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Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.

Publication ,  Journal Article
Motter, JN; Lee, S; Sneed, JR; Doraiswamy, PM; Pelton, GH; Petrella, JR; Devanand, DP
Published in: J Affect Disord
December 1, 2021

BACKGROUND: Depression (DEP) and cognitive impairment (CI) share etiological risk factors, anatomical underpinnings, and interact to produce deleterious treatment outcomes. Both DEP and CI exhibit altered patterns of cortical thickness which may impact the course of antidepressant treatment, though inconsistencies in directionality and affected brain regions have been reported. In this study, we examined the relationship between cortical thickness and treatment outcome in older adults with comorbid DEP-CI. METHODS: 55 patients with DEP-CI received baseline MRI scans as part of a larger clinical trial at NYSPI/Columbia University Medical Center and Duke University Medical Center. Mood was assessed using the Hamilton Depression Rating Scale. Patients received open antidepressant treatment for 8 weeks followed by another 8 weeks of the same medication or switch to another antidepressant for a total of 16 weeks. Cortical thickness was extracted using an automated brain segmentation program (FreeSurfer). Vertex-wise analyses evaluated the relationship between cortical thickness and treatment outcome. RESULTS: Remitters exhibited diffuse clusters of greater cortical thickness and reduced cortical thickness compared to non-remitters. Thicker baseline middle frontal gyrus most consistently predicted greater likelihood and faster rate of remission. White matter hyperintensities and hippocampal volume were not associated with antidepressant treatment outcome. LIMITATIONS: MRI was conducted at baseline only and sample size was small. DISCUSSION: Cortical thickness predicts treatment remission and magnitude of early improvement. Results indicate that individuals with DEP-CI exhibit unique patterns of structural abnormalities compared to their depressed peers without CI that have consequences for their recovery with antidepressant treatment.

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Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

December 1, 2021

Volume

295

Start / End Page

438 / 445

Location

Netherlands

Related Subject Headings

  • Psychiatry
  • Magnetic Resonance Imaging
  • Humans
  • Depressive Disorder, Major
  • Depression
  • Cognitive Dysfunction
  • Antidepressive Agents
  • Aged
  • 52 Psychology
  • 42 Health sciences
 

Citation

APA
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ICMJE
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Motter, J. N., Lee, S., Sneed, J. R., Doraiswamy, P. M., Pelton, G. H., Petrella, J. R., & Devanand, D. P. (2021). Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment. J Affect Disord, 295, 438–445. https://doi.org/10.1016/j.jad.2021.08.062
Motter, Jeffrey N., Seonjoo Lee, Joel R. Sneed, P Murali Doraiswamy, Gregory H. Pelton, Jeffrey R. Petrella, and D. P. Devanand. “Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.J Affect Disord 295 (December 1, 2021): 438–45. https://doi.org/10.1016/j.jad.2021.08.062.
Motter JN, Lee S, Sneed JR, Doraiswamy PM, Pelton GH, Petrella JR, et al. Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment. J Affect Disord. 2021 Dec 1;295:438–45.
Motter, Jeffrey N., et al. “Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.J Affect Disord, vol. 295, Dec. 2021, pp. 438–45. Pubmed, doi:10.1016/j.jad.2021.08.062.
Motter JN, Lee S, Sneed JR, Doraiswamy PM, Pelton GH, Petrella JR, Devanand DP. Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment. J Affect Disord. 2021 Dec 1;295:438–445.
Journal cover image

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

December 1, 2021

Volume

295

Start / End Page

438 / 445

Location

Netherlands

Related Subject Headings

  • Psychiatry
  • Magnetic Resonance Imaging
  • Humans
  • Depressive Disorder, Major
  • Depression
  • Cognitive Dysfunction
  • Antidepressive Agents
  • Aged
  • 52 Psychology
  • 42 Health sciences