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The effect of aging on the apparent diffusion coefficient of normal-appearing white matter.

Publication ,  Journal Article
Engelter, ST; Provenzale, JM; Petrella, JR; DeLong, DM; MacFall, JR
Published in: AJR Am J Roentgenol
August 2000

OBJECTIVE: The purpose of our study was to test the hypothesis that the apparent diffusion coefficient (ADC) of normal-appearing white matter increases with advancing age. SUBJECTS AND METHODS: We selected 38 patients with normal MR imaging findings from 332 patients undergoing clinical MR imaging. Diffusion-weighted MR imaging was performed with diffusion gradients applied in three orthogonal directions. For each patient, the average ADC on trace-weighted diffusion images of white matter at prespecified regions of interest and at the thalamus were compared with the patient's age. RESULTS: For the white matter, ADC sorted by patient age in decades increased with advancing age. Patients at least 60 years old had significantly higher ADC (0.769 +/- 0.019 mm(2)/sec x 10(-3)) than patients less than 60 years old (0.740 +/- 0.013 mm(2)/sec x 10(-3)) (p < 0.001). Comparison of individual white matter ADC and age showed a significant increase with advancing age (p < 0.0001). For the thalamus, the average ADC among patients at least 60 years old (0.766 +/- 0.015 mm(2)/sec x 10(-3)) exceeded the average ADC for patients less than 60 years old (0.745 +/- 0.022 mm(2)/sec x 10(-3)) (p < 0.05). However, comparison of individual thalamic ADC and patient ages, although showing a trend to higher ADC with increasing age, did not reach statistical significance (p = 0.06). CONCLUSION: Advancing age is associated with a small but statistically significant increase of water diffusibility in human white matter. A similar trend was present in the thalamus. These increases may reflect mild structural changes associated with normal aging.

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Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

August 2000

Volume

175

Issue

2

Start / End Page

425 / 430

Location

United States

Related Subject Headings

  • Thalamus
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Diffusion
  • Brain
  • Aging
 

Citation

APA
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ICMJE
MLA
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Engelter, S. T., Provenzale, J. M., Petrella, J. R., DeLong, D. M., & MacFall, J. R. (2000). The effect of aging on the apparent diffusion coefficient of normal-appearing white matter. AJR Am J Roentgenol, 175(2), 425–430. https://doi.org/10.2214/ajr.175.2.1750425
Engelter, S. T., J. M. Provenzale, J. R. Petrella, D. M. DeLong, and J. R. MacFall. “The effect of aging on the apparent diffusion coefficient of normal-appearing white matter.AJR Am J Roentgenol 175, no. 2 (August 2000): 425–30. https://doi.org/10.2214/ajr.175.2.1750425.
Engelter ST, Provenzale JM, Petrella JR, DeLong DM, MacFall JR. The effect of aging on the apparent diffusion coefficient of normal-appearing white matter. AJR Am J Roentgenol. 2000 Aug;175(2):425–30.
Engelter, S. T., et al. “The effect of aging on the apparent diffusion coefficient of normal-appearing white matter.AJR Am J Roentgenol, vol. 175, no. 2, Aug. 2000, pp. 425–30. Pubmed, doi:10.2214/ajr.175.2.1750425.
Engelter ST, Provenzale JM, Petrella JR, DeLong DM, MacFall JR. The effect of aging on the apparent diffusion coefficient of normal-appearing white matter. AJR Am J Roentgenol. 2000 Aug;175(2):425–430.

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

August 2000

Volume

175

Issue

2

Start / End Page

425 / 430

Location

United States

Related Subject Headings

  • Thalamus
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Diffusion
  • Brain
  • Aging