Brenna L Hughes
Associate Professor of Obstetrics and Gynecology
Current Appointments & Affiliations
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2018
Contact Information
- Background
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Education, Training, & Certifications
- M.D., Brown University 1999
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Medical Licensure
- 2016-02015. North Carolina. 2019
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Duke Appointment History
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2017 - 2018
- Instructor, Temporary in the Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2016 - 2017
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Leadership & Clinical Positions at Duke
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- Fellowship Director, Maternal-Fetal Medicine
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Academic Positions Outside Duke
- Fellowship Director, Warren Alpert Medical School of Brown University. 2015 - 2016
- Director, Women and Infants Hospital. 2014 - 2016
- Associate Professor, Warren Alpert Medical School of Brown University. 2012 - 2016
- Assistant Professor, Warren Alpert Medical School of Brown University. 2006 - 2012
- Recognition
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In the News
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Awards & Honors
- Hospital-based Faculty Teaching Award. Chief Resident Class, Brown University. 2016
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2016
- 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology, Best Poster Award. Infectious Disease Society for Obstetrics and Gynecology. 2015
- Best Doctors in America regional list U.S. News and World Report. Castle Connolly. 2015
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2015
- Top 10% of reviewer for Obstetrics & Gynecology awarded by editors. Infectious Disease Society of Obstetrics and Gynecology. 2015
- Hospital-based Faculty Teaching Award. Chief Resident Class, Brown University. 2014
- Top 10% of reviewer for Obstetrics & Gynecology awarded by editors. Infectious Disease Society of Obstetrics and Gynecology. 2012
- Top 5% of reviewers for American Journal of Obstetrics & Gynecology. Editors. 2012
- Best Doctors in America regional list U.S. News and World Report. Castle Connolly. 2011
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2011
- Invited participant in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Scientific Vision Process workshop, “Finale Conference—NICHD: Bringing the Vision Together". National Institute of Child Health and Human Development. 2011
- Top 5% of reviewers 2010 for BJOG: An International Journal of Obstetrics and Gynaecology. International Journal of Obstetrics and Gynaecology awarded by editors. 2011
- Society for Maternal Fetal Medicine Award for Research Excellence for oral presentation, “Cervicovaginal fluid from pregnant and non-pregnant women suppresses HIV infectivity in an in vitro model”. Society for Maternal Fetal Medicine. 2010
- Top 5% of reviewers for American Journal of Obstetrics & Gynecology. Editors. 2010
- Women & Infants Hospital Medical Staff Distinguished Service Award. Women and Infants Hospital. 2010
- Henry L. Darner AAOGF travel award to the annual meeting of the American Gynecological and Obstetrical Society. American Gynecological and Obstetrical Society. 2009
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2009
- Hospital-based Faculty Teaching Award. Chief Resident Class, Brown University. 2008
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2007
- Recipient NIH Young Investigator Travel Award. Perinatal Research Society. 2007
- Top 5% of reviewers for American Journal of Obstetrics & Gynecology. Editors. 2007
- Top full time faculty teacher of the year award. Brown University. 2007
- Young Investigator Award for the Infectious Disease Society of Obstetrics and Gynecology. Infectious Disease Society of Obstetrics and Gynecology. 2007
- Award in Obstetrics and Gynecology. American College of Obstetricians and Gynecologists. 1999
- Janet Glasgow Award for Scholastic Achievement. American Medical Women’s Association. 1999
- Women in Medicine Scholarship. Brown University. 1999
- Phi Kappa Phi Honor. Phi Kappa Phi Honor Society. 1995
- Research
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Selected Grants
- Population Health Research Support IDIQ Base awarded by National Institutes of Health 2018 - 2025
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health 2020 - 2025
- The Role of Calcium Homeostasis in Regulating Uterine Contractility and Tone awarded by National Institutes of Health 2019 - 2024
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A awarded by National Institutes of Health 2019 - 2022
- TIME Aim of the Study of Pregnancy and Neonatal Health (SPAN) Task Order A awarded by National Institutes of Health 2020 - 2021
- MFMU Network Study - Maternal Morbidity and Mortality During the COVID-19 Pandemic awarded by University of North Carolina - Chapel Hill 2020 - 2021
- Clinical and viral characteristics of maternal cytomegalovirus infection among seropositive pregnant women in the United States awarded by National Institutes of Health 2018 - 2021
- MFMU Network Study - AWARE awarded by University of North Carolina - Chapel Hill 2020 - 2021
- MFMU Network Study - PACT awarded by University of North Carolina - Chapel Hill 2020 - 2021
- MFMU Network Study - Prematurity Registry: An Observational Cohort Study of Obstetrical Determinants of Preterm Delivery and Neonatal Outcome awarded by University of North Carolina - Chapel Hill 2020 - 2021
- 2/5 HEAL Consortium: Establishing Innovative Approaches for the HEALthy Brain and Child Development Study awarded by National Institutes of Health 2019 - 2021
- MFMU Network Studies - PREP awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - PROSPECT awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - SLEEP awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - TOPS awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Studies - TXA awarded by University of North Carolina - Chapel Hill 2019 - 2021
- MFMU Network Clinical Center Participation awarded by University of North Carolina - Chapel Hill 2017 - 2021
- Data Coordinating Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units (MFMU) awarded by The George Washington University 1998 - 2021
- Humoral immune correlates of protection against congenital CMV and HSV transmission in HIV-infected women awarded by National Institutes of Health 2019 - 2020
- Chronic Hypertension and Pregnancy (CHAP) NHLBI Multi-Site RCT awarded by University of Alabama at Birmingham 2014 - 2020
- PTN_TO51_BMS01 PK and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants awarded by Duke Clinical Research Institute 2018 - 2020
- Rapid, Near Patient Nucleic Acid Testing for Infant Cytomegalovirus (CMV) Infection awarded by Baebies, Inc 2017 - 2020
- Data Coordinating Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units (MFMU) awarded by The George Washington University 2018 - 2019
- VTEU 12-0021 Task C - Base awarded by National Institutes of Health 2016 - 2018
- VTEU 12-0021 - Task C Option 1 awarded by National Institutes of Health 2017 - 2018
- Effect of Latrogenic Delivery at 34-38 Weeks Gestation on Pregnancy Outcome awarded by Women & Infants Hospital 2016 - 2017
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External Relationships
- Merck
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Craig, Amanda M., Brenna L. Hughes, and Geeta K. Swamy. “Coronavirus disease 2019 vaccines in pregnancy.” Am J Obstet Gynecol Mfm 3, no. 2 (March 2021): 100295. https://doi.org/10.1016/j.ajogmf.2020.100295.Full Text Open Access Copy Link to Item
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Dotters-Katz, Sarah K., Hailey Harris, Sarahn M. Wheeler, Geeta K. Swamy, and Brenna L. Hughes. “Specialized prenatal care delivery for coronavirus disease 2019-exposed or -infected pregnant women.” Am J Obstet Gynecol 224, no. 3 (March 2021): 325–27. https://doi.org/10.1016/j.ajog.2020.11.025.Full Text Link to Item
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Craig, Amanda M., Brenna L. Hughes, and Geeta K. Swamy. “Reply: Coronavirus disease 2019 vaccines in pregnancy.” Am J Obstet Gynecol Mfm 3, no. 3 (February 20, 2021): 100337. https://doi.org/10.1016/j.ajogmf.2021.100337.Full Text Link to Item
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Craig, Amanda M., Brenna L. Hughes, and Geeta K. Swamy. “Coronavirus disease 2019 vaccine in pregnant women: not so far! The importance of counseling and the need for evidence-based data.” Am J Obstet Gynecol Mfm 3, no. 3 (February 1, 2021): 100323. https://doi.org/10.1016/j.ajogmf.2021.100323.Full Text Open Access Copy Link to Item
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DeNoble, Anna E., Frances M. Saccoccio, Sallie R. Permar, and Brenna L. Hughes. “Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report.” Clin Infect Dis 71, no. 9 (December 3, 2020): 2506–8. https://doi.org/10.1093/cid/ciaa305.Full Text Link to Item
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Gatta, Luke A., and Brenna L. Hughes. “Premature Rupture of Membranes with Concurrent Viral Infection.” Obstet Gynecol Clin North Am 47, no. 4 (December 2020): 605–23. https://doi.org/10.1016/j.ogc.2020.08.006.Full Text Link to Item
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Johnson, Jasmine D., Emilie Melvin, Sindhu K. Srinivas, Judette M. Louis, Brenna Hughes, Christina Shih-Chi Han, Mary E. Norton, and Erika F. Werner. “COVID-19 Testing, Personal Protective Equipment, and Staffing Strategies Vary at Obstetrics Centers across the Country.” Am J Perinatol 37, no. 14 (December 2020): 1482–84. https://doi.org/10.1055/s-0040-1718401.Full Text Link to Item
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Sayres, Lauren, and Brenna L. Hughes. “Contemporary Understanding of Ebola and Zika Virus in Pregnancy.” Clin Perinatol 47, no. 4 (December 2020): 835–46. https://doi.org/10.1016/j.clp.2020.08.005.Full Text Link to Item
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Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Dr. Balevic, et al reply.” J Rheumatol 47, no. 10 (October 1, 2020): 1587. https://doi.org/10.3899/jrheum.200681.Full Text Link to Item
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Denoble, Anna E., Jenny Wu, Courtney J. Mitchell, Brenna L. Hughes, and Sarah K. Dotters-Katz. “Chorioamnionitis versus intraamniotic infection among preterm deliveries-is postpartum infectious morbidity different?” Am J Obstet Gynecol Mfm 2, no. 3 (August 2020): 100176. https://doi.org/10.1016/j.ajogmf.2020.100176.Full Text Link to Item
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Prasad, Mona, George Saade, and Brenna Hughes. “In Reply.” Obstet Gynecol 136, no. 2 (August 2020): 427–28. https://doi.org/10.1097/AOG.0000000000004032.Full Text Link to Item
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Werner, Erika F., Judette M. Louis, Brenna Hughes, Christina Shih-Chi Han, Mary E. Norton, and Sindhu K. Srinivas. “Community Obstetrical Units Less Likely than Academic Units to Have Universal COVID-19 Testing.” Am J Perinatol 37, no. 10 (August 2020): 1074–76. https://doi.org/10.1055/s-0040-1712454.Full Text Link to Item
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Mancuso, Abigail C., Lea E. Widdice, Brenna L. Hughes, Patrick Schlievert, Geeta K. Swamy, Colleen K. Stockdale, David I. Bernstein, and Patricia L. Winokur. “Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial.” J Low Genit Tract Dis 24, no. 3 (July 2020): 277–83. https://doi.org/10.1097/LGT.0000000000000543.Full Text Link to Item
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Dotters-Katz, Sarah K., and Brenna L. Hughes. “Considerations for Obstetric Care during the COVID-19 Pandemic.” Am J Perinatol 37, no. 8 (June 2020): 773–79. https://doi.org/10.1055/s-0040-1710051.Full Text Link to Item
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Balevic, Stephen J., Christoph P. Hornik, Thomas P. Green, Megan E. B. Clowse, Daniel Gonzalez, Anil R. Maharaj, Laura E. Schanberg, et al. “Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.” J Rheumatol, May 11, 2020. https://doi.org/10.3899/jrheum.200493.Full Text Link to Item
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Dotters-Katz, S., and B. L. Hughes. “COVID-19: The pathogen that will define the decade.” Contemporary Ob/Gyn 65, no. 4 (April 1, 2020): 11–12.
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Prasad, Mona, George R. Saade, Grecio Sandoval, Brenna L. Hughes, Uma M. Reddy, Lisa Mele, Ashley Salazar, et al. “Hepatitis C Virus Antibody Screening in a Cohort of Pregnant Women: Identifying Seroprevalence and Risk Factors.” Obstet Gynecol 135, no. 4 (April 2020): 778–88. https://doi.org/10.1097/AOG.0000000000003754.Full Text Link to Item
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Clinton, Chelsea M., James R. Bain, Michael J. Muehlbauer, YuanYuan Li, Leping Li, Sara K. O’Neal, Brenna L. Hughes, David E. Cantonwine, Thomas F. Mcelrath, and Kelly K. Ferguson. “Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction.” Sci Rep 10, no. 1 (March 24, 2020): 5307. https://doi.org/10.1038/s41598-020-62131-7.Full Text Link to Item
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Griffiths, Paul, and Brenna Hughes. “Choice of Study Populations for Vaccines.” J Infect Dis 221, no. Suppl 1 (March 5, 2020): S128–34. https://doi.org/10.1093/infdis/jiz537.Full Text Link to Item
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Siegel, Anne M., Chelsea M. Clinton, Annalisa L. Post, Tracy Truong, Carl F. Pieper, and Brenna L. Hughes. “Assessing patient perceptions of cytomegalovirus infection in pregnancy.” J Med Virol, February 19, 2020. https://doi.org/10.1002/jmv.25714.Full Text Link to Item
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Venkatesh, Kartik K., Brenna L. Hughes, Chad A. Grotegut, Robert A. Strauss, David M. Stamilio, R Philip Heine, and Sarah K. Dotters-Katz. “Preoperative cefazolin rather than clindamycin or metronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery.” Am J Obstet Gynecol Mfm 2, no. 1 (February 2020): 100074. https://doi.org/10.1016/j.ajogmf.2019.100074.Full Text Link to Item
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Blackwell, Sean C., Cynthia Gyamfi-Bannerman, Joseph R. Biggio, Suneet P. Chauhan, Brenna L. Hughes, Judette M. Louis, Tracy A. Manuck, et al. “17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG Study): A Multicenter, International, Randomized Double-Blind Trial.” Am J Perinatol 37, no. 2 (January 2020): 127–36. https://doi.org/10.1055/s-0039-3400227.Full Text Link to Item
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Albright, Catherine M., Timothy E. Spillane, Brenna L. Hughes, and Dwight J. Rouse. “A Regression Model for Prediction of Cesarean-Associated Blood Transfusion.” Am J Perinatol 36, no. 9 (July 2019): 879–85. https://doi.org/10.1055/s-0039-1678604.Full Text Link to Item
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Albright, Catherine M., Erika F. Werner, and Brenna L. Hughes. “Cytomegalovirus Screening in Pregnancy: A Cost-Effectiveness and Threshold Analysis.” Am J Perinatol 36, no. 7 (June 2019): 678–87. https://doi.org/10.1055/s-0038-1676495.Full Text Link to Item
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Hamel, Maureen S., Phinnara Has, Ilina Datkhaeva, Kimberly Delacy, Dana Ciolfi, and Brenna Hughes. “The Effect of Intrapartum Vancomycin on Vaginal Group B Streptococcus Colony Counts.” Am J Perinatol 36, no. 6 (May 2019): 555–60. https://doi.org/10.1055/s-0038-1675622.Full Text Link to Item
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Venkatesh, Kartik K., Wesley Jackson, Brenna L. Hughes, Mathew M. Laughon, John M. Thorp, and David M. Stamilio. “Association of chorioamnionitis and its duration with neonatal morbidity and mortality.” J Perinatol 39, no. 5 (May 2019): 673–82. https://doi.org/10.1038/s41372-019-0322-0.Full Text Link to Item
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Venkatesh, Kartik K., Wesley Jackson, Brenna L. Hughes, Mathew M. Laughon, John M. Thorp, and David M. Stamilio. “Correction: Association of chorioamnionitis and its duration with neonatal morbidity and mortality.” J Perinatol 39, no. 5 (May 2019): 761. https://doi.org/10.1038/s41372-019-0341-x.Full Text Link to Item
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Bengtson, Angela M., Alan M. Sanfilippo, Brenna L. Hughes, and David A. Savitz. “Maternal immunisation to improve the health of HIV-exposed infants.” Lancet Infect Dis 19, no. 4 (April 2019): e120–31. https://doi.org/10.1016/S1473-3099(18)30545-0.Full Text Link to Item
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Harris, Benjamin S., Maeve K. Hopkins, Margaret S. Villers, Jeremy M. Weber, Carl Pieper, Chad A. Grotegut, Geeta K. Swamy, Brenna L. Hughes, and R Phillips Heine. “Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections.” Ajp Rep 9, no. 2 (April 2019): e167–71. https://doi.org/10.1055/s-0039-1685503.Full Text Open Access Copy Link to Item
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Bengtson, Angela M., Alan M. Sanfilippo, Brenna L. Hughes, and David A. Savitz. “Maternal immunisation and neonatal infection of hepatitis A or B virus - Authors' reply.” Lancet Infect Dis 19, no. 3 (March 2019): 238–39. https://doi.org/10.1016/S1473-3099(19)30046-5.Full Text Link to Item
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Datkhaeva, Ilina, Phinnara Has, Kelly Fitzgerald, and Brenna L. Hughes. “Outcomes of a Negative Rapid Influenza Diagnostic Test in Pregnant Women.” Am J Perinatol 36, no. 1 (January 2019): 90–96. https://doi.org/10.1055/s-0038-1666975.Full Text Link to Item
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Hughes, B. L. “Group A Streptococcus puerperal sepsis: an emerging obstetric infection?” Bjog 126, no. 1 (January 2019): 54. https://doi.org/10.1111/1471-0528.15485.Full Text Link to Item
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Wood, Amber M., Sarah K. Dotters-Katz, and Brenna L. Hughes. “Cervical Cerclage versus Vaginal Progesterone for Management of Short Cervix in Low-Risk Women.” Am J Perinatol 36, no. 2 (January 2019): 111–17. https://doi.org/10.1055/s-0038-1668547.Full Text Link to Item
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Lantos, Paul M., Gabriela Maradiaga-Panayotti, Xavier Barber, Eileen Raynor, Debara Tucci, Kate Hoffman, Sallie R. Permar, et al. “Geographic and Racial Disparities in Infant Hearing Loss.” Otolaryngol Head Neck Surg, October 9, 2018, 194599818803305. https://doi.org/10.1177/0194599818803305.Full Text Open Access Copy Link to Item
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Blackwell, Sean C., Cynthia Gyamfi-Bannerman, Joseph R. Biggio, Suneet P. Chauhan, Brenna L. Hughes, Judette M. Louis, Tracy Manuck, et al. “PROLONG Clinical Study Protocol: Hydroxyprogesterone Caproate to Reduce Recurrent Preterm Birth.” Am J Perinatol 35, no. 12 (October 2018): 1228–34. https://doi.org/10.1055/s-0038-1642062.Full Text Link to Item
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Froehlich, Rosemary J., Lindsay Maggio, Phinnara Has, Roxanne Vrees, and Brenna L. Hughes. “Improving Obstetric Hypertensive Emergency Treatment in a Tertiary Care Women's Emergency Department.” Obstet Gynecol 132, no. 4 (October 2018): 850–58. https://doi.org/10.1097/AOG.0000000000002809.Full Text Link to Item
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Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, Amy Kind, and Geeta Swamy. “Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy.” J Racial Ethn Health Disparities 5, no. 4 (August 2018): 782–86. https://doi.org/10.1007/s40615-017-0423-4.Full Text Open Access Copy Link to Item
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Sudhof, Leanna S., Phinnara Has, Dwight J. Rouse, and Brenna L. Hughes. “Choice of Trial of Labor after Cesarean and Association with Likelihood of Success.” Am J Perinatol 35, no. 9 (July 2018): 892–97. https://doi.org/10.1055/s-0038-1626714.Full Text Link to Item
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Wood, Amber M., and Brenna L. Hughes. “Detection and Prevention of Perinatal Infection: Cytomegalovirus and Zika Virus.” Clin Perinatol 45, no. 2 (June 2018): 307–23. https://doi.org/10.1016/j.clp.2018.01.005.Full Text Link to Item
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Hughes, B. L., C. M. Page, and J. A. Kuller. “Hepatitis C in pregnancy: Screening, treatment, and management.” Contemporary Ob/Gyn 63, no. 5 (May 1, 2018): 22–31.
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Wood, Amber M., Elizabeth G. Livingston, Brenna L. Hughes, and Jeffrey A. Kuller. “Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management.” Obstet Gynecol Surv 73, no. 2 (February 2018): 103–9. https://doi.org/10.1097/OGX.0000000000000524.Full Text Link to Item
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Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Jeffrey A., Brenna L. Hughes, Charlotte M. Page, and Jeffrey A. Kuller. “Hepatitis C in pregnancy: screening, treatment, and management.” Am J Obstet Gynecol 217, no. 5 (November 2017): B2–12. https://doi.org/10.1016/j.ajog.2017.07.039.Full Text Link to Item
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Albright, Catherine M., Phinnara Has, Dwight J. Rouse, and Brenna L. Hughes. “Internal Validation of the Sepsis in Obstetrics Score to Identify Risk of Morbidity From Sepsis in Pregnancy.” Obstet Gynecol 130, no. 4 (October 2017): 747–55. https://doi.org/10.1097/AOG.0000000000002260.Full Text Link to Item
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Hughes, Brenna L., Kim M. Gans, Christina Raker, Evelyn R. Hipolito, and Dwight J. Rouse. “A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial.” Obstet Gynecol 130, no. 4 (October 2017): 726–34. https://doi.org/10.1097/AOG.0000000000002216.Full Text Link to Item
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Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, and Geeta K. Swamy. “Geographic Disparities in Cytomegalovirus Infection During Pregnancy.” J Pediatric Infect Dis Soc 6, no. 3 (September 1, 2017): e55–61. https://doi.org/10.1093/jpids/piw088.Full Text Link to Item
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Albright, Catherine M., Brenna L. Hughes, and Erika F. Werner. “In Reply.” Obstet Gynecol 130, no. 1 (July 2017): 217–18. https://doi.org/10.1097/AOG.0000000000002122.Full Text Link to Item
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Grupper, Mordechai, Joseph L. Kuti, Morgan L. Swank, Lindsay Maggio, Brenna L. Hughes, and David P. Nicolau. “Population Pharmacokinetics of Cefazolin in Serum and Adipose Tissue From Overweight and Obese Women Undergoing Cesarean Delivery.” J Clin Pharmacol 57, no. 6 (June 2017): 712–19. https://doi.org/10.1002/jcph.851.Full Text Link to Item
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Page, Charlotte M., Brenna L. Hughes, Eleanor H. J. Rhee, and Jeffrey A. Kuller. “Hepatitis C in Pregnancy: Review of Current Knowledge and Updated Recommendations for Management.” Obstet Gynecol Surv 72, no. 6 (June 2017): 347–55. https://doi.org/10.1097/OGX.0000000000000442.Full Text Link to Item
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Datkhaeva, Ilina, Danielle Dray, Phinnara Has, Bianca Stifani, Brenna L. Hughes, and Dwight J. Rouse. “Uptake of a Guideline for the Administration of a Rescue Course of Antenatal Corticosteroids.” Obstet Gynecol 129, no. 4 (April 2017): 720–26. https://doi.org/10.1097/AOG.0000000000001934.Full Text Link to Item
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Hughes, Brenna L., Rebecca G. Clifton, John C. Hauth, Kenneth J. Leveno, Leslie Myatt, Uma M. Reddy, Michael W. Varner, et al. “Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data.” Am J Perinatol 33, no. 10 (August 2016): 983–90. https://doi.org/10.1055/s-0036-1583188.Full Text Link to Item
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Society for Maternal-Fetal Medicine (SMFM), Cynthia, Brenna L. Hughes, and Cynthia Gyamfi-Bannerman. “Diagnosis and antenatal management of congenital cytomegalovirus infection.” Am J Obstet Gynecol 214, no. 6 (June 2016): B5–11. https://doi.org/10.1016/j.ajog.2016.02.042.Full Text Link to Item
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Hughes, B. L. “Antibiotic prophylaxis in pregnancy-benefit without harm?” Bjog 123, no. 6 (May 2016): 994. https://doi.org/10.1111/1471-0528.13624.Full Text Link to Item
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Albright, Catherine M., Niharika D. Mehta, Dwight J. Rouse, and Brenna L. Hughes. “Sepsis in Pregnancy: Identification and Management.” J Perinat Neonatal Nurs 30, no. 2 (April 2016): 95–105. https://doi.org/10.1097/JPN.0000000000000159.Full Text Link to Item
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Briody, Victoria A., Catherine M. Albright, Phinnara Has, and Brenna L. Hughes. “Use of Cefazolin for Group B Streptococci Prophylaxis in Women Reporting a Penicillin Allergy Without Anaphylaxis.” Obstet Gynecol 127, no. 3 (March 2016): 577–83. https://doi.org/10.1097/AOG.0000000000001297.Full Text Link to Item
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Ward, Nicholas S., Brenna L. Hughes, and Leonard A. Mermel. “Enterovirus D68 Infection in an Adult.” Am J Crit Care 25, no. 2 (March 2016): 178–80. https://doi.org/10.4037/ajcc2016955.Full Text Link to Item
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Hamel, M. S., and B. L. Hughes. “Zika infection in pregnancy: Pregnant women are worried, and their concern is warranted. here is what we know now and what’s being done about this health crisis.” Contemporary Ob/Gyn 61, no. 8 (January 1, 2016).
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Mainiero, Alexandra D., Dwight J. Rouse, Vrishali Lopes, and Brenna L. Hughes. “Association of 17α-Hydroxyprogesterone Caproate and Risk of Infection.” Obstet Gynecol 126, no. 1 (July 2015): 103–8. https://doi.org/10.1097/AOG.0000000000000881.Full Text Link to Item
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Hamel, Maureen S., Brenna L. Hughes, and Dwight J. Rouse. “Whither oxygen for intrauterine resuscitation?” Am J Obstet Gynecol 212, no. 4 (April 2015): 461-2.461.e1. https://doi.org/10.1016/j.ajog.2015.01.057.Full Text Link to Item
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Hamel, Maureen S., Brenna L. Hughes, and Dwight J. Rouse. “Reply: To PMID 24412117.” Am J Obstet Gynecol 212, no. 3 (March 2015): 410. https://doi.org/10.1016/j.ajog.2014.11.005.Full Text Link to Item
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Book Sections
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Hughes, B. L. “Cytomegalovirus, Genital Herpes, Rubella, Syphilis, and Toxoplasmosis.” In Protocols for High-Risk Pregnancies: An Evidence-Based Approach: Sixth Edition, 213–21, 2015. https://doi.org/10.1002/9781119001256.ch26.Full Text
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Conference Papers
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Venkatesh, Kartik K., Catherine J. Vladutiu, Robert A. Strauss, John M. Thorp, Jeffrey S. A. Stringer, David M. Stamilio, Brenna L. Hughes, and Sarah Dotters-Katz. “Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort.” In J Womens Health (Larchmt), 29:1507–12, 2020. https://doi.org/10.1089/jwh.2019.8139.Full Text Link to Item
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Varvoutis, Megan, Chelsea Feldman, Emily Reiff, Brenna L. Hughes, and Chad Grotegut. “Is Incision to Delivery Time Associated With Poor Neonatal Neurological Outcomes in Women With Class 3 Obesity? [31L].” In Obstetrics & Gynecology, 133:137S-137S. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.1097/01.aog/01.aog.0000559265.40266.e1.Full Text
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Clinton, Chelsea M., James R. Bain, Michael J. Muehlbauer, Sara K. O’Neal, Brenna L. Hughes, Tracy Truong, Carl F. Pieper, Thomas F. McElrath, and Kelly K. Ferguson. “112: Urinary metabolomic profiles in pregnancy and association with fetal growth restriction.” In American Journal of Obstetrics and Gynecology, 220:S90–91. Elsevier BV, 2019. https://doi.org/10.1016/j.ajog.2018.11.133.Full Text
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Venkatesh, Kartik K., Wesley Jackson, Brenna L. Hughes, Matthew M. Laughon, John M. Thorp, and David M. Stamilio. “568: Association of chorioamnionitis and its duration with neonatal morbidity and mortality.” In American Journal of Obstetrics and Gynecology, 220:S378–S378. Elsevier BV, 2019. https://doi.org/10.1016/j.ajog.2018.11.590.Full Text
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Clinton, C., A. Post, T. Truong, and B. L. Hughes. “Assessing patient perceptions of cytomegalovirus infection in pregnancy.” In American Journal of Obstetrics and Gynecology, 219:647–647. Elsevier BV, 2018. https://doi.org/10.1016/j.ajog.2018.10.044.Full Text
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Froehlich, Rosemary J., Lindsay Maggio, Phinnara Has, Roxanne Vrees, and Brenna L. Hughes. “Improving the Treatment of Obstetric Hypertensive Emergency.” In American Journal of Obstetrics and Gynecology, 218:S537–38. MOSBY-ELSEVIER, 2018.Link to Item
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Hamel, M., P. Has, I. Datkhaeva, K. Delacy, D. Ciofli, and B. L. Hughes. “The effect of intrapartum vancomycin on vaginal Group B streptococcus colony counts.” In American Journal of Obstetrics and Gynecology, 217:719–20. Elsevier BV, 2017. https://doi.org/10.1016/j.ajog.2017.08.096.Full Text
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Post, A., C. Raker, K. Gans, and B. L. Hughes. “Patient perceptions of educational interventions for prevention of perinatal cytomegalovirus infection.” In American Journal of Obstetrics and Gynecology, 217:724–724. MOSBY-ELSEVIER, 2017.Link to Item
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Reiff, E. S., C. A. Grotegut, E. F. Werner, and B. L. Hughes. “A cost analysis of adjunctive azithromycin prophylaxis for women undergoing non-elective cesarean delivery.” In American Journal of Obstetrics and Gynecology, 217:720–720. MOSBY-ELSEVIER, 2017.Link to Item
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Wood, A. M., B. L. Hughes, R. P. Heine, and M. S. Villers. “Group B strep and associated complications in cesarean delivery.” In American Journal of Obstetrics and Gynecology, 217:723–723. MOSBY-ELSEVIER, 2017.Link to Item
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Albright, Catherine M., Caitlin MacGregor, Desmond Sutton, Meena Theva, Brenna L. Hughes, and Erika F. Werner. “Group B Streptococci Screening Before Repeat Cesarean Delivery: A Cost-Effectiveness Analysis.” In Obstet Gynecol, 129:111–19, 2017. https://doi.org/10.1097/AOG.0000000000001800.Full Text Link to Item
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Hughes, Brenna L., Riana Dutt, Christina Raker, Melody Barthelemy, Richard M. Rossoll, Bharat Ramratnam, Charles R. Wira, and Susan Cu-Uvin. “The impact of pregnancy on anti-HIV activity of cervicovaginal secretions.” In Am J Obstet Gynecol, 215:748.e1-748.e12, 2016. https://doi.org/10.1016/j.ajog.2016.06.057.Full Text Link to Item
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Albright, Catherine M., Jenna B. Emerson, Erika F. Werner, and Brenna L. Hughes. “Third-Trimester Prenatal Syphilis Screening: A Cost-Effectiveness Analysis.” In Obstet Gynecol, 126:479–85, 2015. https://doi.org/10.1097/AOG.0000000000000997.Full Text Link to Item
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Maggio, Lindsay, David P. Nicolau, Melissa DaCosta, Dwight J. Rouse, and Brenna L. Hughes. “Cefazolin prophylaxis in obese women undergoing cesarean delivery: a randomized controlled trial.” In Obstet Gynecol, 125:1205–10, 2015. https://doi.org/10.1097/AOG.0000000000000789.Full Text Link to Item
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- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Optimal dosing of pre-cesaren cefazolin prophylaxis in obese women: an individual patient data meta-analysis. Poster Presentation (co-author). Society for Maternal Fetal Medicine. January 2017 2017
- Prediction of cefazolin adipose concentrations using a validated physiologic model. Poster Presentation (co-author). Society for Maternal Fetal Medicine. January 2017 2017
- Validation of the sepsis in obstetrics score: a model to predict intensive care unit transfer for sepsis in pregnancy. Poster Presentation (co-author). Society for Maternal Fetal Medicine. January 2017 2017
- Outcomes of a Negative Rapid Influenza Diagnostic Test in Pregnant Women. Oral Presentation (co-presenter). 43rd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2016 2016
- Uptake of a Guideline for the Administration of a Rescue Course of Antenatal Corticosteroids. Poster Presentation (co-author). Society of Reproductive Investigation Annual Meeting. March 2016 2016
- Are serum levels of enzymes involved in the production of endogenous carbon monoxide and bilirubin elevated in preeclampsia with severe features. Poster Presentation (co-author). 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- Development of a prediction model for cesarean-associated blood transfusion. Poster Presentation (co-author). 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- Randomized trial of behavioral change for cytomegalovirus risk prevention. Oral Presentation. 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- The association of BMI and wound infection after cesarean delivery. Poster Presentation (co-author). 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- Inflammatory Mediators in Cervicovaginal Secretions and Association with HIV Infectivity among Pregnant and Non-pregnant Women. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Longitudinal cohort study of association of HIV infectivity with pregnancy. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Uptake of a Third Trimester HIV Testing Program at a Tertiary Care Hospital. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Use of Cefazolin for Group B streptococcus Prophylaxis in Women Allergic to Penicillin Without Anaphylaxis. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Choice of trial of labor after cesarean and association with likelihood of success. Poster Presentation (co-author). 35th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2015 2015
- Optimal dosing of cefazolin in obese women undergoing cesarean delivery: a double-blinded randomized controlled trial. Oral Presentation (co-presenter). 35th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2015 2015
- Universal Cytomegalovirus screening in pregnancy: a cost-effectiveness analysis. Poster Presentation (co-author). 35th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2015 2015
- Impact of Treatment for Trichomoniasis on Genital Tract Inflammatory Mediators Among HIV-1 Infected Females in South Africa. Oral Presentation (co-presenter). 41st Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 9, 2014 2014
- Third trimester syphilis screening in pregnancy: A cost-benefit analysis. Oral Presentation (co-presenter). 41st Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 9, 2014 2014
- Lactic acid measurement to identify risk of morbidity in pregnanc. Poster Presentation (co-author). 34th annual meeting of the Society for Maternal Fetal Medicine. February 2014 2014
- On behalf of the Maternal Fetal Medicine Units Network, HOMA-IR is not a useful screening tool for peripartum infection. Oral Presentation. 40th Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 10, 2013 2013
- The Sepsis in Obstetrics Score (SOS): A Model for Predicting Morbidity from Sepsis in Pregnancy. Oral Presentation (co-presenter). 40th Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 10, 2013 2013
- Association of early pregnancy hemoglobin A1c with placental lesions in diabetic pregnancy. Poster Presentation (co-author). 33rd annual meeting of the Society for Maternal Fetal Medicine. 2013 2013
- Placental histopathological changes and adverse pregnancy outcome among diabetic gravidas. Poster Presentation (co-author). 33rd annual meeting of the Society for Maternal Fetal Medicine. 2013 2013
- Racial differences in vaginal flora and cytokine concentrations during pregnancy. Poster Presentation. 33rd annual meeting of the Society for Maternal Fetal Medicine. 2013 2013
- Genital Leukocytes and HIV Infectivity in Pregnancy. Oral Presentation. 38th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2011 2011
- Pregnancy Mediated Changes in Vaginal Microflora. Oral Presentation. 38th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2011 2011
- Pregnancy and Changes in Local and Systemic Immune Markers. Poster Presentation. 38th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2011 2011
- Effect of trichomoniasis therapy on genital HIV viral burden among African women. Poster Presentation. 18th Annual Conference on Retroviruses and Opportunistic Infections. March 2011 2011
- Anemia and chorioamnionitis at term. Poster Presentation (co-author). 31st Annual Meeting of the Society for Maternal Fetal Medicine. February 2011 2011
- Cervicovaginal Fluid from Third Trimester Pregnant and Non-Pregnant Women Suppresses HIV Infectivity in an In Vitro Model. Poster Presentation. 37th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2010 2010
- Clinical Characteristics of Pregnant Women with 2009 H1N1 Influenza. Poster Presentation. 37th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2010 2010
- Self-Collected Vaginal Swabs for Trichomoniasis Testing in HIV-infected Women in South Africa. Poster Presentation. 37th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2010 2010
- Morbidity Associated with Postpartum Pyelonephritis as Compared to an Antepartum Population. Poster Presentation (co-author). 58th annual clinical meeting of the American Congress of Obstetricians and Gynecologists. May 2010 2010
- Development and evaluation of a formal research curriculum for obstetrics and gynecology residents. Poster Presentation (co-author). 2010 APGO CREOG Annual Meeting. March 2010 2010
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal Fetal Medicine Units Network. The impact of antibiotic therapy on vaginal flora among women with a positive fetal fibronectin. Poster Presentation. 57th Annual Meeting of the Society for Gynecologic Investigation. March 2010 2010
- Cervicovaginal fluid from pregnant and non-pregnant women suppresses HIV infectivity in an in vitro model. Oral Presentation. 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Elective Inductions at Term and Adverse Neonatal Outcomes. Poster Presentation (co-author). 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Maternal inflammatory mediators are increased as early as the first trimester in low risk pregnancies. Poster Presentation. 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Mersilene Versus Ethibond Suture Efficacy and Cerclage. Poster Presentation (co-author). 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Timing of delivery with placenta previa: maternal and neonatal outcomes. Poster Presentation (co-author). 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- First Trimester Pyelonephritis is Primarily Associated with Lack of Prenatal Care. Oral Presentation (co-presenter). 36th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2009 2009
- Hepatotoxicity and Metabolic Acidosis Manifested as Non-Reassuring Fetal Testing in a Pregnant Woman on Antiretroviral Therapy. Poster Presentation (co-author). 36th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2009 2009
- Subtle Perturbations of Genital Microflora Alter Immunity Among Low Risk Pregnant Women. Oral Presentation. 36th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2009 2009
- Exploring Non-Physician Healthcare Provider Knowledge of Influenza in Pregnancy. Poster Presentation (co-author). ACOG Annual Clinical Meeting. May 2009 2009
- A proposed randomized controlled trial of maternal hyperimmune globulin to prevent fetal infection. Oral Presentation (co-presenter). International Congenital CMV Conference. November 2008 2008
- Assessment of the need for rapid Group B Streptococcus testing during labor and delivery. Poster Presentation (co-author). 35th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2008 2008
- High prevalence of Ureaplasma urealyticum vaginal colonization among low-risk pregnant and non-pregnant women. Poster Presentation. 35th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2008 2008
- Pyelonephritis in pregnancy as a prevention quality indicator for quality of prenatal care. Oral Presentation (co-presenter). 35th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2008 2008
- Recurrent and single-episode pyelonephritis during pregnancy: a case-control study. Poster Presentation (co-author). 56th Annual Clinical Meeting of the American College of Obstetrics and Gynecology (ACOG). May 2008 2008
- Association between genital tract HIV-1 RNA shedding and mucosal inflammation among women on effective ART with undetectable plasma viral load. Poster Presentation (co-author). 15th Annual Conference on Retroviruses and Opportunistic Infections (CROI). February 2008 2008
- Association between genital tract white blood cells and viral shedding among HIV-infected women in the absence of genital infections. Poster Presentation. 45th Annual Meeting of the Infectious Diseases Society of America. October 2007 2007
- Association between genital tract white blood cells and viral shedding among HIV-infected women in the absence of genital infections. Oral Presentation. 2007 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2007 2007
- Varicella zoster meningitis in a pregnant woman with Human Immunodeficiency Virus. Poster Presentation (co-author). August, 2007 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2007 2007
- Additional antibiotic use and preterm birth among women with Group B Streptococcal bacteriuria. Poster Presentation. 2007 Annual Meeting for the Society for Maternal Fetal Medicine. February 2007 2007
- Effect of antenatal indomethacin therapy on fetal ductus arteriosus and amniotic fluid volume. Poster Presentation (co-author). 2007 Annual Meeting for the Society for Maternal Fetal Medicine. February 2007 2007
- Untreated asymptomatic Group B Streptococcal (GBS) bacteriuria early in pregnancy is associated with chorioamnionitis. Poster Presentation. 2005 Annual Meeting for the Society for Gynecologic Investigation. March 2006 2006
- Systemic inflammatory response to sexually transmitted infection in pregnancy. Oral Presentation. 2005 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2005 2005
- Vertebral abscess in pregnancy: a case report. Poster Presentation. 2005 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2005 2005
- Fetal echocardiographic findings are not predictive of death in twin-twin transfusion syndrome. Poster Presentation. 2005 Annual Meeting of Society for Maternal Fetal Medicine. February 2005 2005
- Asymptomatic trichomoniasis during pregnancy is associated with vaginal neutrophil activation. Oral Presentation. 2004 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. 2004 2004
- Improving universal prenatal screening for Human Immunodeficiency Virus. Poster Presentation. 2003 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. 2003 2003
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