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Exercise fails to improve neurocognition in depressed middle-aged and older adults.

Publication ,  Journal Article
Hoffman, BM; Blumenthal, JA; Babyak, MA; Smith, PJ; Rogers, SD; Doraiswamy, PM; Sherwood, A
Published in: Med Sci Sports Exerc
July 2008

PURPOSE: Although cross-sectional studies have demonstrated an association between higher levels of aerobic fitness and improved neurocognitive function, there have been relatively few interventional studies investigating this relationship, and results have been inconsistent. We assessed the effects of aerobic exercise on neurocognitive function in a randomized controlled trial of patients with major depressive disorder (MDD). METHODS: Two-hundred and two sedentary men (n = 49) and women (n = 153), aged 40 yr and over and who met diagnostic criteria for MDD, were randomly assigned to the following: a) supervised exercise, b) home-based exercise, c) sertraline, or d) placebo pill. Before and after 4 months of treatment, participants completed measures of: Executive Function (Trail Making Test B-A difference score, Stroop Color-Word, Ruff 2 & 7 Test, Digit Symbol), Verbal Memory (Logical Memory, Verbal Paired Associates), and Verbal Fluency/Working Memory (Animal Naming, Controlled Oral Word Association Test, Digit Span). Multivariate analyses of covariance were performed to test the effects of treatment on posttreatment neuropsychological test scores, with baseline neuropsychological test scores, age, education, and change in depression scores entered as covariates. RESULTS: The performance of exercise participants was no better than participants receiving placebo across all neuropsychological tests. Exercise participants performed better than participants receiving sertraline on tests of executive function but not on tests of verbal memory or verbal fluency/working memory. CONCLUSIONS: We found little evidence to support the benefits of an aerobic exercise intervention on neurocognitive performance in patients with MDD.

Duke Scholars

Published In

Med Sci Sports Exerc

DOI

ISSN

0195-9131

Publication Date

July 2008

Volume

40

Issue

7

Start / End Page

1344 / 1352

Location

United States

Related Subject Headings

  • Sport Sciences
  • Sertraline
  • Sedentary Behavior
  • Psychometrics
  • Physical Fitness
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoffman, B. M., Blumenthal, J. A., Babyak, M. A., Smith, P. J., Rogers, S. D., Doraiswamy, P. M., & Sherwood, A. (2008). Exercise fails to improve neurocognition in depressed middle-aged and older adults. Med Sci Sports Exerc, 40(7), 1344–1352. https://doi.org/10.1249/MSS.0b013e31816b877c
Hoffman, Benson M., James A. Blumenthal, Michael A. Babyak, Patrick J. Smith, Sharon D. Rogers, P Murali Doraiswamy, and Andrew Sherwood. “Exercise fails to improve neurocognition in depressed middle-aged and older adults.Med Sci Sports Exerc 40, no. 7 (July 2008): 1344–52. https://doi.org/10.1249/MSS.0b013e31816b877c.
Hoffman BM, Blumenthal JA, Babyak MA, Smith PJ, Rogers SD, Doraiswamy PM, et al. Exercise fails to improve neurocognition in depressed middle-aged and older adults. Med Sci Sports Exerc. 2008 Jul;40(7):1344–52.
Hoffman, Benson M., et al. “Exercise fails to improve neurocognition in depressed middle-aged and older adults.Med Sci Sports Exerc, vol. 40, no. 7, July 2008, pp. 1344–52. Pubmed, doi:10.1249/MSS.0b013e31816b877c.
Hoffman BM, Blumenthal JA, Babyak MA, Smith PJ, Rogers SD, Doraiswamy PM, Sherwood A. Exercise fails to improve neurocognition in depressed middle-aged and older adults. Med Sci Sports Exerc. 2008 Jul;40(7):1344–1352.

Published In

Med Sci Sports Exerc

DOI

ISSN

0195-9131

Publication Date

July 2008

Volume

40

Issue

7

Start / End Page

1344 / 1352

Location

United States

Related Subject Headings

  • Sport Sciences
  • Sertraline
  • Sedentary Behavior
  • Psychometrics
  • Physical Fitness
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Humans
  • Female