Brenna L Hughes | Scholars@Duke

Brenna L Hughes
Associate Professor of Obstetrics and Gynecology

Current Appointments & Affiliations

Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2018

Contact Information

Background
Education, Training, & Certifications
- M.D., Brown University 1999
Medical Licensure
- 2016-02015. North Carolina. 2019
Previous Appointments & Affiliations
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2017 - 2018
- Instructor, Temporary in the Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2016 - 2017
Leadership & Clinical Positions at Duke
- - Vice-Chair Obstetrics and Quality
  - Division Chief Maternal Fetal Medicine
  - CSU Director- Women's
Academic Positions Outside Duke
- Fellowship Director, Warren Alpert Medical School of Brown University. 2015 - 2016
- Director, Women and Infants Hospital. 2014 - 2016
- Associate Professor, Warren Alpert Medical School of Brown University. 2012 - 2016
- Assistant Professor, Warren Alpert Medical School of Brown University. 2006 - 2012
Recognition
In the News
- MAR 19, 2020
  
  Duke Faculty Take Lead on Policy Papers Recommendations on COVID Response
Awards & Honors
Research
Selected Grants
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2016 - 2026
- Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program awarded by National Institutes of Health 2021 - 2026
- Population Health Research Support IDIQ Base awarded by National Institutes of Health 2018 - 2025
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
- MFMU Network Studies 2021 awarded by University of North Carolina - Chapel Hill 2021 - 2025
- Large-scale Implementation of Community Co-led Maternal Sepsis Care Practices to Reduce Morbidity and Mortality from Maternal Infection awarded by National Institutes of Health 2021 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A awarded by National Institutes of Health 2019 - 2023
- VTEU HHSN272201300017I/75N93019F00132-FY2020.A1B1C1D1.0123 Task Order #17 16-0076 Task C Option 3 & Task D Option 6 Extension awarded by National Institutes of Health 2021 - 2022
- Clinical and viral characteristics of maternal cytomegalovirus infection among seropositive pregnant women in the United States awarded by National Institutes of Health 2018 - 2022
- PTN_TO51_BMS01 PK and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants awarded by Duke Clinical Research Institute 2018 - 2022
- 2/5 HEAL Consortium: Establishing Innovative Approaches for the HEALthy Brain and Child Development Study awarded by National Institutes of Health 2019 - 2022
- TIME Aim of the Study of Pregnancy and Neonatal Health (SPAN) Task Order A awarded by National Institutes of Health 2020 - 2021
- MFMU Network Study - Maternal Morbidity and Mortality During the COVID-19 Pandemic awarded by University of North Carolina - Chapel Hill 2020 - 2021
- Chronic Hypertension and Pregnancy (CHAP) NHLBI Multi-Site RCT awarded by University of Alabama at Birmingham 2014 - 2021
- MFMU Network Study - AWARE awarded by University of North Carolina - Chapel Hill 2020 - 2021
- MFMU Network Study - PACT awarded by University of North Carolina - Chapel Hill 2020 - 2021
- MFMU Network Study - Prematurity Registry: An Observational Cohort Study of Obstetrical Determinants of Preterm Delivery and Neonatal Outcome awarded by University of North Carolina - Chapel Hill 2020 - 2021
- MFMU Network Studies - PREP awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - PROSPECT awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - SLEEP awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - TOPS awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - TXA awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Clinical Center Participation awarded by University of North Carolina - Chapel Hill 2017 - 2021
- Data Coordinating Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units (MFMU) awarded by The George Washington University 1998 - 2021
- Humoral immune correlates of protection against congenital CMV and HSV transmission in HIV-infected women awarded by National Institutes of Health 2019 - 2020
- The Role of Calcium Homeostasis in Regulating Uterine Contractility and Tone awarded by National Institutes of Health 2019 - 2020
- Rapid, Near Patient Nucleic Acid Testing for Infant Cytomegalovirus (CMV) Infection awarded by Baebies, Inc 2017 - 2020
- Data Coordinating Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units (MFMU) awarded by The George Washington University 2018 - 2019
- VTEU 12-0021 Task C - Base awarded by National Institutes of Health 2016 - 2018
- VTEU 12-0021 - Task C Option 1 awarded by National Institutes of Health 2017 - 2018
- Effect of Latrogenic Delivery at 34-38 Weeks Gestation on Pregnancy Outcome awarded by Women & Infants Hospital 2016 - 2017
External Relationships
- American Board of Obstetrics and Gynecology
- Johns Hopkins University School of Medicine
- Merck
- Society for maternal fetal medicine
- UpToDate, Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gilner, Jennifer, Namita Kansal, Joseph R. Biggio, Shani Delaney, Chad A. Grotegut, Erica Hardy, Adi Hirshberg, et al. “Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing for Obstetric Inpatient Units Across the United States.” Clin Infect Dis 75, no. 1 (August 24, 2022): e322–28. https://doi.org/10.1093/cid/ciab955.
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  - Metz, T. D., R. G. Clifton, B. L. Hughes, G. J. Sandoval, W. A. Grobman, G. R. Saade, T. A. Manuck, et al. “Association of SARS-CoV-2 Infection with Serious Maternal Morbidity and Mortality from Obstetric Complications.” Obstetrical and Gynecological Survey 77, no. 8 (August 1, 2022): 457–59. https://doi.org/10.1097/01.ogx.0000852884.16321.fd.
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  - Nguyen, Nguyen Thao Thi, Kelli Kurtovic, Courtney Mitchell, Marie Evangelista, Rhiann Del Valle, Sarah McWay Boling, and Brenna L. Hughes. “Improving treatment of severe hypertension in pregnancy and postpartum using a hypertensive pathway.” Pregnancy Hypertens 30 (July 29, 2022): 1–6. https://doi.org/10.1016/j.preghy.2022.07.007.
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  - Dinsmoor, Mara J., Lida M. Fette, Brenna L. Hughes, Dwight J. Rouse, George R. Saade, Uma M. Reddy, Donna Allard, et al. “Amniocentesis to diagnose congenital cytomegalovirus infection following maternal primary infection.” Am J Obstet Gynecol Mfm 4, no. 4 (July 2022): 100641. https://doi.org/10.1016/j.ajogmf.2022.100641.
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  - Tita, Alan T., Jeff M. Szychowski, Kim Boggess, Lorraine Dugoff, Baha Sibai, Kirsten Lawrence, Brenna L. Hughes, et al. “Treatment for Mild Chronic Hypertension during Pregnancy.” N Engl J Med 386, no. 19 (May 12, 2022): 1781–92. https://doi.org/10.1056/NEJMoa2201295.
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  - Job, Kathleen M., André Dallmann, Samuel Parry, George Saade, David M. Haas, Brenna Hughes, Pamela Berens, et al. “Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk.” Clin Pharmacol Ther 111, no. 5 (May 2022): 1111–20. https://doi.org/10.1002/cpt.2530.
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  - Hughes, Brenna L., Dwight J. Rouse, and Rebecca G. Clifton. “Hyperimmune Globulin for Congenital Cytomegalovirus Infection. Reply.” N Engl J Med 386, no. 10 (March 10, 2022): 1003. https://doi.org/10.1056/NEJMc2114296.
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  - Gatta, Luke A., Eric Rochat, Jeremy M. Weber, Sarah Valencia, Alaattin Erkanli, Sarah K. Dotters-Katz, Sallie Permar, and Brenna L. Hughes. “Clinical factors associated with cytomegalovirus shedding among seropositive pregnant women.” Am J Obstet Gynecol Mfm 4, no. 2 (March 2022): 100560. https://doi.org/10.1016/j.ajogmf.2021.100560.
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  - Rouse, Dwight J., Lida M. Fette, Brenna L. Hughes, George R. Saade, Mara J. Dinsmoor, Uma M. Reddy, Robert Pass, et al. “Noninvasive Prediction of Congenital Cytomegalovirus Infection After Maternal Primary Infection.” Obstet Gynecol 139, no. 3 (March 1, 2022): 400–406. https://doi.org/10.1097/AOG.0000000000004691.
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  - Savitz, David A., Valery A. Danilack, Jerson Cochancela, Brenna L. Hughes, Dwight J. Rouse, and Roee Gutmann. “Health Outcomes Associated With Clinician-initiated Delivery for Hypertensive Disorders at 34-38 Weeks' Gestation.” Epidemiology 33, no. 2 (March 1, 2022): 260–68. https://doi.org/10.1097/EDE.0000000000001442.
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  - Metz, Torri D., Rebecca G. Clifton, Brenna L. Hughes, Grecio J. Sandoval, William A. Grobman, George R. Saade, Tracy A. Manuck, et al. “Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications.” Jama 327, no. 8 (February 22, 2022): 748–59. https://doi.org/10.1001/jama.2022.1190.
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  - Ramey-Collier, Khaila, Amanda M. Craig, Allison Hall, Kristin E. Weaver, Sarahn M. Wheeler, Jennifer B. Gilner, Geeta K. Swamy, Brenna L. Hughes, and Sarah K. Dotters-Katz. “Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy?” J Matern Fetal Neonatal Med, February 16, 2022, 1–3. https://doi.org/10.1080/14767058.2022.2041597.
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  - Hughes, B. L., R. G. Clifton, D. J. Rouse, G. R. Saade, M. J. Dinsmoor, U. M. Reddy, R. Pass, et al. “A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection.” Obstetrical and Gynecological Survey 77, no. 1 (January 1, 2022): 16–18. https://doi.org/10.1097/01.ogx.0000805168.83387.d5.
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  - Dotters-Katz, S. K., J. A. Kuller, and B. L. Hughes. “Society for Maternal-Fetal Medicine consult series #56: Hepatitis C in pregnancy: Updated guidelines SOCIETY FOR MATERNAL-FETAL MEDICINE (SMFM).” Contemporary Ob/Gyn 66, no. 11 (November 1, 2021): 26–28.
  - Addae-Konadu, Kateena L., Lauren E. Wein, Jerome J. Federspiel, Brenna L. Hughes, and Sarah Dotters-Katz. “Postpartum Pyelonephritis and Risk of Severe Maternal Morbidity.” Am J Perinatol, October 28, 2021. https://doi.org/10.1055/a-1682-3171.
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  - Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Brenna L., Sarah K. Dotters-Katz, Jeffrey A. Kuller, and Brenna L. Hughes. “Society for Maternal-Fetal Medicine Consult Series #56: Hepatitis C in pregnancy-updated guidelines: Replaces Consult Number 43, November 2017.” Am J Obstet Gynecol 225, no. 3 (September 2021): B8–18. https://doi.org/10.1016/j.ajog.2021.06.008.
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  - Kuriakose, Safia, Kanal Singh, Alice K. Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, et al. “Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.” Ann Intern Med 174, no. 8 (August 2021): 1151–58. https://doi.org/10.7326/M21-1647.
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  - Venkatesh, Kartik K., Catherine J. Vladutiu, Angelica V. Glover, Robert A. Strauss, Jeffrey S. A. Stringer, David M. Stamilio, Brenna Hughes, and Sarah Dotters-Katz. “Is Group B Streptococcus Colonization Associated with Maternal Peripartum Infection in an Era of Routine Prophylaxis?” Am J Perinatol 38, no. S 01 (August 2021): e262–68. https://doi.org/10.1055/s-0040-1709666.
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  - Hughes, Brenna L., Rebecca G. Clifton, Dwight J. Rouse, George R. Saade, Mara J. Dinsmoor, Uma M. Reddy, Robert Pass, et al. “A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection.” N Engl J Med 385, no. 5 (July 29, 2021): 436–44. https://doi.org/10.1056/NEJMoa1913569.
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  - Craig, Amanda M., Brenna L. Hughes, and Geeta K. Swamy. “Reply to: Coronavirus disease 2019 vaccine in pregnant women: not so far! The importance of counseling and the need for evidence-based data.” Am J Obstet Gynecol Mfm 3, no. 3 (May 2021): 100323. https://doi.org/10.1016/j.ajogmf.2021.100323.
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  - Craig, Amanda M., Brenna L. Hughes, and Geeta K. Swamy. “Reply: Coronavirus disease 2019 vaccines in pregnancy.” Am J Obstet Gynecol Mfm 3, no. 3 (May 2021): 100337. https://doi.org/10.1016/j.ajogmf.2021.100337.
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  - Metz, Torri D., Rebecca G. Clifton, Brenna L. Hughes, Grecio Sandoval, George R. Saade, William A. Grobman, Tracy A. Manuck, et al. “Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19).” Obstet Gynecol 137, no. 4 (April 1, 2021): 571–80. https://doi.org/10.1097/AOG.0000000000004339.
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  - Craig, Amanda M., Brenna L. Hughes, and Geeta K. Swamy. “Coronavirus disease 2019 vaccines in pregnancy.” Am J Obstet Gynecol Mfm 3, no. 2 (March 2021): 100295. https://doi.org/10.1016/j.ajogmf.2020.100295.
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  - Dotters-Katz, Sarah K., Hailey Harris, Sarahn M. Wheeler, Geeta K. Swamy, and Brenna L. Hughes. “Specialized prenatal care delivery for coronavirus disease 2019-exposed or -infected pregnant women.” Am J Obstet Gynecol 224, no. 3 (March 2021): 325–27. https://doi.org/10.1016/j.ajog.2020.11.025.
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  - Beigi, Richard H., Carleigh Krubiner, Denise J. Jamieson, Anne D. Lyerly, Brenna Hughes, Laura Riley, Ruth Faden, and Ruth Karron. “The need for inclusion of pregnant women in COVID-19 vaccine trials.” Vaccine 39, no. 6 (February 5, 2021): 868–70. https://doi.org/10.1016/j.vaccine.2020.12.074.
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  - DeNoble, Anna E., Frances M. Saccoccio, Sallie R. Permar, and Brenna L. Hughes. “Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report.” Clin Infect Dis 71, no. 9 (December 3, 2020): 2506–8. https://doi.org/10.1093/cid/ciaa305.
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  - Gatta, Luke A., and Brenna L. Hughes. “Premature Rupture of Membranes with Concurrent Viral Infection.” Obstet Gynecol Clin North Am 47, no. 4 (December 2020): 605–23. https://doi.org/10.1016/j.ogc.2020.08.006.
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  - Johnson, Jasmine D., Emilie Melvin, Sindhu K. Srinivas, Judette M. Louis, Brenna Hughes, Christina Shih-Chi Han, Mary E. Norton, and Erika F. Werner. “COVID-19 Testing, Personal Protective Equipment, and Staffing Strategies Vary at Obstetrics Centers across the Country.” Am J Perinatol 37, no. 14 (December 2020): 1482–84. https://doi.org/10.1055/s-0040-1718401.
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  - Sayres, Lauren, and Brenna L. Hughes. “Contemporary Understanding of Ebola and Zika Virus in Pregnancy.” Clin Perinatol 47, no. 4 (December 2020): 835–46. https://doi.org/10.1016/j.clp.2020.08.005.
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  - Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Dr. Balevic, et al reply.” J Rheumatol 47, no. 10 (October 1, 2020): 1587. https://doi.org/10.3899/jrheum.200681.
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  - Denoble, Anna E., Jenny Wu, Courtney J. Mitchell, Brenna L. Hughes, and Sarah K. Dotters-Katz. “Chorioamnionitis versus intraamniotic infection among preterm deliveries-is postpartum infectious morbidity different?” Am J Obstet Gynecol Mfm 2, no. 3 (August 2020): 100176. https://doi.org/10.1016/j.ajogmf.2020.100176.
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  - Werner, Erika F., Judette M. Louis, Brenna Hughes, Christina Shih-Chi Han, Mary E. Norton, and Sindhu K. Srinivas. “Community Obstetrical Units Less Likely than Academic Units to Have Universal COVID-19 Testing.” Am J Perinatol 37, no. 10 (August 2020): 1074–76. https://doi.org/10.1055/s-0040-1712454.
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  - Prasad, Mona, George Saade, and Brenna Hughes. “In Reply.” Obstet Gynecol 136, no. 2 (August 2020): 427–28. https://doi.org/10.1097/AOG.0000000000004032.
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  - Mancuso, Abigail C., Lea E. Widdice, Brenna L. Hughes, Patrick Schlievert, Geeta K. Swamy, Colleen K. Stockdale, David I. Bernstein, and Patricia L. Winokur. “Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial.” J Low Genit Tract Dis 24, no. 3 (July 2020): 277–83. https://doi.org/10.1097/LGT.0000000000000543.
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  - Dotters-Katz, Sarah K., and Brenna L. Hughes. “Considerations for Obstetric Care during the COVID-19 Pandemic.” Am J Perinatol 37, no. 8 (June 2020): 773–79. https://doi.org/10.1055/s-0040-1710051.
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  - Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.” J Rheumatol, May 11, 2020. https://doi.org/10.3899/jrheum.200493.
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  - Dotters-Katz, S., and B. L. Hughes. “COVID-19: The pathogen that will define the decade.” Contemporary Ob/Gyn 65, no. 4 (April 1, 2020): 11–12.
  - Prasad, Mona, George R. Saade, Grecio Sandoval, Brenna L. Hughes, Uma M. Reddy, Lisa Mele, Ashley Salazar, et al. “Hepatitis C Virus Antibody Screening in a Cohort of Pregnant Women: Identifying Seroprevalence and Risk Factors.” Obstet Gynecol 135, no. 4 (April 2020): 778–88. https://doi.org/10.1097/AOG.0000000000003754.
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  - Clinton, Chelsea M., James R. Bain, Michael J. Muehlbauer, YuanYuan Li, Leping Li, Sara K. O’Neal, Brenna L. Hughes, David E. Cantonwine, Thomas F. Mcelrath, and Kelly K. Ferguson. “Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction.” Sci Rep 10, no. 1 (March 24, 2020): 5307. https://doi.org/10.1038/s41598-020-62131-7.
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  - Griffiths, Paul, and Brenna Hughes. “Choice of Study Populations for Vaccines.” J Infect Dis 221, no. Suppl 1 (March 5, 2020): S128–34. https://doi.org/10.1093/infdis/jiz537.
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  - Siegel, Anne M., Chelsea M. Clinton, Annalisa L. Post, Tracy Truong, Carl F. Pieper, and Brenna L. Hughes. “Assessing patient perceptions of cytomegalovirus infection in pregnancy.” J Med Virol, February 19, 2020. https://doi.org/10.1002/jmv.25714.
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  - Venkatesh, Kartik K., Brenna L. Hughes, Chad A. Grotegut, Robert A. Strauss, David M. Stamilio, R Philip Heine, and Sarah K. Dotters-Katz. “Preoperative cefazolin rather than clindamycin or metronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery.” Am J Obstet Gynecol Mfm 2, no. 1 (February 2020): 100074. https://doi.org/10.1016/j.ajogmf.2019.100074.
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  - Blackwell, Sean C., Cynthia Gyamfi-Bannerman, Joseph R. Biggio, Suneet P. Chauhan, Brenna L. Hughes, Judette M. Louis, Tracy A. Manuck, et al. “17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG Study): A Multicenter, International, Randomized Double-Blind Trial.” Am J Perinatol 37, no. 2 (January 2020): 127–36. https://doi.org/10.1055/s-0039-3400227.
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  - Albright, Catherine M., Timothy E. Spillane, Brenna L. Hughes, and Dwight J. Rouse. “A Regression Model for Prediction of Cesarean-Associated Blood Transfusion.” Am J Perinatol 36, no. 9 (July 2019): 879–85. https://doi.org/10.1055/s-0039-1678604.
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  - Albright, Catherine M., Erika F. Werner, and Brenna L. Hughes. “Cytomegalovirus Screening in Pregnancy: A Cost-Effectiveness and Threshold Analysis.” Am J Perinatol 36, no. 7 (June 2019): 678–87. https://doi.org/10.1055/s-0038-1676495.
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  - Hamel, Maureen S., Phinnara Has, Ilina Datkhaeva, Kimberly Delacy, Dana Ciolfi, and Brenna Hughes. “The Effect of Intrapartum Vancomycin on Vaginal Group B Streptococcus Colony Counts.” Am J Perinatol 36, no. 6 (May 2019): 555–60. https://doi.org/10.1055/s-0038-1675622.
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  - Venkatesh, Kartik K., Wesley Jackson, Brenna L. Hughes, Mathew M. Laughon, John M. Thorp, and David M. Stamilio. “Association of chorioamnionitis and its duration with neonatal morbidity and mortality.” J Perinatol 39, no. 5 (May 2019): 673–82. https://doi.org/10.1038/s41372-019-0322-0.
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  - Venkatesh, Kartik K., Wesley Jackson, Brenna L. Hughes, Mathew M. Laughon, John M. Thorp, and David M. Stamilio. “Correction: Association of chorioamnionitis and its duration with neonatal morbidity and mortality.” J Perinatol 39, no. 5 (May 2019): 761. https://doi.org/10.1038/s41372-019-0341-x.
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  - Bengtson, Angela M., Alan M. Sanfilippo, Brenna L. Hughes, and David A. Savitz. “Maternal immunisation to improve the health of HIV-exposed infants.” Lancet Infect Dis 19, no. 4 (April 2019): e120–31. https://doi.org/10.1016/S1473-3099(18)30545-0.
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  - Harris, Benjamin S., Maeve K. Hopkins, Margaret S. Villers, Jeremy M. Weber, Carl Pieper, Chad A. Grotegut, Geeta K. Swamy, Brenna L. Hughes, and R Phillips Heine. “Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.” Ajp Rep 9, no. 2 (April 2019): e167–71. https://doi.org/10.1055/s-0039-1685503.
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  - Bengtson, Angela M., Alan M. Sanfilippo, Brenna L. Hughes, and David A. Savitz. “Maternal immunisation and neonatal infection of hepatitis A or B virus - Authors' reply.” Lancet Infect Dis 19, no. 3 (March 2019): 238–39. https://doi.org/10.1016/S1473-3099(19)30046-5.
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  - Datkhaeva, Ilina, Phinnara Has, Kelly Fitzgerald, and Brenna L. Hughes. “Outcomes of a Negative Rapid Influenza Diagnostic Test in Pregnant Women.” Am J Perinatol 36, no. 1 (January 2019): 90–96. https://doi.org/10.1055/s-0038-1666975.
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  - Hughes, B. L. “Group A Streptococcus puerperal sepsis: an emerging obstetric infection?” Bjog 126, no. 1 (January 2019): 54. https://doi.org/10.1111/1471-0528.15485.
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  - Wood, Amber M., Sarah K. Dotters-Katz, and Brenna L. Hughes. “Cervical Cerclage versus Vaginal Progesterone for Management of Short Cervix in Low-Risk Women.” Am J Perinatol 36, no. 2 (January 2019): 111–17. https://doi.org/10.1055/s-0038-1668547.
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  - Lantos, Paul M., Gabriela Maradiaga-Panayotti, Xavier Barber, Eileen Raynor, Debara Tucci, Kate Hoffman, Sallie R. Permar, et al. “Geographic and Racial Disparities in Infant Hearing Loss.” Otolaryngol Head Neck Surg, October 9, 2018, 194599818803305. https://doi.org/10.1177/0194599818803305.
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  - Blackwell, Sean C., Cynthia Gyamfi-Bannerman, Joseph R. Biggio, Suneet P. Chauhan, Brenna L. Hughes, Judette M. Louis, Tracy Manuck, et al. “PROLONG Clinical Study Protocol: Hydroxyprogesterone Caproate to Reduce Recurrent Preterm Birth.” Am J Perinatol 35, no. 12 (October 2018): 1228–34. https://doi.org/10.1055/s-0038-1642062.
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  - Froehlich, Rosemary J., Lindsay Maggio, Phinnara Has, Roxanne Vrees, and Brenna L. Hughes. “Improving Obstetric Hypertensive Emergency Treatment in a Tertiary Care Women's Emergency Department.” Obstet Gynecol 132, no. 4 (October 2018): 850–58. https://doi.org/10.1097/AOG.0000000000002809.
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  - Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, Amy Kind, and Geeta Swamy. “Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy.” J Racial Ethn Health Disparities 5, no. 4 (August 2018): 782–86. https://doi.org/10.1007/s40615-017-0423-4.
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  - Sudhof, Leanna S., Phinnara Has, Dwight J. Rouse, and Brenna L. Hughes. “Choice of Trial of Labor after Cesarean and Association with Likelihood of Success.” Am J Perinatol 35, no. 9 (July 2018): 892–97. https://doi.org/10.1055/s-0038-1626714.
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  - Wood, Amber M., and Brenna L. Hughes. “Detection and Prevention of Perinatal Infection: Cytomegalovirus and Zika Virus.” Clin Perinatol 45, no. 2 (June 2018): 307–23. https://doi.org/10.1016/j.clp.2018.01.005.
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  - Hughes, B. L., C. M. Page, and J. A. Kuller. “Hepatitis C in pregnancy: Screening, treatment, and management.” Contemporary Ob/Gyn 63, no. 5 (May 1, 2018): 22–31.
  - Wood, Amber M., Elizabeth G. Livingston, Brenna L. Hughes, and Jeffrey A. Kuller. “Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management.” Obstet Gynecol Surv 73, no. 2 (February 2018): 103–9. https://doi.org/10.1097/OGX.0000000000000524.
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  - Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Jeffrey A., Brenna L. Hughes, Charlotte M. Page, and Jeffrey A. Kuller. “Hepatitis C in pregnancy: screening, treatment, and management.” Am J Obstet Gynecol 217, no. 5 (November 2017): B2–12. https://doi.org/10.1016/j.ajog.2017.07.039.
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  - Albright, Catherine M., Phinnara Has, Dwight J. Rouse, and Brenna L. Hughes. “Internal Validation of the Sepsis in Obstetrics Score to Identify Risk of Morbidity From Sepsis in Pregnancy.” Obstet Gynecol 130, no. 4 (October 2017): 747–55. https://doi.org/10.1097/AOG.0000000000002260.
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  - Hughes, Brenna L., Kim M. Gans, Christina Raker, Evelyn R. Hipolito, and Dwight J. Rouse. “A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial.” Obstet Gynecol 130, no. 4 (October 2017): 726–34. https://doi.org/10.1097/AOG.0000000000002216.
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  - Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, and Geeta K. Swamy. “Geographic Disparities in Cytomegalovirus Infection During Pregnancy.” J Pediatric Infect Dis Soc 6, no. 3 (September 1, 2017): e55–61. https://doi.org/10.1093/jpids/piw088.
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  - Albright, Catherine M., Brenna L. Hughes, and Erika F. Werner. “In Reply.” Obstet Gynecol 130, no. 1 (July 2017): 217–18. https://doi.org/10.1097/AOG.0000000000002122.
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  - Grupper, Mordechai, Joseph L. Kuti, Morgan L. Swank, Lindsay Maggio, Brenna L. Hughes, and David P. Nicolau. “Population Pharmacokinetics of Cefazolin in Serum and Adipose Tissue From Overweight and Obese Women Undergoing Cesarean Delivery.” J Clin Pharmacol 57, no. 6 (June 2017): 712–19. https://doi.org/10.1002/jcph.851.
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  - Page, Charlotte M., Brenna L. Hughes, Eleanor H. J. Rhee, and Jeffrey A. Kuller. “Hepatitis C in Pregnancy: Review of Current Knowledge and Updated Recommendations for Management.” Obstet Gynecol Surv 72, no. 6 (June 2017): 347–55. https://doi.org/10.1097/OGX.0000000000000442.
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  - Datkhaeva, Ilina, Danielle Dray, Phinnara Has, Bianca Stifani, Brenna L. Hughes, and Dwight J. Rouse. “Uptake of a Guideline for the Administration of a Rescue Course of Antenatal Corticosteroids.” Obstet Gynecol 129, no. 4 (April 2017): 720–26. https://doi.org/10.1097/AOG.0000000000001934.
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  - Hughes, Brenna L., Rebecca G. Clifton, John C. Hauth, Kenneth J. Leveno, Leslie Myatt, Uma M. Reddy, Michael W. Varner, et al. “Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data.” Am J Perinatol 33, no. 10 (August 2016): 983–90. https://doi.org/10.1055/s-0036-1583188.
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  - Society for Maternal-Fetal Medicine (SMFM), Cynthia, Brenna L. Hughes, and Cynthia Gyamfi-Bannerman. “Diagnosis and antenatal management of congenital cytomegalovirus infection.” Am J Obstet Gynecol 214, no. 6 (June 2016): B5–11. https://doi.org/10.1016/j.ajog.2016.02.042.
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  - Hughes, B. L. “Antibiotic prophylaxis in pregnancy-benefit without harm?” Bjog 123, no. 6 (May 2016): 994. https://doi.org/10.1111/1471-0528.13624.
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  - Albright, Catherine M., Niharika D. Mehta, Dwight J. Rouse, and Brenna L. Hughes. “Sepsis in Pregnancy: Identification and Management.” J Perinat Neonatal Nurs 30, no. 2 (April 2016): 95–105. https://doi.org/10.1097/JPN.0000000000000159.
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  - Briody, Victoria A., Catherine M. Albright, Phinnara Has, and Brenna L. Hughes. “Use of Cefazolin for Group B Streptococci Prophylaxis in Women Reporting a Penicillin Allergy Without Anaphylaxis.” Obstet Gynecol 127, no. 3 (March 2016): 577–83. https://doi.org/10.1097/AOG.0000000000001297.
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  - Ward, Nicholas S., Brenna L. Hughes, and Leonard A. Mermel. “Enterovirus D68 Infection in an Adult.” Am J Crit Care 25, no. 2 (March 2016): 178–80. https://doi.org/10.4037/ajcc2016955.
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  - Hamel, M. S., and B. L. Hughes. “Zika infection in pregnancy: Pregnant women are worried, and their concern is warranted. here is what we know now and what’s being done about this health crisis.” Contemporary Ob/Gyn 61, no. 8 (January 1, 2016).
  - Mainiero, Alexandra D., Dwight J. Rouse, Vrishali Lopes, and Brenna L. Hughes. “Association of 17α-Hydroxyprogesterone Caproate and Risk of Infection.” Obstet Gynecol 126, no. 1 (July 2015): 103–8. https://doi.org/10.1097/AOG.0000000000000881.
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  - Hamel, Maureen S., Brenna L. Hughes, and Dwight J. Rouse. “Whither oxygen for intrauterine resuscitation?” Am J Obstet Gynecol 212, no. 4 (April 2015): 461-2.461.e1. https://doi.org/10.1016/j.ajog.2015.01.057.
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  - Hamel, Maureen S., Brenna L. Hughes, and Dwight J. Rouse. “Reply: To PMID 24412117.” Am J Obstet Gynecol 212, no. 3 (March 2015): 410. https://doi.org/10.1016/j.ajog.2014.11.005.
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  - Kansal, Namita, Lavanya Vasudevan, Jerome J. Federspiel, and Brenna L. Hughes. “Factors Influencing Intent to Receive COVID-19 and Influenza Vaccine in Pregnancy,” n.d.
- Book Sections
  - Hughes, B. L. “Cytomegalovirus, Genital Herpes, Rubella, Syphilis, and Toxoplasmosis.” In Protocols for High-Risk Pregnancies: An Evidence-Based Approach: Sixth Edition, 213–21, 2015. https://doi.org/10.1002/9781119001256.ch26.
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- Conference Papers
  - Cate, Jennifer, Amanda M. Craig, Miriam Estin, Kristin Weaver, Jennifer Gilner, Geeta K. Swamy, Brenna L. Hughes, Sarah K. Dotters-Katz, and Sarahn M. Wheeler. “Preterm birth rates and race disparities pre and post COVID vaccination.” In American Journal of Obstetrics and Gynecology, 226:S625–S625, 2022.
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  - Craig, Amanda M., Khaila Ramey Collier, Kristin Weaver, Sarahn M. Wheeler, Jennifer Gilner, Geeta K. Swamy, Brenna L. Hughes, and Sarah K. Dotters-Katz. “Factors associated with cesarean section in patients with COVID.” In American Journal of Obstetrics and Gynecology, 226:S426–S426, 2022.
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  - Gatta, Luke A., Noor K. Al-Shibli, Melissa Montoya, Brenna L. Hughes, Evan Myers, Krista Haines, and Anne Lyerly. “Pregnancy inclusion in statewide scarce resource allocation guidelines during COVID-19 pandemic.” In American Journal of Obstetrics and Gynecology, 226:S602–3, 2022.
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  - Mallampati, Divya, Jerome Federspiel, Sarahn M. Wheeler, Maria Small, Brenna L. Hughes, Kathryn Menard, Johanna Quist-Nelson, and Marie Louise Meng. “Incidence of severe maternal morbidity by race and payer status at an academic medical system.” In American Journal of Obstetrics and Gynecology, 226:S439–40, 2022.
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  - Sugrue, Ronan, Megan S. Varvoutis, Lauren Wein, Kristin Darwin, Arthur J. Vaught, Marie Louise Meng, Brenna L. Hughes, Chad Grotegut, and Jerome Federspiel. “Extracorporeal Membrane Oxygenation does not confer excess risk in Pregnancy.” In American Journal of Obstetrics and Gynecology, 226:S78–79, 2022.
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  - Craig, Amanda M., Sarah Dotters-Katz, Kristin Weaver, Jennifer Gilner, Geeta Swamy, Brenna L. Hughes, and Sarahn M. Wheeler. “Preterm birth disparities at a single United States academic institution during the COVID pandemic.” In American Journal of Obstetrics and Gynecology, 224:S68–S68, 2021.
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  - Gatta, Luke A., Eric Rochat, Jeremy M. Weber, Sallie Permar, Sarah Valencia, Alaattin Erkanli, Sarah Dotters-Katz, and Brenna L. Hughes. “Urine cytomegalovirus shedding among seropositive pregnant women.” In American Journal of Obstetrics and Gynecology, 224:S365–S365, 2021.
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  - Nguyen, Nguyen Thao T., Kelli Kurtovic, Marie Evangelista, Courtney Mitchell, Rhiann Del Valle, Sarah McWay Boling, and Brenna L. Hughes. “Improving Treatment for Hypertensive Emergencies among Pregnant and Postpartum Women Using a Hypertensive Pathway Intervention.” In American Journal of Obstetrics and Gynecology, 224:S24–S24, 2021.
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  - Ren, Xuehan, Eric Jelovsek, Sheng Luo, Brenna L. Hughes, and Emily Reiff. “Analysis of antepartum obstetric triage utilization at 24 weeks and beyond.” In American Journal of Obstetrics and Gynecology, 224:S679–80, 2021.
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  - Venkatesh, Kartik K., Catherine J. Vladutiu, Robert A. Strauss, John M. Thorp, Jeffrey S. A. Stringer, David M. Stamilio, Brenna L. Hughes, and Sarah Dotters-Katz. “Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort.” In J Womens Health (Larchmt), 29:1507–12, 2020. https://doi.org/10.1089/jwh.2019.8139.
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  - Varvoutis, Megan, Chelsea Feldman, Emily Reiff, Brenna L. Hughes, and Chad Grotegut. “Is Incision to Delivery Time Associated With Poor Neonatal Neurological Outcomes in Women With Class 3 Obesity? [31L].” In Obstetrics &Amp; Gynecology, 133:137S-137S. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.1097/01.aog/01.aog.0000559265.40266.e1.
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  - Clinton, Chelsea M., James R. Bain, Michael J. Muehlbauer, Sara K. O’Neal, Brenna L. Hughes, Tracy Truong, Carl F. Pieper, Thomas F. McElrath, and Kelly K. Ferguson. “112: Urinary metabolomic profiles in pregnancy and association with fetal growth restriction.” In American Journal of Obstetrics and Gynecology, 220:S90–91. Elsevier BV, 2019. https://doi.org/10.1016/j.ajog.2018.11.133.
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  - Venkatesh, Kartik K., Wesley Jackson, Brenna L. Hughes, Matthew M. Laughon, John M. Thorp, and David M. Stamilio. “568: Association of chorioamnionitis and its duration with neonatal morbidity and mortality.” In American Journal of Obstetrics and Gynecology, 220:S378–S378. Elsevier BV, 2019. https://doi.org/10.1016/j.ajog.2018.11.590.
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  - Clinton, C., A. Post, T. Truong, and B. L. Hughes. “Assessing patient perceptions of cytomegalovirus infection in pregnancy.” In American Journal of Obstetrics and Gynecology, 219:647–647. Elsevier BV, 2018. https://doi.org/10.1016/j.ajog.2018.10.044.
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  - Froehlich, Rosemary J., Lindsay Maggio, Phinnara Has, Roxanne Vrees, and Brenna L. Hughes. “905: Improving the Treatment of Obstetric Hypertensive Emergency.” In American Journal of Obstetrics and Gynecology, 218:S537–38. Elsevier BV, 2018. https://doi.org/10.1016/j.ajog.2017.11.492.
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  - Hamel, M., P. Has, I. Datkhaeva, K. Delacy, D. Ciofli, and B. L. Hughes. “The effect of intrapartum vancomycin on vaginal Group B streptococcus colony counts.” In American Journal of Obstetrics and Gynecology, 217:719–20. Elsevier BV, 2017. https://doi.org/10.1016/j.ajog.2017.08.096.
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  - Post, A., C. Raker, K. Gans, and B. L. Hughes. “Patient perceptions of educational interventions for prevention of perinatal cytomegalovirus infection.” In American Journal of Obstetrics and Gynecology, 217:724–724. Elsevier BV, 2017. https://doi.org/10.1016/j.ajog.2017.08.056.
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  - Reiff, E. S., C. A. Grotegut, E. F. Werner, and B. L. Hughes. “A cost analysis of adjunctive azithromycin prophylaxis for women undergoing non-elective cesarean delivery.” In American Journal of Obstetrics and Gynecology, 217:720–720. Elsevier BV, 2017. https://doi.org/10.1016/j.ajog.2017.08.097.
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  - Wood, A. M., B. L. Hughes, R. P. Heine, and M. S. Villers. “Group B strep and associated complications in cesarean delivery.” In American Journal of Obstetrics and Gynecology, 217:723–723. Elsevier BV, 2017. https://doi.org/10.1016/j.ajog.2017.08.052.
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  - Albright, Catherine M., Caitlin MacGregor, Desmond Sutton, Meena Theva, Brenna L. Hughes, and Erika F. Werner. “Group B Streptococci Screening Before Repeat Cesarean Delivery: A Cost-Effectiveness Analysis.” In Obstet Gynecol, 129:111–19, 2017. https://doi.org/10.1097/AOG.0000000000001800.
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  - Hughes, Brenna L., Riana Dutt, Christina Raker, Melody Barthelemy, Richard M. Rossoll, Bharat Ramratnam, Charles R. Wira, and Susan Cu-Uvin. “The impact of pregnancy on anti-HIV activity of cervicovaginal secretions.” In Am J Obstet Gynecol, 215:748.e1-748.e12, 2016. https://doi.org/10.1016/j.ajog.2016.06.057.
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  - Albright, Catherine M., Jenna B. Emerson, Erika F. Werner, and Brenna L. Hughes. “Third-Trimester Prenatal Syphilis Screening: A Cost-Effectiveness Analysis.” In Obstet Gynecol, 126:479–85, 2015. https://doi.org/10.1097/AOG.0000000000000997.
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  - Maggio, Lindsay, David P. Nicolau, Melissa DaCosta, Dwight J. Rouse, and Brenna L. Hughes. “Cefazolin prophylaxis in obese women undergoing cesarean delivery: a randomized controlled trial.” In Obstet Gynecol, 125:1205–10, 2015. https://doi.org/10.1097/AOG.0000000000000789.
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  - Moyett, Julia, Linda Zambrano Guevara, Divya Mallampati, M Kathryn Menard, Brenna Hughes, Maria Small, Elizabeth Livingston, Johanna Quist-Nelson, Marie Meng, and Jerome Federspiel. “Racial and Rural-Urban Disparities in Maternal Cardiac Disease Care in North Carolina: A Call to Action,” n.d.
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