Scholars@Duke
Journal cover image

A magnetic resonance imaging study of putamen nuclei in major depression.

Publication ,  Journal Article
Husain, MM; McDonald, WM; Doraiswamy, PM; Figiel, GS; Na, C; Escalona, PR; Boyko, OB; Nemeroff, CB; Krishnan, KR
Published in: Psychiatry Res
October 1991
Published version (DOI) Link to item

The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depressive mood, and psychosis. Using high resolution, axial T2 intermediate magnetic resonance images, and a systematic sampling stereologic method, we assessed putamen nuclei volumes in 41 patients with major depression (DSM-III) and 44 healthy volunteer controls of similar age. Depressed patients had significantly smaller putamen nuclei compared with controls. Age was negatively correlated with putamen size in both groups. These results are the first demonstration of diminished putamen volumes in depression and further support a role for basal ganglia structures in the etiopathogenesis of depression.

Duke Scholars

P. Murali Doraiswamy
Author P. Murali Doraiswamy Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
K. Ranga Rama Krishnan
Author K. Ranga Rama Krishnan Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...

Published In

Psychiatry Res

DOI

10.1016/0925-4927(91)90001-7

ISSN

0165-1781

Publication Date

October 1991

Volume

40

Issue

2

Start / End Page

95 / 99

Location

Ireland

Related Subject Headings

  • Putamen
  • Psychiatry
  • Neurocognitive Disorders
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Limbic System
  • Humans
  • Female
  • Depressive Disorder
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Husain, M. M., McDonald, W. M., Doraiswamy, P. M., Figiel, G. S., Na, C., Escalona, P. R., … Krishnan, K. R. (1991). A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res, 40(2), 95–99. https://doi.org/10.1016/0925-4927(91)90001-7
Husain, M. M., W. M. McDonald, P. M. Doraiswamy, G. S. Figiel, C. Na, P. R. Escalona, O. B. Boyko, C. B. Nemeroff, and K. R. Krishnan. “A magnetic resonance imaging study of putamen nuclei in major depression.” Psychiatry Res 40, no. 2 (October 1991): 95–99. https://doi.org/10.1016/0925-4927(91)90001-7.
Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Na C, Escalona PR, et al. A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res. 1991 Oct;40(2):95–9.
Husain, M. M., et al. “A magnetic resonance imaging study of putamen nuclei in major depression.” Psychiatry Res, vol. 40, no. 2, Oct. 1991, pp. 95–99. Pubmed, doi:10.1016/0925-4927(91)90001-7.
Husain MM, McDonald WM, Doraiswamy PM, Figiel GS, Na C, Escalona PR, Boyko OB, Nemeroff CB, Krishnan KR. A magnetic resonance imaging study of putamen nuclei in major depression. Psychiatry Res. 1991 Oct;40(2):95–99.
Journal cover image

Published In

Psychiatry Res

DOI

10.1016/0925-4927(91)90001-7

ISSN

0165-1781

Publication Date

October 1991

Volume

40

Issue

2

Start / End Page

95 / 99

Location

Ireland

Related Subject Headings

  • Putamen
  • Psychiatry
  • Neurocognitive Disorders
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Limbic System
  • Humans
  • Female
  • Depressive Disorder