Brenna L Hughes
Associate Professor of Obstetrics and Gynecology
Current Appointments & Affiliations
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2018
Contact Information
- Background
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Education, Training, & Certifications
- M.D., Brown University 1999
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Medical Licensure
- 2016-02015. North Carolina. 2019
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Duke Appointment History
- Associate Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2017 - 2018
- Instructor, Temporary in the Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine, Obstetrics and Gynecology 2016 - 2017
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Leadership & Clinical Positions at Duke
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- Fellowship Director, Maternal-Fetal Medicine
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Academic Positions Outside Duke
- Fellowship Director, Warren Alpert Medical School of Brown University. 2015 - 2016
- Director, Women and Infants Hospital. 2014 - 2016
- Associate Professor, Warren Alpert Medical School of Brown University. 2012 - 2016
- Assistant Professor, Warren Alpert Medical School of Brown University. 2006 - 2012
- Recognition
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Awards & Honors
- Hospital-based Faculty Teaching Award. Chief Resident Class, Brown University. 2016
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2016
- 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology, Best Poster Award. Infectious Disease Society for Obstetrics and Gynecology. 2015
- Best Doctors in America regional list U.S. News and World Report. Castle Connolly. 2015
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2015
- Top 10% of reviewer for Obstetrics & Gynecology awarded by editors. Infectious Disease Society of Obstetrics and Gynecology. 2015
- Hospital-based Faculty Teaching Award. Chief Resident Class, Brown University. 2014
- Top 10% of reviewer for Obstetrics & Gynecology awarded by editors. Infectious Disease Society of Obstetrics and Gynecology. 2012
- Top 5% of reviewers for American Journal of Obstetrics & Gynecology. Editors. 2012
- Best Doctors in America regional list U.S. News and World Report. Castle Connolly. 2011
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2011
- Invited participant in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Scientific Vision Process workshop, “Finale Conference—NICHD: Bringing the Vision Together". National Institute of Child Health and Human Development. 2011
- Top 5% of reviewers 2010 for BJOG: An International Journal of Obstetrics and Gynaecology. International Journal of Obstetrics and Gynaecology awarded by editors. 2011
- Society for Maternal Fetal Medicine Award for Research Excellence for oral presentation, “Cervicovaginal fluid from pregnant and non-pregnant women suppresses HIV infectivity in an in vitro model”. Society for Maternal Fetal Medicine. 2010
- Top 5% of reviewers for American Journal of Obstetrics & Gynecology. Editors. 2010
- Women & Infants Hospital Medical Staff Distinguished Service Award. Women and Infants Hospital. 2010
- Henry L. Darner AAOGF travel award to the annual meeting of the American Gynecological and Obstetrical Society. American Gynecological and Obstetrical Society. 2009
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2009
- Hospital-based Faculty Teaching Award. Chief Resident Class, Brown University. 2008
- Hospital-based faculty Excellence-in-teaching award. Brown University, Obstetrics Residents. 2007
- Recipient NIH Young Investigator Travel Award. Perinatal Research Society. 2007
- Top 5% of reviewers for American Journal of Obstetrics & Gynecology. Editors. 2007
- Top full time faculty teacher of the year award. Brown University. 2007
- Young Investigator Award for the Infectious Disease Society of Obstetrics and Gynecology. Infectious Disease Society of Obstetrics and Gynecology. 2007
- Award in Obstetrics and Gynecology. American College of Obstetricians and Gynecologists. 1999
- Janet Glasgow Award for Scholastic Achievement. American Medical Women’s Association. 1999
- Women in Medicine Scholarship. Brown University. 1999
- Phi Kappa Phi Honor. Phi Kappa Phi Honor Society. 1995
- Research
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Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Chronic Hypertension and Pregnancy (CHAP) NHLBI Multi-Site RCT awarded by University of Alabama at Birmingham 2014 - 2020
- PTN_TO51_BMS01 awarded by Duke Clinical Research Institute 2018 - 2019
- Rapid, Near Patient Nucleic Acid Testing for Infant Cytomegalovirus (CMV) Infection awarded by Baebies, Inc 2017 - 2019
- MFMU Network Clinical Center Participation awarded by University of North Carolina - Chapel Hill 2016 - 2018
- VTEU 12-0021 Task C - Base awarded by National Institutes of Health 2016 - 2018
- VTEU 12-0021 - Task C Option 1 awarded by National Institutes of Health 2017 - 2018
- Effect of Latrogenic Delivery at 34-38 Weeks Gestation on Pregnancy Outcome awarded by Women & Infants Hospital 2016 - 2017
- Publications & Artistic Works
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Selected Publications
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Conference Papers
- Hamel, M, Has, P, Datkhaeva, I, Delacy, K, Ciofli, D, and Hughes, BL. "The effect of intrapartum vancomycin on vaginal Group B streptococcus colony counts." December 2017. Link to Item
- Post, A, Raker, C, Gans, K, and Hughes, BL. "Patient perceptions of educational interventions for prevention of perinatal cytomegalovirus infection." December 2017. Link to Item
- Reiff, ES, Grotegut, CA, Werner, EF, and Hughes, BL. "A cost analysis of adjunctive azithromycin prophylaxis for women undergoing non-elective cesarean delivery." December 2017. Link to Item
- Wood, AM, Hughes, BL, Heine, RP, and Villers, MS. "Group B strep and associated complications in cesarean delivery." December 2017. Link to Item
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Journal Articles
- Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, , Hughes, BL, Page, CM, and Kuller, JA. "Hepatitis C in pregnancy: screening, treatment, and management." American journal of obstetrics and gynecology 217, no. 5 (November 2017): B2-B12. Full Text
- Albright, CM, Has, P, Rouse, DJ, and Hughes, BL. "Internal Validation of the Sepsis in Obstetrics Score to Identify Risk of Morbidity From Sepsis in Pregnancy." Obstetrics and gynecology 130, no. 4 (October 2017): 747-755. Full Text
- Hughes, BL, Gans, KM, Raker, C, Hipolito, ER, and Rouse, DJ. "A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus: A Randomized Controlled Trial." Obstetrics and gynecology 130, no. 4 (October 2017): 726-734. Full Text
- Lantos, PM, Hoffman, K, Permar, SR, Jackson, P, Hughes, BL, and Swamy, GK. "Geographic Disparities in Cytomegalovirus Infection During Pregnancy." Journal of the Pediatric Infectious Diseases Society 6, no. 3 (September 2017): e55-e61. Full Text
- Lantos, PM, Hoffman, K, Permar, SR, Jackson, P, Hughes, BL, Kind, A, and Swamy, G. "Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy." Journal of racial and ethnic health disparities (August 24, 2017). Full Text Open Access Copy
- Albright, CM, Hughes, BL, and Werner, EF. "In Reply." Obstetrics and gynecology 130, no. 1 (July 2017): 217-218. Full Text
- Albright, CM, Hughes, BL, and Werner, EF. "Group B Streptococci Screening Before Repeat Cesarean Delivery: A Cost-Effectiveness Analysis Reply." OBSTETRICS AND GYNECOLOGY 130, no. 1 (July 2017): 217-218. Full Text Link to Item
- Page, CM, Hughes, BL, Rhee, EHJ, and Kuller, JA. "Hepatitis C in Pregnancy: Review of Current Knowledge and Updated Recommendations for Management." Obstetrical & gynecological survey 72, no. 6 (June 2017): 347-355. (Review) Full Text
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- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Optimal dosing of pre-cesaren cefazolin prophylaxis in obese women: an individual patient data meta-analysis. Poster Presentation (co-author). Society for Maternal Fetal Medicine. January 2017 2017
- Prediction of cefazolin adipose concentrations using a validated physiologic model. Poster Presentation (co-author). Society for Maternal Fetal Medicine. January 2017 2017
- Validation of the sepsis in obstetrics score: a model to predict intensive care unit transfer for sepsis in pregnancy. Poster Presentation (co-author). Society for Maternal Fetal Medicine. January 2017 2017
- Outcomes of a Negative Rapid Influenza Diagnostic Test in Pregnant Women. Oral Presentation (co-presenter). 43rd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2016 2016
- Uptake of a Guideline for the Administration of a Rescue Course of Antenatal Corticosteroids. Poster Presentation (co-author). Society of Reproductive Investigation Annual Meeting. March 2016 2016
- Are serum levels of enzymes involved in the production of endogenous carbon monoxide and bilirubin elevated in preeclampsia with severe features. Poster Presentation (co-author). 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- Development of a prediction model for cesarean-associated blood transfusion. Poster Presentation (co-author). 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- Randomized trial of behavioral change for cytomegalovirus risk prevention. Oral Presentation. 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- The association of BMI and wound infection after cesarean delivery. Poster Presentation (co-author). 36th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2016 2016
- Inflammatory Mediators in Cervicovaginal Secretions and Association with HIV Infectivity among Pregnant and Non-pregnant Women. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Longitudinal cohort study of association of HIV infectivity with pregnancy. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Uptake of a Third Trimester HIV Testing Program at a Tertiary Care Hospital. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Use of Cefazolin for Group B streptococcus Prophylaxis in Women Allergic to Penicillin Without Anaphylaxis. 42nd Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 7, 2015 2015
- Choice of trial of labor after cesarean and association with likelihood of success. Poster Presentation (co-author). 35th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2015 2015
- Optimal dosing of cefazolin in obese women undergoing cesarean delivery: a double-blinded randomized controlled trial. Oral Presentation (co-presenter). 35th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2015 2015
- Universal Cytomegalovirus screening in pregnancy: a cost-effectiveness analysis. Poster Presentation (co-author). 35th Annual Meeting of the Society for Maternal Fetal Medicine. February 6, 2015 2015
- Impact of Treatment for Trichomoniasis on Genital Tract Inflammatory Mediators Among HIV-1 Infected Females in South Africa. Oral Presentation (co-presenter). 41st Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 9, 2014 2014
- Third trimester syphilis screening in pregnancy: A cost-benefit analysis. Oral Presentation (co-presenter). 41st Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 9, 2014 2014
- Lactic acid measurement to identify risk of morbidity in pregnanc. Poster Presentation (co-author). 34th annual meeting of the Society for Maternal Fetal Medicine. February 2014 2014
- On behalf of the Maternal Fetal Medicine Units Network, HOMA-IR is not a useful screening tool for peripartum infection. Oral Presentation. 40th Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 10, 2013 2013
- The Sepsis in Obstetrics Score (SOS): A Model for Predicting Morbidity from Sepsis in Pregnancy. Oral Presentation (co-presenter). 40th Annual Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 10, 2013 2013
- Association of early pregnancy hemoglobin A1c with placental lesions in diabetic pregnancy. Poster Presentation (co-author). 33rd annual meeting of the Society for Maternal Fetal Medicine. 2013 2013
- Placental histopathological changes and adverse pregnancy outcome among diabetic gravidas. Poster Presentation (co-author). 33rd annual meeting of the Society for Maternal Fetal Medicine. 2013 2013
- Racial differences in vaginal flora and cytokine concentrations during pregnancy. Poster Presentation. 33rd annual meeting of the Society for Maternal Fetal Medicine. 2013 2013
- Genital Leukocytes and HIV Infectivity in Pregnancy. Oral Presentation. 38th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2011 2011
- Pregnancy Mediated Changes in Vaginal Microflora. Oral Presentation. 38th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2011 2011
- Pregnancy and Changes in Local and Systemic Immune Markers. Poster Presentation. 38th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2011 2011
- Effect of trichomoniasis therapy on genital HIV viral burden among African women. Poster Presentation. 18th Annual Conference on Retroviruses and Opportunistic Infections. March 2011 2011
- Anemia and chorioamnionitis at term. Poster Presentation (co-author). 31st Annual Meeting of the Society for Maternal Fetal Medicine. February 2011 2011
- Cervicovaginal Fluid from Third Trimester Pregnant and Non-Pregnant Women Suppresses HIV Infectivity in an In Vitro Model. Poster Presentation. 37th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2010 2010
- Clinical Characteristics of Pregnant Women with 2009 H1N1 Influenza. Poster Presentation. 37th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2010 2010
- Self-Collected Vaginal Swabs for Trichomoniasis Testing in HIV-infected Women in South Africa. Poster Presentation. 37th Annual Meeting for the Infectious Disease Society for Obstetrics and Gynecology. August 2010 2010
- Morbidity Associated with Postpartum Pyelonephritis as Compared to an Antepartum Population. Poster Presentation (co-author). 58th annual clinical meeting of the American Congress of Obstetricians and Gynecologists. May 2010 2010
- Development and evaluation of a formal research curriculum for obstetrics and gynecology residents. Poster Presentation (co-author). 2010 APGO CREOG Annual Meeting. March 2010 2010
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal Fetal Medicine Units Network. The impact of antibiotic therapy on vaginal flora among women with a positive fetal fibronectin. Poster Presentation. 57th Annual Meeting of the Society for Gynecologic Investigation. March 2010 2010
- Cervicovaginal fluid from pregnant and non-pregnant women suppresses HIV infectivity in an in vitro model. Oral Presentation. 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Elective Inductions at Term and Adverse Neonatal Outcomes. Poster Presentation (co-author). 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Maternal inflammatory mediators are increased as early as the first trimester in low risk pregnancies. Poster Presentation. 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Mersilene Versus Ethibond Suture Efficacy and Cerclage. Poster Presentation (co-author). 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- Timing of delivery with placenta previa: maternal and neonatal outcomes. Poster Presentation (co-author). 30th Annual Meeting of the Society for Maternal Fetal Medicine. February 2010 2010
- First Trimester Pyelonephritis is Primarily Associated with Lack of Prenatal Care. Oral Presentation (co-presenter). 36th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2009 2009
- Hepatotoxicity and Metabolic Acidosis Manifested as Non-Reassuring Fetal Testing in a Pregnant Woman on Antiretroviral Therapy. Poster Presentation (co-author). 36th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2009 2009
- Subtle Perturbations of Genital Microflora Alter Immunity Among Low Risk Pregnant Women. Oral Presentation. 36th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2009 2009
- Exploring Non-Physician Healthcare Provider Knowledge of Influenza in Pregnancy. Poster Presentation (co-author). ACOG Annual Clinical Meeting. May 2009 2009
- A proposed randomized controlled trial of maternal hyperimmune globulin to prevent fetal infection. Oral Presentation (co-presenter). International Congenital CMV Conference. November 2008 2008
- Assessment of the need for rapid Group B Streptococcus testing during labor and delivery. Poster Presentation (co-author). 35th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2008 2008
- High prevalence of Ureaplasma urealyticum vaginal colonization among low-risk pregnant and non-pregnant women. Poster Presentation. 35th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2008 2008
- Pyelonephritis in pregnancy as a prevention quality indicator for quality of prenatal care. Oral Presentation (co-presenter). 35th Annual Scientific Meeting of the Infectious Diseases Society for Obstetrics and Gynecology. August 2008 2008
- Recurrent and single-episode pyelonephritis during pregnancy: a case-control study. Poster Presentation (co-author). 56th Annual Clinical Meeting of the American College of Obstetrics and Gynecology (ACOG). May 2008 2008
- Association between genital tract HIV-1 RNA shedding and mucosal inflammation among women on effective ART with undetectable plasma viral load. Poster Presentation (co-author). 15th Annual Conference on Retroviruses and Opportunistic Infections (CROI). February 2008 2008
- Association between genital tract white blood cells and viral shedding among HIV-infected women in the absence of genital infections. Poster Presentation. 45th Annual Meeting of the Infectious Diseases Society of America. October 2007 2007
- Association between genital tract white blood cells and viral shedding among HIV-infected women in the absence of genital infections. Oral Presentation. 2007 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2007 2007
- Varicella zoster meningitis in a pregnant woman with Human Immunodeficiency Virus. Poster Presentation (co-author). August, 2007 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2007 2007
- Additional antibiotic use and preterm birth among women with Group B Streptococcal bacteriuria. Poster Presentation. 2007 Annual Meeting for the Society for Maternal Fetal Medicine. February 2007 2007
- Effect of antenatal indomethacin therapy on fetal ductus arteriosus and amniotic fluid volume. Poster Presentation (co-author). 2007 Annual Meeting for the Society for Maternal Fetal Medicine. February 2007 2007
- Untreated asymptomatic Group B Streptococcal (GBS) bacteriuria early in pregnancy is associated with chorioamnionitis. Poster Presentation. 2005 Annual Meeting for the Society for Gynecologic Investigation. March 2006 2006
- Systemic inflammatory response to sexually transmitted infection in pregnancy. Oral Presentation. 2005 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2005 2005
- Vertebral abscess in pregnancy: a case report. Poster Presentation. 2005 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. August 2005 2005
- Fetal echocardiographic findings are not predictive of death in twin-twin transfusion syndrome. Poster Presentation. 2005 Annual Meeting of Society for Maternal Fetal Medicine. February 2005 2005
- Asymptomatic trichomoniasis during pregnancy is associated with vaginal neutrophil activation. Oral Presentation. 2004 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. 2004 2004
- Improving universal prenatal screening for Human Immunodeficiency Virus. Poster Presentation. 2003 Annual Meeting of Infectious Diseases Society for Obstetrics and Gynecology. 2003 2003
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