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Electroretinographic findings in sickle cell retinopathy.

Publication ,  Journal Article
Peachey, NS; Charles, HC; Lee, CM; Fishman, GA; Cunha-Vaz, JG; Smith, RT
Published in: Arch Ophthalmol
July 1987

We obtained electroretinograms (ERGs) from normal subjects and from patients with sickle cell disease. The ERG components (a-wave, b-wave, and oscillatory potentials) obtained from normal subjects and patients without peripheral retinal neovascularization did not differ in either amplitude or implicit time. However, ERG components obtained from patients with peripheral retinal neovascularization were reduced in amplitude compared with those obtained from normal subjects or patients without neovascularization. The reduced a-wave, b-wave, and oscillatory potential amplitudes may have been due to photoreceptor dysfunction secondary to choroidal ischemia or possibly increased oxygen demands by the inner retina. Ischemia of the inner retina may also have contributed to the altered b-wave and oscillatory potentials. These results suggest that ERG provides a means of assessing the consequence of peripheral retinal ischemia to retinal cell function and could be of value in monitoring patients with sickle cell disease for the development of clinically significant peripheral retinal neovascularization.

Duke Scholars

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

July 1987

Volume

105

Issue

7

Start / End Page

934 / 938

Location

United States

Related Subject Headings

  • Retinal Diseases
  • Retina
  • Ophthalmology & Optometry
  • Neovascularization, Pathologic
  • Humans
  • Fluorescein Angiography
  • Electroretinography
  • Anemia, Sickle Cell
  • 1113 Opthalmology and Optometry
 

Citation

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Peachey, N. S., Charles, H. C., Lee, C. M., Fishman, G. A., Cunha-Vaz, J. G., & Smith, R. T. (1987). Electroretinographic findings in sickle cell retinopathy. Arch Ophthalmol, 105(7), 934–938. https://doi.org/10.1001/archopht.1987.01060070070031
Peachey, N. S., H. C. Charles, C. M. Lee, G. A. Fishman, J. G. Cunha-Vaz, and R. T. Smith. “Electroretinographic findings in sickle cell retinopathy.Arch Ophthalmol 105, no. 7 (July 1987): 934–38. https://doi.org/10.1001/archopht.1987.01060070070031.
Peachey NS, Charles HC, Lee CM, Fishman GA, Cunha-Vaz JG, Smith RT. Electroretinographic findings in sickle cell retinopathy. Arch Ophthalmol. 1987 Jul;105(7):934–8.
Peachey, N. S., et al. “Electroretinographic findings in sickle cell retinopathy.Arch Ophthalmol, vol. 105, no. 7, July 1987, pp. 934–38. Pubmed, doi:10.1001/archopht.1987.01060070070031.
Peachey NS, Charles HC, Lee CM, Fishman GA, Cunha-Vaz JG, Smith RT. Electroretinographic findings in sickle cell retinopathy. Arch Ophthalmol. 1987 Jul;105(7):934–938.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

July 1987

Volume

105

Issue

7

Start / End Page

934 / 938

Location

United States

Related Subject Headings

  • Retinal Diseases
  • Retina
  • Ophthalmology & Optometry
  • Neovascularization, Pathologic
  • Humans
  • Fluorescein Angiography
  • Electroretinography
  • Anemia, Sickle Cell
  • 1113 Opthalmology and Optometry