Skip to main content

P. Murali Doraiswamy

Professor of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt Street North Pavil, 6th Floor, Room 6032, Durham, NC 27710
2400 Pratt Street North Pavil, Box 102505, Durham, NC 27710

Research Interests


Precision Medicine
Digital Therapeutics
Biomarkers
Clinical Trials
Aging
Artificial Intelligence in Medicine

Selected Grants


Duke University Psychiatry Physician-Scientist Residency Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Cognitive training and neuroplasticity in Mild Cognitive Impairment

ResearchPrincipal Investigator · Awarded by Columbia University · 2017 - 2029

Utility of blood biomarkers for predicting ARIA and its course in MCI and AD subjects undergoing routine clinical treatment

ResearchPrincipal Investigator · Awarded by Cure Alzheimer's Fund · 2024 - 2026

FORD0120-45157 - Alzheimer's Disease Neuroimaging Initiative (ADNI4) Supplement

ResearchPrincipal Investigator · Awarded by Fordham University · 2023 - 2025

Genetic Modulations of Morbidity Compression: A Population-Based Study

ResearchInvestigator · Awarded by National Institute on Aging · 2020 - 2025

Duke University Psychiatry Physician-Scientist Residency Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Cognitive training and neuroplasticity in Mild Cognitive Impairment

ResearchPrincipal Investigator · Awarded by Columbia University · 2017 - 2029

Utility of blood biomarkers for predicting ARIA and its course in MCI and AD subjects undergoing routine clinical treatment

ResearchPrincipal Investigator · Awarded by Cure Alzheimer's Fund · 2024 - 2026

FORD0120-45157 - Alzheimer's Disease Neuroimaging Initiative (ADNI4) Supplement

ResearchPrincipal Investigator · Awarded by Fordham University · 2023 - 2025

Genetic Modulations of Morbidity Compression: A Population-Based Study

ResearchInvestigator · Awarded by National Institute on Aging · 2020 - 2025

Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)"

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2024

Alzheimer's Disease Neuroimaging Initiative (ADNI4)

ResearchPrincipal Investigator · Awarded by University of Southern California · 2022 - 2024

Sex Differences in Alzheimer's Disease Progression: Framingham Heart Study

ResearchPrincipal Investigator · Awarded by Cure Alzheimer's Fund · 2022 - 2023

Impact of Midlife and Late-Life Intake of Flavonoid-Rich Fruits on Dementia Risk in the Framingham Heart Study

ResearchPrincipal Investigator · Awarded by Boston University · 2022 - 2023

Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2023

Gut Liver Brain Biochemical Axis in Alzheimer's Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2023

Metabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to Treatment

ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2023

Phase 3 Clinical Trial for Agitation in Alzheimer's 15-AVP-786-303

ResearchPrincipal Investigator · Awarded by Avanir Pharmaceuticals · 2016 - 2023

Phase 3 Clinical Trial for Agitation in Alzheimer's 15-AVP-786-301

ResearchPrincipal Investigator · Awarded by Avanir Pharmaceuticals · 2016 - 2023

Cognitive Training and Neuroplasticity in Mild Cognitive Impairment

ResearchPrincipal Investigator · Awarded by The Trustees of Columbia University · 2020 - 2023

Blueberry supplementation effects in Subjects at Risk for Alzheimer's Disease

ResearchPrincipal Investigator · Awarded by U.S. Highbush Blueberry Council · 2022 - 2023

ADNI-3 Diversity Supplement

ResearchPrincipal Investigator · Awarded by University of Southern California · 2020 - 2022

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

ResearchPrincipal Investigator · Awarded by University of Southern California · 2016 - 2022

Does rifaximin improve cognition in patients with Alzheimer's disease?" using Manufacturer's drug XIFAXAN

Clinical TrialCo Investigator · Awarded by Bausch Health US LLC · 2019 - 2022

The Role of the Gut Microbiome and Metabolome in Alzheimer's Disease

ResearchCo Investigator · Awarded by North Carolina Biotechnology Center · 2021 - 2021

Effects of Traumatic Brain Injury and Post-Traumatic Stress Disorder and Alzheimer's Disease on Brain Tau in Vietnam Veterans using ADNI

ResearchPrincipal Investigator · Awarded by University of Southern California · 2016 - 2021

Predicting prebiotic effects on human microbiota, behavior, and cognition.

ResearchCollaborator · Awarded by Office of Naval Research · 2018 - 2021

A Clinical-Pathological Study of the Correspondence Between 18F-AV-1451 PET Imaging and Post-Mortem Assessment of Tau Pathology

Clinical TrialPrincipal Investigator · Awarded by Avid Radiopharmaceuticals Inc · 2015 - 2021

High Resolution Intracortical DTI for Early Detection of Alzheimer┬┐s Disease

ResearchCo Investigator · Awarded by Neuroradiology Education and Reserach Foundation (formerly Foundation of the ASNR) · 2016 - 2020

Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2020

Metabolic Network Analysis of Biochemical Trajectories in Alzheimer's Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2020

A Biomarker-Based Trial of Plasmalogen Repletion in MCI/AD

ResearchCo Investigator · Awarded by University of Pennsylvania · 2019 - 2020

Metabolic Networks and Pathways in Alzheimer's Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2019

Lifestyle, CVD Risk and Cognitive Impairment

ResearchCo Investigator · Awarded by National Institutes of Health · 2011 - 2018

EVP-6124-026

Clinical TrialPrincipal Investigator · Awarded by FORUM Pharmaceuticals Inc. · 2014 - 2017

EVP-6124-025

Clinical TrialPrincipal Investigator · Awarded by FORUM Pharmaceuticals Inc. · 2014 - 2017

Baseline Bio-molecular Models to Predict Infectious Disease Susceptibility

ResearchClinical Investigator · Awarded by Defense Advanced Research Projects Agency · 2015 - 2016

Pilot Combination Trial of Mild Cognitive Impairment with Depression Supplement

ResearchPrincipal Investigator · Awarded by Research Foundation for Mental Hygiene, Inc. · 2013 - 2016

Pilot Combination Trial of Mild Cognitive Impairment with Depression

ResearchPrincipal Investigator · Awarded by Research Foundation for Mental Hygiene, Inc. · 2011 - 2015

Cortical Beta-amyloid Levels and Neurocognitive Performance After Cardiac Surgery

ResearchCo Investigator · Awarded by National Institutes of Health · 2011 - 2014

Vascular Depression: Longitudinal Changes

ResearchInvestigator · Awarded by National Institutes of Health · 2007 - 2011

Metabolic Signatures for Alzheimer's Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2011

PREMIER Mental Health Interventions Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2010

fMRI Studies in Early Alzheimer's Disease

ResearchInvestigator · Awarded by National Institutes of Health · 2001 - 2008

Exercise Training And Depression In Older Adults

ResearchCo Investigator · Awarded by National Institutes of Health · 1998 - 2007

Treatment Outcomes of Vascular Depression

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2007

Development of the Inventory of Depressive Symptomatology

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2006

A Clinical Trial of Donepezil for Down Syndrome

ResearchCollaborator · Awarded by National Institutes of Health · 2001 - 2004

A Placebo...Extract Hypericum Perforatum In Major Depressi

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Alzheimers Disease-- Antemortem Markers

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

External Relationships


  • AHEL Ltd
  • Alzheon
  • Cornell University
  • Evidation Health
  • Hakcnesack Medical Center
  • AHEL Ltd
  • Alzheon
  • Cornell University
  • Evidation Health
  • Hakcnesack Medical Center
  • Keel Digital
  • Live Love Laugh - non-profit organization devoted to improving mental health.
  • Lumos Labs
  • Lundbeck
  • MarvelBiome
  • Prospiral
  • Transposon Therapeutics
  • UMethod

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.