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Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.

Publication ,  Journal Article
Plassman, BL; Chanti-Ketterl, M; Pieper, CF; Yaffe, K
Published in: Alzheimers Dement
November 2022

INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-National Research Council's Twins Registry of World War II male veterans were assigned a cognitive outcome based on a multi-step assessment protocol. History of TBI was obtained via interviews. RESULTS: Among 8302 individuals, risk of non-Alzheimer's disease (non-AD) dementia was higher in those with TBI (hazard ratio [HR] = 2.00, 95% confidence interval [CI], 0.97-4.12), than for AD (HR = 1.23, 95% CI, 0.76-2.00). To add more control of genetic and shared environmental factors, we analyzed 100 twin pairs discordant for both TBI and dementia onset, and found TBI-associated risk for non-AD dementia increased further (McNemar odds ratio = 2.70; 95% CI, 1.27-6.25). DISCUSSION: These findings suggest that non-AD mechanisms may underlie the association between TBI and dementia, potentially providing insight into inconsistent results from prior studies.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

November 2022

Volume

18

Issue

11

Start / End Page

2234 / 2242

Location

United States

Related Subject Headings

  • Veterans
  • Risk Factors
  • Registries
  • Odds Ratio
  • Male
  • Humans
  • Geriatrics
  • Dementia
  • Brain Injuries, Traumatic
  • 5202 Biological psychology
 

Citation

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Chicago
ICMJE
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Plassman, B. L., Chanti-Ketterl, M., Pieper, C. F., & Yaffe, K. (2022). Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors. Alzheimers Dement, 18(11), 2234–2242. https://doi.org/10.1002/alz.12571
Plassman, Brenda L., Marianne Chanti-Ketterl, Carl F. Pieper, and Kristine Yaffe. “Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.Alzheimers Dement 18, no. 11 (November 2022): 2234–42. https://doi.org/10.1002/alz.12571.
Plassman BL, Chanti-Ketterl M, Pieper CF, Yaffe K. Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors. Alzheimers Dement. 2022 Nov;18(11):2234–42.
Plassman, Brenda L., et al. “Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.Alzheimers Dement, vol. 18, no. 11, Nov. 2022, pp. 2234–42. Pubmed, doi:10.1002/alz.12571.
Plassman BL, Chanti-Ketterl M, Pieper CF, Yaffe K. Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors. Alzheimers Dement. 2022 Nov;18(11):2234–2242.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

November 2022

Volume

18

Issue

11

Start / End Page

2234 / 2242

Location

United States

Related Subject Headings

  • Veterans
  • Risk Factors
  • Registries
  • Odds Ratio
  • Male
  • Humans
  • Geriatrics
  • Dementia
  • Brain Injuries, Traumatic
  • 5202 Biological psychology