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Carl F. Pieper

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 3003, Durham, NC 27710
1513 Busse Bldg, Durham, NC 27710

Overview


Analytic Interests.

1) Issues in the Design of Medical Experiments: I explore the use of reliability/generalizability models in experimental design. In addition to incorporation of reliability, I study powering longitudinal trials with multiple outcomes and substantial missing data using Mixed models.

2) Issues in the Analysis of Repeated Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed Models in modeling trajectories of multiple variables over time (e.g., physical and cognitive functioning and Blood Pressure). My current work involves methodologies in simultaneous estimation of trajectories for multiple variables within and between domains, modeling co-occuring change.

Areas of Substantive interest: (1) Experimental design and analysis in gerontology and geriatrics, and psychiatry,
(2) Multivariate repeated measures designs,

Current Appointments & Affiliations


Professor of Biostatistics & Bioinformatics · 2022 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics

In the News


Published January 8, 2024
Study of Duke Heart Attack Patients Finds Definitive Benefit of Cardiac Rehab
Published September 7, 2023
Concussions May Cause Cognitive Declines Later in Life

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Recent Publications


Association of multimorbidity trajectories from early adulthood through middle age with middle-age physical function.

Journal Article J Gerontol A Biol Sci Med Sci · June 28, 2025 BACKGROUND: Chronic conditions can develop early in the adult life course and accumulate at different rates. However, the association between multimorbidity trajectory groups from young adulthood and physical function in midlife has not been well studied. ... Full text Link to item Cite

Plasma Insulin-like Growth Factor-Binding Protein-7 Is Positively Associated with Age, Obesity, Mortality, and Cancer in Postmenopausal Women.

Journal Article Cancer Epidemiol Biomarkers Prev · June 3, 2025 BACKGROUND: Predictors of premature death and cancer development are needed to more precisely identify individuals who may warrant preventive intervention. Circulating insulin-like growth factor (IGF)-binding protein-7 (IGFBP7) and, to a lesser extent, the ... Full text Link to item Cite

Association of Coprescribing of Gabapentinoid and Other Psychoactive Medications With Altered Mental Status and Falls in Adults Receiving Dialysis.

Journal Article Am J Kidney Dis · February 2025 RATIONALE & OBJECTIVE: Prescribing psychoactive medications for patients with kidney disease is common, but for patients receiving dialysis some medications may be inappropriate. We evaluated the association of coprescribing gabapentinoids and other psycho ... Full text Link to item Cite
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Recent Grants


Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging

ResearchCo Investigator · Awarded by Tufts Medical Center · 2022 - 2026

Influence of Vision Impairments on Dementia in Stroke Survivors: A Longitudinal Analysis

ResearchAdvisor · Awarded by National Institutes of Health · 2023 - 2026

Assessing the feasibility and acceptability of a Time Restricted Feeding intervention among older adults with Mild Cognitive Impairment

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2026

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Education, Training & Certifications


Columbia University · 1990 DrPH