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The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials.

Publication ,  Journal Article
Doraiswamy, PM; Bieber, F; Kaiser, L; Krishnan, KR; Reuning-Scherer, J; Gulanski, B
Published in: Neurology
June 1997

The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-Cog) is used as an efficacy measure in clinical drug trials of Alzheimer's disease (AD). We used data from 1,648 AD participants in two identical 26-week multicenter drug trials to examine the distribution of baseline ADAS-Cog scores in relation to selected demographic and clinical variables, Mini-Mental State Exam (MMSE), Global Deterioration Scale (GDS), and Geriatric Evaluation by Relative's Rating Instrument (GERRI) scores. At baseline, the mean (+/-SD) MMSE score was 18 +/- 4, the ADAS-Cog score was 28 +/- 11, and most subjects were in GDS stage 4 or 5. The ADAS-Cog score was statistically significantly correlated with MMSE (R = -0.76, p < 0.0001) and GERRI (R = 0.40, p < 0.0001) total scores. Correlations among the ADAS-Cog items ranged from 0.19 to 0.59 and all were statistically significant (p < 0.0001). In a multiple regression model, younger age, male gender, older age at onset of dementia, use of concurrent estrogen, and use of concurrent anti-inflammatory agents were statistically significantly associated with superior cognitive performance. We also present data on the distribution of ADAS-Cog scores in relation to subjects' age, level of education, MMSE score, and GDS stage. Because age, MMSE score, and GDS stage (and not the ADAS-Cog) are commonly used to select subjects for AD clinical trials, our data should improve the ability of sponsors to predict ADAS-Cog scores of the subjects in their trials on the basis of the inclusion criteria used. Our data also suggest that age, gender, age at onset of dementia, level of education, and use of estrogen (in women) or anti-inflammatory drugs are related to cognitive abilities in AD. Further studies are needed to assess how and when cognitive differences related to these variables arise.

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Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

June 1997

Volume

48

Issue

6

Start / End Page

1511 / 1517

Location

United States

Related Subject Headings

  • Psychomotor Performance
  • Predictive Value of Tests
  • Placebos
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Status Schedule
  • Male
  • Humans
  • Female
  • Estrogens
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Doraiswamy, P. M., Bieber, F., Kaiser, L., Krishnan, K. R., Reuning-Scherer, J., & Gulanski, B. (1997). The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology, 48(6), 1511–1517. https://doi.org/10.1212/wnl.48.6.1511
Doraiswamy, P. M., F. Bieber, L. Kaiser, K. R. Krishnan, J. Reuning-Scherer, and B. Gulanski. “The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials.Neurology 48, no. 6 (June 1997): 1511–17. https://doi.org/10.1212/wnl.48.6.1511.
Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, Reuning-Scherer J, Gulanski B. The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology. 1997 Jun;48(6):1511–7.
Doraiswamy, P. M., et al. “The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials.Neurology, vol. 48, no. 6, June 1997, pp. 1511–17. Pubmed, doi:10.1212/wnl.48.6.1511.
Doraiswamy PM, Bieber F, Kaiser L, Krishnan KR, Reuning-Scherer J, Gulanski B. The Alzheimer's Disease Assessment Scale: patterns and predictors of baseline cognitive performance in multicenter Alzheimer's disease trials. Neurology. 1997 Jun;48(6):1511–1517.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

June 1997

Volume

48

Issue

6

Start / End Page

1511 / 1517

Location

United States

Related Subject Headings

  • Psychomotor Performance
  • Predictive Value of Tests
  • Placebos
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Status Schedule
  • Male
  • Humans
  • Female
  • Estrogens