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Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.

Publication ,  Journal Article
Wu, B; Lyu, YB; Cao, ZJ; Wei, Y; Shi, WY; Gao, X; Zhou, JH; Kraus, VB; Zhao, F; Chen, X; Lu, F; Zhang, MY; Liu, YC; Tan, QY; Song, SX ...
Published in: Biomed Environ Sci
November 20, 2021

OBJECTIVE: To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults. METHODS: Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment. RESULTS: The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio ( OR) for cognitive impairment in individuals with sarcopenia was 2.55 [95% confidence interval (95% CI): 1.86-3.50]. Compared with individuals in the first quartile (Q 1) of calf circumference, the adjusted ORs in the second, third, and fourth quartiles (Q 2, Q 3, and Q 4) were 0.75 (95% CI: 0.58-0.96), 0.59 (95% CI: 0.44-0.79), and 0.62 (95% CI: 0.45-0.8), respectively. Compared with individuals in Q 1 of handgrip strength, the adjusted ORs for Q 2, Q 3, and Q 4 were 0.49 (95% CI: 0.38-0.62), 0.31 (95% CI: 0.23-0.41), and 0.30 (95% CI: 0.21-0.44), respectively. CONCLUSION: Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.

Duke Scholars

Published In

Biomed Environ Sci

DOI

EISSN

2214-0190

Publication Date

November 20, 2021

Volume

34

Issue

11

Start / End Page

859 / 870

Location

China

Related Subject Headings

  • Toxicology
  • Sarcopenia
  • Male
  • Logistic Models
  • Leg
  • Humans
  • Hand Strength
  • Female
  • Cognitive Dysfunction
  • China
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, B., Lyu, Y. B., Cao, Z. J., Wei, Y., Shi, W. Y., Gao, X., … Shi, X. M. (2021). Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults. Biomed Environ Sci, 34(11), 859–870. https://doi.org/10.3967/bes2021.119
Wu, Bing, Yue Bin Lyu, Zhao Jin Cao, Yuan Wei, Wan Ying Shi, Xiang Gao, Jin Hui Zhou, et al. “Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.Biomed Environ Sci 34, no. 11 (November 20, 2021): 859–70. https://doi.org/10.3967/bes2021.119.
Wu B, Lyu YB, Cao ZJ, Wei Y, Shi WY, Gao X, et al. Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults. Biomed Environ Sci. 2021 Nov 20;34(11):859–70.
Wu, Bing, et al. “Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.Biomed Environ Sci, vol. 34, no. 11, Nov. 2021, pp. 859–70. Pubmed, doi:10.3967/bes2021.119.
Wu B, Lyu YB, Cao ZJ, Wei Y, Shi WY, Gao X, Zhou JH, Kraus VB, Zhao F, Chen X, Lu F, Zhang MY, Liu YC, Tan QY, Song SX, Qu YL, Zheng XL, Shen C, Mao C, Shi XM. Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults. Biomed Environ Sci. 2021 Nov 20;34(11):859–870.

Published In

Biomed Environ Sci

DOI

EISSN

2214-0190

Publication Date

November 20, 2021

Volume

34

Issue

11

Start / End Page

859 / 870

Location

China

Related Subject Headings

  • Toxicology
  • Sarcopenia
  • Male
  • Logistic Models
  • Leg
  • Humans
  • Hand Strength
  • Female
  • Cognitive Dysfunction
  • China