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Brenda Lee Plassman

Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt St 6th Floor, Durham, NC 27710
2400 Pratt St 6th Floor, Rm 6012, Durham, NC 27705

Overview


My research interests include the following areas:
1) Epidemiological studies to examine the prevalence and incidence of dementia and cognitive impairment, not dementia (CIND)
2) Studies examining risk and protective factors for dementia and CIND
3) Behavioral genetics of aging and dementia with an emphasis on twin studies
4) Long term outcomes of traumatic brain injury
5) Oral health and cognition in later life

Current Appointments & Affiliations


Professor in Psychiatry and Behavioral Sciences · 2021 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences
Professor of Neurology · 2020 - Present Neurology, Behavioral Neurology, Neurology
Faculty Network Member of the Duke Institute for Brain Sciences · 2014 - Present Duke Institute for Brain Sciences, University Institutes and Centers

In the News


Published April 11, 2024
Bridging the Gap in Brain Health Research
Published September 7, 2023
Concussions May Cause Cognitive Declines Later in Life
Published May 7, 2015
War on Alzheimer's: Durham firms lead push in treatment R&D

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Recent Publications


Genetic and environmental influences on alcohol consumption in middle to late life.

Journal Article Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · November 2025 ObjectiveAlcohol use is common in older adults and linked to poor health and aging outcomes. Studies have demonstrated genetic and environmental contributions to the quantity of alcohol consumption in mid-to-late life, but less is known about whet ... Full text Cite

Quality-of-life factors at home and in health care settings for people living with dementia.

Journal Article Gerontologist · October 22, 2025 BACKGROUND AND OBJECTIVES: Person-centered "home time" measures track time spent in health care versus home using claims data. These measures can indicate patient preferences, quality of care, or quality of life. However, for people living with dementia, t ... Full text Link to item Cite

Insights from recruiting individuals with mild dementia and care partners for a multi-site oral hygiene intervention

Journal Article Aging and Health Research · September 1, 2025 Background: Maintaining oral health is essential for individuals with dementia, yet they often need support. We sought to identify insights gained during the recruitment process for an intervention designed to teach care partners skills to guide individual ... Full text Cite
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Recent Grants


Pesticide Use and Markers of ADRD Neurodegeneration among US Farmers

ResearchPrincipal Investigator · Awarded by Michigan State University · 2025 - 2030

National Health and Aging Trends Study

ResearchPrincipal Investigator · Awarded by Johns Hopkins University · 2019 - 2029

Improving the lives of persons living with dementia and their families through person-centered measurement of home time

ResearchCo Investigator · Awarded by National Institute on Aging · 2021 - 2027

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Education, Training & Certifications


University of Arizona · 1986 Ph.D.