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Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.

Publication ,  Journal Article
Goode, AP; Cleveland, RJ; George, SZ; Schwartz, TA; Kraus, VB; Renner, JB; Gracely, RH; DeFrate, LE; Hu, D; Jordan, JM; Golightly, YM
Published in: Arthritis care & research
October 2022

To determine the incidence and worsening of lumbar spine structure and low back pain (LBP) and whether they are predicted by demographic characteristics or clinical characteristics or appendicular joint osteoarthritis (OA).Paired baseline (2003-2004) and follow-up (2006-2010) lumbar spine radiographs from the Johnston County Osteoarthritis Project were graded for osteophytes (OST), disc space narrowing (DSN), spondylolisthesis, and presence of facet joint OA (FOA). Spine OA was defined as at least mild OST and mild DSN at the same level for any level of the lumbar spine. LBP, comorbidities, and back injury were self-reported. Weibull models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of spine phenotypes accounting for potential predictors including demographic characteristics, clinical characteristics, comorbidities, obesity, and appendicular OA.Obesity was a consistent and strong predictor of incidence of DSN (HR 1.80 [95% CI 1.09-2.98]), spine OA (HR 1.56 [95% CI 1.01-2.41]), FOA (HR 4.99 [95% CI 1.46-17.10]), spondylolisthesis (HR 1.87 [95% CI 1.02-3.43]), and LBP (HR 1.75 [95% CI 1.19-2.56]), and worsening of DSN (HR 1.51 [95% CI 1.09-2.09]) and LBP (HR 1.51 [95% CI 1.12-2.06]). Knee OA was a predictor of incident FOA (HR 4.18 [95% CI 1.44-12.2]). Spine OA (HR 1.80 [95% CI 1.24-2.63]) and OST (HR 1.85 [95% CI 1.02-3.36]) were predictors of incidence of LBP. Hip OA (HR 1.39 [95% CI 1.04-1.85]) and OST (HR 1.58 [95% CI 1.00-2.49]) were predictors of LBP worsening.Among the multiple predictors of spine phenotypes, obesity was a common predictor for both incidence and worsening of lumbar spine degeneration and LBP.

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Published In

Arthritis care & research

DOI

EISSN

2151-4658

ISSN

2151-464X

Publication Date

October 2022

Volume

74

Issue

10

Start / End Page

1659 / 1666

Related Subject Headings

  • Spondylolisthesis
  • Osteophyte
  • Osteoarthritis, Spine
  • Osteoarthritis, Hip
  • Obesity
  • Lumbar Vertebrae
  • Low Back Pain
  • Humans
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences
 

Citation

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Goode, A. P., Cleveland, R. J., George, S. Z., Schwartz, T. A., Kraus, V. B., Renner, J. B., … Golightly, Y. M. (2022). Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project. Arthritis Care & Research, 74(10), 1659–1666. https://doi.org/10.1002/acr.24643
Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Jordan B. Renner, Richard H. Gracely, et al. “Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.Arthritis Care & Research 74, no. 10 (October 2022): 1659–66. https://doi.org/10.1002/acr.24643.
Goode AP, Cleveland RJ, George SZ, Schwartz TA, Kraus VB, Renner JB, et al. Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project. Arthritis care & research. 2022 Oct;74(10):1659–66.
Goode, Adam P., et al. “Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.Arthritis Care & Research, vol. 74, no. 10, Oct. 2022, pp. 1659–66. Epmc, doi:10.1002/acr.24643.
Goode AP, Cleveland RJ, George SZ, Schwartz TA, Kraus VB, Renner JB, Gracely RH, DeFrate LE, Hu D, Jordan JM, Golightly YM. Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project. Arthritis care & research. 2022 Oct;74(10):1659–1666.
Journal cover image

Published In

Arthritis care & research

DOI

EISSN

2151-4658

ISSN

2151-464X

Publication Date

October 2022

Volume

74

Issue

10

Start / End Page

1659 / 1666

Related Subject Headings

  • Spondylolisthesis
  • Osteophyte
  • Osteoarthritis, Spine
  • Osteoarthritis, Hip
  • Obesity
  • Lumbar Vertebrae
  • Low Back Pain
  • Humans
  • 4201 Allied health and rehabilitation science
  • 3202 Clinical sciences