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The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential.

Publication ,  Journal Article
Doraiswamy, PM
Published in: Curr Neurol Neurosci Rep
September 2003

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an unknown etiology. Pathologic processes implicated in AD include b-amyloid-induced synaptic failure; tau hyperphosphorylation; inflammation; oxidative stress; abnormal neurotransmission involving acetylcholine, glutamate, norepinephrine, serotonin, and dopamine; and abnormalities in second messengers, protein kinases, and apoptosis. Although each of these pathways offers potential therapeutic targets, pharmacologic manipulation of the glutamatergic N-methyl-D-aspartate receptor pathway, alone or in combination with cholinergic therapies, is emerging as the next promising strategy for the treatment of AD and vascular dementia.

Duke Scholars

Published In

Curr Neurol Neurosci Rep

DOI

ISSN

1528-4042

Publication Date

September 2003

Volume

3

Issue

5

Start / End Page

373 / 378

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Receptors, N-Methyl-D-Aspartate
  • Neurology & Neurosurgery
  • Humans
  • Glutamic Acid
  • Excitatory Amino Acid Antagonists
  • Clinical Trials as Topic
  • Brain
  • Animals
  • Alzheimer Disease
 

Citation

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Doraiswamy, P. M. (2003). The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential. Curr Neurol Neurosci Rep, 3(5), 373–378. https://doi.org/10.1007/s11910-003-0019-8
Doraiswamy, P Murali. “The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential.Curr Neurol Neurosci Rep 3, no. 5 (September 2003): 373–78. https://doi.org/10.1007/s11910-003-0019-8.
Doraiswamy PM. The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential. Curr Neurol Neurosci Rep. 2003 Sep;3(5):373–8.
Doraiswamy, P. Murali. “The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential.Curr Neurol Neurosci Rep, vol. 3, no. 5, Sept. 2003, pp. 373–78. Pubmed, doi:10.1007/s11910-003-0019-8.
Doraiswamy PM. The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential. Curr Neurol Neurosci Rep. 2003 Sep;3(5):373–378.
Journal cover image

Published In

Curr Neurol Neurosci Rep

DOI

ISSN

1528-4042

Publication Date

September 2003

Volume

3

Issue

5

Start / End Page

373 / 378

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Receptors, N-Methyl-D-Aspartate
  • Neurology & Neurosurgery
  • Humans
  • Glutamic Acid
  • Excitatory Amino Acid Antagonists
  • Clinical Trials as Topic
  • Brain
  • Animals
  • Alzheimer Disease