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An osteoarthritis pathophysiological continuum revealed by molecular biomarkers.

Publication ,  Journal Article
Kraus, VB; Sun, S; Reed, A; Soderblom, EJ; Moseley, MA; Zhou, K; Jain, V; Arden, N; Li, Y-J
Published in: Sci Adv
April 26, 2024

We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding to six proteins, reached AUC 77% probability to distinguish those who developed OA from age-matched individuals who did not develop OA up to 8 years later. Prediction based on these blood biomarkers was superior to traditional prediction based on age and BMI (AUC 51%) or knee pain (AUC 57%). These results identify a prolonged molecular derangement of joint tissue before the onset of radiographic OA abnormalities consistent with an unresolved acute phase response. Among all 24 protein biomarkers predicting incident knee OA, the majority (58%) also predicted knee OA progression, revealing the existence of a pathophysiological "OA continuum" based on considerable similarity in the molecular pathophysiology of the progression to incident OA and the progression of established OA.

Duke Scholars

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Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

April 26, 2024

Volume

10

Issue

17

Start / End Page

eadj6814

Location

United States

Related Subject Headings

  • Osteoarthritis, Knee
  • Middle Aged
  • Humans
  • Female
  • Disease Progression
  • Biomarkers
  • Aged
 

Citation

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Kraus, V. B., Sun, S., Reed, A., Soderblom, E. J., Moseley, M. A., Zhou, K., … Li, Y.-J. (2024). An osteoarthritis pathophysiological continuum revealed by molecular biomarkers. Sci Adv, 10(17), eadj6814. https://doi.org/10.1126/sciadv.adj6814
Kraus, Virginia Byers, Shuming Sun, Alexander Reed, Erik J. Soderblom, M Arthur Moseley, Kaile Zhou, Vaibhav Jain, Nigel Arden, and Yi-Ju Li. “An osteoarthritis pathophysiological continuum revealed by molecular biomarkers.Sci Adv 10, no. 17 (April 26, 2024): eadj6814. https://doi.org/10.1126/sciadv.adj6814.
Kraus VB, Sun S, Reed A, Soderblom EJ, Moseley MA, Zhou K, et al. An osteoarthritis pathophysiological continuum revealed by molecular biomarkers. Sci Adv. 2024 Apr 26;10(17):eadj6814.
Kraus, Virginia Byers, et al. “An osteoarthritis pathophysiological continuum revealed by molecular biomarkers.Sci Adv, vol. 10, no. 17, Apr. 2024, p. eadj6814. Pubmed, doi:10.1126/sciadv.adj6814.
Kraus VB, Sun S, Reed A, Soderblom EJ, Moseley MA, Zhou K, Jain V, Arden N, Li Y-J. An osteoarthritis pathophysiological continuum revealed by molecular biomarkers. Sci Adv. 2024 Apr 26;10(17):eadj6814.

Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

April 26, 2024

Volume

10

Issue

17

Start / End Page

eadj6814

Location

United States

Related Subject Headings

  • Osteoarthritis, Knee
  • Middle Aged
  • Humans
  • Female
  • Disease Progression
  • Biomarkers
  • Aged