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Louis Edwin DeFrate

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
Orthopaedic Surgery
MSRB Room 379, Box 3093 DUMC, Durham, NC 27710
Room 379, Medical Sciences Research Building, Box 3093 Med. Ctr., Durham, NC 27710

Current Duke Appointments & Affiliations


Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery · 2023 - Present Orthopaedic Surgery, Clinical Science Departments
Professor in Orthopaedic Surgery · 2019 - Present Orthopaedic Surgery, Clinical Science Departments
Professor of Biomedical Engineering · 2020 - Present Biomedical Engineering, Pratt School of Engineering
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments
Professor in the Department of Mechanical Engineering & Materials Science · 2025 - Present Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering

Recent News Items


Published October 14, 2024
The Science Behind ACL: Why Women are Prone to a Debilitating Knee Injury
Published May 4, 2023
Duke Awards 44 Distinguished Professorships
Published April 18, 2018
US News and World Report
His and Her Knee Injuries Occur the Same Way

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Recent Scholarly Works


The influence of walking speed on the mechanoresponsiveness of biomarkers.

Journal article Connect Tissue Res · September 2026 PURPOSE: The goal of this study was to examine short-term biomarker responses to walking at three different speeds in healthy individuals. METHODS: Healthy participants completed three study visits. At each visit, participants rested supine for 45 minutes, ... Full text Link to item Cite

The application of transfer learning to T1ρ MRI tibiofemoral cartilage segmentation.

Journal article J Biomech · January 2026 Proteoglycans are critical to the ability of cartilage to withstand loading, and their concentration can be probed in vivo through measurement of T1ρ MRI relaxation times. Machine learning models have demonstrated the potential to replace manual segmentati ... Full text Link to item Cite

A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.

Journal article J Biomech · November 2025 While knee osteoarthritis (OA) is a leading cause of disability in the United States, OA within the patellofemoral joint is understudied compared to the tibiofemoral joint. Mechanical alterations to cartilage may be among the first changes indicative of ea ... Full text Link to item Cite
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Recent Grants


Mechanical Biomarkers of Chronic Low Back Pain

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2026 - 2031

Obesity, cartilage mechanics, and joint health

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031

In vivo ACL mechanics and risk factors for injury

ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2024 - 2030

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Education


Massachusetts Institute of Technology · 2005 Sc.D.