physiologic process underlying normal memory. The authors examined whether older subjects with subsyndromal depressive symptoms show impaired PMC deactivation. DESIGN: Subje ... Full text Link to item Cite

Modulation of Human Memory Circuit by Minor Depression in Late Life: An fMRI Study

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus?

Journal Article Expert Rev Neurother · February 2008 Featured Publication Full text Link to item Cite

Imaging genetics of brain longevity and mental wellness: the next frontier?

Journal Article Radiology · January 2008 Featured Publication The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great inte ... Full text Link to item Cite

Prognostic value of posteromedial cortex deactivation in mild cognitive impairment.

Journal Article PLoS One · October 31, 2007 Featured Publication BACKGROUND: Normal subjects deactivate specific brain regions, notably the posteromedial cortex (PMC), during many tasks. Recent cross-sectional functional magnetic resonance imaging (fMRI) data suggests that deactivation during memory tasks is impaired in ... Full text Link to item Cite

Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.

Journal Article Radiology · October 2007 Featured Publication PURPOSE: To prospectively identify brain regions in which task-related changes in activation during a memory encoding task, measured with functional magnetic resonance (MR) imaging, correlate with degree of memory impairment across Alzheimer disease (AD), ... Full text Link to item Cite

Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment.

Journal Article AJR Am J Roentgenol · May 2007 OBJECTIVE: The purpose of this study was to examine the diagnostic efficacy of hippocampal volumetry and the Mini-Mental State Examination (MMSE) in differentiating amnestic mild cognitive impairment from the normal changes of aging. SUBJECTS AND METHODS: ... Full text Link to item Cite

Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.

Journal Article AJNR Am J Neuroradiol · September 2006 Featured Publication BACKGROUND AND PURPOSE: Functional MR imaging has been used to study patterns of hippocampal activation that distinguish pathologic from normal memory loss in the elderly population. Our objective was to assess whether hippocampal atrophy confounds measure ... Link to item Cite

Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors.

Journal Article Radiology · September 2006 Featured Publication PURPOSE: To prospectively evaluate the effect of preoperative functional magnetic resonance (MR) imaging localization of language and motor areas on therapeutic decision making in patients with potentially resectable brain tumors. MATERIALS AND METHODS: Th ... Full text Link to item Cite

Mild cognitive impairment: evaluation with 4-T functional MR imaging.

Journal Article Radiology · July 2006 Featured Publication PURPOSE: To prospectively assess abnormalities in brain activation patterns during encoding and retrieval in subjects with mild cognitive impairment by using 4-T functional magnetic resonance (MR) imaging. MATERIALS AND METHODS: The institutional review bo ... Full text Link to item Cite

Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders.

Journal Article Neuroimage · June 2006 Featured Publication Functional magnetic resonance imaging (fMRI) studies in memory impairment have detected functional alterations in medial temporal lobe (MTL) structures, notably the hippocampus. Many of these studies employ spatial normalization to place subjects in a stan ... Full text Link to item Cite

Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research.

Journal Article Neuroimaging Clin N Am · November 2005 Featured Publication Advanced MR techniques, such as functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging, offer the capability of detecting early functional, hemodynamic, and microstructural alterations in Alzheimer's disease before gross anatomic a ... Full text Link to item Cite

Alzheimer's disease: 100 Years of progress

Journal Article Neuroimaging Clinics of North America · November 1, 2005 Full text Cite

Association of internal carotid artery injury with carotid canal fractures in patients with head trauma.

Journal Article AJR Am J Roentgenol · May 2005 OBJECTIVE: The purpose of our study was to determine the degree to which carotid canal fracture and other CT findings are associated with internal carotid artery (ICA) injury in patients with head trauma. MATERIALS AND METHODS: Three neuroradiologists retr ... Full text Link to item Cite

Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?

Journal Article Prim Care Companion J Clin Psychiatry · 2005 Background: The objective of this study was to compare the performance of the Mini-Mental State Examination (MMSE) total score as well as item scores in separating 4 groups of elderly (55-85 years of age) subjects-normal controls, subjects with mild cognit ... Full text Link to item Cite

Increasing memory load modulates regional brain activity in older adults as measured by fMRI.

Journal Article J Neuropsychiatry Clin Neurosci · 2005 Featured Publication Several recent studies using functional magnetic resonance imaging (fMRI) during recognition memory tests have suggested that the ability to neuromodulate as a function of cognitive demand may be impaired in older adults due to age-related cell loss and ne ... Full text Link to item Cite

Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI.

Journal Article AJR Am J Roentgenol · November 2004 OBJECTIVE: The purpose of the study was to determine whether dynamic susceptibility contrast perfusion MRI allowed distinction of cerebral abscesses from cystic high-grade brain neoplasms. CONCLUSION: In this small preliminary study, dynamic susceptibility ... Full text Link to item Cite

In vivo amyloid imaging in Alzheimer's disease.

Journal Article Neuroradiology · February 2004 Featured Publication Targeted approaches to therapy for Alzheimer's disease have evolved based on detailed understanding of the genetic, molecular biologic, and neuropathologic basis of the disease. Given the potential for greater treatment efficacy in the earlier stages of th ... Full text Link to item Cite

Developmental aspects of language processing: fMRI of verbal fluency in children and adults.

Journal Article Hum Brain Mapp · March 2003 We examined developmental differences, in location and extent of fMRI language activation maps, between adults and children while performing a semantic fluency task. We studied 29 adults and 16 children with echo planar imaging BOLD fMRI at 1.5 T using cov ... Full text Link to item Cite

Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.

Journal Article Radiology · February 2003 Featured Publication Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Current consensus statements have emphasized the need for early recognition and the fact that a diagnosis of AD can be made with high acc ... Full text Link to item Cite

Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke.

Journal Article Cerebrovasc Dis · 2003 BACKGROUND: Diffusion-weighted MRI (DWI) can depict acute ischemia based on decreased apparent diffusion coefficient (ADC) values. ADC maps, unlike DWI (which have contributions from T2 properties), solely reflect diffusion properties. Recent studies indic ... Full text Link to item Cite

A functional magnetic resonance imaging study of left hemisphere language dominance in children.

Journal Article Arch Neurol · July 2002 BACKGROUND: Functional magnetic resonance imaging is a noninvasive method of assessing language dominance in a pediatric population. OBJECTIVE: To determine the pattern of receptive language lateralization in healthy children. DESIGN: We used functional ma ... Full text Link to item Cite

Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging.

Journal Article AJR Am J Roentgenol · March 2002 OBJECTIVE: The purpose of this study was to compare permeability measurements in high-grade and low-grade glial neoplasms using a T2(*)-weighted method. Our hypothesis was that permeability measurements using a T2(*)-weighted technique would show permeabil ... Full text Link to item Cite

Dynamic CT perfusion imaging with acetazolamide challenge for the preprocedural evaluation of a patient with symptomatic middle cerebral artery occlusive disease.

Journal Article AJNR Am J Neuroradiol · February 2002 We describe the use of a CT-based method of cerebral perfusion imaging, dynamic CT perfusion imaging, for the pre- and postprocedural assessment of cerebral blood flow in a patient with symptomatic middle cerebral artery occlusive disease who underwent bal ... Link to item Cite

Prefrontal activation patterns in subjects at risk for Alzheimer disease.

Journal Article Am J Geriatr Psychiatry · 2002 Featured Publication Link to item Cite

The role of neuroimaging in geriatric psychiatry

Journal Article Current Opinion in Psychiatry · January 1, 2002 Purpose of review: This article reviews some of the key neuroimaging advances that have occurred over the past year, of relevance to Alzheimer's disease and late-life depression. As the number of elderly in the population continues to grow, the prevalence ... Full text Cite

Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome.

Journal Article AJNR Am J Neuroradiol · September 2001 BACKGROUND AND PURPOSE: Previous studies have shown that lesions in posterior reversible encephalopathy syndrome are often isointense on diffusion-weighted MR images. We hypothesized that 1) apparent diffusion coefficient (ADC) maps using various threshold ... Link to item Cite

Cortical localization of reading in normal children: an fMRI language study.

Journal Article Neurology · July 10, 2001 BACKGROUND: fMRI provides a noninvasive means of identifying the location and organization of neural networks that underlie cognitive functions. OBJECTIVE: To identify, using fMRI, brain regions involved in processing written text in children. METHODS: The ... Full text Link to item Cite

Cerebral abscesses: investigation using apparent diffusion coefficient maps.

Journal Article Neuroradiology · May 2001 The combination of high signal and reduced apparent diffusion coefficients (ADC) within abscesses on diffusion-weighted MRI (DWI) has been reported as characteristic of abscesses, and useful for distinguishing them from cystic or necrotic neoplasms. To ass ... Full text Link to item Cite

Use of exponential diffusion imaging to determine the age of ischemic infarcts.

Journal Article J Neuroimaging · April 2001 Diffusion-weighted magnetic resonance imaging (DWI) detects acute ischemic infarcts with high lesion conspicuity. Determination of infarct age is difficult on DWI alone because infarct signal intensity (SIinfarct) on DWI is influenced by T2 properties ("T2 ... Full text Link to item Cite

Evaluation of white matter anisotropy in Krabbe disease with diffusion tensor MR imaging: initial experience.

Journal Article Radiology · March 2001 PURPOSE: To compare diffusion tensor magnetic resonance imaging with conventional T2-weighted imaging for evaluation of white matter changes in patients with Krabbe disease. MATERIALS AND METHODS: In eight patients with Krabbe disease and eight age-matched ... Full text Link to item Cite

Assessment of vasogenic edema in eclampsia using diffusion imaging.

Journal Article Neuroradiology · November 2000 We qualitatively assessed the regional distribution of vasogenic edema in a case of postpartum eclampsia. Although diffusion-weighted imaging showed no abnormalities, bilateral high signal was seen on T2-weighted images and apparent diffusion coefficient ( ... Full text Link to item Cite

Rapid three-dimensional MR imaging method for tracking a bolus of contrast agent through the brain.

Journal Article Radiology · August 2000 A gradient-echo three-dimensional magnetic resonance imaging technique (principles of echo shifting with a train of observations, or PRESTO) is presented for use in tracking a bolus of paramagnetic contrast agent through the brain. The approach combines a ... Full text Link to item Cite

The effect of aging on the apparent diffusion coefficient of normal-appearing white matter.

Journal Article AJR Am J Roentgenol · August 2000 OBJECTIVE: The purpose of our study was to test the hypothesis that the apparent diffusion coefficient (ADC) of normal-appearing white matter increases with advancing age. SUBJECTS AND METHODS: We selected 38 patients with normal MR imaging findings from 3 ... Full text Link to item Cite

MR perfusion imaging of the brain: techniques and applications.

Journal Article AJR Am J Roentgenol · July 2000 Featured Publication Full text Link to item Cite

Perfusion MR imaging of brain neoplasms.

Journal Article AJR Am J Roentgenol · April 2000 Full text Link to item Cite

Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study.

Journal Article AJNR Am J Neuroradiol · January 1998 Featured Publication PURPOSE: We examined age-related changes in baseline regional cerebral blood volume (rCBV) and response to acetazolamide stimulation by using dynamic contrast-enhanced MR imaging. METHODS: Thirty healthy volunteers ranging widely in age (23 to 82 years) we ... Link to item Cite

Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst.

Journal Article AJNR Am J Neuroradiol · 1997 Featured Publication PURPOSE: To determine whether whole-brain acetazolamide-induced changes in regional cerebral blood volume (rCBV) can be assessed on a conventional gradient 1.5-T MR system using 3-D dynamic susceptibility contrast-enhanced MR imaging. METHODS: A 3-D freque ... Link to item Cite

Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect.

Journal Article AJNR Am J Neuroradiol · 1996 PURPOSE: To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect. METHODS: Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement patt ... Link to item Cite