Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
Publication
, Journal Article
Azevedo, T; Bethlehem, RAI; Whiteside, DJ; Swaddiwudhipong, N; Rowe, JB; Lió, P; Rittman, T; Li, G; Petrie, EC; Peskind, ER; Villena, T ...
Published in: Communications Medicine
December 1, 2023
Spotting people with dementia early is challenging, but important to identify people for trials of treatment and prevention. We used brain scans of people with Alzheimer’s disease, the commonest type of dementia, and applied an artificial intelligence method to spot people with Alzheimer’s disease. We used this to find people in the Healthy UK Biobank study who might have early Alzheimer’s disease. The people we found had subtle changes in their memory and thinking to suggest they may have early disease, and we also found they had high blood pressure and smoked for longer. We have demonstrated an approach that could be used to select people at high risk of future dementia for clinical trials.
Duke Scholars
Published In
Communications Medicine
DOI
EISSN
2730-664X
Publication Date
December 1, 2023
Volume
3
Issue
1
Citation
APA
Chicago
ICMJE
MLA
NLM
Azevedo, T., Bethlehem, R. A. I., Whiteside, D. J., Swaddiwudhipong, N., Rowe, J. B., Lió, P., … Atri, A. (2023). Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank. Communications Medicine, 3(1). https://doi.org/10.1038/s43856-023-00313-w
Azevedo, T., R. A. I. Bethlehem, D. J. Whiteside, N. Swaddiwudhipong, J. B. Rowe, P. Lió, T. Rittman, et al. “Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank.” Communications Medicine 3, no. 1 (December 1, 2023). https://doi.org/10.1038/s43856-023-00313-w.
Azevedo T, Bethlehem RAI, Whiteside DJ, Swaddiwudhipong N, Rowe JB, Lió P, et al. Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank. Communications Medicine. 2023 Dec 1;3(1).
Azevedo, T., et al. “Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank.” Communications Medicine, vol. 3, no. 1, Dec. 2023. Scopus, doi:10.1038/s43856-023-00313-w.
Azevedo T, Bethlehem RAI, Whiteside DJ, Swaddiwudhipong N, Rowe JB, Lió P, Rittman T, Li G, Petrie EC, Peskind ER, Villena T, Martinez W, Sadowsky C, Lee A, Ravdin L, Lin M, Chiang G, Relkin N, Santulli RB, Hynes ML, Seltzer M, Flashman LA, Anderson K, Blank K, Pearlson GD, Kittur S, Correia S, Malloy P, Salloway S, Potkin S, Newhouse P, Garcia A, Shi J, Masdeu J, Wiliams A, Mintzer J, O’Connelll A, Mintz A, Munic D, Bernick C, Ritter A, Drake JD, Daiello LA, Tremont G, Drake J, Ott BR, Sink KM, Yang M, Cleveland J, Craft S, Williamson JD, Schultz SK, Nam KW, Shim H, Koleva H, Smith KE, Boles Ponto LL, Miller DD, Celmins D, Zimmerman EA, Hart D, Kelley B, Tarawneh R, Kataki M, Scharre DW, Burke A, Perrin A, Carlsson CM, Asthana S, Johnson S, Bartha R, Lee TY, Borrie M, Rainka M, Capote H, Bates V, Carmichael O, DeCarli C, Olichney J, Maillard P, Fletcher E, Fatica P, Tatsuoka C, Ogrocki P, Lerner A, Nadarajah S, Nwulia E, Khan JI, Wolday S, Ntekim OE, Obisesan TO, Budson AE, Kowall N, Mez J, Stern R, Killiany R, Sabbagh M, Clark Edward Zamrini KA, Spann BM, Atri A. Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank. Communications Medicine. 2023 Dec 1;3(1).
Published In
Communications Medicine
DOI
EISSN
2730-664X
Publication Date
December 1, 2023
Volume
3
Issue
1