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Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.

Publication ,  Journal Article
Lora-Michiels, M; Yu, D; Sanders, L; Poulson, JM; Azuma, C; Case, B; Vujaskovic, Z; Thrall, DE; Charles, HC; Dewhirst, MW
Published in: Clin Cancer Res
October 1, 2006

PURPOSE: The objective was to test whether tumor pH and (31)P magnetic resonance spectroscopic end points were related to treatment outcome in pet canine patients with spontaneous soft tissue sarcomas treated with thermoradiotherapy. EXPERIMENTAL DESIGN: Forty-two dogs with evaluable (31)P magnetic resonance spectroscopic end points and pH data were included in this study. Tumor variables (grade and volume), extracellular pH (pHe), T(2) relaxation times, intracellular pH, and selected phosphometabolite ratios were examined for correlation with clinical outcome. RESULTS: From 39 dogs, pHe was a predictor of metastasis-free survival (MFS), with hazard ratio (HR, 0.29; P = 0.005) and overall survival (OS) with (HR, 0.36; P = 0.013). Tumor volume (>19 cm(3)) was related to MFS (HR, 2.14; P = 0.04), time to local failure (HR, 3.4; P = 0.025), and OS (HR, 2.27; P = 0.03). There was no association between T(2) or intracellular pH and clinical outcome. Tumor grade (high versus low/intermediate) and phosphodiester/betaATP ratio were identified as significant predictors for MFS, with (HR, 2.66; P = 0.009) and (HR, 0.75; P = 0.027), respectively, and as predictors of OS with (HR, 2.66; P = 0.009) and (HR, 0.76; P = 0.03), respectively. The phosphodiester/phosphocreatinine ratio predicted time to local failure (HR, 1.24; P = 0.017). CONCLUSIONS: pHe was predictive of metastasis and OS in canine spontaneous sarcomas. To our knowledge, this is the first time that pHe has been shown to be predictive of clinical outcome. The results suggest that additional studies should be considered evaluating the prognostic significance of this variable. Phospholipid resonances, related to membrane metabolism, were related to clinical outcome, confirming recent results reported in human patients with soft tissue sarcomas treated with thermoradiotherapy.

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Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

October 1, 2006

Volume

12

Issue

19

Start / End Page

5733 / 5740

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Soft Tissue Neoplasms
  • Sarcoma
  • Radiotherapy Dosage
  • Prospective Studies
  • Phosphorus Isotopes
  • Oncology & Carcinogenesis
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging
 

Citation

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Lora-Michiels, M., Yu, D., Sanders, L., Poulson, J. M., Azuma, C., Case, B., … Dewhirst, M. W. (2006). Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clin Cancer Res, 12(19), 5733–5740. https://doi.org/10.1158/1078-0432.CCR-05-2669
Lora-Michiels, Michaël, Daohai Yu, Linda Sanders, Jean M. Poulson, Chieko Azuma, Beth Case, Zeljko Vujaskovic, Donald E. Thrall, H Cecil Charles, and Mark W. Dewhirst. “Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.Clin Cancer Res 12, no. 19 (October 1, 2006): 5733–40. https://doi.org/10.1158/1078-0432.CCR-05-2669.
Lora-Michiels M, Yu D, Sanders L, Poulson JM, Azuma C, Case B, et al. Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clin Cancer Res. 2006 Oct 1;12(19):5733–40.
Lora-Michiels, Michaël, et al. “Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.Clin Cancer Res, vol. 12, no. 19, Oct. 2006, pp. 5733–40. Pubmed, doi:10.1158/1078-0432.CCR-05-2669.
Lora-Michiels M, Yu D, Sanders L, Poulson JM, Azuma C, Case B, Vujaskovic Z, Thrall DE, Charles HC, Dewhirst MW. Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clin Cancer Res. 2006 Oct 1;12(19):5733–5740.

Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

October 1, 2006

Volume

12

Issue

19

Start / End Page

5733 / 5740

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Soft Tissue Neoplasms
  • Sarcoma
  • Radiotherapy Dosage
  • Prospective Studies
  • Phosphorus Isotopes
  • Oncology & Carcinogenesis
  • Male
  • Magnetic Resonance Spectroscopy
  • Magnetic Resonance Imaging