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Pre-exposure cognitive performance variability is associated with severity of respiratory infection.

Publication ,  Journal Article
Zhai, Y; Doraiswamy, PM; Woods, CW; Turner, RB; Burke, TW; Ginsburg, GS; Hero, AO
Published in: Sci Rep
December 30, 2022

Using data from a longitudinal viral challenge study, we find that the post-exposure viral shedding and symptom severity are associated with a novel measure of pre-exposure cognitive performance variability (CPV), defined before viral exposure occurs. Each individual's CPV score is computed from data collected from a repeated NeuroCognitive Performance Test (NCPT) over a 3 day pre-exposure period. Of the 18 NCPT measures reported by the tests, 6 contribute materially to the CPV score, prospectively differentiating the high from the low shedders. Among these 6 are the 4 clinical measures digSym-time, digSym-correct, trail-time, and reaction-time, commonly used for assessing cognitive executive functioning. CPV is found to be correlated with stress and also with several genes previously reported to be associated with cognitive development and dysfunction. A perturbation study over the number and timing of NCPT sessions indicates that as few as 5 sessions is sufficient to maintain high association between the CPV score and viral shedding, as long as the timing of these sessions is balanced over the three pre-exposure days. Our results suggest that variations in cognitive function are closely related to immunity and susceptibility to severe infection. Further studying these relationships may help us better understand the links between neurocognitive and neuroimmune systems which is timely in this COVID-19 pandemic era.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 30, 2022

Volume

12

Issue

1

Start / End Page

22589

Location

England

Related Subject Headings

  • Respiratory Tract Infections
  • Reaction Time
  • Pandemics
  • Humans
  • Cognition
  • COVID-19
 

Citation

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Zhai, Y., Doraiswamy, P. M., Woods, C. W., Turner, R. B., Burke, T. W., Ginsburg, G. S., & Hero, A. O. (2022). Pre-exposure cognitive performance variability is associated with severity of respiratory infection. Sci Rep, 12(1), 22589. https://doi.org/10.1038/s41598-022-26081-6
Zhai, Yaya, P Murali Doraiswamy, Christopher W. Woods, Ronald B. Turner, Thomas W. Burke, Geoffrey S. Ginsburg, and Alfred O. Hero. “Pre-exposure cognitive performance variability is associated with severity of respiratory infection.Sci Rep 12, no. 1 (December 30, 2022): 22589. https://doi.org/10.1038/s41598-022-26081-6.
Zhai Y, Doraiswamy PM, Woods CW, Turner RB, Burke TW, Ginsburg GS, et al. Pre-exposure cognitive performance variability is associated with severity of respiratory infection. Sci Rep. 2022 Dec 30;12(1):22589.
Zhai, Yaya, et al. “Pre-exposure cognitive performance variability is associated with severity of respiratory infection.Sci Rep, vol. 12, no. 1, Dec. 2022, p. 22589. Pubmed, doi:10.1038/s41598-022-26081-6.
Zhai Y, Doraiswamy PM, Woods CW, Turner RB, Burke TW, Ginsburg GS, Hero AO. Pre-exposure cognitive performance variability is associated with severity of respiratory infection. Sci Rep. 2022 Dec 30;12(1):22589.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

December 30, 2022

Volume

12

Issue

1

Start / End Page

22589

Location

England

Related Subject Headings

  • Respiratory Tract Infections
  • Reaction Time
  • Pandemics
  • Humans
  • Cognition
  • COVID-19