Skip to main content
Journal cover image

fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.

Publication ,  Journal Article
Voyvodic, JT; Petrella, JR; Friedman, AH
Published in: J Magn Reson Imaging
April 2009

PURPOSE: To evaluate the performance of a relative activation amplitude algorithm, versus standard t-value thresholding, for reliably establishing the location, amplitude, and spatial extent of functional magnetic resonance imaging (fMRI) brain activation for presurgical planning. MATERIALS AND METHODS: Diagnostic fMRI maps from 42 neurosurgical patients performing a simple hand movement task were analyzed. Relative activation maps were made by normalizing statistical t-value maps to the local peak activation amplitude within each functional brain region. The spatial distribution of activation was quantified and compared across mapping algorithms, subjects, and scan duration. RESULTS: Whereas the spatial distribution of blood oxygenation level-dependent (BOLD) t-value statistical activation maps was highly variable across subjects and scan duration, the spatial distribution of relative activation maps was highly reproducible both within individual subjects and across different subjects. In every case the 40% most active voxels in the cortical hand region were consistently localized to the pre- and postcentral gyri of the sensorimotor cortex. CONCLUSION: The reproducibility and anatomical specificity of the spatiotemporal pattern of BOLD activation makes relative amplitude fMRI mapping a useful tool for clinical imaging, where accuracy, reproducibility, and quality control are critical concerns.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

April 2009

Volume

29

Issue

4

Start / End Page

751 / 759

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Retrospective Studies
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Motor Cortex
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Voyvodic, J. T., Petrella, J. R., & Friedman, A. H. (2009). fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment. J Magn Reson Imaging, 29(4), 751–759. https://doi.org/10.1002/jmri.21716
Voyvodic, James T., Jeffrey R. Petrella, and Allan H. Friedman. “fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.J Magn Reson Imaging 29, no. 4 (April 2009): 751–59. https://doi.org/10.1002/jmri.21716.
Voyvodic JT, Petrella JR, Friedman AH. fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment. J Magn Reson Imaging. 2009 Apr;29(4):751–9.
Voyvodic, James T., et al. “fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.J Magn Reson Imaging, vol. 29, no. 4, Apr. 2009, pp. 751–59. Pubmed, doi:10.1002/jmri.21716.
Voyvodic JT, Petrella JR, Friedman AH. fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment. J Magn Reson Imaging. 2009 Apr;29(4):751–759.
Journal cover image

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

April 2009

Volume

29

Issue

4

Start / End Page

751 / 759

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Retrospective Studies
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Motor Cortex
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Interpretation, Computer-Assisted
  • Humans