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Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.

Publication ,  Journal Article
Sperling, RA; Johnson, KA; Doraiswamy, PM; Reiman, EM; Fleisher, AS; Sabbagh, MN; Sadowsky, CH; Carpenter, A; Davis, MD; Lu, M; Flitter, M ...
Published in: Neurobiol Aging
March 2013

The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 ((18)F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assessed with a brief cognitive test battery and positron emission tomography (PET) imaging with (18)F-AV-45. A standard uptake value ratio was computed for mean data from 6 cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive or amyloid negative by 3 readers. Higher standard uptake value ratio correlated with lower immediate memory (r = -0.33; p = 0.003) and delayed recall scores (r = -0.25; p = 0.027). Performance on immediate recall was also lower in the visually rated amyloid positive compared with amyloid negative HC (p = 0.04), with a similar trend observed in delayed recall (p = 0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether (18)F-AV-45 may also predict subsequent cognitive decline.

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Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

March 2013

Volume

34

Issue

3

Start / End Page

822 / 831

Location

United States

Related Subject Headings

  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Recall
  • Memory, Episodic
  • Memory Disorders
  • Male
  • Humans
 

Citation

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Sperling, R. A., Johnson, K. A., Doraiswamy, P. M., Reiman, E. M., Fleisher, A. S., Sabbagh, M. N., … AV45-A05 Study Group, . (2013). Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging, 34(3), 822–831. https://doi.org/10.1016/j.neurobiolaging.2012.06.014
Sperling, Reisa A., Keith A. Johnson, P Murali Doraiswamy, Eric M. Reiman, Adam S. Fleisher, Marwan N. Sabbagh, Carl H. Sadowsky, et al. “Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.Neurobiol Aging 34, no. 3 (March 2013): 822–31. https://doi.org/10.1016/j.neurobiolaging.2012.06.014.
Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh MN, et al. Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging. 2013 Mar;34(3):822–31.
Sperling, Reisa A., et al. “Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.Neurobiol Aging, vol. 34, no. 3, Mar. 2013, pp. 822–31. Pubmed, doi:10.1016/j.neurobiolaging.2012.06.014.
Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh MN, Sadowsky CH, Carpenter A, Davis MD, Lu M, Flitter M, Joshi AD, Clark CM, Grundman M, Mintun MA, Skovronsky DM, Pontecorvo MJ, AV45-A05 Study Group. Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging. 2013 Mar;34(3):822–831.
Journal cover image

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

March 2013

Volume

34

Issue

3

Start / End Page

822 / 831

Location

United States

Related Subject Headings

  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Recall
  • Memory, Episodic
  • Memory Disorders
  • Male
  • Humans