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Assessing patient perceptions of cytomegalovirus infection in pregnancy.

Publication ,  Journal Article
Siegel, AM; Clinton, CM; Post, AL; Truong, T; Pieper, CF; Hughes, BL
Published in: J Med Virol
December 2020

Pregnant women impacted by cytomegalovirus (CMV) make clinical decisions despite uncertain outcomes. Intolerance of uncertainty score (IUS) is a validated measure of tendency for individuals to find unacceptable that a negative event might occur. We investigated patient perceptions of CMV infection during pregnancy and correlated IUS and knowledge with decision-making. Electronic questionnaire was sent to women from July to August 2017. The questionnaire evaluated knowledge of CMV, IUS, and responses regarding management to three clinical scenarios with escalating risk of CMV including choices for no further testing, ultrasound, amniocentesis, or abortion. For each scenario, logistic regression was used to model IUS on responses. A total of 815 women were included. The majority of participants was white (63.1%) and 42% had a postgraduate degree. Over 70% reported that they had not previously heard of CMV. In the scenario with only CMV exposure, participants with increasing IUS were more likely to choose abortion (odds ratio [OR]  =  1.04; 95% confidence interval [CI]: 1.01, 1.06) and no further testing (OR  =  0.97; 95% CI: 0.95, 0.99). In the scenario with mild ultrasound findings in setting of CMV exposure, increasing IUS was associated with higher odds of choosing no further testing (OR = 0.97; 95% CI, 0.94, 0.99). No significant association was observed between IUS and responses in the scenario with severe ultrasound abnormalities in setting of CMV exposure. The majority of patients had no knowledge of CMV. Higher IUS was associated more intervention in low severity scenarios, but in severe scenarios, IUS was not associated with participants' choices.

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Published In

J Med Virol

DOI

EISSN

1096-9071

Publication Date

December 2020

Volume

92

Issue

12

Start / End Page

3658 / 3664

Location

United States

Related Subject Headings

  • Virology
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

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Chicago
ICMJE
MLA
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Siegel, A. M., Clinton, C. M., Post, A. L., Truong, T., Pieper, C. F., & Hughes, B. L. (2020). Assessing patient perceptions of cytomegalovirus infection in pregnancy. J Med Virol, 92(12), 3658–3664. https://doi.org/10.1002/jmv.25714
Siegel, Anne M., Chelsea M. Clinton, Annalisa L. Post, Tracy Truong, Carl F. Pieper, and Brenna L. Hughes. “Assessing patient perceptions of cytomegalovirus infection in pregnancy.J Med Virol 92, no. 12 (December 2020): 3658–64. https://doi.org/10.1002/jmv.25714.
Siegel AM, Clinton CM, Post AL, Truong T, Pieper CF, Hughes BL. Assessing patient perceptions of cytomegalovirus infection in pregnancy. J Med Virol. 2020 Dec;92(12):3658–64.
Siegel, Anne M., et al. “Assessing patient perceptions of cytomegalovirus infection in pregnancy.J Med Virol, vol. 92, no. 12, Dec. 2020, pp. 3658–64. Pubmed, doi:10.1002/jmv.25714.
Siegel AM, Clinton CM, Post AL, Truong T, Pieper CF, Hughes BL. Assessing patient perceptions of cytomegalovirus infection in pregnancy. J Med Virol. 2020 Dec;92(12):3658–3664.
Journal cover image

Published In

J Med Virol

DOI

EISSN

1096-9071

Publication Date

December 2020

Volume

92

Issue

12

Start / End Page

3658 / 3664

Location

United States

Related Subject Headings

  • Virology
  • 3207 Medical microbiology
  • 3202 Clinical sciences
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology