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Analysis of European mitochondrial haplogroups with Alzheimer disease risk.

Publication ,  Journal Article
van der Walt, JM; Dementieva, YA; Martin, ER; Scott, WK; Nicodemus, KK; Kroner, CC; Welsh-Bohmer, KA; Saunders, AM; Roses, AD; Small, GW ...
Published in: Neurosci Lett
July 15, 2004
Published version (DOI) Link to item

We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs). Logistic regression analyses were used to assess risk of haplogroups and SNPs with AD in both main effects and interaction models. Males classified as haplogroup U showed an increase in risk (OR = 2.30; 95% CI, 1.03-5.11; P = 0.04) of AD relative to the most common haplogroup H, while females demonstrated a significant decrease in risk with haplogroup U (OR = 0.44 ; 95% CI, 0.24-0.80; P = 0.007). Our results were independent of APOE genotype, demonstrating that the effect of mt variation is not confounded by APOE4 carrier status. We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE.

Duke Scholars

Kathleen Anne Welsh-Bohmer
Author Kathleen Anne Welsh-Bohmer Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
P. Murali Doraiswamy
Author P. Murali Doraiswamy Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
Margaret Ann Pericak-Vance
Author Margaret Ann Pericak-Vance Medicine, Hematology
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Published In

Neurosci Lett

DOI

10.1016/j.neulet.2004.04.051

ISSN

0304-3940

Publication Date

July 15, 2004

Volume

365

Issue

1

Start / End Page

28 / 32

Location

Ireland

Related Subject Headings

  • White People
  • Sex Factors
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Mitochondria
  • Male
  • Humans
  • Haplotypes
  • Genetic Predisposition to Disease
 

Citation

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van der Walt, J. M., Dementieva, Y. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Kroner, C. C., … Pericak-Vance, M. A. (2004). Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett, 365(1), 28–32. https://doi.org/10.1016/j.neulet.2004.04.051
Walt, Joelle M. van der, Yulia A. Dementieva, Eden R. Martin, William K. Scott, Kristin K. Nicodemus, Charles C. Kroner, Kathleen A. Welsh-Bohmer, et al. “Analysis of European mitochondrial haplogroups with Alzheimer disease risk.” Neurosci Lett 365, no. 1 (July 15, 2004): 28–32. https://doi.org/10.1016/j.neulet.2004.04.051.
van der Walt JM, Dementieva YA, Martin ER, Scott WK, Nicodemus KK, Kroner CC, et al. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett. 2004 Jul 15;365(1):28–32.
van der Walt, Joelle M., et al. “Analysis of European mitochondrial haplogroups with Alzheimer disease risk.” Neurosci Lett, vol. 365, no. 1, July 2004, pp. 28–32. Pubmed, doi:10.1016/j.neulet.2004.04.051.
van der Walt JM, Dementieva YA, Martin ER, Scott WK, Nicodemus KK, Kroner CC, Welsh-Bohmer KA, Saunders AM, Roses AD, Small GW, Schmechel DE, Murali Doraiswamy P, Gilbert JR, Haines JL, Vance JM, Pericak-Vance MA. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett. 2004 Jul 15;365(1):28–32.
Journal cover image

Published In

Neurosci Lett

DOI

10.1016/j.neulet.2004.04.051

ISSN

0304-3940

Publication Date

July 15, 2004

Volume

365

Issue

1

Start / End Page

28 / 32

Location

Ireland

Related Subject Headings

  • White People
  • Sex Factors
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Mitochondria
  • Male
  • Humans
  • Haplotypes
  • Genetic Predisposition to Disease