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High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment.

Publication ,  Journal Article
Kraus, VB; Worrell, TW; Renner, JB; Coleman, RE; Pieper, CF
Published in: Osteoarthritis Cartilage
November 2013

OBJECTIVE: To evaluate ankle joint abnormalities in a knee osteoarthritis (OA) cohort. METHODS: Participants (n = 159) with symptomatic and radiographic OA in at least one knee underwent technetium-99m methylene diphosphonate bone scan (scored 0-3) of the ankles and forefeet. Knee radiographs were graded for OA features of joint space narrowing (JSN) and osteophyte (OST). Ankle symptoms and history of ankle injury were assessed by self-report. Knee alignment was measured from a long-limb radiograph. Ankle radiographs were obtained on those who returned for follow-up (n = 138) and were graded for ankle tibiotalar JSN and OST. DESIGN: Ankle scintigraphic abnormalities were frequent (31% of individuals, one-third bilateral). Ankle symptoms were reported by 23% of individuals and history of ankle injury by 24%. Controlling for gender, age, body mass index (BMI), and contralateral predictor, ankle scintigraphic abnormalities were associated with: ipsilateral ankle symptoms (P = 0.005); contralateral knee JSN (P = 0.001), knee OST (P = 0.006) and knee malalignment (P = 0.08); and history of ankle injury or surgery of either ankle (P < 0.0001). At follow-up, scintigraphic abnormalities of the ankle were strongly associated with presence of tibiotalar radiographic OA (P < 0.0001). CONCLUSIONS: Although considered rare, we observed a high prevalence of radiographic features of ankle OA in this knee OA cohort. History of overt ankle injury did not appear to account for the majority of ankle abnormalities. These results are consistent with a probable kinematic association of knee OA pathology and contralateral ankle abnormalities and suggest that interventions targeting mechanical factors may be needed to prevent ankle OA in the setting of knee OA.

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Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

November 2013

Volume

21

Issue

11

Start / End Page

1693 / 1699

Location

England

Related Subject Headings

  • Risk Factors
  • Radionuclide Imaging
  • Radiography
  • Osteoarthritis, Knee
  • Osteoarthritis
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Kraus, V. B., Worrell, T. W., Renner, J. B., Coleman, R. E., & Pieper, C. F. (2013). High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment. Osteoarthritis Cartilage, 21(11), 1693–1699. https://doi.org/10.1016/j.joca.2013.07.008
Kraus, V. B., T. W. Worrell, J. B. Renner, R. E. Coleman, and C. F. Pieper. “High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment.Osteoarthritis Cartilage 21, no. 11 (November 2013): 1693–99. https://doi.org/10.1016/j.joca.2013.07.008.
Kraus VB, Worrell TW, Renner JB, Coleman RE, Pieper CF. High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment. Osteoarthritis Cartilage. 2013 Nov;21(11):1693–9.
Kraus, V. B., et al. “High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment.Osteoarthritis Cartilage, vol. 21, no. 11, Nov. 2013, pp. 1693–99. Pubmed, doi:10.1016/j.joca.2013.07.008.
Kraus VB, Worrell TW, Renner JB, Coleman RE, Pieper CF. High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment. Osteoarthritis Cartilage. 2013 Nov;21(11):1693–1699.
Journal cover image

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

November 2013

Volume

21

Issue

11

Start / End Page

1693 / 1699

Location

England

Related Subject Headings

  • Risk Factors
  • Radionuclide Imaging
  • Radiography
  • Osteoarthritis, Knee
  • Osteoarthritis
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female