Scholars@Duke
Carl F. Pieper

Carl F. Pieper

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
carl.pieper@duke.edu
Duke Box 3003, Durham, NC 27710
1513 Busse Bldg, Durham, NC 27710

Selected Publications

Effect of donepezil on bone metabolism among older adults with Alzheimer's disease.

Journal Article Contemp Clin Trials · November 19, 2024 Older adults with Alzheimer's disease (AD), in addition to significant cognitive disability, have twice the risk of fracture compared to those with normal cognition. Fractures among older adults with AD are associated with substantial morbidity, loss of ph ... Full text Link to item Cite

Association of Coprescribing of Gabapentinoid and Other Psychoactive Medications With Altered Mental Status and Falls in Adults Receiving Dialysis.

Journal Article Am J Kidney Dis · October 3, 2024 RATIONALE & OBJECTIVE: Prescribing psychoactive medications for patients with kidney disease is common, but for patients receiving dialysis some medications may be inappropriate. We evaluated the association of coprescribing gabapentinoids and other psycho ... Full text Link to item Cite

Central nervous system medication use around hospitalization.

Journal Article J Am Geriatr Soc · June 2024 BACKGROUND: Central nervous system (CNS) medication use is common among older adults, yet the impact of hospitalizations on use remains unclear. This study details CNS medication use, discontinuations, and user profiles during hospitalization periods. METH ... Full text Link to item Cite

Grief Training in Palliative Care Fellowships.

Journal Article J Pain Symptom Manage · April 2024 INTRODUCTION: No prior study has assessed grief and bereavement curriculum in Hospice and Palliative Medicine (HPM) fellowship programs in the United States. METHODS: A 14-item survey was created and distributed to Accreditation Council for Graduate Medica ... Full text Link to item Cite

A Detailed Analysis of Cardiac Rehabilitation on 180-Day All-Cause Hospital Readmission and Mortality.

Journal Article J Cardiopulm Rehabil Prev · March 1, 2024 PURPOSE: Cardiac rehabilitation (CR) is endorsed for coronary artery disease (CAD), but studies report inconsistent findings regarding efficacy. The objective of this study was to determine whether confounding factors, potentially contributing to these het ... Full text Link to item Cite

Effect of Remotely Supervised Weight Loss and Exercise Training Versus Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial.

Journal Article ACR Open Rheumatol · March 2024 OBJECTIVE: To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, disease activity, and patient-reported outcomes in older patients with rheumatoid arthritis (RA) and overw ... Full text Link to item Cite

A Pragmatic Clinical Trial of Hearing Screening in Primary Care Clinics: Effect of Setting and Provider Encouragement.

Journal Article Ear Hear · January 2024 OBJECTIVES: The prevalence of hearing loss increases with age. Untreated hearing loss is associated with poorer communication abilities and negative health consequences, such as increased risk of dementia, increased odds of falling, and depression. Nonethe ... Full text Link to item Cite

Association of prior treatment with nitrogen-containing bisphosphonates on outcomes of COVID-19 positive patients.

Journal Article Osteoporos Int · January 2024 UNLABELLED: COVID-19 infection has resulted in significant morbidity and mortality globally, especially among older adults. Repurposed drugs have demonstrated activity in respiratory illnesses, including nitrogen-containing bisphosphonates. In this retrosp ... Full text Link to item Cite

Multimorbidity trajectories in early adulthood and middle age: Findings from the CARDIA prospective cohort study.

Journal Article J Multimorb Comorb · 2024 BACKGROUND: Multimorbidity research has focused on the prevalence and consequences of multimorbidity in older populations. Less is known about the accumulation of chronic conditions earlier in the life course. METHODS: We identified patterns of longitudina ... Full text Link to item Cite

Self-Reported Dysphagia and Psychosocial Health Among Community-Dwelling Older Adults: Results of a National Study.

Journal Article J Gen Intern Med · November 2023 BACKGROUND: The risk of dysphagia increases with age, affecting up to 33% of adults over the age of 65. Older adults with dysphagia are at increased risk for negative physical health outcomes such as aspiration pneumonia and death. However, the relationshi ... Full text Link to item Cite

Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study.

Journal Article Neurology · October 31, 2023 BACKGROUND AND OBJECTIVES: Traumatic brain injuries (TBIs) are associated with increased risk of dementia, but whether lifetime TBI influences cognitive trajectories in later life is less clear. Cognitive interventions after TBI may improve cognitive traje ... Full text Link to item Cite

Factors Associated with COVID-19 Vaccination Promptness after Eligibility in a North Carolina Longitudinal Cohort Study.

Journal Article Vaccines (Basel) · October 26, 2023 Many studies identified factors associated with vaccination intention and hesitancy, but factors associated with vaccination promptness and the effect of vaccination intention on vaccination promptness are unknown. This study identified factors associated ... Full text Open Access Link to item Cite

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound.

Journal Article J Appl Gerontol · September 2023 Objective: Our aim was to evaluate relationships between swallowing difficulty (dysphagia) and social determinants of health (SDOH) in older adults ≥65 years. Method: Cross-sectional analyses were performed in community-dwelling Medicare beneficiaries from ... Full text Link to item Cite

Demographically-adjusted normative data among Latinos for the version 3 of the Alzheimer's Disease Centers' Neuropsychological Test Battery in the Uniform Data Set.

Journal Article Alzheimers Dement · September 2023 INTRODUCTION: We developed demographically-adjusted normative data for Spanish- and English-speaking Latinos on the Version 3.0 of the National Alzheimer's Coordinating Center Uniform Data Set Neuropsychological Battery (UDS3-NB). METHODS: Healthy Latino a ... Full text Link to item Cite

A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium.

Journal Article Appl Neuropsychol Adult · August 12, 2023 The present prospective randomized study was designed to investigate whether the development of Post Operative Cognitive Decline (POCD) is related to anesthesia type in older adults. All patients were screened for delirium and mental status, received basel ... Full text Link to item Cite

Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case-control study.

Journal Article Osteoporos Int · July 2023 UNLABELLED: Older adults with type 2 diabetes mellitus have an increased risk of fracture despite a paradoxically higher average bone mineral density. This study identified additional markers of fracture risk in this at-risk population. Non-esterified fatt ... Full text Open Access Link to item Cite

Exploration of model misspecification in latent class methods for longitudinal data: Correlation structure matters.

Journal Article Statistics in medicine · June 2023 Modeling longitudinal trajectories and identifying latent classes of trajectories is of great interest in biomedical research, and software to identify latent classes of such is readily available for latent class trajectory analysis (LCTA), growth mixture ... Full text Cite

Use of Quantile Treatment Effects Analysis to Describe Antidepressant Response in Randomized Clinical Trials Submitted to the US Food and Drug Administration: A Secondary Analysis of Pooled Trial Data.

Journal Article JAMA Netw Open · June 1, 2023 IMPORTANCE: Major depressive disorder (MDD) is a leading cause of global distress and disability. Earlier studies have indicated that antidepressant therapy confers a modest reduction in depressive symptoms on average, but the distribution of this reductio ... Full text Open Access Link to item Cite

Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training-Rheumatoid Arthritis Trial.

Journal Article ACR Open Rheumatol · May 2023 Patients with rheumatoid arthritis (RA) remain at an increased risk for cardiovascular disease (CVD) and mortality. RA CVD results from a combination of traditional risk factors and RA-related systemic inflammation. One hypothetical means of improving over ... Full text Open Access Link to item Cite

A Novel Movement-Evoked Pain Provocation Test for Older Adults With Persistent Low Back Pain: Safety, Feasibility, and Associations With Self-reported Physical Function and Usual Gait Speed.

Journal Article Clin J Pain · April 1, 2023 OBJECTIVES: Low back pain (LBP) is highly prevalent and disabling for older adults. Movement-evoked pain is an emerging measure that may help to predict disability; but is not currently a part of geriatric LBP clinical care. This study tested the safety an ... Full text Link to item Cite

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Journal Article Nat Aging · March 2023 The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1-3. Caloric restriction (CR), defined as lessening caloric intake without ... Full text Link to item Cite

Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.

Journal Article Circulation · January 10, 2023 BACKGROUND: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examinin ... Full text Link to item Cite

Effects of high-intensity interval training on health-related quality of life in chronic lymphocytic leukemia: A pilot study.

Journal Article J Geriatr Oncol · January 2023 INTRODUCTION: Chronic lymphocytic leukemia (CLL) is the most common incurable leukemia/lymphoma in the United States. Individuals with CLL are at risk for disability, frailty, and cancer-specific complications that negatively affect health-related quality ... Full text Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

Mitigation behavior prior to COVID-19 vaccination availability is associated with COVID-19 infection and time to vaccination.

Journal Article PLoS One · 2023 BACKGROUND: Mitigation behaviors reduce the incidence of COVID-19 infection. Determining characteristics of groups defined by mitigation behaviors compliance may be useful to inform targeted public health policies and interventions. This study aimed to ide ... Full text Open Access Link to item Cite

COVID-19 Infection Risk Among Previously Uninfected Adults: Development of a Prognostic Model.

Journal Article Health Serv Res Manag Epidemiol · 2023 BACKGROUND: Few models exist that incorporate measures from an array of individual characteristics to predict the risk of COVID-19 infection in the general population. The aim was to develop a prognostic model for COVID-19 using readily obtainable clinical ... Full text Open Access Link to item Cite

Nightshift imposes irregular lifestyle behaviors in police academy trainees.

Journal Article Sleep Adv · 2023 STUDY OBJECTIVE: Shiftwork increases risk for numerous chronic diseases, which is hypothesized to be linked to disruption of circadian timing of lifestyle behaviors. However, empirical data on timing of lifestyle behaviors in real-world shift workers are l ... Full text Open Access Link to item Cite

Clinical readiness for essential maternal and child health services in Kenya: A cross-sectional survey.

Journal Article PLOS Glob Public Health · 2023 High rates of maternal and neonatal morbidity and mortality in Kenya may be influenced by provider training and knowledge in emergency obstetric and neonatal care in addition to availability of supplies necessary for this care. While post-abortion care is ... Full text Link to item Cite

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.

Journal Article J Gerontol A Biol Sci Med Sci · December 29, 2022 Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes in animal models. In the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIETM ... Full text Link to item Cite

Identification of Trajectory-Based Acute Kidney Injury Phenotypes Among Cardiac Surgery Patients.

Journal Article Ann Thorac Surg · December 2022 BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of cardiac surgical procedures for which unrecognized heterogeneity may underpin poor success in identifying effective therapies. We aimed to identify phenotypically similar groups ... Full text Link to item Cite

Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.

Journal Article Alzheimers Dement · November 2022 INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-Nat ... Full text Link to item Cite

Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults.

Journal Article EBioMedicine · November 2022 BACKGROUND: The hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data. METHODS: Using a framework that combines loc ... Full text Link to item Cite

Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy.

Journal Article Am J Perinatol · October 2022 OBJECTIVE: This study compares the number of units of red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated with or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and ... Full text Link to item Cite

Data from: Clinical knowledge among health care providers of essential maternal and child health services in Kenya: A cross-sectional survey

Dataset · September 14, 2022 We conducted a cross-sectional survey of providers at health facilities in western Kenya providing inpatient maternity services. Providers estimated facility capacity through perceived availability of both general and specialized supplies. Providers report ... Full text Cite

Impact of increasing antimüllerian hormone level on in vitro fertilization fresh transfer and live birth rate.

Journal Article F S Rep · September 2022 OBJECTIVE: The objective of our study was to assess the association between AMH and live birth among women with elevated AMH undergoing first fresh IVF. Serum antimüllerian hormone (AMH) correlates with oocyte yield during in vitro fertilization (IVF). How ... Full text Link to item Cite

Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.

Journal Article Exp Gerontol · August 2022 Aging is a multifactorial process associated with progressive degradation of physiological integrity and function. One of the greatest factors contributing to the deleterious effects of aging is the decline of functional ability due to loss of muscle mass, ... Full text Link to item Cite

Comparison of a Blood Self-Collection System with Routine Phlebotomy for SARS-CoV-2 Antibody Testing.

Journal Article Diagnostics (Basel) · July 31, 2022 The Coronavirus Disease 2019 (COVID-19) pandemic forced researchers to reconsider in-person assessments due to transmission risk. We conducted a pilot study to evaluate the feasibility of using the Tasso-SST (Tasso, Inc, Seattle, Washington) device for blo ... Full text Open Access Link to item Cite

A pragmatic clinical trial of hearing screening in primary care clinics: cost-effectiveness of hearing screening.

Journal Article Cost Eff Resour Alloc · June 25, 2022 BACKGROUND: Hearing loss is a high prevalence condition among older adults, is associated with higher-than-average risk for poor health outcomes and quality of life, and is a public health concern to individuals, families, communities, professionals, gover ... Full text Link to item Cite

Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2.

Journal Article Exp Gerontol · June 1, 2022 BACKGROUND: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 trial tested the effects of two years of 25% calorie restriction (CR) on aging in humans. CALERIE 2 was one of the first studies to use a graph of ... Full text Link to item Cite

Impact of a Novel Training Approach on Hemodynamic and Vascular Profiles in Older Adults.

Journal Article J Aging Phys Act · April 1, 2022 Exercise training beneficially moderates the effects of vascular aging. This study compared the efficacy of Peripheral Remodeling through Intermittent Muscular Exercise (PRIME), a novel training regimen, versus aerobic training on hemodynamic profiles in p ... Full text Link to item Cite

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

Journal Article Lancet Public Health · March 2022 BACKGROUND: Although 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality. ... Full text Link to item Cite

Grief in Medical Students: The Short and Long-Term Impacts on Health and Well-Being.

Journal Article Am J Hosp Palliat Care · February 2022 CONTEXT: Healthcare workers often experience grief stemming from the loss of patients under their care. The impact of personal grief on healthcare workers' wellbeing is less well described, particularly for trainees. To better characterize the prevalence a ... Full text Link to item Cite

Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.

Journal Article EClinicalMedicine · January 2022 BACKGROUND: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metab ... Full text Link to item Cite

Evaluating the Association Between Hearing Loss and Falls in Adults With Vestibular Dysfunction or Nonvestibular Dizziness.

Journal Article Ear Hear · 2022 OBJECTIVES: Although emerging evidence suggests that hearing loss (HL) is an independent risk factor for falls, it is unclear how HL may impact falls risk in adults with vestibular dysfunction and nonvestibular dizziness. The purpose of this study was to c ... Full text Link to item Cite

Protocol for the models of primary osteoporosis screening in men (MOPS) cluster randomized trial.

Journal Article Contemp Clin Trials · January 2022 Current guidelines recommend primary osteoporosis screening for at-risk men to reduce the morbidity, mortality, and cost associated with osteoporotic fractures. However, analyses in a national Veterans Health Administration cohort of over 4,000,000 men dem ... Full text Link to item Cite

Physical activity is a potential measure of physical resilience in older adults receiving hemodialysis.

Journal Article Front Nephrol · 2022 BACKGROUND: Physical resilience, or the ability to recover after a physical stressor, declines with aging. Efforts to preserve physical resilience in the older dialysis population are critically needed; however, validated, patient-centered measures that ar ... Full text Link to item Cite

Comparing the Chemical Profiles of Plant-Based and Traditional Meats Using GC–MS-Based Metabolomics

Journal Article LC-GC North America · January 1, 2022 As the consumer interest and market for plant-based meat alternatives grows, understanding the nutritional differences between alternative and traditional meats is essential. This article describes an untargeted gas chromatography–mass spectrometry (GC–MS) ... Full text Cite

A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia.

Journal Article Sci Rep · November 30, 2021 Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to im ... Full text Link to item Cite

Sustained SBP control and long-term nursing home admission among Medicare beneficiaries.

Journal Article J Hypertens · November 1, 2021 OBJECTIVES: Sustaining SBP control reduces the risk for cardiovascular events that impair function but its association with nursing home admission has not been well studied. METHODS: We conducted an analysis of sustained SBP control and long-term nursing h ... Full text Link to item Cite

A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

Journal Article J Am Geriatr Soc · November 2021 BACKGROUND: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, ... Full text Link to item Cite

Association of Sustained Blood Pressure Control with Lower Risk for High-Cost Multimorbidities Among Medicare Beneficiaries in ALLHAT.

Journal Article J Gen Intern Med · August 2021 BACKGROUND: Clustering of chronic conditions is associated with high healthcare costs. Sustaining blood pressure (BP) control could be a strategy to prevent high-cost multimorbidity clusters. OBJECTIVE: To determine the association between sustained systol ... Full text Link to item Cite

Psychometrics of the Balance Beam Functional Test in C57BL/6 Mice.

Journal Article Comp Med · August 1, 2021 Aging is associated with a progressive decline in physical function characterized by decreased mobility, which is an important risk factor for loss of independence and reduced quality of life. Functional testing conducted in animals has advanced our unders ... Full text Link to item Cite

Vaginal Mycoplasmataceae colonization and association with immune mediators in pregnancy.

Journal Article J Matern Fetal Neonatal Med · July 2021 OBJECTIVE: To determine the prevalence of Mycoplasmataceae species in pregnant women and evaluate their association with immune system mediators. METHODS: Women were prospectively enrolled between 16-22 weeks' gestation. Vaginal swabs were self-collected a ... Full text Link to item Cite

A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable Nutrition Facts panels.

Journal Article Scientific reports · July 2021 A new generation of plant-based meat alternatives-formulated to mimic the taste and nutritional composition of red meat-have attracted considerable consumer interest, research attention, and media coverage. This has raised questions of whether plant-based ... Full text Open Access Cite

Preoperative Care Assessment of Need Scores Are Associated With Postoperative Mortality and Length of Stay in Veterans Undergoing Knee Replacement.

Journal Article Fed Pract · July 2021 BACKGROUND: Care Assessment of Need (CAN) scores predicting 90-day mortality and hospitalization are automatically computed each week for patients receiving care at Veterans Health Administration facilities. While currently used only by primary care teams ... Full text Link to item Cite

Zoledronic acid reduces the rate of clinical fractures after surgical repair of a hip fracture regardless of the Pretreatment bone mineral density.

Journal Article Osteoporos Int · June 2021 UNLABELLED: In patients with surgical repair of a low-trauma hip fracture, zoledronic acid (ZA) reduced the risk of subsequent fractures regardless of pretreatment femoral neck and total hip bone mineral density (BMD). INTRODUCTION: Zoledronic acid reduces ... Full text Link to item Cite

Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.

Journal Article Sci Adv · June 2021 Highly sensitive, specific, and point-of-care (POC) serological assays are an essential tool to manage coronavirus disease 2019 (COVID-19). Here, we report on a microfluidic POC test that can profile the antibody response against multiple severe acute resp ... Full text Link to item Cite

Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.

Journal Article Sci Transl Med · April 7, 2021 Ebola virus (EBOV) hemorrhagic fever outbreaks have been challenging to deter due to the lack of health care infrastructure in disease-endemic countries and a corresponding inability to diagnose and contain the disease at an early stage. EBOV vaccines and ... Full text Link to item Cite

Cue-based treatment for light smokers: A proof of concept pilot.

Journal Article Addict Behav · March 2021 INTRODUCTION: Light smoking (smoking ≤ 10 cigarettes per day or on some days) has become increasingly prevalent in the US and increases morbidity and mortality. Many light smokers do not experience significant nicotine withdrawal but instead smoke in respo ... Full text Open Access Link to item Cite

Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.

Journal Article Nutr Rev · January 1, 2021 Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on ag ... Full text Link to item Cite

Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study.

Journal Article J Nutr Gerontol Geriatr · 2021 In contrast to recommendations for young and middle-aged adults, intentional weight loss among older adults remains controversial and is inconsistently advised. Recent research suggests that a higher protein diet can mitigate loss of lean mass during perio ... Full text Link to item Cite

The Relation of Accelerometer-Measured Physical Activity and Serum Uric Acid Using the National Health and Nutrition Survey (NHANES) 2003-2004.

Journal Article Front Sports Act Living · 2021 Objective: Gout is a crystal-induced inflammatory arthritis caused by elevated uric acid. Physical activity has the potential to reduce serum uric acid (SUA), thus improving the disease burden of gout. In this study, we examined the association of objectiv ... Full text Open Access Link to item Cite

Cost trajectories as a measure of functional resilience after hospitalization in older adults.

Journal Article Aging Clin Exp Res · December 2020 BACKGROUND: Administrative data sets lack functional measures. AIM: We examined whether trajectories of cost can be used as a marker of functional recovery after hospitalization. METHODS: Secondary analysis of the National Health and Aging Trends Study mer ... Full text Link to item Cite

Single blastocyst transfer yields similar pregnancy rates compared with multiple cleavage embryo transfer, with reduced twin rate, in patients with low number of fertilized oocytes

Journal Article Middle East Fertility Society Journal · December 1, 2020 Background: In patients with low numbers of embryos, there is not yet consensus on whether to extend culture to the blastocyst stage, especially due to the risk that some or all of the embryos will not make it to the blastocyst stage. The objective of our ... Full text Cite

Assessing patient perceptions of cytomegalovirus infection in pregnancy.

Journal Article J Med Virol · December 2020 Pregnant women impacted by cytomegalovirus (CMV) make clinical decisions despite uncertain outcomes. Intolerance of uncertainty score (IUS) is a validated measure of tendency for individuals to find unacceptable that a negative event might occur. We invest ... Full text Link to item Cite

Warrior Wellness: A Randomized Controlled Pilot Trial of the Effects of Exercise on Physical Function and Clinical Health Risk Factors in Older Military Veterans With PTSD.

Journal Article J Gerontol A Biol Sci Med Sci · October 15, 2020 BACKGROUND: Military veterans living with post-traumatic stress disorder (PTSD) face significant physical and functional health disparities, which are often aggravated over time and in the context aging. Evidence has shown that physical activity can positi ... Full text Open Access Link to item Cite

Biomarkers Associated with Physical Resilience After Hip Fracture.

Journal Article J Gerontol A Biol Sci Med Sci · September 25, 2020 BACKGROUND: Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derive ... Full text Link to item Cite

Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.

Journal Article J Gerontol A Biol Sci Med Sci · September 16, 2020 Quantification of biological aging has been proposed for population surveillance of age-related decline in system integrity and evaluation of geroprotective therapies. However, methods of quantifying biological aging have been little studied in geriatric p ... Full text Link to item Cite

Association of Sustained Blood Pressure Control with Multimorbidity Progression Among Older Adults.

Journal Article J Am Geriatr Soc · September 2020 BACKGROUND/OBJECTIVES: Due to the high costs and excess mortality associated with multimorbidity, there is a need to develop approaches for delaying its progression. High blood pressure (BP) is a common chronic condition and a risk factor for many addition ... Full text Link to item Cite

Pilot randomized controlled trial of exercise training for older veterans with PTSD.

Journal Article J Behav Med · August 2020 Exercise training positively impacts mental health, yet remains untested in older adults with posttraumatic stress disorder (PTSD). We conducted a randomized controlled pilot trial to test the feasibility and acceptability of exercise training in older vet ... Full text Open Access Link to item Cite

Determinants of Maintenance and Recovery of Function in a Representative Older Community-Resident Biracial Sample.

Journal Article J Am Med Dir Assoc · August 2020 OBJECTIVES: Focus on decline in performance of activities of daily living (ADL) has not been matched by studies of recovery of function. Advised by a broad conceptual model of physical resilience, we ascertain characteristics that identify (1) maintenance, ... Full text Link to item Cite

Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial.

Journal Article Eur J Clin Nutr · August 2020 BACKGROUND/OBJECTIVES: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE) study showed that individuals who are nonobese were able to undergo significant calorie restriction (CR), yet the time course changes in ... Full text Link to item Cite

Near Real Time EHR Data Utilization in a Clinical Study.

Journal Article Stud Health Technol Inform · June 16, 2020 Extraction and use of Electronic Health Record (EHR) data is common in retrospective observational studies. However, electronic extraction and use of EHR data is rare during longitudinal prospective studies. One of the reasons is the amount of processing n ... Full text Link to item Cite

Comparative implementation-effectiveness of three strategies to perform hearing screening among older adults in primary care clinics: study design and protocol.

Journal Article BMC Geriatr · May 11, 2020 BACKGROUND: The burden of hearing loss among older adults could be mitigated with appropriate care. This study compares implementation of three hearing screening strategies in primary care, and examines the reliability and validity of patient self-assessme ... Full text Link to item Cite

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.

Journal Article Elife · May 5, 2020 Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints in trials of therapies designed to ... Full text Open Access Link to item Cite

Pre-implantation genetic testing alters the sex ratio: an analysis of 91,805 embryo transfer cycles.

Journal Article J Assist Reprod Genet · May 2020 PURPOSE: To determine if pre-implantation genetic testing (PGT) shifts the sex ratio (SER), the ratio of male to female births in a population normalized to 100 and typically stable at 105, following in vitro fertilization (IVF). METHODS: Data from 2014 to ... Full text Link to item Cite

Physical Activity in the Hospital: Documentation and Influence on Venous Thromboembolism Prophylaxis.

Journal Article J Aging Phys Act · April 24, 2020 This study describes the availability of physical activity information in the electronic health record, explores how electronic health record documentation correlates with accelerometer-derived physical activity data, and examines whether measured physical ... Full text Link to item Cite

Two Approaches to Classifying and Quantifying Physical Resilience in Longitudinal Data.

Journal Article J Gerontol A Biol Sci Med Sci · March 9, 2020 BACKGROUND: Approaches for quantifying physical resilience in older adults have not been described. METHODS: We apply two conceptual approaches to defining physical resilience to existing longitudinal data sets in which outcomes are measured after an acute ... Full text Link to item Cite

Age matters: older age as a risk factor for CMV reactivation in the CMV serostatus-positive kidney transplant recipient.

Journal Article Eur J Clin Microbiol Infect Dis · March 2020 Evaluate risk factors for cytomegalovirus (CMV) reactivation during the first year after kidney transplantation in the CMV-seropositive older recipient. Retrospective single-center study. Between 2011 and 2015, 91 patients ≥ 65 years received a kidney tran ... Full text Link to item Cite

Accelerometer-Measured Hospital Physical Activity and Hospital-Acquired Disability in Older Adults.

Journal Article J Am Geriatr Soc · February 2020 BACKGROUND: Hospital-acquired disability (HAD) is common and often related to low physical activity while in the hospital. OBJECTIVE: To examine whether wearable hospital activity trackers can be used to predict HAD. DESIGN: A prospective observational stu ... Full text Link to item Cite

Lidocaine-Prilocaine Cream Compared With Injected Lidocaine for Vulvar Biopsy: A Randomized Controlled Trial.

Journal Article Obstet Gynecol · February 2020 OBJECTIVE: To compare pain control during vulvar biopsy after either application of 5% lidocaine-prilocaine cream or injection of 1% lidocaine. METHODS: In a single-site randomized trial, patients who needed vulvar biopsy on a non-hair-bearing surface were ... Full text Link to item Cite

A study of decompression sickness using recorded depth-time profiles.

Journal Article Undersea Hyperb Med · 2020 INTRODUCTION: 122,129 dives by 10,358 recreational divers were recorded by dive computers from 11 manufacturers in an exploratory study of how dive profile, breathing gas (air or nitrox [N2/O2] mixes), repetitive diving, gender, age, and dive site conditio ... Full text Link to item Cite

Physical Function Assessment in Older Hemodialysis Patients.

Journal Article Kidney Med · 2020 RATIONALE & OBJECTIVE: Physical function is not routinely measured in older adults receiving dialysis. We evaluated the appropriateness of repeated measurements of physical function, including Short Physical Performance Battery (SPPB), handgrip strength, a ... Full text Link to item Cite

Resiliency Groups Following Hip Fracture in Older Adults.

Journal Article J Am Geriatr Soc · December 2019 OBJECTIVES: Defining common patterns of recovery after an acute health stressor (resiliency groups) has both clinical and research implications. We sought to identify groups of patients with similar recovery patterns across 10 outcomes following hip fractu ... Full text Link to item Cite

Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.

Journal Article J Bone Miner Res · November 2019 Diabetes mellitus among older men has been associated with increased bone mineral density but paradoxically increased fracture risk. Given the interactions among medication treatment, glycemic control, and diabetes-associated comorbidities, the relative ef ... Full text Link to item Cite

Clinical pregnancy and live birth increase significantly with every additional blastocyst up to five and decline after that: an analysis of 16,666 first fresh single-blastocyst transfers from the Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · November 2019 OBJECTIVE: To study the association between the number of blastocysts available and pregnancy outcomes in first fresh autologous single blastocyst transfer cycles. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): Patients from the S ... Full text Link to item Cite

Clinical pregnancy (CP) and live birth (LB) increase significantly with each additional fertilized oocyte up to nine, and CP and LB decline after that: an analysis of 15,803 first fresh in vitro fertilization cycles from the Society for Assisted Reproductive Technology registry.

Journal Article Fertil Steril · September 2019 OBJECTIVE: To study the association between the total number of fertilized oocytes available and pregnancy outcomes in first fresh IVF cycles with a single blastocyst transfer. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): A tota ... Full text Link to item Cite

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.

Journal Article Lancet Diabetes Endocrinol · September 2019 BACKGROUND: For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction ... Full text Link to item Cite

Gabapentin for Perioperative Pain Management for Uterine Aspiration: A Randomized Controlled Trial.

Journal Article Obstet Gynecol · September 2019 OBJECTIVE: To evaluate the effect of oral gabapentin in conjunction with usual oral pain management regimens of lorazepam, ibuprofen, oxycodone, and acetaminophen for surgical abortion on pain 5 minutes postprocedure. METHODS: This was a randomized, double ... Full text Open Access Link to item Cite

Association of Sensory and Cognitive Impairment With Healthcare Utilization and Cost in Older Adults.

Journal Article J Am Geriatr Soc · August 2019 OBJECTIVES: To examine the association between self-reported vision impairment (VI), hearing impairment (HI), and dual-sensory impairment (DSI), stratified by dementia status, on hospital admissions, hospice use, and healthcare costs. DESIGN: Retrospective ... Full text Link to item Cite

Impact of a documentation intervention on health-assessment metrics on an inpatient gynecologic oncology service.

Journal Article Gynecol Oncol · May 2019 OBJECTIVE: Accurate documentation is critical for patient care and hospital reimbursement. We sought to improve the accuracy of severity of illness (SOI) and risk of mortality (ROM) scores through implementation of documentation initiatives. METHODS: We pe ... Full text Link to item Cite

Infections after kidney transplantation. Does age matter?

Journal Article Clin Transplant · April 2019 Infections threaten successful outcomes after kidney transplantation. Our aim was to determine if the number, types of infections and the risk factors for common infections differed between older compared to younger kidney transplant (KT) recipients in the ... Full text Link to item Cite

Sustained blood pressure control and coronary heart disease, stroke, heart failure, and mortality: An observational analysis of ALLHAT.

Journal Article J Clin Hypertens (Greenwich) · April 2019 Achieving blood pressure (BP) control is associated with lower cardiovascular disease (CVD) risk, but less is known about CVD risk associated with sustained BP control over time. This observational analysis of the Antihypertensive and Lipid-Lowering Treatm ... Full text Link to item Cite

Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.

Journal Article AJP Rep · April 2019 Objective  To examine the association between perioperative Beta ( β ))-lactam versus non- β -lactam antibiotics and cesarean delivery surgical site infection (SSI). Study Design  Retrospective cohort of women undergoing cesarean delivery from January 1 to ... Full text Open Access Link to item Cite

Efficacy and Safety of Massage for Osteoarthritis of the Knee: a Randomized Clinical Trial.

Journal Article J Gen Intern Med · March 2019 BACKGROUND: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis. OBJECTIVE: Examine effects of whole-b ... Full text Link to item Cite

Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Journal Article J Gerontol A Biol Sci Med Sci · February 15, 2019 Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers ... Full text Open Access Link to item Cite

Single-center analysis of infectious complications in older adults during the first year after kidney transplantation.

Journal Article Eur J Clin Microbiol Infect Dis · January 2019 Infections are among the top three causes of death of older adults in the first year after kidney transplantation (KT). Our aim was to describe infectious complications among KT recipients aged ≥ 65 during the first 12 months post-transplant. Single-center ... Full text Link to item Cite

112: Urinary metabolomic profiles in pregnancy and association with fetal growth restriction

Conference American Journal of Obstetrics and Gynecology · January 2019 Full text Cite

Influence of Weight Reduction and Enhanced Protein Intake on Biomarkers of Inflammation in Older Adults with Obesity.

Journal Article J Nutr Gerontol Geriatr · 2019 Both aging and obesity are associated with increased levels of pro-inflammatory metabolites, while weight reduction is associated with improvements in inflammatory status. However, few studies have explored the response of key inflammatory markers to the c ... Full text Link to item Cite

Sibling bereavement in late life

Journal Article · January 1, 2019 Elders are more likely to confront the death of a sibling than any other kinship bereavement. Yet we know almost nothing about the impact of sibling deaths on older adults. We used attachment theory to generate hypotheses about the impact of this life even ... Cite

Limited Osteoporosis Screening Effectiveness Due to Low Treatment Rates in a National Sample of Older Men.

Journal Article Mayo Clin Proc · December 2018 OBJECTIVE: To determine the association between dual-energy x-ray absorptiometry (DXA) testing for osteoporosis and subsequent fractures in US male veterans without a previous fracture. PATIENTS AND METHODS: This is a propensity score-matched observational ... Full text Link to item Cite

Intraoperative Renal Resistive Index as an Acute Kidney Injury Biomarker: Development and Validation of an Automated Analysis Algorithm.

Journal Article J Cardiothorac Vasc Anesth · October 2018 OBJECTIVE: Intraoperative Doppler-determined renal resistive index (RRI) is a promising early acute kidney injury (AKI) biomarker. As RRI continues to be studied, its clinical usefulness and robustness in research settings will be linked to the ease, effic ... Full text Link to item Cite

Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study.

Journal Article J Crit Care · October 2018 PURPOSE: Septic shock is a highly heterogeneous condition which is part of the challenge in its diagnosis and treatment. In this study we aim to identify clinically relevant subphenotypes of septic shock using a novel statistic al approach. METHODS: Baseli ... Full text Link to item Cite

Beet the Best?

Journal Article Circ Res · August 31, 2018 RATIONALE: A primary goal of therapy for patients with peripheral artery disease (PAD) and intermittent claudication is increased ambulatory function. Supervised exercise rehabilitation was recently shown to confer superior walking benefits to pharmacologi ... Full text Link to item Cite

Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.

Journal Article J Am Geriatr Soc · July 2018 OBJECTIVES: To determine whether combinations of inflammatory markers are related to physical function. DESIGN AND SUBJECTS: secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data fr ... Full text Open Access Link to item Cite

Automated versus Manual Data Extraction of the Padua Prediction Score for Venous Thromboembolism Risk in Hospitalized Older Adults.

Journal Article Appl Clin Inform · July 2018 OBJECTIVE: Venous thromboembolism (VTE) prophylaxis is an important consideration for hospitalized older adults, and the Padua Prediction Score (PPS) is a risk prediction tool used to prioritize patient selection. We developed an automated PPS (APPS) algor ... Full text Link to item Cite

Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults.

Journal Article Clin Kidney J · June 2018 BACKGROUND: Biomarkers improving risk prediction for elderly populations with chronic kidney disease (CKD), an independent predictor of mortality, could be particularly useful. We previously observed that interleukin-6 (IL-6), D-dimer and soluble vascular ... Full text Link to item Cite

PRIME: A Novel Low-Mass, High-Repetition Approach to Improve Function in Older Adults.

Journal Article Med Sci Sports Exerc · May 2018 INTRODUCTION: The ability to maintain functional independence in a rapidly aging population results in an increased life expectancy without corresponding increases in health care costs. The accelerated decline in V˙O2peak after the age of 65 yr is primaril ... Full text Link to item Cite

Is objective mobility data associated with pharmacologic venous thromboembolism (VTE) prophylaxis use among hospitalized older adults?

Conference Journal of Hospital Medicine · April 10, 2018 Background: Clinical practice guidelines state that mobility is supposed to play an important role in determining use and duration of pharmacologic VTE prophylaxis. This study examines whether measured mobility levels relate to pharmacologic VTE prophylaxi ... Open Access Link to item Cite

Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.

Journal Article Aging Cell · April 2018 Calorie restriction (CR) without malnutrition slows aging in animal models. Oxidative stress reduction was proposed to mediate CR effects. CR effect on urinary F2-isoprostanes, validated oxidative stress markers, was assessed in CALERIE, a two-year randomi ... Full text Link to item Cite

The Warrior Wellness Study: A Randomized Controlled Exercise Trial for Older Veterans with PTSD.

Journal Article Transl J Am Coll Sports Med · March 15, 2018 Posttraumatic stress disorder (PTSD) affects up to 30% of military veterans. Older veterans, many of whom have lived with PTSD symptoms for several decades, report a number of negative health outcomes. Despite the demonstrated benefits of regular exercise ... Full text Open Access Link to item Cite

Competing Risks of Fracture and Death in Older Adults with Chronic Kidney Disease.

Journal Article J Am Geriatr Soc · March 2018 OBJECTIVES: To examine whether chronic kidney disease (CKD) at any stage is associated with fracture risk after adjusting for competing mortality and to determine whether age or race modify the relationship between CKD and fracture risk. DESIGN: Prospectiv ... Full text Link to item Cite

Association of Kidney Disease Quality of Life (KDQOL-36) with mortality and hospitalization in older adults receiving hemodialysis.

Journal Article BMC Nephrol · January 15, 2018 BACKGROUND: For older adults receiving dialysis, health-related quality of life is not often considered in prognostication of death or future hospitalizations. To determine if routine health-related quality of life measures may be useful for prognosticatio ... Full text Link to item Cite

Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Rheumatol · January 2018 OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structural worsening). METHODS: The Foundation for the National Institutes of He ... Full text Link to item Cite

Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.

Journal Article J Clin Endocrinol Metab · January 1, 2018 INTRODUCTION: Type 2 diabetes mellitus among older women has been associated with increased bone mineral density, but paradoxically with increased fracture risk. Findings among older men have varied, and potential mechanisms have not been fully elucidated. ... Full text Link to item Cite

Markers of Renal Function in Older Adults Completing a Higher Protein Obesity Intervention and One Year Later: Findings from the MEASUR-UP Trial.

Journal Article J Nutr Gerontol Geriatr · 2018 Increases in rates of obesity in the older population are hastening the development of chronic illnesses, including chronic kidney disease (CKD). However, obesity reduction in older adults is besought with concerns about the long-term benefit/risk, especia ... Full text Link to item Cite

Quality of Life and Mental Health in Older Adults with Obesity and Frailty: Associations with a Weight Loss Intervention.

Journal Article J Nutr Health Aging · 2018 OBJECTIVE: To examine the bi-directional associations of a weight loss intervention with quality of life and mental health in obese older adults with functional limitations. DESIGN: Combined-group analyses of secondary variables from the MEASUR-UP randomiz ... Full text Link to item Cite

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.

Journal Article J Gerontol A Biol Sci Med Sci · December 12, 2017 Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these methods are sensi ... Full text Open Access Link to item Cite

Does accounting for seizure frequency variability increase clinical trial power?

Journal Article Epilepsy Res · November 2017 OBJECTIVE: Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that direc ... Full text Link to item Cite

Combined Dietary Nitrate and Exercise Intervention in Peripheral Artery Disease: Protocol Rationale and Design.

Journal Article JMIR Res Protoc · October 3, 2017 BACKGROUND: Peripheral artery disease (PAD) is caused by atherosclerotic occlusions in the legs. It affects approximately 8-12 million people in the United States alone, one-third of whom suffer from intermittent claudication (IC), defined as ischemic leg ... Full text Link to item Cite

Anxiety symptoms bias memory assessment in older adults.

Journal Article Int J Geriatr Psychiatry · September 2017 BACKGROUND: Older adults with anxiety and/or depression experience additional memory dysfunction beyond that of the normal aging process. However, few studies have examined test bias in memory assessments due to anxiety and/or depressive symptoms. The curr ... Full text Link to item Cite

Analysis of professional competencies for the clinical research data management profession: implications for training and professional certification.

Journal Article J Am Med Inform Assoc · July 1, 2017 OBJECTIVE: To assess and refine competencies for the clinical research data management profession. MATERIALS AND METHODS: Based on prior work developing and maintaining a practice standard and professional certification exam, a survey was administered to a ... Full text Link to item Cite

Influence of Protein Intake, Race, and Age on Responses to a Weight-Reduction Intervention in Obese Women.

Journal Article Curr Dev Nutr · May 1, 2017 BACKGROUND: Women have higher rates of obesity than men and develop more pronounced functional deficits as a result. Yet, little is known about how obesity reduction affects their functional status, including whether their responses differ when protein int ... Full text Link to item Cite

Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity.

Journal Article J Gerontol A Biol Sci Med Sci · April 1, 2017 BACKGROUND: A number of large-scale population studies have provided valuable information about physical performance in aged individuals; however, there is little information about trajectories of function and associations with age across the adult life sp ... Full text Link to item Cite

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.

Journal Article Am J Clin Nutr · April 2017 Background: Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition.Objective: We evaluated the effect of a 2-y CR regi ... Full text Link to item Cite

Economic Analysis of Primary Care-Based Physical Activity Counseling in Older Men: The VA-LIFE Trial.

Journal Article J Am Geriatr Soc · March 2017 OBJECTIVES: To perform an economic evaluation of a primary care-based physical activity counseling intervention that improved physical activity levels and rapid gait speed in older veterans. DESIGN: Secondary objective of randomized trial that assessed the ... Full text Open Access Link to item Cite

Diminished physical function in older HIV-infected adults in the Southeastern U.S. despite successful antiretroviral therapy.

Journal Article PLoS One · 2017 BACKGROUND: As antiretroviral therapy efficacy improves, HIV is gradually being recognized more as a chronic disease within the aging HIV-infected population. While these individuals are surviving into old age, they may, however, be experiencing "accelerat ... Full text Link to item Cite

Assessing the quality of electronic health record data and patient self-report data

Conference Proceedings of the 22nd MIT International Conference on Information Quality, ICIQ 2017 · January 1, 2017 © 2017 MIT Information Quality Program. All rights reserved. Knowing the accuracy of self-reported medical data is critical to using the data in clinical decision-making and research. The same is true for data in Electronic Health Records (EHRs). For these ... Cite

Assessing the quality of electronic health record data and patient self-report data

Conference Proceedings of the 22nd MIT International Conference on Information Quality, ICIQ 2017 · January 1, 2017 © 2017 MIT Information Quality Program. All rights reserved. Knowing the accuracy of self-reported medical data is critical to using the data in clinical decision-making and research. The same is true for data in Electronic Health Records (EHRs). For these ... Cite

Assessing the quality of electronic health record data and patient self-report data

Conference Proceedings of the 22nd MIT International Conference on Information Quality, ICIQ 2017 · January 1, 2017 Knowing the accuracy of self-reported medical data is critical to using the data in clinical decision-making and research. The same is true for data in Electronic Health Records (EHRs). For these data, accuracy reported in the literature varies widely leav ... Cite

Application of the Marginal Structural Model to Account for Suboptimal Adherence in a Randomized Controlled Trial.

Journal Article Contemp Clin Trials Commun · December 15, 2016 BACKGROUND: There is considerable interest in adjusting for suboptimal adherence in randomized controlled trials. A per-protocol analysis, for example removes individuals who fail to achieve a minimal level of adherence. One can also reassign non-adherers ... Full text Link to item Cite

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

Journal Article J Gerontol A Biol Sci Med Sci · November 2016 BACKGROUND: Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (AC ... Full text Link to item Cite

Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults.

Journal Article J Gerontol A Biol Sci Med Sci · October 2016 BACKGROUND: Obesity is a significant cause of functional limitations in older adults; yet, concerns that weight reduction could diminish muscle along with fat mass have impeded progress toward an intervention. Meal-based enhancement of protein intake could ... Full text Open Access Link to item Cite

Use and Interpretation of Propensity Scores in Aging Research: A Guide for Clinical Researchers.

Journal Article J Am Geriatr Soc · October 2016 Observational studies are an important source of evidence for evaluating treatment benefits and harms in older adults, but lack of comparability in the outcome risk factors between the treatment groups leads to confounding. Propensity score (PS) analysis i ... Full text Link to item Cite

Direct in vivo evidence of activated macrophages in human osteoarthritis.

Conference Osteoarthritis Cartilage · September 2016 OBJECTIVE: Through binding to folate receptor-β (FR-β), the new (99m)Tc-EC20 (Etarfolatide) imaging technique detects activated but not resting macrophages in vivo. The goal of this study was to investigate macrophage-related inflammation in osteoarthritis ... Full text Link to item Cite

Identifying Patterns of Multimorbidity in Older Americans: Application of Latent Class Analysis.

Journal Article J Am Geriatr Soc · August 2016 OBJECTIVES: To define multimorbidity "classes" empirically based on patterns of disease co-occurrence in older Americans and to examine how class membership predicts healthcare use. DESIGN: Retrospective cohort study. SETTING: Nationally representative sam ... Full text Link to item Cite

Heterogeneity in the three-year course of major depression among older adults.

Journal Article Int J Geriatr Psychiatry · July 2016 OBJECTIVE: The objective of this research was to identify distinct trajectories of recovery in older depressed patients in order to identify optimal samples and points for interventions. METHODS: The sample was 368 patients ages 60 years and older diagnose ... Full text Link to item Cite

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.

Journal Article Aging (Albany NY) · July 2016 Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on ... Full text Link to item Cite

Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial.

Journal Article JAMA Intern Med · June 1, 2016 IMPORTANCE: Calorie restriction (CR) increases longevity in many species and reduces risk factors for chronic diseases. In humans, CR may improve health span, yet concerns remain about potential negative effects of CR. OBJECTIVE: To test the effect of CR o ... Full text Link to item Cite

Automated versus manual data extraction of venous thromboembolism risk among hospitalized older adults

Conference Journal of the American Geriatrics Society, Special Issue 2016: Annual Scientific Meeting Abstract Book · April 22, 2016 Full text Link to item Cite

Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study.

Journal Article J Gerontol A Biol Sci Med Sci · March 2016 BACKGROUND: Levels of circulating progenitor cells (CPCs) are depleted with aging and chronic injury and are associated with level of physical functioning; however, little is known about the correlation of CPCs with longer-term measures of physical capabil ... Full text Link to item Cite

A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.

Journal Article J Gerontol A Biol Sci Med Sci · February 2016 Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers woul ... Full text Link to item Cite

Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis.

Journal Article J Neurosurg · February 2016 OBJECTIVE: Mild traumatic brain injury (TBI) has been proposed as a risk factor for the development of Alzheimer's disease, Parkinson's disease, depression, and other illnesses. This study's objective was to determine the association of prior mild TBI with ... Full text Link to item Cite

Late-life Depression Modifies the Association Between Cerebral White Matter Hyperintensities and Functional Decline Among Older Adults.

Journal Article Am J Geriatr Psychiatry · January 2016 OBJECTIVE: Vascular lesions seen through brain imaging as hyperintensities are associated with both depression and functional impairment in older adults. Our objective was to determine if the relationship between the volume of cerebral white matter hyperin ... Full text Link to item Cite

Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial.

Journal Article J Bone Miner Res · January 2016 Although caloric restriction (CR) could delay biologic aging in humans, it is unclear if this would occur at the cost of significant bone loss. We evaluated the effect of prolonged CR on bone metabolism and bone mineral density (BMD) in healthy younger adu ... Full text Link to item Cite

Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults

Journal Article JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES · 2016 Full text Cite

Effects of tai chi chuan on anxiety and sleep quality in young adults: lessons from a randomized controlled feasibility study.

Journal Article Nat Sci Sleep · 2016 OBJECTIVE: To determine feasibility and estimate the effect of a 10-week tai chi chuan (TCC) intervention on anxiety and sleep quality in young adults. PARTICIPANTS: Seventy-five adults (18-40 years) from a predominately undergraduate midsized university. ... Full text Link to item Cite

Correlation of hip fracture with other fracture types: Toward a rational composite hip fracture endpoint.

Journal Article Bone · December 2015 PURPOSE: With ethical requirements to the enrollment of lower risk subjects, osteoporosis trials are underpowered to detect reduction in hip fractures. Different skeletal sites have different levels of fracture risk and response to treatment. We sought to ... Full text Link to item Cite

Functional Impairments Mediate Association Between Clinical Fracture Risk and Type 2 Diabetes Mellitus in Older Women.

Journal Article J Am Geriatr Soc · August 2015 OBJECTIVES: To examine the effect of functional impairments in older women with diabetes mellitus (DM) on incident clinical fractures. DESIGN: Secondary analysis of two large prospective cohort studies. SETTING: North Carolina Established Populations for E ... Full text Link to item Cite

Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis.

Journal Article Arthritis Rheumatol · April 2015 OBJECTIVE: To evaluate the ability of the macrophage markers CD163 and CD14 to predict different osteoarthritis (OA) phenotypes defined by severity of joint inflammation, radiographic features and progression, and joint pain. METHODS: We evaluated 2 differ ... Full text Link to item Cite

Meal-based enhancement of protein quality and quantity during weight loss in obese older adults with mobility limitations: rationale and design for the MEASUR-UP trial.

Journal Article Contemp Clin Trials · January 2015 Obese older adults with even modest functional limitations are at a disadvantage for maintaining their independence into late life. However, there is no established intervention for obesity in older individuals. The Measuring Eating, Activity, and Strength ... Full text Link to item Cite

Self-efficacy for exercise, more than disease-related factors, is associated with objectively assessed exercise time and sedentary behaviour in rheumatoid arthritis.

Journal Article Scand J Rheumatol · 2015 OBJECTIVES: Until recently, reports of physical activity in rheumatoid arthritis (RA) were limited to self-report methods and/or leisure-time physical activity. Our objectives were to assess, determine correlates of, and compare to well-matched controls bo ... Full text Link to item Cite

Factors Affecting Accuracy of Data Abstracted from Medical Records.

Journal Article PLoS One · 2015 OBJECTIVE: Medical record abstraction (MRA) is often cited as a significant source of error in research data, yet MRA methodology has rarely been the subject of investigation. Lack of a common framework has hindered application of the extant literature in ... Full text Link to item Cite

Differences between completely physically inactive and low active older men and their response to an exercise intervention: the Veterans LIFE study.

Journal Article Healthy Aging Res · 2015 BACKGROUND: Physical activity interventions typically do not report behavioral changes in activity sub-groups. The aim of this study was to compare baseline differences and changes in physical activity between truly physically inactive men and low active m ... Full text Open Access Link to item Cite

Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.

Journal Article J Bone Miner Res · December 2014 Minimizing post-fracture bone loss is an important aspect of recovery from hip fracture, and determination of factors that affect bone mineral density (BMD) response to treatment after hip fracture may assist in the development of targeted therapeutic inte ... Full text Link to item Cite

Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

Journal Article Neurobiol Aging · November 2014 Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal co ... Full text Link to item Cite

Disinhibited eating and weight-related insulin mismanagement among individuals with type 1 diabetes.

Journal Article Appetite · October 2014 OBJECTIVE: Withholding insulin for weight control is a dangerous practice among individuals with type 1 diabetes; yet little is known about the factors associated with this behavior. Studies of nondiabetic individuals with weight concerns suggest that eati ... Full text Link to item Cite

Vascular lesions and functional limitations among older adults: does depression make a difference?

Journal Article Int Psychogeriatr · September 2014 BACKGROUND: The association between disability and depression is complex, with disability well established as a correlate and consequence of late life depression. Studies in community samples report that greater volumes of cerebral white matter hyperintens ... Full text Link to item Cite

Effects of elevated oxygen and carbon dioxide partial pressures on respiratory function and cognitive performance.

Journal Article J Appl Physiol (1985) · August 15, 2014 Hyperoxia during diving has been suggested to exacerbate hypercapnic narcosis and promote unconsciousness. We tested this hypothesis in male volunteers (12 at rest, 10 at 75 W cycle ergometer exercise) breathing each of four gases in a hyperbaric chamber. ... Full text Link to item Cite

Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults.

Journal Article J Aging Health · June 2014 OBJECTIVE: The aim of this study was to examine inflammation and coagulation, which are positively linked to disability and inversely linked to increased religious attendance, as mediators in the cross-sectional relationships between religious attendance a ... Full text Link to item Cite

Community engagement in diverse populations for Alzheimer disease prevention trials.

Journal Article Alzheimer Dis Assoc Disord · 2014 The recruitment of asymptomatic volunteers has been identified as a critical factor that is delaying the development and validation of preventive therapies for Alzheimer disease (AD). Typical recruitment strategies involve the use of convenience samples or ... Full text Link to item Cite

PTSD is negatively associated with physical performance and physical function in older overweight military Veterans.

Journal Article J Rehabil Res Dev · 2014 This study examines the effect of posttraumatic stress disorder (PTSD) on function and physical performance in older overweight military Veterans with comorbid conditions. This is a secondary data analysis of older Veterans (mean age = 62.9 yr) participati ... Full text Open Access Link to item Cite

Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial.

Journal Article J Gerontol A Biol Sci Med Sci · December 2013 BACKGROUND: Aging is marked by a decline in physical function. Although the biological underpinnings for this remain unclear, loss of regenerative capacity has been proposed as one cause of the loss of physical function that occurs over time. The quantity ... Full text Link to item Cite

High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment.

Journal Article Osteoarthritis Cartilage · November 2013 OBJECTIVE: To evaluate ankle joint abnormalities in a knee osteoarthritis (OA) cohort. METHODS: Participants (n = 159) with symptomatic and radiographic OA in at least one knee underwent technetium-99m methylene diphosphonate bone scan (scored 0-3) of the ... Full text Link to item Cite

A day-centered approach to modeling cortisol: diurnal cortisol profiles and their associations among U.S. adults.

Journal Article Psychoneuroendocrinology · October 2013 Diurnal cortisol is a marker of HPA-axis activity that may be one of the biological mechanisms linking stressors to age-related health declines. The current study identified day-centered profiles of diurnal cortisol among 1101 adults living in the United S ... Full text Link to item Cite

Unlocking the barriers to improved functional capacity in the elderly: rationale and design for the "Fit for Life trial".

Journal Article Contemp Clin Trials · September 2013 Advancing age is associated with an increase in physical impairment, functional limitations, disability, and loss of independence. Regular physical activity conveys health benefits, but the yield on physical function in the elderly, is less clear. Current ... Full text Link to item Cite

Pregnancy outcomes among patients with vasculitis.

Journal Article Arthritis Care Res (Hoboken) · August 2013 OBJECTIVE: Pregnancy outcomes of patients with vasculitis are unknown, but are of great concern to patients and physicians. Through an online survey, this study assessed pregnancy outcomes among patients with vasculitis. METHODS: Participants in the Vascul ... Full text Link to item Cite

The impact of cyclophosphamide on menstruation and pregnancy in women with rheumatologic disease.

Journal Article Lupus · January 2013 BACKGROUND: While cyclophosphamide (CYC) can save the life of a young woman with severe rheumatologic disease, it may lead to the long-term side-effects of infertility and premature menopause. We compared the reproductive health histories of young women wi ... Full text Link to item Cite

Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: methods and results.

Journal Article Contemp Clin Trials · January 2013 The Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE) study is a systematic investigation of sustained 25% calorie restriction (CR) in non-obese humans. CALERIE is a multicenter (3 clinical sites, one coordina ... Full text Link to item Cite

The association of health and income in the elderly: experience from a southern state of Brazil.

Journal Article PLoS One · 2013 OBJECTIVES: In high income, developed countries, health status tends to improve as income increases, but primarily through the 50(th)-66(th) percentile of income. It is unclear whether the same limitation holds in middle income countries, and for both gene ... Full text Link to item Cite

Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trial.

Journal Article J Diabetes Complications · 2013 BACKGROUND: One theory of aging and disease development is that chronic injury (pathology) results in activation of regenerative processes and initial repair, with overt disease arising only after exhaustion of reparative capability leads to inadequate rep ... Full text Link to item Cite

Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.

Journal Article J Am Geriatr Soc · November 2012 OBJECTIVES: To examine whether performance on a brief memory test is related to functional outcomes in older individuals undergoing low-vision rehabilitation (LVR) for macular disease. DESIGN: Observational cohort study of individuals receiving outpatient ... Full text Link to item Cite

Treatment course with antidepressant therapy in late-life depression.

Journal Article Am J Psychiatry · November 2012 OBJECTIVE: In order to assess the effect of gray matter volumes and cortical thickness on antidepressant treatment response in late-life depression, the authors examined the relationship between brain regions identified a priori and Montgomery-Åsberg Depre ... Full text Link to item Cite

Religious coping and quality of life among individuals living with schizophrenia.

Journal Article Psychiatr Serv · October 1, 2012 OBJECTIVE This study investigated the relationship between positive and negative religious coping and quality of life among outpatients with schizophrenia. METHODS Interviews were conducted with 63 adults in the southeastern United States. Religious coping ... Full text Link to item Cite

Enhanced fitness: a randomized controlled trial of the effects of home-based physical activity counseling on glycemic control in older adults with prediabetes mellitus.

Journal Article J Am Geriatr Soc · September 2012 OBJECTIVES: To determine whether a home-based multicomponent physical activity counseling (PAC) intervention is effective in reducing glycemic measures in older outpatients with prediabetes mellitus. DESIGN: Controlled clinical trial. SETTING: Primary care ... Full text Open Access Link to item Cite

Daily Variation of Serum Acylcarnitines and Amino Acids.

Journal Article Metabolomics · August 2012 To characterize daily variation of amino acids (AAs) and acylcarnitines (ACs) in response to feeding and activity, we measured serum metabolites at various times and after various activities during the day. Subjects were admitted overnight for serial serum ... Full text Link to item Cite

Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset.

Journal Article Am J Geriatr Psychiatry · August 2012 OBJECTIVES: To test the hypothesis that the degree of vascular burden and/or age of onset may influence the degree to which cognition can improve during the course of treatment in late-life depression. DESIGN: Measurement of cognition both before and follo ... Full text Link to item Cite

Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study.

Journal Article Am J Physiol Endocrinol Metab · February 15, 2012 Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieve ... Full text Link to item Cite

A preliminary predictive model for wheelchair use 4~months after receipt

Journal Article Technology and Disability · February 10, 2012 Objectives: To explore whether use of wheeled mobility devices 4 months after receipt can be predicted based on the type of information available at the time of initial wheelchair prescription/provision across diverse settings and providers. Design: Longit ... Full text Cite

End-of-life care at an academic medical center: are attending physicians, house staff, nurses, and bereaved family members equally satisfied? Implications for palliative care.

Journal Article Am J Hosp Palliat Care · February 2012 BACKGROUND: End-of-life care is deemed to be poor in the United States - particularly in large teaching hospitals. Via a brief survey, we examined satisfaction with end-of-life care for those patients who died in our academic medical center from provider a ... Full text Link to item Cite

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.

Journal Article PLoS One · 2012 OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to dete ... Full text Open Access Link to item Cite

Spirituality and religion in outpatients with schizophrenia: a multi-site comparative study of Switzerland, Canada, and the United States.

Journal Article Int J Psychiatry Med · 2012 OBJECTIVE: To assess the importance of spirituality and religious coping among outpatients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder living in three countries. METHOD: A total of 276 outpatients (92 from Geneva, Switzerland, 121 ... Full text Link to item Cite

Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.

Journal Article J Gerontol A Biol Sci Med Sci · December 2011 BACKGROUND: We wished to determine if a marker of endothelial dysfunction/activation soluble vascular cell adhesion molecule (s-VCAM)-was related to functional status and mortality in community-dwelling older adults independent of the known effects of mark ... Full text Link to item Cite

Subtrochanteric fractures in bisphosphonate-naive patients: results from the HORIZON-recurrent fracture trial.

Journal Article Calcif Tissue Int · December 2011 Our purpose was to characterize the risks of osteoporosis-related subtrochanteric fractures in bisphosphonate-naive individuals. Baseline characteristics of patients enrolled in the HORIZON-Recurrent Fracture Trial with a study-qualifying hip fracture were ... Full text Link to item Cite

Lessons learned when innovations go awry: a baseline description of a behavioral trial-the Enhancing Fitness in Older Overweight Veterans with Impaired Fasting Glucose study.

Journal Article Transl Behav Med · November 2011 Individuals diagnosed with impaired glucose tolerance (i.e., prediabetes) are at increased risk for developing diabetes. We proposed a clinical trial with a novel adaptive randomization designed to examine the impact of a home-based physical activity (PA) ... Full text Open Access Link to item Cite

Zoledronic acid results in better health-related quality of life following hip fracture: the HORIZON-Recurrent Fracture Trial.

Journal Article Osteoporos Int · September 2011 UNLABELLED: This study evaluated the benefits of ZOL versus placebo on health-related quality of life (HRQoL) among patients from HORIZON-RFT. At month 24 and end of the study visit, ZOL significantly improved patients' overall health state compared to pla ... Full text Link to item Cite

Plasma acylcarnitines are associated with physical performance in elderly men.

Journal Article J Gerontol A Biol Sci Med Sci · May 2011 BACKGROUND: Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults. METHODS: A targeted mass spectrometry-based platform was used to identify and quantify 45 plasma acylcarnitines in 77 older men with a mean ... Full text Link to item Cite

Clinical risk factors for recurrent fracture after hip fracture: a prospective study.

Journal Article Calcif Tissue Int · May 2011 Additional fractures after hip fracture are common, but little is known about the risk factors associated with these events. We determined the clinical risk factors associated with fracture following a low-trauma hip fracture and whether clinical risk fact ... Full text Link to item Cite

Development of adherence metrics for caloric restriction interventions.

Journal Article Clin Trials · April 2011 BACKGROUND: objective measures are needed to quantify dietary adherence during caloric restriction (CR) while participants are freeliving. One method to monitor adherence is to compare observed weight loss to the expected weight loss during a prescribed le ... Full text Link to item Cite

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.

Journal Article J Clin Endocrinol Metab · February 2011 OBJECTIVES: The objective of the study was to evaluate whether serum concentrations of metabolic intermediates are related to adiposity and insulin sensitivity (Si) in overweight healthy subjects and compare changes in metabolic intermediates with similar ... Full text Link to item Cite

Lower extremity physical performance, self-reported mobility difficulty, and use of compensatory strategies for mobility by elderly women.

Journal Article Arch Phys Med Rehabil · February 2011 OBJECTIVE: To describe the relationship between lower extremity physical performance, self-reported mobility difficulty, and self-reported use of compensatory strategies (CSs) for mobility inside the home. DESIGN: Cross-sectional exploratory study. SETTING ... Full text Link to item Cite

Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time.

Journal Article Alzheimer Dis Assoc Disord · 2011 The neuropsychological battery from the National Alzheimer's Disease Coordinating Center is designed to provide a sensitive assessment of mild cognitive disorders for multicenter investigations. Comprising 8 common neuropsychological tests (12 measures), t ... Full text Link to item Cite

Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.

Journal Article Aging Clin Exp Res · 2011 BACKGROUND AND AIMS: Comorbid cognitive impairment is common among visually impaired older adults. This study investigated whether baseline cognitive status predicts functional trajectories among older adults in low vision rehabilitation (LVR) for macular ... Full text Link to item Cite

Long-term changes in physical activity following a one-year home-based physical activity counseling program in older adults with multiple morbidities.

Journal Article J Aging Res · December 26, 2010 This study assessed the sustained effect of a physical activity (PA) counseling intervention on PA one year after intervention, predictors of sustained PA participation, and three classes of post-intervention PA trajectories (improvers, maintainers, and de ... Full text Open Access Link to item Cite

Chronic medical conditions and the sex-based disparity in disability: the Cardiovascular Health Study.

Journal Article J Gerontol A Biol Sci Med Sci · December 2010 BACKGROUND: Older women experience disability more commonly than their male peers. This disparity may be due, in part, to sex-based differences in the prevalence or the disabling effects of common medical conditions. The objectives of this analysis were to ... Full text Link to item Cite

Patellar skin surface temperature by thermography reflects knee osteoarthritis severity.

Journal Article Clin Med Insights Arthritis Musculoskelet Disord · October 15, 2010 BACKGROUND: Digital infrared thermal imaging is a means of measuring the heat radiated from the skin surface. Our goal was to develop and assess the reproducibility of serial infrared measurements of the knee and to assess the association of knee temperatu ... Full text Open Access Link to item Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal Article J Gerontol A Biol Sci Med Sci · October 2010 BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

Walking in old age and development of metabolic syndrome: the health, aging, and body composition study.

Journal Article Metab Syndr Relat Disord · August 2010 BACKGROUND: The specific health benefits of meeting physical activity guidelines are unclear in older adults. We examined the association between meeting, not meeting, or change in status of meeting physical activity guidelines through walking and the 5-ye ... Full text Open Access Link to item Cite

The impact of self-reported arthritis and diabetes on response to a home-based physical activity counselling intervention.

Journal Article Scand J Rheumatol · May 2010 OBJECTIVES: Physical activity (PA) has the potential to improve outcomes in both arthritis and diabetes, but these conditions are rarely examined together. Our objective was to explore whether persons with arthritis alone or those with both arthritis and d ... Full text Link to item Cite

Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.

Journal Article Arch Gen Psychiatry · March 2010 CONTEXT: Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity. OBJECTIVE: To evaluate the relationship of neuropsychological performance and white matt ... Full text Link to item Cite

Warfarin use and outcomes in patients with atrial fibrillation complicating acute coronary syndromes.

Journal Article Am J Med · February 2010 BACKGROUND: We examined warfarin use at discharge (according to Congestive heart failure, Hypertension, Age>75 years, Diabetes, Prior Stroke/transient ischemic attack score and bleeding risk) and its association with 6-month death or myocardial infarction ... Full text Link to item Cite

Potential mediators of the mortality reduction with zoledronic acid after hip fracture.

Journal Article J Bone Miner Res · January 2010 Featured Publication Zoledronic acid reduces the risk of death by 28% after hip fracture, but the mechanisms are not known. This exploratory analysis sought to identify potential pathways for the reduction in mortality with zoledronic acid after hip fracture. This was a retros ... Full text Link to item Cite

Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease.

Journal Article Arch Gerontol Geriatr · 2010 Featured Publication The prevalence of comorbid cognitive impairment among older adults referred to low vision rehabilitation (LVR) for macular disease is unknown. We performed cognitive testing on 101 adults aged 65 years or older with macular disease who were referred to The ... Full text Link to item Cite

Trajectories of mobility and IADL function in older patients diagnosed with major depression.

Journal Article Int J Geriatr Psychiatry · January 2010 Featured Publication OBJECTIVE: Research has shown an association between depression and functional limitations in older adults. Our aim was to explore the latent traits of trajectories of limitations in mobility and instrumental activities of daily living (IADL) tasks in a sa ... Full text Link to item Cite

Is diabetes associated with poorer self-efficacy and motivation for physical activity in older adults with arthritis?

Journal Article Scand J Rheumatol · 2010 OBJECTIVES: The primary aim was to explore whether arthritis is associated with poorer self-efficacy and motivation for, and participation in, two specific types of physical activity (PA): endurance training (ET) and strength training (ST). A further objec ... Full text Link to item Cite

The complex relationship between depressive symptoms and functional limitations in community-dwelling older adults: the impact of subthreshold depression.

Journal Article Psychol Med · October 2009 Featured Publication BACKGROUND: Depressive symptoms above screening thresholds have been shown to predict functional decline in older adults. Less is known about the impact of subthreshold depression, and whether more symptoms confer significantly greater risk compared to few ... Full text Link to item Cite

Underuse of indicated medications among physically frail older US veterans at the time of hospital discharge: results of a cross-sectional analysis of data from the Geriatric Evaluation and Management Drug Study.

Journal Article Am J Geriatr Pharmacother · October 2009 BACKGROUND: Medication underutilization, or the omission of a potentially beneficial medication indicated for disease management, is common among older adults but poorly understood. OBJECTIVES: The aims of this work were to assess the prevalence of medicat ... Full text Link to item Cite

Epidemiology and geriatric psychiatry.

Journal Article Am J Geriatr Psychiatry · August 2009 Featured Publication Full text Link to item Cite

Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture.

Journal Article J Bone Miner Res · July 2009 Featured Publication Annual infusions of zoledronic acid (5 mg) significantly reduced the risk of vertebral, hip, and nonvertebral fractures in a study of postmenopausal women with osteoporosis and significantly reduced clinical fractures and all-cause mortality in another stu ... Full text Link to item Cite

The Veterans Learning to Improve Fitness and Function in Elders Study: a randomized trial of primary care-based physical activity counseling for older men.

Journal Article J Am Geriatr Soc · July 2009 Featured Publication OBJECTIVES: To determine the effects of primary care-based, multicomponent physical activity counseling (PAC) promoting physical activity (PA) guidelines on gait speed and related measures of PA and function in older veterans. DESIGN: Randomized controlled ... Full text Link to item Cite

Resolution and severity in decompression illness.

Journal Article Aviat Space Environ Med · May 2009 Featured Publication omegaWe review the terminology of decompression illness (DCI), investigations of residual symptoms of decompression sickness (DCS), and application of survival analysis for investigating DCI severity and resolution. The Type 1 and Type 2 DCS classification ... Full text Link to item Cite

Profiles of depressive symptoms in older adults diagnosed with major depression: latent cluster analysis.

Journal Article Am J Geriatr Psychiatry · May 2009 Featured Publication OBJECTIVE: To explore the underlying structure of symptom presentation in older adults with major depression by identifying homogeneous clusters of individuals based on symptom profiles. DESIGN: Secondary data analysis using latent class cluster analysis. ... Full text Link to item Cite

What can we learn from a decade of database audits? The Duke Clinical Research Institute experience, 1997--2006.

Journal Article Clin Trials · April 2009 Featured Publication BACKGROUND: Despite a pressing and well-documented need for better sharing of information on clinical trials data quality assurance methods, many research organizations remain reluctant to publish descriptions of and results from their internal auditing an ... Full text Link to item Cite

Cerebrovascular smooth muscle actin is increased in nondemented subjects with frequent senile plaques at autopsy: implications for the pathogenesis of Alzheimer disease.

Journal Article J Neuropathol Exp Neurol · April 2009 Featured Publication We previously found that vascular smooth muscle actin (SMA) is reduced in the brains of patients with late stage Alzheimer disease (AD) compared with brains of nondemented, neuropathologically normal subjects. To assess the pathogenetic significance and di ... Full text Link to item Cite

Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal cancer.

Journal Article Psychooncology · April 2009 OBJECTIVE: Cure rates for cancer are increasing, especially for breast, prostate, and colorectal cancer. Despite positive trends in survivorship, a cancer diagnosis can trigger accelerated functional decline that can threaten independence, reduce quality-o ... Full text Link to item Cite

Correlation between symptoms and function in older adults with comorbidity.

Journal Article J Am Geriatr Soc · April 2009 Featured Publication OBJECTIVES: To describe the relationship between symptom scores and mobility function measures, assess whether symptom scores and disease scores are similarly associated with mobility function, and identify clusters of symptoms that are most strongly assoc ... Full text Link to item Cite

A centralized informatics infrastructure for the National Institute on Drug Abuse Clinical Trials Network.

Journal Article Clin Trials · February 2009 Featured Publication BACKGROUND: Clinical trial networks (CTNs) were created to provide a sustaining infrastructure for the conduct of multisite clinical trials. As such, they must withstand changes in membership. Centralization of infrastructure including knowledge management ... Full text Link to item Cite

Physical activity as a preventative factor for frailty: the health, aging, and body composition study.

Journal Article J Gerontol A Biol Sci Med Sci · January 2009 Featured Publication BACKGROUND: It is unclear if physical activity (PA) can prevent or reverse frailty. We examined different doses and types of PA and their association with the onset and severity of frailty. METHODS: Health, Aging and Body Composition (Health ABC) study par ... Full text Link to item Cite

Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study.

Journal Article Clin Neuropsychol · January 2009 Featured Publication The Cache County Study of Memory in Aging (CCMS) is an epidemiological study of Alzheimer's disease (AD), mild cognitive disorders, and aging in a population of exceptionally long-lived individuals (7th to 11th decade). Observation of population members wi ... Full text Link to item Cite

Depressive symptomatology and fracture risk in community-dwelling older men and women.

Journal Article Aging Clin Exp Res · December 2008 Featured Publication BACKGROUND AND AIMS: Previous studies suggest that depression increases risk of falls, low bone mineral density, and fractures. Our aim was to evaluate whether depressive symptomatology alone predicts 5- year clinical fracture risk in older adults. METHODS ... Full text Link to item Cite

New light on an age-old issue.

Journal Article Mech Ageing Dev · November 2008 Featured Publication In this issue, Varadhan and colleagues propose a methodologic framework that seeks to quantify impaired resiliency in dynamic systems underlying the frailty syndrome. We view this work, which is based on modeling stimulus-response data, as an exciting expa ... Full text Link to item Cite

Death or hospitalization of patients on chronic hemodialysis is associated with a physician-based diagnosis of depression.

Journal Article Kidney Int · October 2008 Featured Publication Depressive symptoms, assessed using a self-report type of questionnaire, have been associated with poor outcomes in dialysis patients. Here we determined if depressive disorders diagnosed by physicians are also associated with such outcomes. Ninety-eight c ... Full text Link to item Cite

Effect of physical activity guidelines on physical function in older adults.

Journal Article J Am Geriatr Soc · October 2008 Featured Publication OBJECTIVES: To determine whether elderly people who meet national guidelines have higher physical function (PF) scores than those who do not and the effect on functional trajectory when physical activity (PA) levels change from above to below this threshol ... Full text Link to item Cite

Quantifying data quality for clinical trials using electronic data capture.

Journal Article PLoS One · August 25, 2008 Featured Publication BACKGROUND: Historically, only partial assessments of data quality have been performed in clinical trials, for which the most common method of measuring database error rates has been to compare the case report form (CRF) to database entries and count discr ... Full text Open Access Link to item Cite

Neuropsychological performance in advanced age: Influences of Demographic factors and Apolipoprotein E: Findings from the Cache County Memory Study.

Journal Article The Clinical neuropsychologist · June 2008 The Cache County Study of Memory in Aging (CCMS) is an epidemiological study of Alzheimer's disease (AD), mild cognitive disorders, and aging in a population of exceptionally long-lived individuals (7th to 11th decade). Observation of population members wi ... Cite

Quality of pharmacotherapy and outcomes for older veterans discharged from the emergency department.

Journal Article J Am Geriatr Soc · May 2008 Featured Publication OBJECTIVES: To determine whether suboptimal pharmacotherapy increases the risk of adverse outcomes in older adults discharged from the emergency department (ED). DESIGN: Retrospective, cohort study. SETTING: Academically affiliated Veterans Affairs Medical ... Full text Link to item Cite

The course of depressive symptoms in older adults with comorbid major depression and dysthymia.

Journal Article Am J Geriatr Psychiatry · April 2008 Featured Publication OBJECTIVE: To examine the course of depressive symptoms in older patients with comorbid major depression and dysthymia. DESIGN: Secondary data analysis using both proportional hazards modeling and a repeated measures mixed model. SETTING: Clinical Research ... Full text Link to item Cite

Profiles of Functional Impairment in Older Patients Treated for Major Depression

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · February 2008 BACKGROUND: Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community. OBJECTIVE: To estimate point and 5-year period prevalence of neuropsychiatric symptoms in an incident sample of 40 ... Full text Link to item Cite

Common causes of open-circuit recreational diving fatalities.

Journal Article Undersea Hyperb Med · 2008 Featured Publication Diving fatalities causes were investigated in 947 recreational open-circuit scuba diving deaths from 1992-2003. Where possible, cases were classified at each step of a four step sequence: trigger, disabling agent, disabling injury, cause of death (COD). Th ... Link to item Cite

Project LIFE--Learning to Improve Fitness and Function in Elders: methods, design, and baseline characteristics of randomized trial.

Journal Article J Rehabil Res Dev · 2008 Featured Publication Insufficient levels of physical activity have significant clinical consequences. Primary care settings typically do not emphasize physical activity counseling. We describe the design, methods, and baseline characteristics of "Learning to Improve Fitness an ... Full text Link to item Cite

Home or nursing home: does place of residence affect longevity in patients with Alzheimer's disease? The experience of CERAD patients.

Journal Article Public Health Nurs · 2008 Featured Publication There is concern that life is curtailed when patients with Alzheimer's disease (AD) are institutionalized. To determine whether placement in a nursing home reduces their remaining years of life, we examined the experience of White patients with AD (n=890) ... Full text Link to item Cite

Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture.

Journal Article Am J Geriatr Pharmacother · December 2007 Featured Publication BACKGROUND: Vitamin D deficiency is common in older populations, particularly during the winter months due to low levels of ultraviolet light exposure, and in nursing home residents. OBJECTIVE: The main objective of the current study was to assess the dist ... Full text Link to item Cite

Effect of telephone exercise counseling on frailty in older veterans: project LIFE.

Journal Article Am J Mens Health · December 2007 Featured Publication This study sought to determine if telephone exercise counseling attenuates frailty in older, male veterans through increased levels of physical activity. Eighty-one elderly, male veterans (age = 78.4 +/- 4.9 years) randomized to intervention (n = 39) or co ... Full text Link to item Cite

The Diet Quality Index-Revised: a tool to promote and evaluate dietary change among older cancer survivors enrolled in a home-based intervention trial.

Journal Article J Am Diet Assoc · September 2007 OBJECTIVE: To utilize the Diet Quality Index-Revised (DQI-R) as a framework for delivering and evaluating an intervention to improve overall diet quality among older cancer survivors. DESIGN: As part of a randomized controlled trial to improve lifestyle be ... Full text Link to item Cite

Does NSAID use modify cognitive trajectories in the elderly? The Cache County study.

Journal Article Neurology · July 17, 2007 Featured Publication BACKGROUND: Epidemiologic studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may be useful for the prevention of Alzheimer disease (AD). By contrast, clinical trials have not supported NSAID use to delay or treat AD. Few studies have ... Full text Link to item Cite

Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.

Journal Article J Clin Exp Neuropsychol · July 2007 Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically ... Full text Link to item Cite

Association of AGTR1 with 18-month treatment outcome in late-life depression.

Journal Article Am J Geriatr Psychiatry · July 2007 Featured Publication OBJECTIVE: Converging lines of evidence implicate vascular factors in late-life depression, and argue that late-life depression is a distinct entity among the mood disorders. The A1166C polymorphism in the angiotensin II receptor, vascular type 1 (AGTR1) g ... Full text Link to item Cite

The combined effect of visual impairment and cognitive impairment on disability in older people.

Journal Article J Am Geriatr Soc · June 2007 Featured Publication OBJECTIVES: To determine the risk of disability in individuals with coexisting visual and cognitive impairment and to compare the magnitude of risk associated with visual impairment, cognitive impairment, or the multimorbidity. DESIGN: Prospective cohort. ... Full text Link to item Cite

Effect of motorized scooters on physical performance and mobility: a randomized clinical trial.

Journal Article Arch Phys Med Rehabil · March 2007 OBJECTIVE: To investigate the effects of providing a motorized scooter on physical performance and mobility. DESIGN: Randomized clinical trial comparing scooter users with usual care. SETTING: One academic and 1 Veterans Affairs medical center. PARTICIPANT ... Full text Link to item Cite

Brief meditation training can improve perceived stress and negative mood.

Journal Article Altern Ther Health Med · 2007 Featured Publication OBJECTIVES: To test a brief, non-sectarian program of meditation training for effects on perceived stress and negative emotion, and to determine effects of practice frequency and test the moderating effects of neuroticism (emotional lability) on treatment ... Link to item Cite

The distribution of cerebrovascular amyloid in Alzheimer's disease varies with ApoE genotype.

Journal Article Acta Neuropathol · January 2007 We performed a comparative study to assess cerebral amyloid angiopathy and ApoE genotype in cases of Alzheimer's disease (AD). Ten ApoE 3,3 and ten ApoE 4,4 AD brains, as well as ten normal control brains, were selected after matching for age, sex, and dur ... Full text Link to item Cite

Influence of bottom time on preflight surface intervals before flying after diving.

Journal Article Undersea Hyperb Med · 2007 Featured Publication Previous trials of flying at 8,000 ft after a single 60 fsw, 55 min no-stop air dive found low decompression sickness (DCS) risk for a 11:00 preflight surface interval (PFSI). Repetitive 60 fsw no-stop dives with 75 and 95 min total bottom times found 16:0 ... Link to item Cite

Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture.

Journal Article N Engl J Med · 2007 Featured Publication BACKGROUND: Mortality is increased after a hip fracture, and strategies that improve outcomes are needed. METHODS: In this randomized, double-blind, placebo-controlled trial, 1065 patients were assigned to receive yearly intravenous zoledronic acid (at a d ... Full text Link to item Cite

The impact of acute herpes zoster pain and discomfort on functional status and quality of life in older adults.

Journal Article Clin J Pain · 2007 OBJECTIVES: To describe the interference of herpes zoster (HZ) pain and discomfort with activities of daily living (ADLs) and health-related quality of life (HRQL) during the acute rash phase, and to quantify the relationship between acute HZ pain and disc ... Full text Link to item Cite

Clinically important drug-disease interactions and their prevalence in older adults.

Journal Article Clin Ther · August 2006 Featured Publication BACKGROUND: Older adults may have decreased homeostatic reserve, have multiple chronic diseases, and take multiple medications. Therefore, they are at risk for adverse outcomes after receiving a drug that exacerbates a chronic disease. OBJECTIVES: The aims ... Full text Link to item Cite

Lifestyle intervention development study to improve physical function in older adults with cancer: outcomes from Project LEAD.

Journal Article J Clin Oncol · July 20, 2006 Featured Publication PURPOSE: Declines in physical functioning (PF) among elderly cancer patients threaten quality of life and the ability to maintain independence. Adherence to healthy lifestyle behaviors may prevent functional decline. PATIENTS AND METHODS: Project Leading t ... Full text Link to item Cite

Adding injury to insult: fracture risk after stroke in veterans.

Journal Article J Am Geriatr Soc · July 2006 Featured Publication OBJECTIVES: To determine fracture risk in U.S. stroke patients and identify patient characteristics that predict highest fracture risk in two complementary cohorts. DESIGN: Secondary analyses of two prospective cohorts. SETTING: Veterans Affairs (VA) Medic ... Full text Link to item Cite

Project LIFE: a partnership to increase physical activity in elders with multiple chronic illnesses.

Journal Article J Aging Phys Act · July 2006 The authors describe a medical center-based randomized trial aimed at determining the feasibility and effectiveness of partnering patients and primary-care providers with an exercise health counselor. Study participants included 165 veterans age 70 years a ... Full text Link to item Cite

Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed.

Journal Article Biol Psychiatry · July 1, 2006 BACKGROUND: A number of studies have examined clinical factors linked to worse neuropsychological performance in late life depression (LLD). To understand the influence of LLD on cognition, it is important to determine if deficits in a number of cognitive ... Full text Link to item Cite

Provider characteristics related to antidepressant use in older people.

Journal Article J Am Geriatr Soc · June 2006 Featured Publication OBJECTIVES: To determine whether the characteristics of the usual medical care providers of older antidepressant users changed between 1986 and 1997 with the introduction of selective serotonin reuptake inhibitors. DESIGN: Longitudinal study. SETTING: Five ... Full text Link to item Cite

Sociodemographic characteristics of the neighborhood and depressive symptoms in older adults: using multilevel modeling in geriatric psychiatry.

Journal Article Am J Geriatr Psychiatry · June 2006 Featured Publication OBJECTIVE: Neighborhood sociodemographic characteristics may be important to the mental health of older adults who have decreased mobility and fewer resources. Our objective was to examine the association between neighborhood context and level of depressiv ... Full text Link to item Cite

A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study.

Journal Article Int J Geriatr Psychiatry · June 2006 BACKGROUND: The relationship between coronary artery bypass graft (CABG) surgery and cognitive decline remains uncertain, in particular with regard to whether there is delayed cognitive decline associated with this procedure. METHODS: This was a population ... Full text Link to item Cite

Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay.

Journal Article J Gerontol A Biol Sci Med Sci · May 2006 Featured Publication BACKGROUND: Adverse drug reactions (ADR) negatively impact life quality and are sometimes fatal. This study examines the incidence and predictors of all and preventable ADRs in frail elderly persons after hospital discharge, a highly vulnerable but rarely ... Full text Link to item Cite

Ten dimensions of health and their relationships with overall self-reported health and survival in a predominately religiously active elderly population: the cache county memory study.

Journal Article J Am Geriatr Soc · February 2006 OBJECTIVES: To document the extent of healthy aging along 10 different dimensions in a population known for its longevity. DESIGN: A cohort study with baseline measures of overall self-reported health and health along 10 specific dimensions; analyses inves ... Full text Link to item Cite

Lower extremity physical performance and use of compensatory strategies for mobility.

Journal Article J Am Geriatr Soc · February 2006 OBJECTIVES: To compare measured lower extremity physical performance in the clinic with the methods used to carry out mobility tasks at home and to identify key factors influencing day-to-day task performance. DESIGN: Cross-sectional analysis of the Women' ... Full text Link to item Cite

Number of children and risk of metabolic syndrome in women.

Journal Article J Womens Health (Larchmt) · 2006 Featured Publication BACKGROUND: In the United States, there is a high prevalence of metabolic syndrome, as defined by The Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP I ... Full text Link to item Cite

Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study.

Journal Article Alzheimer Dis Assoc Disord · 2006 Featured Publication Vascular risk factors for Alzheimer disease (AD) and vascular dementia (VaD) have been evaluated; however, few studies have compared risks by dementia subtypes and sex. We evaluated relationships between cardiovascular risk factors (hypertension, high chol ... Full text Link to item Cite

Therapeutic failure-related hospitalisations in the frail elderly.

Journal Article Drugs Aging · 2006 Featured Publication BACKGROUND AND OBJECTIVE: Although therapeutic failure may be a common cause of drug-related morbidity in older adults, few studies have focused on this problem. The study objective was to determine the frequency and types of, and the factors associated wi ... Full text Link to item Cite

Is the prevalence of dehydration among community-dwelling older adults really low? Informing current debate over the fluid recommendation for adults aged 70+years.

Journal Article Public Health Nutr · December 2005 Featured Publication OBJECTIVE: The fluid recommendation for adults aged 70+ years has been criticised on the basis of a low prevalence of dehydration in community-dwelling older adults. This study explores whether the low prevalence might reflect limitations of individual deh ... Full text Link to item Cite

Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.

Journal Article Ann Pharmacother · December 2005 Featured Publication BACKGROUND: Since increased oxidative stress may impair cognition and be a risk factor for dementia, there has been interest in determining whether use of antioxidants could protect against such events. OBJECTIVE: To determine whether supplement use of vit ... Full text Link to item Cite

Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort.

Journal Article J Am Geriatr Soc · November 2005 Featured Publication OBJECTIVES: To apply diagnostic criteria for mild cognitive impairment (MCI) to a geographically representative sample, to estimate the prevalence of MCI, and to estimate 10-year trajectories of incident disability for cognitively intact participants and s ... Full text Link to item Cite

A clinical trial of a rehabilitation expert clinician versus usual care for providing manual wheelchairs.

Journal Article J Am Geriatr Soc · October 2005 OBJECTIVES: To determine the effect of differing methods of dispensing wheelchairs. DESIGN: Quasi-experimental by day of week. SETTING: Department of Veterans Affairs Medical Center. PARTICIPANTS: Eighty-four community-dwelling, cognitively intact patients ... Full text Link to item Cite

Medication use and control of urination among community-dwelling older adults.

Journal Article J Aging Health · October 2005 Featured Publication OBJECTIVE: The purpose of this study is to evaluate whether the use of medications with urological activity (UA) is associated with self-reported difficulty in control of urination. METHODS: This is a cross-sectional study using data from the Duke Establis ... Full text Link to item Cite

Variation of serum hyaluronan with activity in individuals with knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · September 2005 Featured Publication PURPOSE: Serum hyaluronan (HA) was evaluated for diurnal variation in participants with osteoarthritis (OA) of the knee. METHODS: Twenty participants with radiographic OA of at least one knee were admitted overnight to the General Clinical Research Center ... Full text Link to item Cite

Unnecessary drug use in frail older people at hospital discharge.

Journal Article J Am Geriatr Soc · September 2005 Featured Publication OBJECTIVES: To determine the prevalence and predictors of unnecessary drug use at hospital discharge in frail elderly patients. DESIGN: Cross-sectional. SETTING: Eleven Veterans Affairs Medical Centers. PARTICIPANTS: Three hundred eighty-four frail older p ... Full text Link to item Cite

Identification of VaD and AD prodromes: the Cache County Study.

Journal Article Alzheimers Dement · July 2005 Featured Publication BACKGROUND: It is unclear whether vascular dementia (VaD) has a cognitive prodrome, akin to the mild cognitive impairment (MCI) prodrome to Alzheimer's dementia (AD). To evaluate whether VaD has a cognitive prodrome, and if it can be differentiated from pr ... Full text Link to item Cite

Apolipoprotein E genotype and mortality: findings from the Cache County Study.

Journal Article J Am Geriatr Soc · June 2005 Featured Publication OBJECTIVES: To evaluate the association between apolipoprotein E (apo E) epsilon4 and mortality, the population attributable risk for mortality with epsilon4, and relative contributions of cardiovascular disease (CVD) and Alzheimer's disease (AD). DESIGN: ... Full text Link to item Cite

Physical Activity And Disability

Conference Medicine & Science in Sports & Exercise · May 2005 Full text Cite

The effect of increasing age on the risk of surgical site infection.

Journal Article J Infect Dis · April 1, 2005 BACKGROUND: An increasing number of older persons undergo surgery, but the relationship between increasing age and risk of surgical site infection (SSI) has not been established. The objective of the present study was to determine the relationship between ... Full text Link to item Cite

Predictors of antidepressant use among older adults: have they changed over time?

Journal Article Am J Psychiatry · April 2005 Featured Publication OBJECTIVE: Antidepressant use increased substantially among older adults with the introduction of the new-generation medications such as the selective serotonin reuptake inhibitors. The authors analyzed data from two follow-up intervals-1986-1987 to 1989-1 ... Full text Link to item Cite

Biological and social predictors of long-term geriatric depression outcome.

Journal Article Int Psychogeriatr · March 2005 Featured Publication OBJECTIVE: In this study, we examined 204 older depressed individuals for up to 64 months to determine factors related to depression outcome. We hypothesized that both presence of vascular brain lesions seen on baseline magnetic resonance imaging (MRI) sca ... Full text Link to item Cite

Potential drug-disease interactions in frail, hospitalized elderly veterans.

Journal Article Ann Pharmacother · March 2005 Featured Publication BACKGROUND: Drugs can improve quality of life for many older people, but they may cause adverse health outcomes (eg, drug-disease interactions) if used inappropriately. OBJECTIVE: To determine the prevalence of potential drug-disease interactions as define ... Full text Link to item Cite

Statistical models of acute mountain sickness.

Journal Article High Alt Med Biol · 2005 Featured Publication Acute mountain sickness (AMS) is caused by exposure to altitudes exceeding 2500 m and often resolves by acclimatization without further ascent. Statistical models of AMS score and the probability of an AMS diagnosis were developed to allow the combination ... Full text Link to item Cite

Walking speed predicts health status and hospital costs for frail elderly male veterans.

Journal Article J Rehabil Res Dev · 2005 Featured Publication This study evaluated the use of walking speed as an indicator of function and health status in acutely ill, hospitalized, older male veterans. Hospital inpatients in a Department of Veterans Affairs (VA) study of Geriatric Evaluation and Management (GEM) ( ... Full text Link to item Cite

A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.

Journal Article Care Manag J · 2005 There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been followi ... Full text Link to item Cite

Consensus factors used by experts in the diagnosis of decompression illness.

Journal Article Aviat Space Environ Med · December 2004 Featured Publication INTRODUCTION: The diagnosis of decompression illness (DCI) is entirely based on clinical findings and DCI experts are rare. Of all the chambers reporting to Diver's Alert Network (DAN), 86% see less than 10 cases per year. Simulated diving injury cases (vi ... Link to item Cite

Effects of cancer history and comorbid conditions on mortality and healthcare use among older cancer survivors.

Journal Article Cancer · November 15, 2004 Featured Publication BACKGROUND: Older cancer survivors use healthcare services to an increased extent relative to their counterparts who have no history of malignant disease. In the current study, the authors set out to assess the effects of cancer history and comorbid condit ... Full text Link to item Cite

Results of a randomized controlled trial of intervention to implement smoking guidelines in Veterans Affairs medical centers: increased use of medications without cessation benefit.

Journal Article Med Care · November 2004 Featured Publication BACKGROUND: The AHRQ Clinical Practice Guideline for Treating Tobacco Use and Dependence recommends screening and treatment of all tobacco users. Effective methods to implement recommendations are needed because simple guideline dissemination does not nece ... Full text Link to item Cite

Physical function and associations with diet and exercise: Results of a cross-sectional survey among elders with breast or prostate cancer.

Journal Article Int J Behav Nutr Phys Act · October 29, 2004 Featured Publication BACKGROUND: Functional decline threatens independent living and is common among individuals diagnosed with cancer, especially those who are elderly. The purpose of this study was to explore whether dietary and exercise practices are associated with physica ... Full text Open Access Link to item Cite

Group treatment improves trunk strength and psychological status in older women with vertebral fractures: results of a randomized, clinical trial.

Journal Article J Am Geriatr Soc · September 2004 Featured Publication OBJECTIVES: To assess whether group exercise and coping classes reduce physical and psychological impairments and functional disability in older women with prevalent vertebral fractures (VFs). DESIGN: Randomized, controlled trial (modified cross-over) with ... Full text Link to item Cite

Plasma hypertonicity: another marker of frailty?

Journal Article J Am Geriatr Soc · August 2004 Featured Publication OBJECTIVES: To determine whether plasma hypertonicity might be a marker of early frailty, this study tested the associations between plasma hypertonicity, incident disability, and mortality in nondisabled older adults. DESIGN: Longitudinal, observational s ... Full text Link to item Cite

Assessment of hand osteoarthritis: correlation between thermographic and radiographic methods.

Journal Article Rheumatology (Oxford) · July 2004 Featured Publication OBJECTIVE: Anatomical stages of digital osteoarthritis (OA) have been characterized radiographically as progressing through sequential phases from normal to osteophyte formation, progressive loss of joint space, joint erosion and joint remodelling. Our stu ... Full text Link to item Cite

The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair.

Journal Article Curr Med Res Opin · June 2004 Featured Publication OBJECTIVE: To present the novel design of a trial testing the safety and efficacy of a yearly bisphosponate, zoledronic acid, in preventing new clinical fractures in patients with recent low trauma hip fracture repair. RESEARCH DESIGN AND METHODS: Randomiz ... Full text Link to item Cite

Self- or proxy-reported stroke and the risk of Alzheimer disease.

Journal Article Arch Neurol · June 2004 Featured Publication Full text Link to item Cite

Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly.

Journal Article Am J Med · March 15, 2004 Featured Publication PURPOSE: To determine if inpatient or outpatient geriatric evaluation and management, as compared with usual care, reduces adverse drug reactions and suboptimal prescribing in frail elderly patients. METHODS: The study employed a randomized 2 x 2 factorial ... Full text Link to item Cite

Experimental trials to assess the risks of decompression sickness in flying after diving.

Journal Article Undersea Hyperb Med · 2004 Featured Publication We conducted experimental trials of flying after diving using profiles near the no-decompression exposure limits for recreational diving. The objective was to determine the dependence of DCS occurrence during or after flight on the length of the preflight ... Link to item Cite

Hypertonic hyperglycemia progresses to diabetes faster than normotonic hyperglycemia.

Journal Article Eur J Epidemiol · 2004 Featured Publication To explore whether elevated plasma glucose might progress to diabetes via a mechanism that involves plasma hypertonicity, we evaluated the independent and joint effects of these variables on diabetes risk. Community-dwelling older adults (70+years), who re ... Full text Link to item Cite

Inappropriate medication use among frail elderly inpatients.

Journal Article Ann Pharmacother · January 2004 Featured Publication BACKGROUND: Inappropriate prescribing in frail elderly inpatients has not received as much investigation as in frail elderly nursing home patients. OBJECTIVE: To determine the prevalence and predictors of inappropriate prescribing for hospitalized frail el ... Full text Link to item Cite

Trajectories of leg strength and gait speed among sedentary older adults: longitudinal pattern of dose response.

Journal Article J Gerontol A Biol Sci Med Sci · December 2003 Featured Publication BACKGROUND: Current theory about how an older adult's leg strength influences walking speed is based primarily on nonlinear patterns of association observed in cross-sectional data. Compared with adults with normal or high levels of leg muscle strength, we ... Full text Link to item Cite

Function in elderly cancer survivors depends on comorbidities.

Journal Article J Gerontol A Biol Sci Med Sci · December 2003 Featured Publication BACKGROUND: Factors associated with functional status in elderly cancer survivors, in particular, comorbidity, have been inadequately studied. METHODS: Of 4162 participants aged 65 and older enrolled in the Duke Established Populations for Epidemiologic St ... Full text Link to item Cite

Adverse drug reaction risk factors in older outpatients.

Journal Article Am J Geriatr Pharmacother · December 2003 Featured Publication BACKGROUND: Adverse drug reactions (ADRs) are common in older (age >or=65 years) outpatients (prevalence, 5%-35%), but there is no consensus on factors that put these patients at high risk for ADRs. Identifying a uniform set of risk factors would be helpfu ... Full text Link to item Cite

Cancer in the elderly: to screen or not to screen?

Journal Article J Am Geriatr Soc · December 2003 Full text Link to item Cite

The above letter was referred to the author(s) of the original paper and their reply follows

Journal Article Journal of the American Geriatrics Society · December 2003 Full text Cite

The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies.

Journal Article Osteoporos Int · November 2003 BACKGROUND: The contribution of hip fracture to the risk of subsequent fractures is unclear. METHODS: Data from the Baltimore Hip Studies and the Established Populations for Epidemiologic Studies of the Elderly (EPESE) were used. Baltimore subjects enrolle ... Full text Link to item Cite

Cross-linked fibrin degradation products (D-dimer), plasma cytokines, and cognitive decline in community-dwelling elderly persons.

Journal Article J Am Geriatr Soc · October 2003 Featured Publication OBJECTIVES: To investigate the effect of coagulation and inflammatory pathway activation on future cognitive decline in older persons. DESIGN: Prospective cohort study. SETTING: Rural and urban communities in North Carolina. PARTICIPANTS: Community-dwellin ... Full text Link to item Cite

Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivors.

Journal Article Control Clin Trials · April 2003 Featured Publication The U.S. population is aging, bringing with it an increased prevalence of chronic disease and concomitant declines in physical function. The risk of developing cancer increases significantly with age, and functional decline is much more likely once a cance ... Full text Link to item Cite

Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly.

Journal Article Am J Med · February 15, 2003 Featured Publication PURPOSE: This study was performed to determine the effects of markers of inflammation (interleukin 6) and coagulation (D-dimer) on mortality and functional status in older persons. METHODS: Subjects were selected for the Duke Established Populations for Ep ... Full text Link to item Cite

Competing risk of household expansion or institutionalization in late life.

Journal Article J Gerontol B Psychol Sci Soc Sci · January 2003 Featured Publication OBJECTIVES: The purpose of this study was to evaluate predictors of change in household size and institutionalization in late life. METHODS: The Duke Established Populations for Epidemiologic Studies of the Elderly cohort (n = 3730) was assessed annually ( ... Full text Link to item Cite

A three-factor analytic model of the MADRS in geriatric depression.

Journal Article Int J Geriatr Psychiatry · January 2003 Featured Publication OBJECTIVE: Major depression is a heterogeneous disorder, perhaps comprising several clinical subtypes or subgroups of symptoms. This study examined whether items on the Montgomery-Asberg Depression Rating Scale (MADRS) form distinct symptom subgroups among ... Full text Link to item Cite

Accuracy of VO2(max) prediction equations in older adults.

Journal Article Med Sci Sports Exerc · January 2003 Featured Publication PURPOSE: We explored the accuracy and bias of prediction equations (ACSM and Foster) in older, deconditioned men and women. We also examined the predictors of VO2(max) to further understand which variables affect respiratory fitness in the elderly. METHODS ... Full text Link to item Cite

Natural history of change in physical function among long-stay nursing home residents.

Journal Article Nurs Res · 2003 Featured Publication BACKGROUND: Few longitudinal studies exist to guide clinicians or administrators on what functional outcomes can be expected among nursing home residents with different levels of cognitive impairment. Extrapolating from cross-sectional studies or from long ... Full text Link to item Cite

Can historical and functional risk factors be used to predict fractures in community-dwelling older adults? development and validation of a clinical tool.

Journal Article Osteoporos Int · December 2002 Featured Publication The objectives of the study were: (1) to evaluate the contribution of impaired functional status, cognition and medication to fracture risk; (2) to determine whether risk factor profiles differ between regionally and socially diverse populations; and (3) t ... Full text Link to item Cite

Exercise adherence and 10-year mortality in chronically ill older adults.

Journal Article J Am Geriatr Soc · December 2002 Featured Publication OBJECTIVES: To compare mortality of adherents and nonadherents of an exercise program. DESIGN: Prospective intervention study. SETTING: Supervised geriatric fitness program called Gerofit. PARTICIPANTS: One hundred thirty-five adults aged 65 and older who ... Full text Link to item Cite

Effects of cognitive performance on change in physical function in long-stay nursing home residents.

Journal Article J Gerontol A Biol Sci Med Sci · December 2002 Featured Publication BACKGROUND: Determining the nature and rate of change in physical function among long-stay nursing home (NH) residents classified by cognitive performance is needed to inform judgments about prognosis and design of clinical trials to minimize functional de ... Full text Link to item Cite

The relative risk of decompression sickness during and after air travel following diving.

Journal Article Aviat Space Environ Med · October 2002 Featured Publication BACKGROUND: Decompression sickness (DCS) can be provoked by post-dive flying but few data exist to quantify the risk of different post-dive, preflight surface intervals (PFSI). METHODS: We conducted a case-control study using field data from the Divers Ale ... Link to item Cite

The effect of comorbid illness on receipt of cancer screening by older people.

Journal Article J Am Geriatr Soc · October 2002 Featured Publication OBJECTIVES: To identify associations between the type and number of diagnoses and receipt of screening for breast, cervical, and colorectal cancer by older people. DESIGN: Sixth annual follow-up of a community-based survey with 4,162 participants aged 65 a ... Full text Link to item Cite

A randomized controlled trial of the psychosocial impact of providing internet training and access to older adults.

Journal Article Aging Ment Health · August 2002 The Internet (electronic mail and the World Wide Web) may provide new opportunities for communication that can help older adults avoid social isolation. This randomized controlled trial assessed the psychosocial impact of providing Internet access to older ... Full text Link to item Cite

Wheelchair users are not necessarily wheelchair bound.

Journal Article J Am Geriatr Soc · April 2002 OBJECTIVES: To determine the patterns of wheelchair use in terms of locations of use, whether wheelchair use in one location was related to wheelchair use in other locations, and factors associated with wheelchair use in different locations. DESIGN: Longit ... Full text Link to item Cite

Relationship of race/ethnicity and blood pressure to change in cognitive function.

Journal Article J Am Geriatr Soc · March 2002 Featured Publication OBJECTIVES: To determine whether there are racial/ethnic differences regarding the relationship of level of blood pressure to change in cognitive function in older people. DESIGN: Longitudinal data 1986 to 1989 on representative, older, community-residing ... Full text Link to item Cite

The association of depression and mortality in elderly persons.

Journal Article J Gerontol A Biol Sci Med Sci · February 2002 Full text Link to item Cite

Relationship between all-cause mortality and cumulative working life course psychosocial and physical exposures in the United States labor market from 1968 to 1992.

Journal Article Psychosom Med · 2002 Featured Publication OBJECTIVE: To examine the relationship between cumulative exposures to psychosocial and physical work conditions and mortality in a nationally representative sample. METHODS: A working cohort was created using the U.S. Panel Study of Income Dynamics. Infor ... Full text Link to item Cite

The incidence of venous gas emboli in recreational diving.

Journal Article Undersea Hyperb Med · 2002 Featured Publication From 1989-91, the Divers Alert Network monitored recreational divers for Doppler-detected venous gas emboli (VGE) and depth-time profiles following multi-day, repetitive, multi-level exposures. A Spencer score >0 occurred in 61 of 67 subjects (91%) and 205 ... Link to item Cite

Caffeine affects cardiovascular and neuroendocrine activation at work and home.

Journal Article Psychosom Med · 2002 Featured Publication OBJECTIVE: This study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate, urinary excretion of epinephrine, norepinephrine, and cortisol, and subjective measures of stress during normal activities at work and ... Full text Link to item Cite

Sex differences in the relationship between subthreshold depression and mortality in a community sample of older adults.

Journal Article Am J Geriatr Psychiatry · 2002 Featured Publication The authors investigated the increased risk of mortality from subthreshold depression and examined differences in risk by gender. Data from the Duke University Established Populations for Epidemiologic Studies of the Elderly (EPESE) longitudinal study of 4 ... Link to item Cite

Psychometric evaluation of 2 comprehensive condition-specific quality of life instruments for women with pelvic floor disorders.

Journal Article Am J Obstet Gynecol · December 2001 OBJECTIVE: To evaluate the psychometric properties of the Pelvic Floor Distress Inventory (PFDI) and the Pelvic Floor Impact Questionnaire (PFIQ). METHODS: The PFDI and PFIQ are based on the structure and content of two previously validated questionnaires ... Full text Link to item Cite

Comparison of survival after mitral valve replacement with biologic and mechanical valves in 1139 patients.

Journal Article J Thorac Cardiovasc Surg · September 2001 OBJECTIVE: We sought to compare 10-year survival in patients after mitral valve replacement with biologic or mechanical valve prostheses. METHODS: Retrospective survival analysis was performed on data from 1139 consecutive patients older than 18 years of a ... Full text Link to item Cite

Subtypes of mania determined by grade of membership analysis.

Journal Article Neuropsychopharmacology · September 2001 Featured Publication Classical descriptions of mania subtypes extend back to Kraepelin; however, in marked contrast to the study of depression subtypes, validation of mania subtypes by multivariate statistical methods has seldom been attempted. We applied Grade of Membership ( ... Full text Link to item Cite

The association of depression and mortality in elderly persons: a case for multiple, independent pathways.

Journal Article J Gerontol A Biol Sci Med Sci · August 2001 Featured Publication BACKGROUND: The evidence for an association between depression and mortality among community-dwelling elderly persons remains inconclusive, although it is well established for younger individuals. Extant studies suggest that this association weakens when a ... Full text Link to item Cite

Use and cost of outpatient visits of AD patients: CERAD XXII.

Journal Article Neurology · June 26, 2001 Featured Publication OBJECTIVE: To determine the probability, frequency, and cost of outpatient visits of patients with AD in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) as a function of stage of dementia and institutional status. METHODS: Clinical i ... Full text Link to item Cite

Toward a threshold for subthreshold depression: an analysis of correlates of depression by severity of symptoms using data from an elderly community sample.

Journal Article Gerontologist · June 2001 Featured Publication PURPOSE: The prevalence of depressive symptoms in elderly adults is high, yet the criteria to identify clinically significant depression may leave many elders undiagnosed and untreated. We explored the demographic and risk factor profiles of two groups, on ... Full text Link to item Cite

Use and cost of hospitalization of patients with AD by stage and living arrangement: CERAD XXI.

Journal Article Neurology · January 23, 2001 Featured Publication OBJECTIVE: To determine the probability, frequency, length of stay, and Medicare costs of hospitalization of institutionalized and noninstitutionalized patients with AD at various stages of dementia. METHODS: The authors analyzed the 1991 to 1995 Medicare ... Full text Link to item Cite

Psychological variables in hypertension: relationship to casual or ambulatory blood pressure in men.

Journal Article Psychosom Med · 2001 OBJECTIVE: The evidence linking hypertension with personality or psychological characteristics, such as anger, anxiety, or depression, remains equivocal. This may be due in part to limitations of personality theory, confounding by awareness of hypertension ... Full text Link to item Cite

Age, functional status, and racial differences in plasma D-dimer levels in community-dwelling elderly persons.

Journal Article J Gerontol A Biol Sci Med Sci · November 2000 Featured Publication BACKGROUND: Dysregulation of immunologic and coagulation systems is common in elderly persons and is associated with many diseases of aging. Thrombotic events are a major cause of morbidity and mortality in the elderly population. This study assesses wheth ... Full text Link to item Cite

Expert physician recommendations and current practice patterns for evaluating and treating men with osteoporotic hip fracture.

Journal Article J Am Geriatr Soc · October 2000 Featured Publication OBJECTIVES: To develop recommendations for the evaluation and the treatment of men with osteoporotic hip fracture from expert publications in the field of male osteoporosis, and to define the current practice patterns in a tertiary care VA Medical Center i ... Full text Link to item Cite

Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery.

Journal Article J Gerontol A Biol Sci Med Sci · April 2000 Featured Publication BACKGROUND: Although it has been demonstrated that physical performance measures predict incident disability in previously nondisabled older persons, the available data have not been fully developed to create usable methods for determining risk profiles in ... Full text Link to item Cite

Calcium channel blockers and cancer.

Journal Article Am J Med · February 15, 2000 Featured Publication PURPOSE: We sought to explore the relation that has been previously reported between calcium channel blockers and an increased risk of cancer. SUBJECTS AND METHODS: We followed 3,511 participants, age 65 years or older, in the Duke Established Populations ... Full text Link to item Cite

Frequency and duration of hospitalization of patients with AD based on Medicare data: CERAD XX.

Journal Article Neurology · February 8, 2000 Medicare records on 477 Consortium to Establish a Registry for Alzheimer's Disease patients with AD for 1991 through 1995 showed a hospitalization rate of 0.37/person-year with a length of stay of 3.7 days/ person-year (average of 10 days/hospitalization). ... Full text Link to item Cite

An application of generalizability theory to study a physical performance measure in Parkinson's disease.

Journal Article Aging (Milano) · February 2000 Clinicians and researchers frequently quantify impairments and functional ability to monitor patient's symptoms and progress. For some patients, such as those with Parkinson's disease (PD), symptoms can fluctuate from day to day, making reliable measuremen ... Full text Link to item Cite

The effect of race and health-related factors on naming and memory. The MacArthur Studies of Successful Aging.

Journal Article J Aging Health · February 2000 OBJECTIVES: The purpose of the analyses was to examine the impact of health-related variables on race differences in neuropsychological functioning (Boston Naming Task). METHODS: Using cross-sectional data from the MacArthur Successful Aging Study, the aut ... Full text Link to item Cite

Comorbidity of five chronic health conditions in elderly community residents: determinants and impact on mortality.

Journal Article J Gerontol A Biol Sci Med Sci · February 2000 Featured Publication BACKGROUND: Comorbidity is common in elderly persons. Its extent, correlates, and life-threatening impact in representative community residents are unclear. METHODS: Self-reported information of physician-diagnosed coronary artery disease (CAD), cerebrovas ... Full text Link to item Cite

Timed loaded standing: a measure of combined trunk and arm endurance suitable for people with vertebral osteoporosis.

Journal Article Osteoporos Int · 2000 Chronic back tiredness or fatigue is a common complaint of people who have a history of osteoporotic vertebral fracture. Trunk muscle endurance has not been studied in people with vertebral osteoporosis, partly due to the lack of assessment tools. We devel ... Full text Link to item Cite

Factors associated with self-rated health in patients with Paget's disease of bone.

Journal Article J Bone Miner Res · October 1999 Featured Publication Multiple studies show that poor self-rated health (SRH) increases the risk of mortality up to 5-fold when compared to excellent SRH. This powerful association remains even with objective health status and risk factors controlled. However, few studies have ... Full text Link to item Cite

Spinal deformity and mobility self-confidence among women with osteoporosis and vertebral fractures.

Journal Article Aging (Milano) · August 1999 Featured Publication This study evaluated the direct and indirect effects of spinal deformity on confidence in mobility among 185 older women with osteoporosis and vertebral fractures. We administered multidimensional tests of physical and psychosocial impairment and function ... Full text Link to item Cite

Spinal-flexibility-plus-aerobic versus aerobic-only training: effect of a randomized clinical trial on function in at-risk older adults.

Journal Article J Gerontol A Biol Sci Med Sci · July 1999 Featured Publication BACKGROUND: As exercise is associated with favorable health outcomes, impaired older adults may benefit from specialized exercise interventions to achieve gains in function. The purpose of this study was to determine the added benefit of a spinal flexibili ... Full text Link to item Cite

Comparison of Lewy body variant of Alzheimer's disease with pure Alzheimer's disease: Consortium to Establish a Registry for Alzheimer's Disease, Part XIX.

Journal Article Neurology · June 10, 1999 OBJECTIVE: To compare the clinical, neuropsychological, and neuropathologic findings in patients with AD alone with those in patients with the Lewy body variant of AD (LBV). BACKGROUND: Prior studies indicate that patients with LBV not only have distinct c ... Full text Link to item Cite

Reliability of physical performance tests in four different randomized clinical trials.

Journal Article Arch Phys Med Rehabil · May 1999 Featured Publication OBJECTIVES: (1) To assess the test-retest reliability of physical performance tests in subject groups with different levels of impairment and disability, and (2) to assess the stability of these tests over different time intervals. DESIGN: Test-retest, rep ... Full text Link to item Cite

Evidence for a black-white crossover in all-cause and coronary heart disease mortality in an older population: the North Carolina EPESE.

Journal Article Am J Public Health · March 1999 OBJECTIVES: This cohort study evaluated racial differences in mortality among Blacks and Whites 65 years and older. METHODS: A total of 4136 men and women (1875 Whites and 2261 Blacks) living in North Carolina were interviewed in 1986 and followed up for m ... Full text Link to item Cite

The effect of major depression on functional status in patients with coronary artery disease.

Journal Article J Am Geriatr Soc · March 1999 Featured Publication OBJECTIVE: To examine the effect of major depression on reported functional status in a group of patients with coronary artery disease (CAD). SETTING: An inpatient cardiology service. PARTICIPANTS: Three hundred thirty-five inpatients with coronary artery ... Full text Link to item Cite

Association of interleukin-6 and other biologic variables with depression in older people living in the community.

Journal Article J Am Geriatr Soc · January 1999 Featured Publication OBJECTIVES: The prevalence of depression increases with age, as does the prevalence of higher levels of the cytokine interleukin-6 (IL-6). This analysis was performed to determine the association between increased levels of this cytokine and depression in ... Full text Link to item Cite

Benzodiazepine use and cognitive function among community-dwelling elderly.

Journal Article Clin Pharmacol Ther · December 1998 Featured Publication OBJECTIVE: To evaluate the relation between benzodiazepine use and cognitive function among community-dwelling elderly. METHODS: This prospective cohort study included 2765 self-reporting subjects from the Duke Established Populations for Epidemiologic Stu ... Full text Link to item Cite

Predictors of Short-Term Changes in Serum Intact Parathyroid Hormone Levels in Hemodialysis Patients: Role of Phosphorus, Calcium, and Gender1

Journal Article The Journal of Clinical Endocrinology & Metabolism · November 1, 1998 Several factors have been identified as important in the pathogenesis of secondary hyperparathyroidism in end-stage renal disease, including serum calcium, phosphorus, and calcitriol. To examine the independent effects of key factors, we prospectiv ... Full text Cite

Racial and psychosocial risk factors for herpes zoster in the elderly.

Journal Article J Infect Dis · November 1998 Featured Publication The effects of black race and psychologic stress on the risk of acquiring herpes zoster in late life were examined. Subjects were participants of a stratified probability sample of community-dwelling persons > or = 65 years old. A comprehensive health surv ... Full text Link to item Cite

Predictors of short-term changes in serum intact parathyroid hormone levels in hemodialysis patients: role of phosphorus, calcium, and gender.

Journal Article J Clin Endocrinol Metab · November 1998 Featured Publication Several factors have been identified as important in the pathogenesis of secondary hyperparathyroidism in end-stage renal disease, including serum calcium, phosphorus, and calcitriol. To examine the independent effects of key factors, we prospectively stud ... Full text Link to item Cite

Exercise to improve spinal flexibility and function for people with Parkinson's disease: a randomized, controlled trial.

Journal Article J Am Geriatr Soc · October 1998 Featured Publication OBJECTIVES: The effectiveness of an exercise intervention for people in early and midstage Parkinson's disease (stages 2 and 3 of Hoehn and Yahr) in improving spinal flexibility and physical performance in a sample of community-dwelling older people is des ... Full text Link to item Cite

Developing a summary measure of medical status.

Journal Article Aging (Milano) · October 1998 Featured Publication Health status surveys and assessments typically obtain detailed information on specific physical health conditions. While such specific details are important, it is frequently also valuable to have a summarized evaluation of medical conditions which can be ... Full text Link to item Cite

The association of weight change in Alzheimer's disease with severity of disease and mortality: a longitudinal analysis.

Journal Article J Am Geriatr Soc · October 1998 OBJECTIVE: To describe weight loss in relation to the severity of Alzheimer's disease (AD), to identify confounders that might account for weight loss, and to investigate the association of weight change with mortality. METHODS: This study included 666 sub ... Full text Link to item Cite

Taste and smell complaints in HIV-infected patients.

Journal Article AIDS · September 10, 1998 Featured Publication OBJECTIVES: To define the scope of taste and smell (chemosensory) complaints amongst HIV-infected persons in the study population; to evaluate the clinical factors associated with chemosensory complaints; and to determine the impact of chemosensory complai ... Full text Link to item Cite

Depression and social support in elderly patients with cardiac disease.

Journal Article Am Heart J · September 1998 Featured Publication BACKGROUND: Depression is common among patients with cardiac disease. A number of psychosocial factors may affect the relationship between physical health and depression. There is evidence from the psychiatric literature suggesting that negative life event ... Full text Link to item Cite

Private health insurance coverage and disability among older Americans.

Journal Article J Gerontol B Psychol Sci Soc Sci · September 1998 Featured Publication OBJECTIVES: This study examines the relationship between the lack of private supplemental health insurance coverage and the development of disability among adults aged 65 and older. METHODS: Data are from the baseline and six follow-up waves of the Duke Es ... Full text Link to item Cite

Race and stress in the incidence of herpes zoster in older adults.

Journal Article J Am Geriatr Soc · August 1998 Featured Publication OBJECTIVES: To examine the effect of black race and acute (negative life events) and chronic (lack of social support) psychological stress on the risk of herpes zoster in late life. DESIGN: A population-based, prospective cohort study. SETTING: Central Nor ... Full text Link to item Cite

Is there a threshold between peak oxygen uptake and self-reported physical functioning in older adults?

Journal Article Med Sci Sports Exerc · August 1998 Featured Publication PURPOSE: Few studies have examined the relationship between directly measured oxygen uptake (VO2) and self-reported physical function (PF). The purpose of this study was: 1) to examine the relationship between peak V02 and PF and 2) to determine whether a ... Full text Link to item Cite

Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease.

Journal Article Neurology · July 1998 Featured Publication OBJECTIVE: To study the relation between cerebral infarction and clinical and neuropsychologic manifestations in patients with autopsy-proven Alzheimer's disease (AD) enrolled in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). BACKG ... Full text Link to item Cite

Medication use patterns among demented, cognitively impaired and cognitively intact community-dwelling elderly people.

Journal Article Age Ageing · July 1998 OBJECTIVE: To determine whether medication use patterns in community-dwelling elderly people vary with level of cognitive function-dementia, cognitive impairment (but not dementia) and intact cognition. DESIGN: Cross-sectional survey. SETTING: A five-count ... Full text Link to item Cite

Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly.

Journal Article Am J Med · May 1998 Featured Publication PURPOSE: To determine if there is an increased prevalence of monoclonal gammopathy in elderly blacks compared with whites, analogous to the difference in incidence of multiple myeloma reported for the two racial groups and to confirm age and gender relatio ... Full text Link to item Cite

Physical fitness and functional limitations in community-dwelling older adults.

Journal Article Med Sci Sports Exerc · May 1998 Featured Publication BACKGROUND: Conceptual models of disability have focused on disease-specific factors as the primary cause of disability. Functional limitations in the performance of basic tasks are considered primary mediators on the causal pathway from disease to disabil ... Full text Link to item Cite

The generalizability of cardiovascular responses across settings.

Journal Article J Psychosom Res · February 1998 The generalizability of cardiovascular reactivity change scores remains largely unsupported. In previous studies, several factors differed between laboratory and field, making poor lab-to-life correlations difficult to interpret. The present study varied o ... Full text Link to item Cite

Caffeine raises blood pressure at work.

Journal Article Psychosom Med · 1998 Featured Publication OBJECTIVE: The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS: Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of ... Full text Link to item Cite

Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Treatments.

Journal Article Crit Care Med · December 1997 Featured Publication OBJECTIVE: To determine if body mass Index (BMI = weight [kg]/height [m]2), predictive of mortality in longitudinal epidemiologic studies, was also predictive of mortality in a sample of seriously ill hospitalized subjects. DESIGN: Prospective, multicenter ... Full text Link to item Cite

Adverse events after discontinuing medications in elderly outpatients.

Journal Article Arch Intern Med · October 27, 1997 Featured Publication BACKGROUND: Discontinuation of drug therapy is an important intervention in elderly outpatients receiving multiple medications, but it may be associated with adverse drug withdrawal events (ADWEs). OBJECTIVE: To determine the frequency, types, timing, seve ... Link to item Cite

Psychosocial and physical correlates of chronic depression.

Journal Article Psychiatry Res · October 10, 1997 Featured Publication This study used a case-control design to address differences in psychosocial, physical and clinical profiles between subjects who presented with a chronic index episode of major depression and those who presented with a non-chronic index episode. Subjects ... Full text Link to item Cite

Depression in medically ill hospitalized older adults: prevalence, characteristics, and course of symptoms according to six diagnostic schemes.

Journal Article Am J Psychiatry · October 1997 Featured Publication OBJECTIVE: The purpose of this study was to examine and compare rates of depression, correlates, and course of symptoms in medically ill hospitalized elders through use of six diagnostic schemes (inclusive, etiologic, exclusive-inclusive, exclusive-etiolog ... Full text Link to item Cite

The association of plasma IL-6 levels with functional disability in community-dwelling elderly.

Journal Article J Gerontol A Biol Sci Med Sci · July 1997 Featured Publication BACKGROUND: IL-6 is a multifunctional cytokine that has been shown to increase with age. METHODS: Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly subjects whose blood was drawn during the third in-person survey of the Duke Established ... Full text Link to item Cite

Peyronie's disease is associated with Paget's disease of bone.

Journal Article J Bone Miner Res · June 1997 Featured Publication Peyronie's disease is an idiopathic disorder in which an inflammatory fibrosis occurs in the tunica albuginea of the corpora cavernosa which causes the erect penis to become deformed. Peyronie's disease has a prevalence of 1% in men over age 50 years. Page ... Full text Link to item Cite

Psychosocial correlates of job strain in a sample of working women.

Journal Article Arch Gen Psychiatry · June 1997 Featured Publication BACKGROUND: This study identifies potential mediators of job strain effects on health by determining whether psychosocial factors known to predict an increased risk of cardiovascular disease and all-cause mortality are higher among women who report high le ... Full text Link to item Cite

Predictors of time to institutionalization of patients with Alzheimer's disease: the CERAD experience, part XVII.

Journal Article Neurology · May 1997 We studied the time to institutionalization (or death as the first event) in 727 white patients with Alzheimer's disease (AD) enrolled in the Consortium to Establish a Registry for Alzheimer's disease (CERAD). At the time of analysis, 417 patients had been ... Full text Link to item Cite

Relationship of job strain to standard coronary risk factors and psychological characteristics in women and men of the Family Heart Study.

Journal Article Health Psychol · May 1997 This study reports on standard coronary risk factors (plasma lipids and lipoproteins, blood pressure, heart rate, age, body mass index) and psychosocial variables (job strain, Type A behavior, hostility, illnesses, medical and psychological symptoms, healt ... Full text Link to item Cite

Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.

Journal Article Ann Epidemiol · February 1997 Featured Publication PURPOSE: To evaluate the relationship of nonsteroidal antiinflammatory drug (NSAID) use to level of cognitive function in community-dwelling elderly persons. METHODS: The prospective cohort study included 2765 nonproxy subjects from the Duke University Est ... Full text Link to item Cite

An empirical evaluation of the predictive mean matching method for imputing missing values

Journal Article Sociological Methods and Research · January 1, 1997 This article reports empirical explorations of how well the predictive mean matching method for imputing missing data works for an often problematic variable - income -when income is used as an explanatory variable in a substantive regression model. It is ... Full text Cite

Reliability of impairment and physical performance measures for persons with Parkinson's disease.

Journal Article Phys Ther · January 1997 BACKGROUND AND PURPOSE: Parkinson's disease (PD) is characterized by rigidity, postural instability, bradykinesia, and tremor, as well as other musculoskeletal impairments and functional limitations. The purpose of this investigation was to determine the r ... Full text Link to item Cite

Effects of psychological stress on human semen quality.

Journal Article J Androl · 1997 We investigated the relationship between psychological stress and sperm concentration, motility, and morphometry in a prospective study of 157 volunteers who were enrolled in a prepaid health plan. We measured psychological job stress and life-event stress ... Link to item Cite

Paget's disease of bone and quality of life.

Journal Article J Bone Miner Res · December 1996 Featured Publication Little is known about how Paget's disease of bone affects quality of life. To better understand the relative impact of factors on quality of life, we mailed a brief survey to 2000 people randomly selected from the Paget's Foundation mailing list. The sampl ... Full text Link to item Cite

The application of generalizability theory to blood pressure resting levels and mental stress responses

Journal Article Blood Pressure Monitoring · December 1, 1996 Background: Blood pressure measurements taken in the clinic or laboratory are assumed to generalize to the world outside. This is true both of casual blood pressure measurements and of changes in blood pressure responses to stress. Such generalizability is ... Cite

Pain measurement in elders with chronic low back pain: traditional and alternative approaches.

Journal Article Pain · October 1996 Pain evaluation typically relies upon the use of self-report instruments. The validity of these tools is questionable in many older adults, however, particularly those with cognitive impairment. Rating of pain behavior (e.g. grimacing, sighing) by an objec ... Full text Link to item Cite

Five-year performance trends for older exercisers: a hierarchical model of endurance, strength, and flexibility.

Journal Article J Am Geriatr Soc · October 1996 Featured Publication OBJECTIVE: To examine 5-year trends in measures of physical performance, and the impact of disease upon performance, in three domains: cardiovascular fitness, musculo-skeletal strength, and flexibility among older adults participating in a medically superv ... Full text Link to item Cite

The reliability, validity, and stability of a measure of physical activity in the elderly.

Journal Article Arch Phys Med Rehabil · August 1996 OBJECTIVE: To assess the reliability, validity, and stability of an accelerometer-based monitor of physical activity in an elderly population. DESIGN: Six studies were conducted to assess the Tritrac, a newly available accelerometer capable of storing thre ... Full text Link to item Cite

Medical illness, religion, health control and depression of institutionalized medically ill veterans in long-term care

Journal Article International Journal of Geriatric Psychiatry · July 1, 1996 Utilizing multivariable multivariate regression procedures, we examine the relationships among medical illness, religion, health control beliefs and depression in 97 mostly elderly, institutionalized medically ill veterans in long term-care. Controlling fo ... Full text Cite

Job stress and preeclampsia.

Journal Article Epidemiology · May 1996 Featured Publication We conducted a case-control study to determine whether job strain (or stress) during pregnancy resulted in an increased risk of preeclampsia. We compared 110 nulliparous Caucasian and African-American women who had preeclampsia with 115 healthy nulliparous ... Full text Link to item Cite

Do racial differences in hypertension persist in successful agers? Findings from the MacArthur Study of Successful Aging.

Journal Article J Aging Health · May 1996 Featured Publication The objective of this study was to determine whether racial differences in hypertension in a random sample of community-dwelling older adults also remained significant in a sample of successful agers. Data for the random sample of community-dwelling older ... Full text Link to item Cite

Sit to stand from progressively lower seat heights -- alterations in angular velocity.

Journal Article Clin Biomech (Bristol) · April 1996 This study investigates the influence of chair height on the dynamics of sit-to-stand for two age groups. Eleven young (25-36 years) and 10 older (61-79 years) adults participated. Subjects rose from chairs set at four heights relative to knee height. Moti ... Full text Link to item Cite

The consortium to establish a registry for Alzheimer's disease (CERAD). Part XIV: Demographic and clinical predictors of survival in patients with Alzheimer's disease.

Journal Article Neurology · March 1996 We made follow-up observations on 1,036 Consortium to Establish a Registry for Alzheimer's Disease (CERAD) patients with Alzheimer's disease (AD) enrolled in 21 university medical centers in the United States. Evaluations were scheduled annually for as lon ... Full text Link to item Cite

Weight change in Alzheimer's disease.

Journal Article J Am Geriatr Soc · March 1996 PURPOSE: To determine the natural history of weight change and the occurrence of clinically significant weight loss in subjects with Alzheimer's disease (AD). PATIENTS AND METHODS: Subjects with AD and cognitively normal older controls were recruited from ... Full text Link to item Cite

The perceived racism scale: a multidimensional assessment of the experience of white racism among African Americans.

Journal Article Ethn Dis · 1996 Featured Publication The experience of racism is a complex, multidimensional phenomenon. At present, there are few instruments that attempt to capture the experience of racism in all of its complexity. For this study, a new instrument, the Perceived Racism Scale, has been cons ... Link to item Cite

Risk factors for nosocomial pneumonia: comparing adult critical-care populations.

Journal Article Am J Respir Crit Care Med · January 1996 The purpose of the study was to examine risk factors for nosocomial pneumonia in the surgical and medical/respiratory intensive care unit (ICU) populations. In a public teaching hospital, all cases of nosocomial pneumonia in the surgical and medical/respir ... Full text Link to item Cite

Psychologic stress in the workplace and spontaneous abortion.

Journal Article Am J Epidemiol · December 1, 1995 The relation of work-related psychologic stress to spontaneous abortion was examined in a prospective study of 3,953 pregnant, employed members of a prepaid health plan in California, recruited between 1990 and 1991. Information on occupation, psychologic ... Full text Link to item Cite

Functional and mobility impairments associated with Paget's disease of bone.

Journal Article J Am Geriatr Soc · May 1995 Featured Publication OBJECTIVE: To determine if patients with Paget's disease of bone involving the tibia, femur, and/or acetabular portion of the ilium had more impairments in function and mobility than age- and sex-matched control subjects. PATIENTS AND METHODS: A case contr ... Full text Link to item Cite

Racial differences in the occurrence of herpes zoster.

Journal Article J Infect Dis · March 1995 Featured Publication The purpose of this study was to determine if there are racial differences in the occurrence of herpes zoster (shingles). The study population was the Duke Established Populations for Epidemiologic Studies of the Elderly, a probability sample of community- ... Full text Link to item Cite

The ambulatory blood pressure in normotensive and hypertensive subjects: results from an international database.

Journal Article Neth J Med · February 1995 OBJECTIVE: To delineate more precisely an operational threshold for making clinical decisions based on ambulatory blood pressure (ABP) measurement by studying the ABP in subjects who were diagnosed as either normotensive or hypertensive by conventional blo ... Full text Link to item Cite

Effects of racist provocation and social support on cardiovascular reactivity in African American women.

Journal Article Int J Behav Med · 1995 Featured Publication It has been speculated that exposure to the chronic stress of racism contributes to the high rates of hypertension among African Americans. Social support may buffer the effects of stress on cardiovascular (CV) health by attenuating stress-induced CV respo ... Full text Link to item Cite

Improved spatial resolution for cardiac mapping using current source density-based electrode arrays.

Journal Article Pacing Clin Electrophysiol · January 1995 The time of the minimum slope (i.e., the fastest negative deflection) in monopolar (MP) electrograms from normal hearts compares closely with time of phase 0 of the action potential in cells underlying the electrode, but poor rejection of far-field activit ... Full text Link to item Cite

Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects.

Journal Article Am J Clin Pathol · December 1994 Because obtaining multiple blood samples from individuals involved in epidemiologic studies is difficult, conclusions must be drawn on the basis of one or two samples. In this study, the authors attempted to determine the variability of two plasma markers ... Full text Link to item Cite

Spectral analysis of activation time sequences.

Journal Article Pacing Clin Electrophysiol · July 1994 Adequate spatial resolution of local activation is fundamental for the correct depiction of myocardial activation during ablative treatment of ventricular tachycardia. The widest allowable distances between recording sites that provide an accurate descript ... Full text Link to item Cite

Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer.

Journal Article Cancer · May 1, 1994 Featured Publication BACKGROUND: Several molecular-genetic alterations in endometrial cancers, including aneuploidy and aberrant expression of p53 and HER-2/neu, have been associated with poor prognosis. To determine the importance of molecular-genetic factors relative to more ... Full text Link to item Cite

Nutrition and function: is there a relationship between body mass index and the functional capabilities of community-dwelling elderly?

Journal Article J Am Geriatr Soc · April 1994 Featured Publication OBJECTIVE: To determine if there is a relationship between body mass index and the ability to perform the usual activities of living in a sample of community-dwelling elderly. DESIGN: Secondary data analysis of The National Health and Nutrition Examination ... Full text Link to item Cite

Anticipatory and residual effects of an active coping task on pre- and post-stress baselines.

Journal Article J Psychosom Res · February 1994 This study examined several issues concerning baseline measurement in cardiovascular reactivity testing: effects of anticipation of stress on baseline, point at which initial baseline stabilizes, effects of a stressful task on a succeeding baseline, and ge ... Full text Link to item Cite

Ambulatory blood pressure in normotensive and hypertensive subjects: Results from an international database

Journal Article Journal of Hypertension · January 1, 1994 Objective: To delineate more precisely an operational threshold for making clinical decisions based on ambulatory blood pressure (ABP) measurement by studying the ABP in subjects who were diagnosed as either normotensive or hypertensive by conventional blo ... Cite

Ambulatory blood pressure in normotensive and hypertensive subjects: results from an international database.

Journal Article J Hypertens Suppl · 1994 OBJECTIVE: To delineate more precisely an operational threshold for making clinical decisions based on ambulatory blood pressure (ABP) measurement by studying the ABP in subjects who were diagnosed as either normotensive or hypertensive by conventional blo ... Link to item Cite

Sociodemographic correlates of health beliefs among black and white community dwelling elderly individuals.

Journal Article Int J Aging Hum Dev · 1994 Featured Publication This study examined the hypothesis that sociodemographic characteristics such as age, education, race, and gender would be predictive of Multidimensional Health Locus of Control Subscale scores in a population-based sample of 342 community dwelling elderly ... Full text Link to item Cite

Caffeine and cholesterol: interactions with hostility.

Journal Article Psychosom Med · 1994 Featured Publication The consumption of caffeinated beverages has been linked to elevated serum cholesterol and an increased risk of coronary disease, although the relationships are inconsistent across studies and remain controversial. The effect of caffeine on cholesterol and ... Full text Link to item Cite

A test of generalizability of cardiovascular reactivity using a controlled ambulatory procedure.

Journal Article Psychosom Med · 1994 This study tested the hypothesis that reports of poor generalizability of cardiovascular reactivity measured in the laboratory to changes observed during everyday life are due to a lack of standardization of activities and position (sitting, standing) in t ... Full text Link to item Cite

Short report: ambulatory blood pressure in normotensive compared with hypertensive subjects. The Ad-Hoc Working Group.

Journal Article J Hypertens · November 1993 OBJECTIVE: To delineate more precisely an operational threshold for making clinical decisions based on ambulatory blood pressure (ABP) measurement by studying the ABP in subjects who were diagnosed as either normotensive or hypertensive by conventional blo ... Link to item Cite

A test of reproducibility of blood pressure and heart rate variability using a controlled ambulatory procedure.

Journal Article J Hypertens · October 1993 OBJECTIVE: To determine whether the previously reported poor reproducibility of blood pressure variability measured by ambulatory blood pressure monitoring (ABPM) is due to the uncontrolled nature of physical and mental activity during the monitoring perio ... Full text Link to item Cite

Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging.

Journal Article J Am Geriatr Soc · July 1993 Featured Publication OBJECTIVE: To assess the validity of several equations for estimating creatinine clearance in a large sample of high-functioning, community-dwelling elderly. DESIGN: Serum and 12-hour urine samples were collected and assayed for creatinine using the Jaffe ... Full text Link to item Cite

Measurement reliability of cardiovascular reactivity change scores: a comparison of intermittent and continuous methods of assessment.

Journal Article J Psychosom Res · July 1993 Cardiovascular reactivity testing is a widely used measure of risk for hypertension and coronary heart disease. Evidence for the reliability of the measures, however, is weak. If the measures (usually change scores) are unreliable, the usefulness of testin ... Full text Link to item Cite

Association of osteoporotic vertebral compression fractures with impaired functional status.

Journal Article Am J Med · June 1993 Featured Publication PURPOSE: To determine if vertebral compression fractures in elderly women were associated with impairments in physical, functional, and psychosocial performance. SUBJECTS AND METHODS: Ten white women with confirmed vertebral compression fractures were age- ... Full text Link to item Cite

The epicardial field potential in dog: implications for recording site density during epicardial mapping.

Journal Article Pacing Clin Electrophysiol · June 1993 Investigations into mechanisms and successful surgical therapy of ventricular tachycardia (VT) depend upon accurate endocardial/epicardial mapping. Deduction of local activation is based upon parameters derived from the field potential (FP) (monopolar reco ... Full text Link to item Cite

Simultaneously collected monopolar and discrete bipolar electrograms: comparison of activation time detection algorithms.

Journal Article Pacing Clin Electrophysiol · March 1993 Designation of the time of local activation is fundamental to electrophysiological mapping. In normal myocardium, the minimum slope in extracellular monopolar (MP) electrograms has been linked through simultaneous intracellular and extracellular recordings ... Full text Link to item Cite

A comparison of ambulatory blood pressure and heart rate at home and work on work and non-work days.

Journal Article J Hypertens · February 1993 OBJECTIVES: First, to test whether there was a change in the blood pressure and heart rate on work days relative to non-work days; secondly, to assess whether there were work-home differences on these days; and, thirdly, to assess whether these changes wer ... Full text Link to item Cite

Assessment of cardiovascular reactivity: a methodological overview.

Journal Article Ethn Dis · 1993 The purpose of this article is to provide an overview of the rationale and methodological procedures for the assessment of cardiovascular reactivity. We hope that this introduction to the field will facilitate studies on cardiovascular reactivity in popula ... Link to item Cite

Religious coping and depression among elderly, hospitalized medically ill men.

Journal Article Am J Psychiatry · December 1992 OBJECTIVE: The investigators examined the frequency of religious coping among older medical inpatients, the characteristics of those who use it, and the relation between this behavior and depression. METHOD: The subjects were 850 men aged 65 years and over ... Full text Link to item Cite

Observations on the epicardial activation of the normal human heart.

Journal Article Pacing Clin Electrophysiol · December 1992 Serial hand mapping techniques in man have identified 3 to 5 sites of epicardial breaktrough (EBT). However, transmural epicardial excitation from the widely distributed His/Purkinje system suggests a more complicated pattern may exist. Multielectrode arra ... Full text Link to item Cite

The impact of anticipation of job loss on psychological distress and worksite blood pressure.

Journal Article Am J Ind Med · 1992 Featured Publication The impact of occupational stressful life events on psychological distress and blood pressure was examined among employees of a major New York City brokerage firm undergoing massive layoffs. One hundred thirty-nine employees of the firm, who had participat ... Full text Link to item Cite

The effect of legal drinking age on fatal injuries of adolescents and young adults.

Journal Article Am J Public Health · January 1992 Featured Publication This study examined the effect of legal drinking age (LDA) on fatal injuries in persons aged 15 to 24 years in the United States between 1979 and 1984. Effects on pre-LDA teens, adolescents targeted by LDA, initiation at LDA, and post-LDA drinking experien ... Full text Link to item Cite

Social support in social interaction: a moderator of cardiovascular reactivity.

Journal Article Psychosom Med · 1992 This study examines the possibility that social support operates as a moderator of cardiovascular reactivity, which may be a factor in the development of heart disease and hypertension. An experiment was performed in which each of 40 subjects was the objec ... Full text Link to item Cite

The multi-dimensional nature of active coping: differential effects of effort and enhanced control on cardiovascular reactivity.

Journal Article Psychosom Med · 1992 Some studies show that enhanced control increases cardiovascular reactivity; other studies show decreases. This disparity may be due to a confound: enhanced control may reduce reactivity, but effort accompanying active coping may increase it. The present s ... Full text Link to item Cite

Can behavioural factors produce a sustained elevation of blood pressure? Some observations and a hypothesis.

Journal Article J Hypertens Suppl · December 1991 Featured Publication A major problem confronting behavioural theories of hypertension, such as the reactivity hypothesis, is that stress is likely to be intermittent, whereas the early stages of hypertension appear to be characterized by an increase in the tonic level of blood ... Link to item Cite

Influence of time of sampling onset on parameters used for activation time determination in computerized intraoperative mapping.

Journal Article Pacing Clin Electrophysiol · December 1991 The purpose of this work is to determine the sensitivity of the estimated time of peaks and maximum slopes, commonly used in activation time computations, to the instant at which sampling is initiated. Based on complex and quickly changing waveforms, 471 m ... Full text Link to item Cite

The range and limits of 'normal' ambulatory blood pressure

Journal Article Journal of Hypertension · December 1, 1991 Cite

Can behavioural factors produce a sustained elevation of blood pressure? Some observations and a hypothesis

Journal Article Journal of Hypertension · December 1, 1991 A major problem confronting behavioural theories of hypertension, such as the reactivity hypothesis, is that stress is likely to be intermittent, whereas the early stages of hypertension appear to be characterized by an increase in the tonic level of blood ... Cite

Design and implementation of a new computerized system for intraoperative cardiac mapping.

Journal Article J Appl Physiol (1985) · October 1991 A rapid, portable, yet inexpensive and expandable computer-based system utilizing current technology has been developed from experience in the operating room. An efficient operating system well suited for surgery is defined. New technology recording arrays ... Full text Link to item Cite

Bandwidth-induced errors in parameters used for automated activation time determination during computerized intraoperative cardiac mapping: theoretical limits.

Journal Article Pacing Clin Electrophysiol · February 1991 Two parameters commonly used when determining the time of local activation during computerized intraoperative cardiac mapping are the time of the peak in bipolar electrograms (BP) and the time of the largest negative slope (LNS) in monopolar electrograms ( ... Full text Link to item Cite

Activation Time Detection Algorithms Used in Computerized Intraoperative Cardiac Mapping: A Comparison with Manually Determined Activation Times

Journal Article Journal of Cardiovascular Electrophysiology · January 1, 1991 Activation Time Detection for Intraoperative Mapping. Introduction: Local activation determined from monopolar electrograms usually is marked at the time of the minimum slope. In bipolar recordings, the peak, the maximum absolute slope, the baseline crossi ... Full text Cite

The role of behavioral factors in white coat and sustained hypertension.

Journal Article J Hypertens Suppl · December 1990 Studies using ambulatory monitoring of blood pressure have indicated that patients with persistently elevated clinic pressures may be subdivided into two groups, those in whom ambulatory pressure is also elevated (persistent hypertension), and those in who ... Link to item Cite

The relationship between 'job strain,' workplace diastolic blood pressure, and left ventricular mass index. Results of a case-control study.

Journal Article JAMA · April 11, 1990 To determine whether "job strain" (defined as high psychological demands and low decision latitude on the job) is associated with increased workplace diastolic blood pressure and the left ventricular mass index, we conducted a case-control study at seven u ... Link to item Cite

Experience with Kapton‐Based Bipolar Electrode Arrays Used During Computerized Intraoperative Mapping

Journal Article Journal of Cardiovascular Electrophysiology · January 1, 1990 Kapton Arrays for Computerized Mapping. A new technology for intraoperative mapping of the sites of origin and propagation of supraventricular (SVT) and ventricular tachycardia (VT) was implemented and evaluated. Kapton forms a thin, flexible substrate on ... Full text Cite

The relation of psychosocial dimensions of work with coronary heart disease risk factors: a meta-analysis of five United States data bases.

Journal Article Am J Epidemiol · March 1989 The relation of job psychologic demands and decision latitude to four coronary heart disease risk factors (cholesterol, smoking, and systolic and diastolic blood pressures) was tested among 12,555 men in five investigations conducted in the United States d ... Full text Link to item Cite

A procedure for linking psychosocial job characteristics data to health surveys.

Journal Article Am J Public Health · August 1988 Featured Publication A system is presented for linking information about psychosocial characteristics of job situations to national health surveys. Job information can be imputed to individuals on surveys that contain three-digit US Census occupation codes. Occupational mean s ... Full text Link to item Cite

Job characteristics in relation to the prevalence of myocardial infarction in the US Health Examination Survey (HES) and the Health and Nutrition Examination Survey (HANES).

Journal Article Am J Public Health · August 1988 Featured Publication Associations between psychosocial job characteristics and past myocardial infarction (MI) prevalence for employed males were tested with the Health Examination Survey (HES) 1960-61, N = 2,409, and the Health and Nutrition Examination Survey (HANES) 1971-75 ... Full text Link to item Cite

TBI and Increased Risk of Non-Alzheimer’s disease dementia in older male twins

Conference Background: Several studies have reported an association between traumatic brain injury(TBI) and increased risk of Alzheimer’s disease(AD) and all cause dementia. Considering the heterogeneous genetic and environmental factors that may contribute to develo ... Full text Link to item Cite