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Brenna L Hughes

Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Maternal Fetal Medicine

Selected Grants


Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

Duke MFMU Capitation Record

Clinical TrialPrincipal Investigator · Awarded by The George Washington University · 2023 - 2030

North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2001 - 2030

Large-scale Implementation of Community Co-led Maternal Sepsis Care Practices to Reduce Morbidity and Mortality from Maternal Infection

ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026

Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

Duke MFMU Capitation Record

Clinical TrialPrincipal Investigator · Awarded by The George Washington University · 2023 - 2030

North Carolina Clinical Center for the Eunice Kennedy Shiver NICHD Cooperative Multicenter Neonatal Research Network

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2001 - 2030

Large-scale Implementation of Community Co-led Maternal Sepsis Care Practices to Reduce Morbidity and Mortality from Maternal Infection

ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2016 - 2026

Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2021 - 2026

Population Health Research Support IDIQ Base

Clinical TrialCo-Principal Investigator · Awarded by National Institutes of Health · 2018 - 2025

TIME Aim of the Study of Pregnancy and Neonatal Health (SPAN) Task Order A

Clinical TrialPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2020 - 2025

Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A

Clinical TrialPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2019 - 2025

Duke Women's Reproductive Health Research Scholars

Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2020 - 2025

MFMU Network Studies 2021

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2021 - 2025

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Clinical and viral characteristics of maternal cytomegalovirus infection among seropositive pregnant women in the United States

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2022

PTN_TO51_BMS01 PK and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Clinical TrialPrincipal Investigator · Awarded by Duke Clinical Research Institute · 2018 - 2022

2/5 HEAL Consortium: Establishing Innovative Approaches for the HEALthy Brain and Child Development Study

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2022

MFMU Network Study - Maternal Morbidity and Mortality During the COVID-19 Pandemic

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2020 - 2021

Chronic Hypertension and Pregnancy (CHAP) NHLBI Multi-Site RCT

Clinical TrialPrincipal Investigator · Awarded by University of Alabama at Birmingham · 2014 - 2021

MFMU Network Study - AWARE

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2020 - 2021

MFMU Network Study - PACT

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2020 - 2021

MFMU Network Study - Prematurity Registry: An Observational Cohort Study of Obstetrical Determinants of Preterm Delivery and Neonatal Outcome

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2020 - 2021

MFMU Network Studies - PREP

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2019 - 2021

MFMU Network Studies - SLEEP

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2019 - 2021

MFMU Network Studies - PROSPECT

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2019 - 2021

MFMU Network Studies - TOPS

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2019 - 2021

MFMU Network Studies - TXA

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2019 - 2021

MFMU Network Clinical Center Participation

Clinical TrialPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2017 - 2021

Data Coordinating Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units (MFMU)

ResearchPrincipal Investigator · Awarded by The George Washington University · 1998 - 2021

Humoral immune correlates of protection against congenital CMV and HSV transmission in HIV-infected women

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2020

The Role of Calcium Homeostasis in Regulating Uterine Contractility and Tone

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2020

Rapid, Near Patient Nucleic Acid Testing for Infant Cytomegalovirus (CMV) Infection

ResearchCo Investigator · Awarded by Baebies, Inc · 2017 - 2020

Data Coordinating Center - NICHD Cooperative Multicenter Maternal Fetal Medicine Units (MFMU)

ResearchPrincipal Investigator · Awarded by The George Washington University · 2018 - 2019

Effect of Latrogenic Delivery at 34-38 Weeks Gestation on Pregnancy Outcome

ResearchPrincipal Investigator · Awarded by Women & Infants Hospital · 2016 - 2017

External Relationships


  • American Board of Obstetrics and Gynecology
  • Johns Hopkins University School of Medicine
  • Society for maternal fetal medicine
  • UpToDate, Inc

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.