Skip to main content

Brenda Lee Plassman

Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt St 6th Floor, Durham, NC 27710
2400 Pratt St 6th Floor, Rm 6012, Durham, NC 27705

Selected Publications


An Early and Unequal Decline: Life Course Trajectories of Cognitive Aging in the United States.

Journal Article J Aging Health · March 2024 Objectives: Cognitive aging is a lifelong process with implications for Alzheimer's disease and dementia. This study aims to fill major gaps in research on the natural history of and social disparities in aging-related cognitive decline over the life span. ... Full text Link to item Cite

Preventing cognitive decline by reducing BP target (PCOT): A randomized, pragmatic, multi-health systems clinical trial.

Journal Article Contemp Clin Trials · January 12, 2024 BACKGROUND: Growing evidence suggests that intensive lowering of systolic blood pressure (BP) may prevent mild cognitive impairment (MCI) and dementia. However, current guidelines provide inconsistent recommendations regarding optimal BP targets, citing sa ... Full text Link to item Cite

Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI ... Full text Link to item Cite

Association between results of an amyloid PET scan and healthcare utilization in individuals with cognitive impairment.

Journal Article J Am Geriatr Soc · December 9, 2023 BACKGROUND: The Imaging Dementia Evidence for Amyloid Scanning (IDEAS) study reports that amyloid PET scans help providers diagnose and manage Alzheimer's disease and related dementias (ADRD). Using CARE-IDEAS, an IDEAS supplemental study, we examined the ... Full text Link to item Cite

Patient Cognitive Status and Physician Recommendations for Cardiovascular Disease Treatment: Results of Two Nationwide, Randomized Survey Studies.

Journal Article J Gen Intern Med · November 2023 BACKGROUND: Clinical guidelines recommend that older patients (65+) with mild cognitive impairment (MCI) and early-stage dementia receive similar guideline-concordant care after cardiovascular disease (CVD) events as those with normal cognition (NC). Howev ... Full text Link to item Cite

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Journal Article EBioMedicine · November 2023 BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. T ... Full text Link to item Cite

Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study.

Journal Article Neurology · October 31, 2023 BACKGROUND AND OBJECTIVES: Traumatic brain injuries (TBIs) are associated with increased risk of dementia, but whether lifetime TBI influences cognitive trajectories in later life is less clear. Cognitive interventions after TBI may improve cognitive traje ... Full text Link to item Cite

Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment.

Journal Article J Affect Disord · August 1, 2023 BACKGROUND: Depression and cognitive impairment commonly co-occur, and it has been hypothesized that the two share pathological processes. Our objective for this study was to determine the relationship between elevated β-amyloid level and the prevalence an ... Full text Link to item Cite

Diabetes, Edentulism, and Cognitive Decline: A 12-Year Prospective Analysis.

Journal Article J Dent Res · July 2023 Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is associated with cognitive impairment and dementia. However, the effect of the co-occurrence of DM and edentulism on cognitive decline is under ... Full text Link to item Cite

Influence of mild cognitive impairment on patient and care partner decision-making for acute ischemic stroke.

Journal Article J Stroke Cerebrovasc Dis · June 2023 GOALS: Evidence suggests that patients with mild cognitive impairment (MCI) receive fewer treatments for acute ischemic stroke and other cardiovascular diseases than patients with normal cognition. Little is known about how patient and care partner prefere ... Full text Link to item Cite

Systematic Review, Meta-Analysis, and Population Attributable Risk of Dementia Associated with Traumatic Brain Injury in Civilians and Veterans.

Journal Article J Neurotrauma · April 2023 Traumatic brain injury (TBI) is an established risk factor for dementia. However, the magnitude of risk is highly variable across studies. Identification of sub-populations at highest risk, with careful consideration of potential sources of bias, is urgent ... Full text Link to item Cite

Remember This: Age Moderation of Genetic and Environmental Contributions to Verbal Episodic Memory from Midlife through Late Adulthood.

Journal Article Intelligence · 2023 It is well documented that memory is heritable and that older adults tend to have poorer memory performance than younger adults. However, whether the magnitudes of genetic and environmental contributions to late-life verbal episodic memory ability differ f ... Full text Link to item Cite

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3 carriers. The results from prior studies are inconsistent. It is also unclear whether specific APO ... Full text Open Access Link to item Cite

Comparing the Experiences of Participants With Mild Cognitive Impairment and Mild Dementia During an Oral Health Intervention.

Journal Article Innov Aging · 2023 BACKGROUND AND OBJECTIVES: Cognitive impairment is associated with poor oral health outcomes. Oral hygiene tasks are an essential target of interventions aiming to improve oral health for older adults with cognitive impairment. We aimed to examine whether ... Full text Link to item Cite

The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

Journal Article Contemp Clin Trials · December 2022 BACKGROUND: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially av ... Full text Link to item Cite

Advance directives among cognitively impaired persons who had an amyloid PET scan and their care partners: a mixed-methods study.

Journal Article BMC Palliat Care · November 6, 2022 BACKGROUND: Little research exists on the role of β-amyloid PET scans as part of Alzheimer's diagnostic tests and documentation of end-of-life preferences for persons with cognitive impairment. The study objectives were to examine the association of amyloi ... Full text Link to item Cite

Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.

Journal Article Alzheimers Dement · November 2022 INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-Nat ... Full text Link to item Cite

Lifecourse Traumatic Events and Cognitive Aging in the Health and Retirement Study.

Journal Article Am J Prev Med · November 2022 INTRODUCTION: Much of the heterogeneity in the rate of cognitive decline and the age of dementia onset remains unexplained, and there is compelling data supporting psychosocial stressors as important risk factors. However, the literature has yet to come to ... Full text Link to item Cite

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.

Journal Article Commun Biol · October 8, 2022 Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzhe ... Full text Link to item Cite

Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · October 6, 2022 OBJECTIVES: To better understand the temporal dynamics of progression from cognitive decline to onset of dementia in the dementia-free older population in the United States. METHODS: We used longitudinal data from a diverse national population-based sample ... Full text Link to item Cite

An Early and Unequal Decline: Life Course Trajectories of Cognitive Aging in the United States.

Journal Article J Aging Health · March 2024 Objectives: Cognitive aging is a lifelong process with implications for Alzheimer's disease and dementia. This study aims to fill major gaps in research on the natural history of and social disparities in aging-related cognitive decline over the life span. ... Full text Link to item Cite

Preventing cognitive decline by reducing BP target (PCOT): A randomized, pragmatic, multi-health systems clinical trial.

Journal Article Contemp Clin Trials · January 12, 2024 BACKGROUND: Growing evidence suggests that intensive lowering of systolic blood pressure (BP) may prevent mild cognitive impairment (MCI) and dementia. However, current guidelines provide inconsistent recommendations regarding optimal BP targets, citing sa ... Full text Link to item Cite

Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI ... Full text Link to item Cite

Association between results of an amyloid PET scan and healthcare utilization in individuals with cognitive impairment.

Journal Article J Am Geriatr Soc · December 9, 2023 BACKGROUND: The Imaging Dementia Evidence for Amyloid Scanning (IDEAS) study reports that amyloid PET scans help providers diagnose and manage Alzheimer's disease and related dementias (ADRD). Using CARE-IDEAS, an IDEAS supplemental study, we examined the ... Full text Link to item Cite

Patient Cognitive Status and Physician Recommendations for Cardiovascular Disease Treatment: Results of Two Nationwide, Randomized Survey Studies.

Journal Article J Gen Intern Med · November 2023 BACKGROUND: Clinical guidelines recommend that older patients (65+) with mild cognitive impairment (MCI) and early-stage dementia receive similar guideline-concordant care after cardiovascular disease (CVD) events as those with normal cognition (NC). Howev ... Full text Link to item Cite

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Journal Article EBioMedicine · November 2023 BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. T ... Full text Link to item Cite

Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study.

Journal Article Neurology · October 31, 2023 BACKGROUND AND OBJECTIVES: Traumatic brain injuries (TBIs) are associated with increased risk of dementia, but whether lifetime TBI influences cognitive trajectories in later life is less clear. Cognitive interventions after TBI may improve cognitive traje ... Full text Link to item Cite

Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment.

Journal Article J Affect Disord · August 1, 2023 BACKGROUND: Depression and cognitive impairment commonly co-occur, and it has been hypothesized that the two share pathological processes. Our objective for this study was to determine the relationship between elevated β-amyloid level and the prevalence an ... Full text Link to item Cite

Diabetes, Edentulism, and Cognitive Decline: A 12-Year Prospective Analysis.

Journal Article J Dent Res · July 2023 Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is associated with cognitive impairment and dementia. However, the effect of the co-occurrence of DM and edentulism on cognitive decline is under ... Full text Link to item Cite

Influence of mild cognitive impairment on patient and care partner decision-making for acute ischemic stroke.

Journal Article J Stroke Cerebrovasc Dis · June 2023 GOALS: Evidence suggests that patients with mild cognitive impairment (MCI) receive fewer treatments for acute ischemic stroke and other cardiovascular diseases than patients with normal cognition. Little is known about how patient and care partner prefere ... Full text Link to item Cite

Systematic Review, Meta-Analysis, and Population Attributable Risk of Dementia Associated with Traumatic Brain Injury in Civilians and Veterans.

Journal Article J Neurotrauma · April 2023 Traumatic brain injury (TBI) is an established risk factor for dementia. However, the magnitude of risk is highly variable across studies. Identification of sub-populations at highest risk, with careful consideration of potential sources of bias, is urgent ... Full text Link to item Cite

Remember This: Age Moderation of Genetic and Environmental Contributions to Verbal Episodic Memory from Midlife through Late Adulthood.

Journal Article Intelligence · 2023 It is well documented that memory is heritable and that older adults tend to have poorer memory performance than younger adults. However, whether the magnitudes of genetic and environmental contributions to late-life verbal episodic memory ability differ f ... Full text Link to item Cite

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3 carriers. The results from prior studies are inconsistent. It is also unclear whether specific APO ... Full text Open Access Link to item Cite

Comparing the Experiences of Participants With Mild Cognitive Impairment and Mild Dementia During an Oral Health Intervention.

Journal Article Innov Aging · 2023 BACKGROUND AND OBJECTIVES: Cognitive impairment is associated with poor oral health outcomes. Oral hygiene tasks are an essential target of interventions aiming to improve oral health for older adults with cognitive impairment. We aimed to examine whether ... Full text Link to item Cite

The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

Journal Article Contemp Clin Trials · December 2022 BACKGROUND: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially av ... Full text Link to item Cite

Advance directives among cognitively impaired persons who had an amyloid PET scan and their care partners: a mixed-methods study.

Journal Article BMC Palliat Care · November 6, 2022 BACKGROUND: Little research exists on the role of β-amyloid PET scans as part of Alzheimer's diagnostic tests and documentation of end-of-life preferences for persons with cognitive impairment. The study objectives were to examine the association of amyloi ... Full text Link to item Cite

Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.

Journal Article Alzheimers Dement · November 2022 INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-Nat ... Full text Link to item Cite

Lifecourse Traumatic Events and Cognitive Aging in the Health and Retirement Study.

Journal Article Am J Prev Med · November 2022 INTRODUCTION: Much of the heterogeneity in the rate of cognitive decline and the age of dementia onset remains unexplained, and there is compelling data supporting psychosocial stressors as important risk factors. However, the literature has yet to come to ... Full text Link to item Cite

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.

Journal Article Commun Biol · October 8, 2022 Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzhe ... Full text Link to item Cite

Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · October 6, 2022 OBJECTIVES: To better understand the temporal dynamics of progression from cognitive decline to onset of dementia in the dementia-free older population in the United States. METHODS: We used longitudinal data from a diverse national population-based sample ... Full text Link to item Cite

"Now at least we have something to call it": Patient and care partner experiences receiving an amyloid PET scan.

Journal Article J Am Geriatr Soc · October 2022 BACKGROUND: The primary objective of this paper was to examine perspectives and experiences of individuals with cognitive impairment who received an amyloid PET scan and their care partners, with regard to the process, logistics, and decision-making associ ... Full text Link to item Cite

Sex Differences in the Association Between Metabolic Dysregulation and Cognitive Aging: The Health and Retirement Study.

Journal Article J Gerontol A Biol Sci Med Sci · September 1, 2022 BACKGROUND: Dysregulation of some metabolic factors increases the risk of dementia. It remains unclear if overall metabolic dysregulation, or only certain components, contribute to cognitive aging and if these associations are sex specific. METHODS: Data f ... Full text Link to item Cite

Oral Health, Diabetes, and Inflammation: Effects of Oral Hygiene Behaviour.

Journal Article Int Dent J · August 2022 INTRODUCTION: The aim of this research was to assess the association between inflammation and oral health and diabetes, as well as the mediating role of oral hygiene practice in this association. METHODS: Data were from the 2009-2010 National Health and Nu ... Full text Link to item Cite

Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.

Journal Article Ophthalmol Retina · July 2022 PURPOSE: To assess the baseline differences and longitudinal rate of change in retinal and choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and noncarriers with normal cognition. DESIGN: Prospective study. SUBJECTS: Four hundred th ... Full text Link to item Cite

Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group.

Journal Article Lancet Healthy Longev · July 2022 Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted ... Full text Link to item Cite

Study protocol for a randomised controlled trial of a care partner assisted intervention to improve oral health of individuals with mild dementia.

Journal Article BMJ Open · June 22, 2022 INTRODUCTION: Individuals with mild dementia are at high risk of poor oral health outcomes. To address this issue, we describe an intervention to teach care partners skills to guide individuals with mild dementia in proper oral hygiene techniques and provi ... Full text Link to item Cite

The Association Between Mild Cognitive Impairment Diagnosis and Patient Treatment Preferences: a Survey of Older Adults.

Journal Article J Gen Intern Med · June 2022 BACKGROUND: Older patients (65+) with mild cognitive impairment (MCI) receive less guideline-concordant care for cardiovascular disease (CVD) and other conditions than patients with normal cognition (NC). One potential explanation is that patients with MCI ... Full text Link to item Cite

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.

Journal Article Mov Disord · May 2022 BACKGROUND: Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological ... Full text Link to item Cite

Occupational cognitive stimulation, socioeconomic status, and cognitive functioning in young adulthood.

Journal Article SSM Popul Health · March 2022 BACKGROUND: Occupational characteristics are associated with late-life cognition. However, little is known about the association between occupational factors and cognition in early adulthood, especially when controlling for early life socioeconomic status ... Full text Link to item Cite

A Mixed-Methods Study of the Impact of Mild Cognitive Impairment Diagnosis on Patient and Care Partner Perception of Health Risks.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Older patients (≥65 years) with mild cognitive impairment (MCI) are undertreated for cardiovascular disease (CVD). One reason for this disparity could be that patients with MCI might underestimate the chances of CVD and overestimate dementia. O ... Full text Link to item Cite

Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Diagnostic tests, such as amyloid-β positron emission tomography (PET) scans, can increase appropriate therapeutic management for the underlying causes of cognitive decline. To evaluate the full utility of this diagnostic tool, information is n ... Full text Link to item Cite

Sensory impairment and cognitive decline among older adults: An analysis of mediation and moderation effects of loneliness.

Journal Article Front Neurosci · 2022 BACKGROUND: Multiple studies have reported that hearing and vision impairment are linked to cognitive decline. Yet little is known about factors that may influence the association between sensory impairment and cognitive decline. This study examined if lon ... Full text Link to item Cite

Analysis of pleiotropic genetic effects on cognitive decline and systemic inflammation in the Women's Health Initiative Memory Study

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2021 BACKGROUND: SNPs associated with C-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease (AD) risk SNPs. Previously, we reported pleiotropic effects between SNPs associated with cognitive impairment ... Full text Cite

Immune function, cortisol, and cognitive decline & dementia in an aging latino population.

Journal Article Psychoneuroendocrinology · November 2021 BACKGROUND: The etiology of dementias and cognitive decline remain largely unknown. It is widely accepted that inflammation in the central nervous system plays a critical role in the pathogenesis of dementia. However, less is known about the role of the pe ... Full text Link to item Cite

Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.

Journal Article J Am Med Dir Assoc · October 2021 OBJECTIVES: To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia. DESIGN: Longitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 ... Full text Link to item Cite

Care partner-assisted intervention to improve oral health for older adults with cognitive impairment: A feasibility study.

Journal Article Gerodontology · September 2021 BACKGROUND AND OBJECTIVES: Older adults with cognitive impairment often experience poor oral health outcomes due to inadequate oral hygiene practices. This pilot study aimed to evaluate the feasibility of a care partner-assisted intervention to improve the ... Full text Link to item Cite

Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.

Journal Article Lancet Neurol · July 2021 BACKGROUND: The identification of people at risk of cognitive impairment is essential for improving recruitment in secondary prevention trials of Alzheimer's disease. We aimed to test and qualify a biomarker risk assignment algorithm (BRAA) to identify par ... Full text Link to item Cite

Drivers of Long-Term Care Considerations by Persons With Cognitive Impairment.

Journal Article J Appl Gerontol · June 2021 Consideration of place of care is the first step in long-term care (LTC) planning and is critical for patients diagnosed with Alzheimer's disease; yet, drivers of consideration of place of care are unknown. We apply machine learning algorithms to cross-sec ... Full text Link to item Cite

Longitudinal Association Between Hearing Loss, Vision Loss, Dual Sensory Loss, and Cognitive Decline.

Journal Article J Am Geriatr Soc · March 2021 BACKGROUND/OBJECTIVES: To better understand the role of sensory loss as a potentially modifiable risk factor for cognitive decline, this study examined cognitive decline in relation to single modality hearing or vision loss and dual sensory loss. DESIGN: L ... Full text Link to item Cite

Video-Enhanced Care Management for Medically Complex Older Adults with Cognitive Impairment.

Journal Article J Am Geriatr Soc · January 2021 OBJECTIVE: This pilot study assessed feasibility of video-enhanced care management for complex older veterans with suspected mild cognitive impairment (CI) and their care partners, compared with telephone delivery. DESIGN: Pilot randomized controlled trial ... Full text Link to item Cite

Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.

Journal Article Curr Alzheimer Res · 2021 OBJECTIVE: Both diabetes mellitus (DM) and poor oral health are common chronic conditions and risk factors of Alzheimer's disease and related dementia among older adults. This study assessed the effects of DM and complete tooth loss (TL) on cognitive funct ... Full text Link to item Cite

Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults.

Journal Article J Vitreoretin Dis · 2021 PURPOSE: This work assesses the intrasession repeatability of capillary perfusion density (CPD) and capillary flux index (CFI) measurements on peripapillary optical coherence tomography angiography (OCTA) in healthy eyes of older adults. METHODS: In this c ... Full text Link to item Cite

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.

Journal Article Cell Rep Med · November 17, 2020 Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes and identify genes in the alternative bile ... Full text Link to item Cite

Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans.

Journal Article Neurology · September 29, 2020 OBJECTIVE: To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS: Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with ... Full text Link to item Cite

The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS).

Journal Article Aging Ment Health · September 2020 Background: A small but growing body of evidence supports a relationship between neighborhood socioeconomic status (NSES) and cognitive decline. Additional work is needed to characterize this relationship controlling for risk factors such as cardiovascular ... Full text Link to item Cite

Measurement Properties of the CAPACITY Instrument to Assess Perceived Communication With the Health Care Team Among Care Partners of Patients With Cognitive Impairment.

Journal Article Med Care · September 2020 BACKGROUND: The CAregiver Perceptions About CommunIcaTion with Clinical Team members (CAPACITY) instrument measures how care partners perceive themselves to be supported by the patient's health care team and their experiences communicating with the team. O ... Full text Link to item Cite

Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies.

Journal Article Alzheimers Dement · August 2020 INTRODUCTION: The Alzheimer's Disease Prevention Registry (ADPR) of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center at Duke University has been successful in achieving a racially diverse and "research ready" cohort of cognitively healthy ... Full text Link to item Cite

Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol.

Journal Article BMJ Open · June 3, 2020 INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia. Individual epidemiological studies have controlled for several confounders of the relationship between PTSD and increased dementia risk, yet particular ri ... Full text Link to item Cite

Investigating Predictors of Cognitive Decline Using Machine Learning.

Journal Article J Gerontol B Psychol Sci Soc Sci · March 9, 2020 OBJECTIVES: Genetic risks for cognitive decline are not modifiable; however their relative importance compared to modifiable factors is unclear. We used machine learning to evaluate modifiable and genetic risk factors for Alzheimer's disease (AD), to predi ... Full text Link to item Cite

Willingness to Undergo a Risky Treatment to Improve Cognition Among Persons With Cognitive Impairment Who Received an Amyloid PET Scan.

Journal Article Alzheimer Dis Assoc Disord · 2020 OBJECTIVE: To evaluate determinants of willingness to accept a treatment to return memory to normal among persons with cognitive impairment who received an amyloid positron emission tomography (PET) scan and their care partner and discordance in risk takin ... Full text Link to item Cite

How Accurately Do Patients and Their Care Partners Report Results of Amyloid-β PET Scans for Alzheimer's Disease Assessment?

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Amyloid-β PET scans will likely become an integral part of the diagnostic evaluation for Alzheimer's disease if Medicare approves reimbursement for the scans. However, little is known about patients' and their care partners' interpretation of s ... Full text Link to item Cite

The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update.

Journal Article Twin Res Hum Genet · December 2019 The National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917-1927 (N = 31.848), both of whom ... Full text Link to item Cite

Validating Silicone Wristbands to Measure Pesticide Exposures Among Older Adults -- Proof-of-Concept Study

Conference · November 8, 2019 Silicone wristbands have been used to measure exposure to pesticides and other chemicals among children and younger farm workers, but not in older adults. Thus, we aimed to examine exposure to pesticides using silicone wristbands in a small cohort of older ... Full text Link to item Cite

Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study.

Journal Article Neurobiol Aging · August 2019 Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease risk variants. We examined pleiotropic genetic effects on cognitive impairment conditioned on genetic va ... Full text Link to item Cite

A blood-based signature of cerebrospinal fluid Aβ1-42 status.

Journal Article Sci Rep · March 11, 2019 It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of ... Full text Link to item Cite

Working together to learn new oral hygiene techniques: Pilot of a carepartner-assisted intervention for persons with cognitive impairment.

Journal Article Geriatr Nurs · 2019 We pilot tested a carepartner-assisted intervention to improve oral hygiene in persons with cognitive impairment (participants) and help carepartners become leaders who can adapt approaches that foster participants' ability to develop new skills for oral h ... Full text Link to item Cite

Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults.

Journal Article Alzheimers Dement (N Y) · 2019 INTRODUCTION: Mitochondrial dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). Accordingly, drugs that positively influence mitochondrial function are being evaluated in delay-of-onset clinical trials with at-risk individuals. Su ... Full text Link to item Cite

The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.

Journal Article Alzheimers Dement (N Y) · 2019 INTRODUCTION: Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more disease-modifying approaches to test treatments administered before full disease expres ... Full text Link to item Cite

Short-Term Changes in the Prevalence of Probable Dementia: An Analysis of the 2011-2015 National Health and Aging Trends Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · April 16, 2018 OBJECTIVES: Studies have reported decreasing dementia prevalence in recent decades in the United States. We explore with a new national data source whether declines have occurred since 2011, whether trends are attributable to shifts in dementia incidence o ... Full text Link to item Cite

Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?

Journal Article Alzheimers Dement · April 2018 INTRODUCTION: We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. METHODS: Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multi ... Full text Link to item Cite

Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task co ... Full text Link to item Cite

TOMMORROW neuropsychological battery: German language validation and normative study.

Journal Article Alzheimers Dement (N Y) · 2018 INTRODUCTION: Assessment of preclinical Alzheimer's disease (AD) requires reliable and validated methods to detect subtle cognitive changes. The battery of standardized cognitive assessments that is used for diagnostic criteria for mild cognitive impairmen ... Full text Link to item Cite

Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).

Journal Article J Prev Alzheimers Dis · 2018 BACKGROUND: Continuing advances in the understanding of Alzheimer's disease progression have inspired development of disease-modifying therapeutics intended for use in preclinical populations. However, identification of clinically meaningful cognitive and ... Full text Link to item Cite

Trends in decayed teeth among middle-aged and older adults in the United States: socioeconomic disparities persist over time.

Journal Article J Public Health Dent · September 2016 OBJECTIVES: While trends in tooth loss among older adults have been well documented and show a decline over the last few decades, little is known about trends in tooth decay which may lead to tooth loss. The study aim was to examine trends in tooth decay a ... Full text Link to item Cite

Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline.

Journal Article Hypertension · July 2016 The association between visit-to-visit variability of blood pressure (BP) and cognitive decline over time remains incompletely understood in a general population of older adults. We assessed the hypothesis that higher visit-to-visit variability in BP, but ... Full text Link to item Cite

Mediation Effect of Oral Hygiene on the Relationship Between Cognitive Function and Oral Health in Older Adults.

Journal Article J Gerontol Nurs · May 1, 2016 Poor oral health is a common problem among older adults in general and particularly among those with cognitive impairment. The current study was conducted to (a) explore direct and indirect relationships between cognitive function and oral health outcomes ... Full text Link to item Cite

Epigenetic assimilation in the aging human brain.

Journal Article Genome Biol · April 28, 2016 BACKGROUND: Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages ... Full text Link to item Cite

Association Between Oral Health and Cognitive Status: A Systematic Review.

Journal Article J Am Geriatr Soc · April 2016 OBJECTIVES: To systematically review longitudinal studies examining the association between oral health and cognitive decline. DESIGN: Studies published between January 1993 and March 2013 were identified by search of English language publications in PubMe ... Full text Link to item Cite

Authors' Response to Kaufman and Muntaner.

Journal Article Int J Epidemiol · April 2016 Full text Link to item Cite

The association between intelligence and lifespan is mostly genetic.

Journal Article Int J Epidemiol · February 2016 BACKGROUND: Several studies in the new field of cognitive epidemiology have shown that higher intelligence predicts longer lifespan. This positive correlation might arise from socioeconomic status influencing both intelligence and health; intelligence lead ... Full text Link to item Cite

Trajectories of depressive symptoms and oral health outcomes in a community sample of older adults.

Journal Article Int J Geriatr Psychiatry · January 2016 OBJECTIVE: Adverse outcomes associated with chronic depressive symptoms are of clinical importance. The objective was to identify subgroups of older adults based on their trajectories of depressive symptoms over a 10-year period and determine if these subg ... Full text Link to item Cite

Heritability of Health and Aging Limitations on Personally Desired Activities.

Journal Article Health Psychol Res · September 30, 2015 The aim of this study is to estimate heritability of incident limitations on personally desired activities within the eighth decade of life. We measured self-rated ability to perform ten personally desired activities in 1606 male veteran twin pairs at base ... Full text Link to item Cite

Dietary Patterns and Cognitive Decline Among Chinese Older Adults.

Journal Article Epidemiology · September 2015 BACKGROUND: Prospective evidence of associations of dietary patterns with cognitive decline is limited and inconsistent. We examined how cognitive changes among Chinese older adults relate to either an adapted Mediterranean diet score or factor analysis-de ... Full text Link to item Cite

Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.

Journal Article J Am Geriatr Soc · June 2015 OBJECTIVES: To describe the stability of cognitive impairment, not dementia (CIND) in a longitudinal cohort of primary care veterans. To examine the association between baseline brief cognitive screening tests, demographic and clinical characteristics, and ... Full text Link to item Cite

Dental care utilization among older adults with cognitive impairment in the USA.

Journal Article Geriatr Gerontol Int · March 2015 AIM: We examined the relationship between cognitive impairment and dental care utilization among older adults in the USA. METHODS: A total of 329 older adults aged 70 years and older in West Virginia, USA, were included in the present analyses. We carried ... Full text Link to item Cite

Factors associated with cognitive evaluations in the United States.

Journal Article Neurology · January 6, 2015 OBJECTIVE: We aimed to explore factors associated with clinical evaluations for cognitive impairment among older residents of the United States. METHODS: Two hundred ninety-seven of 845 subjects in the Aging, Demographics, and Memory Study (ADAMS), a natio ... Full text Link to item Cite

Traumatic brain injury and late-life dementia.

Journal Article Handb Clin Neurol · 2015 Little is known of the impact of traumatic brain injury (TBI) on outcomes decades later when the effects of the injury interact with the aging brain. Some, but not all, epidemiologic studies have reported an association between TBI and increased risk of Al ... Full text Link to item Cite

Effect of APOE and CD33 on Cognitive Decline.

Journal Article PLoS One · 2015 OBJECTIVE: An Alzheimer's disease (AD) diagnosis is preceded by a long period of cognitive decline. We previously demonstrated increased risk of decline among individuals possessing one or more APOE ε4 alleles together with a family history of AD. The obje ... Full text Link to item Cite

Social stratification and tooth loss among middle-aged and older Americans from 1988 to 2004.

Journal Article Community Dent Oral Epidemiol · December 2014 OBJECTIVES: Tooth retention has improved over the past few decades, but it is not known whether these trends have been observed across all demographic/socioeconomic subgroups. We examined number of missing teeth among dentate individuals (n = 9,113) as wel ... Full text Link to item Cite

A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.

Journal Article Alzheimers Dement · November 2014 BACKGROUND: Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials. METHODS: Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) we ... Full text Link to item Cite

Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

Journal Article Neurobiol Aging · November 2014 Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal co ... Full text Link to item Cite

Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.

Journal Article Am J Geriatr Psychiatry · November 2014 BACKGROUND: Cognitive profiles for pre-clinical Alzheimer disease (AD) can be used to identify groups of individuals at risk for disease and better characterize pre-clinical disease. Profiles or patterns of performance as pre-clinical phenotypes may be mor ... Full text Link to item Cite

Fish intake is associated with slower cognitive decline in Chinese older adults.

Journal Article J Nutr · October 2014 Modifiable lifestyle changes, including dietary changes, could translate into a great reduction in the global burden of cognitive impairment and dementia. Few studies evaluated the benefits of fish intake for delaying cognitive decline, and no studies were ... Full text Link to item Cite

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

Journal Article Alzheimers Dement · October 2014 With increasing numbers of people with Alzheimer's and other dementias across the globe, many countries have developed national plans to deal with the resulting challenges. In the United States, the National Alzheimer's Project Act, signed into law in 2011 ... Full text Link to item Cite

Social stratification, oral hygiene, and trajectories of dental caries among old Americans.

Journal Article J Aging Health · September 2014 OBJECTIVE: This study analyzed how oral hygiene (i.e., brushing, rinsing, and flossing) influences the trajectories of dental caries (i.e., numbers of decayed, missing, and filled teeth) among older Americans within the context of social stratification. ME ... Full text Link to item Cite

Community engagement in diverse populations for Alzheimer disease prevention trials.

Journal Article Alzheimer Dis Assoc Disord · 2014 The recruitment of asymptomatic volunteers has been identified as a critical factor that is delaying the development and validation of preventive therapies for Alzheimer disease (AD). Typical recruitment strategies involve the use of convenience samples or ... Full text Link to item Cite

Racial disparities in trajectories of dental caries experience.

Journal Article Community Dent Oral Epidemiol · December 2013 OBJECTIVES: This study charted the trajectories of dental caries, including decayed teeth, missing teeth and filled teeth among older Americans over a 5-year period. In particular, it focused on racial differences in the levels of and rates of change in de ... Full text Link to item Cite

Trends of edentulism among middle-aged and older Asian Americans.

Journal Article Am J Public Health · September 2013 OBJECTIVES: We estimated national trends of the prevalence of edentulism (complete tooth loss) for Asian American subgroups in the United States and investigated factors that could contribute to improvements in edentulism across populations over time. METH ... Full text Link to item Cite

Cognitive function and oral health-related quality of life in older adults.

Journal Article J Am Geriatr Soc · September 2013 OBJECTIVES: To examine the relationship between cognitive function and self-reported oral health-related quality of life (HRQoL) in community-dwelling older adults. DESIGN: Cross-sectional. SETTING: Community in West Virginia. PARTICIPANTS: Two hundred twe ... Full text Link to item Cite

Functional limitations in older adults who have cognitive impairment without dementia.

Journal Article J Geriatr Psychiatry Neurol · June 2013 OBJECTIVE: To characterize the prevalence of functional limitations among older adults with cognitive impairment without dementia (CIND). METHODS: Secondary data analysis was performed using the Aging, Demographics, and Memory Study data set. A total of 85 ... Full text Link to item Cite

Neuropsychological predictors of dementia in late-life major depressive disorder.

Journal Article Am J Geriatr Psychiatry · March 2013 OBJECTIVE: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.

Journal Article Neuropsychology · January 2013 OBJECTIVE: The ε4 allele of the apolipoprotein E (APOE) genotype is the most widely accepted genetic risk factor for Alzheimer's dementia (AD), but findings on whether it is a risk factor for the AD prodrome, mild cognitive impairment (MCI), have been inco ... Full text Link to item Cite

High throughput DNA sequencing to detect differences in the subgingival plaque microbiome in elderly subjects with and without dementia.

Journal Article Investig Genet · September 21, 2012 BACKGROUND: To investigate the potential association between oral health and cognitive function, a pilot study was conducted to evaluate high throughput DNA sequencing of the V3 region of the 16S ribosomal RNA gene for determining the relative abundance of ... Full text Link to item Cite

Screening for cognitive impairment: comparing the performance of four instruments in primary care.

Journal Article J Am Geriatr Soc · June 2012 OBJECTIVES: To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia. DESIGN: A cross-sectional comparison of cognitive screening tests to an indepe ... Full text Link to item Cite

Edentulism trends among middle-aged and older adults in the United States: comparison of five racial/ethnic groups.

Journal Article Community Dent Oral Epidemiol · April 2012 OBJECTIVES: This study examined edentulism trends among adults aged 50 and above in five ethnic groups in the United States: Asians, African Americans, Hispanics, Native Americans, and non-Hispanic Caucasians. METHODS: Data came from the National Health In ... Full text Link to item Cite

Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.

Journal Article Am J Geriatr Psychiatry · March 11, 2012 OBJECTIVE:: Major depressive disorder is a likely risk factor for dementia, but some cases of major depressive disorder in older adults may actually represent a prodrome of this condition. The purpose of this study was to use neuropsychological test scores ... Full text Link to item Cite

Utility of NPI Scores Predicting Progression of CIND to Dementia

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2012 Link to item Cite

Hygiene self-care of older adults in West Virginia: effects of gender.

Journal Article Journal of dental hygiene : JDH · January 2012 PurposeThis study investigated whether oral hygiene self-care behavior differs between genders in older adults in Appalachia, a geographic area with significant oral health concerns. Identify ing the practices of older adults may provide valuable ... Cite

Social network and health: A comparison of Chinese older adults in Shanghai and elderly immigrants in Boston

Journal Article International Journal of Social Welfare · October 1, 2011 The association between social network and health in older Chinese immigrants in the USA and their counterparts in China was examined using data from 177 Chinese immigrants in Boston, USA and 428 respondents in Shanghai, China. The results showed that Chin ... Full text Cite

Incidence of dementia and cognitive impairment, not dementia in the United States.

Journal Article Ann Neurol · September 2011 Featured Publication OBJECTIVE: Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild cognitive impairment) are important for public health and clinical care policy. In this paper, we report US national incidence rates for dementia ... Full text Link to item Cite

Risk factors and preventive interventions for Alzheimer disease: state of the science.

Journal Article Arch Neurol · September 2011 BACKGROUND: Numerous studies have investigated risk factors for Alzheimer disease (AD). However, at a recent National Institutes of Health State-of-the-Science Conference, an independent panel found insufficient evidence to support the association of any m ... Full text Link to item Cite

Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis.

Journal Article Brain Res · April 18, 2011 The brain reserve hypothesis has been posited as being one important mediating factor for developing dementia, especially Alzheimer's disease (AD). Evidence for this hypothesis is mixed though different methodologies have made these findings difficult to i ... Full text Link to item Cite

Differences in self-reported oral health among community-dwelling black, Hispanic, and white elders.

Journal Article J Aging Health · March 2011 OBJECTIVE: To compare differences in self-rated oral health among community-dwelling Black, Hispanic, and White adults aged 60 and older. METHOD: A total of 4,859 participants in the National Health and Nutrition Examination Survey (1999-2004) provided sel ... Full text Link to item Cite

Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · March 2011 OBJECTIVES: To examine the association between neuropsychiatric symptoms and risk of institutionalization and death. DESIGN: Analysis of longitudinal data. SETTING: The Aging, Demographics, and Memory Study (ADAMS). PARTICIPANTS: Five hundred thirty-seven ... Full text Link to item Cite

Caring for individuals with dementia and cognitive impairment, not dementia: findings from the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · March 2011 OBJECTIVES: To compare the characteristics and outcomes of caregivers of adults with dementia with those of caregivers of adults with cognitive impairment, not dementia (CIND). DESIGN: Cross-sectional. SETTING: In-home assessment for cognitive impairment a ... Full text Link to item Cite

Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time.

Journal Article Alzheimer Dis Assoc Disord · 2011 The neuropsychological battery from the National Alzheimer's Disease Coordinating Center is designed to provide a sensitive assessment of mild cognitive disorders for multicenter investigations. Comprising 8 common neuropsychological tests (12 measures), t ... Full text Link to item Cite

Oral health among white, black, and Mexican-American elders: an examination of edentulism and dental caries.

Journal Article J Public Health Dent · 2011 OBJECTIVES: To examine racial/ethnic disparities in oral health among older Americans. METHODS: Differences in frequency of edentulism and number of decayed, missing, and filled teeth were assessed in 2,679 non-Hispanic white, 742 non-Hispanic black, and 9 ... Full text Link to item Cite

Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2.

Journal Article Alzheimers Dement · January 2011 This article focuses on the effects of operational differences in case ascertainment on estimates of prevalence and incidence of cognitive impairment and/or dementia of the Alzheimer type. Experience and insights are discussed by investigators from the Fra ... Full text Link to item Cite

National estimates of the prevalence of Alzheimer's disease in the United States.

Journal Article Alzheimers Dement · January 2011 Several methods of estimating prevalence of dementia are presented in this article. For both Brookmeyer and the Chicago Health and Aging project (CHAP), the estimates of prevalence are derived statistically, forward calculating from incidence and survival ... Full text Link to item Cite

Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States.

Journal Article Alzheimers Dement · January 2011 BACKGROUND: The prevalence of Alzheimer's disease (AD) in the United States was estimated at 2.3 million in 2002 by the Aging, Demographics, and Memory Study (ADAMS), which is almost 50% less than the estimate of 4.5 million in 2000 derived from the Chicag ... Full text Link to item Cite

Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 1.

Journal Article Alzheimers Dement · January 2011 Establishing methods for ascertainment of dementia and cognitive impairment that are accurate and also cost-effective is a challenging enterprise. Large population-based studies often using administrative data sets offer relatively inexpensive and reliable ... Full text Link to item Cite

Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

Journal Article Ann Intern Med · August 3, 2010 Featured Publication BACKGROUND: Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline. PURPOSE: To summarize evidence about putative risk and protective factors for cognitive decline in older adults and t ... Full text Link to item Cite

Depressive symptoms and health problems among Chinese immigrant elders in the US and Chinese elders in China.

Journal Article Aging Ment Health · August 2010 OBJECTIVES: Researchers speculate that depression tends to be more prevalent among immigrant elders due to their lack of resources, acculturation stress, language problems, and social isolation. However, other characteristics of elderly immigrants, such as ... Full text Link to item Cite

Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.

Journal Article Alzheimers Res Ther · June 24, 2010 INTRODUCTION: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon4 (APOE) are associated with dementia. METHODS: A population-based sample of 856 individuals aged 7 ... Full text Link to item Cite

Differences in functional impairment across subtypes of dementia.

Journal Article J Gerontol A Biol Sci Med Sci · April 2010 BACKGROUND: Dementia is a cause of disability in later life. Despite the importance of functional status to the diagnosis of dementia, limited information exists on differences in functional limitations by dementia subtype. We conducted a cross-sectional a ... Full text Link to item Cite

Preventing Alzheimer's disease and cognitive decline.

Journal Article Evid Rep Technol Assess (Full Rep) · April 2010 OBJECTIVES: To assess whether previous research on purported risk or protective factors for Alzheimer's disease (AD) and cognitive decline is of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical interventi ... Link to item Cite

Hyposalivation and xerostomia in dentate older adults.

Journal Article J Am Dent Assoc · March 2010 BACKGROUND: Older adults are susceptible to reduced saliva production related to certain medications, radiation and chronic conditions. Many of these people have many physical and oral health problems and limited access to dental care. The use of effective ... Full text Link to item Cite

Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.

Journal Article J Am Geriatr Soc · February 2010 OBJECTIVES: To estimate the prevalence of neuropsychiatric symptoms and examine their association with functional limitations. DESIGN: Cross-sectional analysis. SETTING: The Aging, Demographics, and Memory Study (ADAMS). PARTICIPANTS: A sample of adults ag ... Full text Link to item Cite

Recruitment of rural and cognitively impaired older adults for dental research.

Journal Article Spec Care Dentist · 2010 The recruitment of community-dwelling older adults, particularly those with cognitive impairment and those residing in rural areas, has been consistently challenging for researchers, especially in the dental field. This study reports on recruitment experie ... Full text Link to item Cite

Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease

Journal Article Annual Review of Gerontology and Geriatrics · January 1, 2010 Inheritance appears to play a strong role in terms of human longevity and also in risk for chronic neurodegenerative diseases of late life such as Alzheimer's disease (AD). Understanding the role of genes in normal biological aging of the nervous system an ... Full text Cite

Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.

Journal Article Alzheimers Dement · November 2009 BACKGROUND: The diagnosis of cognitive impairment and dementia must reflect an increasingly diverse and aging United States population. This study compared direct testing and informant reports of cognition with clinical diagnoses of cognitive impairment an ... Full text Link to item Cite

Prevalence of depression among older Americans: the Aging, Demographics and Memory Study.

Journal Article Int Psychogeriatr · October 2009 BACKGROUND: Previous studies have attempted to provide estimates of depression prevalence in older adults. The Aging, Demographics and Memory Study (ADAMS) is a population-representative study that included a depression assessment, providing an opportunity ... Full text Link to item Cite

A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.

Journal Article Behav Genet · September 2009 Previous research has shown cognitive abilities to have different biometric patterns of age-changes. We examined the variation in episodic memory (word recall task) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed ... Full text Link to item Cite

Correction: Prevalence of Cognitive Impairment Without Dementia

Journal Article Annals of Internal Medicine · August 18, 2009 Full text Cite

Lifespan influences on mid- to late-life cognitive function in a Chinese birth cohort.

Journal Article Neurology · July 21, 2009 OBJECTIVE: To explore factors throughout the lifespan that influence cognition in midlife to late life. METHODS: We conducted a retrospective birth cohort study of 2,062 individuals born during 1921-1954 in Beijing, China. In 2003-2005, birth records were ... Full text Link to item Cite

Twin pairs discordant for neuropathologically confirmed Lewy body dementia.

Journal Article J Neurol Neurosurg Psychiatry · May 2009 AIM: Little is known about the concordance rate in twins for dementia with Lewy bodies (DLB). The rate of agreement between clinical and pathological diagnoses for DLB is typically low, necessitating confirmation of the diagnosis neuropathologically. METHO ... Full text Link to item Cite

Parental education and late-life dementia in the United States.

Journal Article J Geriatr Psychiatry Neurol · March 2009 We investigated the relation between parental education and dementia in the United States. Participants in the Aging, Demographics, and Memory Study were included, with information regarding parental education obtained from the Health and Retirement Study. ... Full text Link to item Cite

Longitudinal Outcomes of Subtypes of Cognitive Impairment Not Dementia (CIND)

Journal Article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2009 Link to item Cite

The accuracy of Medicare claims as an epidemiological tool: the case of dementia revisited.

Journal Article J Alzheimers Dis · 2009 Our study estimates the sensitivity and specificity of Medicare claims to identify clinically-diagnosed dementia, and documents how errors in dementia assessment affect dementia cost estimates. We compared Medicare claims from 1993-2005 to clinical dementi ... Full text Link to item Cite

Midlife activity predicts risk of dementia in older male twin pairs.

Journal Article Alzheimers Dement · September 2008 BACKGROUND: This was a prospective study of dementia to elucidate mechanisms of disease risk factors amenable to modification and specifically to determine whether midlife cognitive and physical leisure activities are associated with delayed onset or reduc ... Full text Link to item Cite

Associations of job demands and intelligence with cognitive performance among men in late life.

Journal Article Neurology · May 6, 2008 OBJECTIVE: To examine the association of job characteristics and intelligence to cognitive status in members of the National Academy of Sciences-National Research Council Twins Registry of World War II veterans. METHODS: Participants (n = 1,036) included i ... Full text Link to item Cite

Cognitive function and oral health among community-dwelling older adults.

Journal Article J Gerontol A Biol Sci Med Sci · May 2008 BACKGROUND: Both oral health problems and cognitive impairment are relatively common among older adults. Poorer oral health appears to contribute to a decline in quality of life and to be related to various medical conditions. Little is known about the rel ... Full text Link to item Cite

Prevalence of cognitive impairment without dementia in the United States.

Journal Article Ann Intern Med · March 18, 2008 Featured Publication BACKGROUND: Cognitive impairment without dementia is associated with increased risk for disability, increased health care costs, and progression to dementia. There are no population-based prevalence estimates of this condition in the United States. OBJECTI ... Full text Link to item Cite

Identification of dementia: agreement among national survey data, medicare claims, and death certificates.

Journal Article Health Serv Res · February 2008 OBJECTIVE: To estimate the proportion of seniors with dementia from three independent data sources and their agreement. DATA SOURCES: The longitudinal Asset and Health Dynamics among the Oldest Old (AHEAD) study (n=7,974), Medicare claims, and death certif ... Full text Link to item Cite

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.

Journal Article Int J Geriatr Psychiatry · February 2008 BACKGROUND: Neuropsychiatric symptoms are nearly universal in dementia, yet little is known about their longitudinal course in the community. OBJECTIVE: To estimate point and 5-year period prevalence of neuropsychiatric symptoms in an incident sample of 40 ... Full text Link to item Cite

The effect of spousal caregiving and bereavement on depressive symptoms.

Journal Article Aging Ment Health · January 2008 The objective of the study was to determine whether spousal caregiving and bereavement increases caregiver depressive symptoms. We followed 1,967 community-dwelling elderly couples from the 1993 Health and Retirement Study (HRS) until 2002 (five bi-annual ... Full text Link to item Cite

Children of persons with Alzheimer disease: what does the future hold?

Journal Article Alzheimer Dis Assoc Disord · 2008 Children of persons with Alzheimer disease (AD), as a group, face an increased risk of developing AD. Many of them, throughout their adult lives, seek input on how to reduce their chances of one day suffering their parent's fate. We examine the state of kn ... Full text Link to item Cite

Cognitive function and dental care utilization among community-dwelling older adults.

Journal Article Am J Public Health · December 2007 OBJECTIVES: We sought to investigate the relationship between varying levels of cognitive function and dental care utilization. METHODS: Using data obtained from the National Health and Nutrition Examination Survey (1999-2002), we performed weighted descri ... Full text Link to item Cite

Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.

Journal Article Am J Geriatr Psychiatry · October 2007 OBJECTIVE: Several studies suggest that depression is a risk factor for development of dementia in the elderly. In a study of older depressed individuals, the authors examined both neuroimaging and genetic factors in development of dementia. The authors hy ... Full text Link to item Cite

Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.

Journal Article J Clin Exp Neuropsychol · July 2007 Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically ... Full text Link to item Cite

Job demands and dementia risk among male twin pairs.

Journal Article Alzheimers Dement · July 2007 BACKGROUND: Job characteristics may influence dementia risk, but some types of job complexity remain to be examined. Twin studies provide a useful methodology to examine job differences between pairs who share many environmental and genetic influences. MET ... Full text Link to item Cite

Intelligence in early adulthood and life span up to 65 years later in male elderly twins.

Journal Article Age Ageing · May 2007 BACKGROUND: Previous research has reported that greater intelligence in early life is associated with longer lifespan. Whether this relationship is mediated by genetic factors or environmental factors, some of which could be modified by an individual, is u ... Full text Link to item Cite

Reply from the authors [5]

Journal Article Neurology · May 1, 2007 Full text Cite

Prevalence of dementia in the United States: the aging, demographics, and memory study.

Journal Article Neuroepidemiology · 2007 Featured Publication AIM: To estimate the prevalence of Alzheimer's disease (AD) and other dementias in the USA using a nationally representative sample. METHODS: The Aging, Demographics, and Memory Study sample was composed of 856 individuals aged 71 years and older from the ... Full text Link to item Cite

Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.

Journal Article Twin Res Hum Genet · December 2006 The Duke Twins Study of Memory in Aging is an ongoing, longitudinal study of cognitive change and dementia in the population-based National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry of World War II Male Veterans. The primary goa ... Full text Link to item Cite

Vascular risk factors and cognitive decline among elderly male twins.

Journal Article Neurology · November 14, 2006 BACKGROUND: Studies investigating the association between cardiovascular risk factors and cognitive decline report discrepant outcomes. The co-twin control method improves on traditional case-control approaches by controlling for within-twin pair similarit ... Full text Link to item Cite

Occupational characteristics and cognitive performance among elderly male twins.

Journal Article Neurology · October 24, 2006 OBJECTIVE: To examine the effect of occupational characteristics on cognitive status change in members of the NAS-NRC Twins Registry of World War II veterans. METHODS: Participants completed the modified Telephone Interview for Cognitive Status (TICS-m) on ... Full text Link to item Cite

A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study.

Journal Article Int J Geriatr Psychiatry · June 2006 BACKGROUND: The relationship between coronary artery bypass graft (CABG) surgery and cognitive decline remains uncertain, in particular with regard to whether there is delayed cognitive decline associated with this procedure. METHODS: This was a population ... Full text Link to item Cite

Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.

Journal Article Alzheimers Dement · January 2006 BACKGROUND: Studies of dementia in populations avoid many of the selection biases in clinical samples but require special evaluation and diagnostic methods to obtain high participation rates. To address this issue, we developed a unique in-home dementia as ... Full text Link to item Cite

Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later.

Journal Article Twin Res Hum Genet · August 2005 The National Academy of Sciences -- National Research Council (NAS-NRC) twin panel, created nearly 50 years ago, had twin zygosity determined primarily via a similarity questionnaire that has been estimated to correctly classify at least 95% of twins. In t ... Full text Link to item Cite

The Aging, Demographics, and Memory Study: study design and methods.

Journal Article Neuroepidemiology · 2005 OBJECTIVE: We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and "cognitive impairment, not demented" (CIND) ... Full text Link to item Cite

Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.

Journal Article Am J Alzheimers Dis Other Demen · 2005 The purpose of this research was to assess the frequency and severity of neuropsychiatric and behavioral symptoms and to examine the association between preexisting medical conditions and specific neuropsychiatric symptoms in demented individuals. We studi ... Full text Link to item Cite

A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.

Journal Article Care Manag J · 2005 There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of "oldest-old" members. This study, which has been followi ... Full text Link to item Cite

Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.

Journal Article Neurology · December 28, 2004 BACKGROUND: Research regarding long-term cognitive outcome following coronary artery bypass graft (CABG) is inconsistent, which may be due in part to differential genetic and environmental influences within most study samples. METHODS: The authors examined ... Full text Link to item Cite

Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.

Journal Article J Geriatr Psychiatry Neurol · December 2004 A methodology is presented for following a cohort of older depressed patients to examine neurocognitive outcomes of depression. A total of 265 depressed individuals and 138 healthy, nondepressed controls age 60 and older who completed at least 1 year of fo ... Full text Link to item Cite

A twin study of the genetic contribution to age-related functional impairment.

Journal Article J Gerontol A Biol Sci Med Sci · August 2004 BACKGROUND: A key element in the quality of later life is the prevalence of age-related functional impairments. The objective of this study was to quantify the genetic and environmental influences on age-related functional impairment in a population of whi ... Full text Link to item Cite

Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging.

Journal Article Neuropsychology · July 2003 Neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with Alzheimer's disease (AD), non-AD dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all w ... Full text Link to item Cite

Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study.

Journal Article Psychol Med · April 2003 BACKGROUND: The role of allelic variation in APOE, the genetic locus for apolipoprotein E, in geriatric depression is poorly understood. There are conflicting reports as to an association between the epsilon4 allele and depression in late life. METHOD: Usi ... Full text Link to item Cite

Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.

Journal Article JAMA · November 6, 2002 CONTEXT: Previous studies have shown a sex-specific increased risk of Alzheimer disease (AD) in women older than 80 years. Basic neuroscience findings suggest that hormone replacement therapy (HRT) could reduce a woman's risk of AD. Epidemiologic findings ... Full text Link to item Cite

Dementia, asymmetry of temporal lobe structures, and apolipoprotein E genotype: relationships to cerebral atrophy and neuropsychological impairment.

Journal Article J Int Neuropsychol Soc · November 2002 We examined asymmetry of hippocampal volume as well as other temporal lobe structures (temporal lobe, temporal horn of the lateral ventricular system, parahippocampal and fusiform gyri) in 194 subjects from the Cache County, Utah study, with varying disord ... Full text Link to item Cite

An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study.

Journal Article Neuropsychiatry Neuropsychol Behav Neurol · March 2002 OBJECTIVES: To present a new version of the Modified Mini-Mental State Examination (3MS-R), provide normative information extending to individuals in the 10th decade, and examine the effects of demographic variables on test performance. BACKGROUND: The Mod ... Link to item Cite

Head injury in early adulthood and the lifetime risk of depression.

Journal Article Arch Gen Psychiatry · January 2002 BACKGROUND: Depressive symptoms are common and can be debilitating in the months after head injury. Head injury can also have long-term cognitive effects, but little is known about the long-term risk of depression associated with head injury. We investigat ... Full text Link to item Cite

Hormone replacement therapy and reduced cognitive decline in older women: the Cache County Study.

Journal Article Neurology · December 26, 2001 OBJECTIVE: To examine the association between postmenopausal hormone replacement therapy (HRT) and the trajectory of global cognitive change with age. METHODS: The Modified Mini-Mental State Examination (MMSE) was administered to a population sample of 2,0 ... Full text Link to item Cite

Documented head injury in early adulthood and risk of stroke in late life.

Journal Article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2001 Link to item Cite

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias.

Journal Article Neurology · October 24, 2000 Featured Publication BACKGROUND: The association between antecedent head injury and AD is inconsistent. OBJECTIVE: To examine the association between early adult head injury, as documented by military hospital records, and dementia in late life; and to evaluate the interaction ... Full text Link to item Cite

Prevalence of depression and its treatment in an elderly population: the Cache County study.

Journal Article Arch Gen Psychiatry · June 2000 BACKGROUND: Previous estimates of the prevalence of geriatric depression have varied. There are few large population-based studies; most of these focused on individuals younger than 80 years. No US studies have been published since the advent of the newer ... Full text Link to item Cite

APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives.

Journal Article Neurology · February 8, 2000 OBJECTIVE: To examine the independent effects of the APOE genotype (APOE) and concordance for AD in twin pairs on the occurrence of AD in first-degree relatives. BACKGROUND: Studies of twins have been undertaken to investigate the influence of genes in a v ... Full text Link to item Cite

Telephone adaptation of the Modified Mini-Mental State Exam (3MS). The Cache County Study.

Journal Article Neuropsychiatry Neuropsychol Behav Neurol · October 1999 OBJECTIVE: To examine the concurrent validity of a newly developed telephone adaptation of the Modified Mini-Mental State Exam. BACKGROUND: Longitudinal studies of cognition may be advantaged by availability of assessment instruments that can be used over ... Link to item Cite

Enhanced cognitive performance with estrogen use in nondemented community-dwelling older women.

Journal Article J Am Geriatr Soc · October 1999 OBJECTIVE: To examine the association between history of postmenopausal estrogen use and cognitive function in a large sample of nondemented community-dwelling older women. SETTING: A community of older residents in Cache County, Utah. PARTICIPANTS: A tota ... Full text Link to item Cite

APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.

Journal Article Neurology · July 22, 1999 OBJECTIVE: To examine the prevalence of Alzheimer's disease (AD) and other dementias in relation to age, education, sex, and genotype at APOE. Recent studies suggest age heterogeneity in the risk of AD associated with the APOE genotype and a possible inter ... Full text Link to item Cite

Cognitive decline in aging: What is the role of education?

Journal Article CLINICAL NEUROPSYCHOLOGIST · May 1, 1998 Link to item Cite

A new method for quantifying cerebral atrophy in Alzheimer's disease

Journal Article CLINICAL NEUROPSYCHOLOGIST · May 1, 1998 Link to item Cite

Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years.

Journal Article Alzheimer Dis Assoc Disord · March 1998 The epsilon4 allele at APOE, the polymorphic locus for apolipoprotein E, increases the risk of Alzheimer disease (AD), especially among those with the homozygous epsilon4/epsilon4 genotype. In family studies, epsilon4 homozygotes typically develop AD at 55 ... Full text Link to item Cite

A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease.

Journal Article Biol Psychiatry · April 15, 1997 A prior history of depression and the epsilon 4 allele of apolipoprotein E (APOE) have each been associated with development of Alzheimer's disease (AD). In a sample of 142 elderly twins from a large study of dementia, we examined the relation of major dep ... Full text Link to item Cite

Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.

Journal Article Neurology · April 1997 We examined the relation of APOE-epsilon 4, hippocampal volume, and cognitive performance in ten pairs of cognitively normal twins who had a mean age of 62.5 years (SD = 7.8). There were no significant differences in neuropsychological measures of the grou ... Full text Link to item Cite

The genetics of dementia in late life.

Journal Article Psychiatr Clin North Am · March 1997 Recent advances in the genetics of AD and other late-life dementias have provided new insights but also have raised new queries and ethical issues. This review reflects the current state of knowledge in a rapidly evolving field. The complex relation of gen ... Full text Link to item Cite

Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions.

Journal Article J Am Geriatr Soc · October 1996 OBJECTIVE: To review recent findings in the genetics of Alzheimer's disease (AD) and vascular dementia (VaD) with particular emphasis on gene-environment interactions. DESIGN: A survey and critique of recent literature on the genetic etiology of AD and VaD ... Full text Link to item Cite

A twin study of late-onset depression and APOE e4 as risk factors for dementia

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · September 1, 1996 Link to item Cite

Intelligence and education as predictors of cognitive state in late life: a 50-year follow-up.

Journal Article Neurology · August 1995 We evaluated the relation of education and intelligence in early adult life to cognitive function in a group of elderly male twins. The Army General Classification Test (AGCT) was administered to US armed forces inductees in the early 1940s. Fifty years la ... Full text Link to item Cite

Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance.

Journal Article Arch Neurol · August 1995 OBJECTIVES: To detect cases of Alzheimer's disease (AD) in a large population of twins living throughout the United States and to examine concordance for AD in twins as a function of age and genotype for apolipoprotein E (APOE). SETTING: Nationwide survey. ... Full text Link to item Cite

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

Journal Article Neurology · February 1994 We conducted a co-twin control study among 50 elderly twin pairs with onsets of Alzheimer's disease (AD) separated by 3 or more years. Twenty-three male pairs (46%) were screened from the (U.S.) National Academy of Sciences-National Research Council Regist ... Full text Link to item Cite

Properties of the telephone interview for cognitive status: Application in epidemiological and longitudinal studies

Journal Article Neuropsychiatry, Neuropsychology and Behavioral Neurology · January 1, 1994 We evaluated the utility of telephone screening for dementia in epidemiologic research by comparing performance on the modified Telephone Interview for Cognitive Status (TICS-m) with results from in-person neuropsychological measures in 67 elderly males. L ... Cite

Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction.

Journal Article Thorax · November 1992 BACKGROUND: This study investigated whether the inspiratory muscles are susceptible to fatigue during acute airway narrowing because of increased airway resistance and hyperinflation. METHODS: Asthmatic subjects performed up to four series (on separate day ... Full text Link to item Cite

Activation of human respiratory muscles during different voluntary manoeuvres.

Journal Article J Physiol · September 1990 1. This study used three techniques (bilateral phrenic nerve stimulation, motor cortex stimulation and quantitative electromyography) to assess the degree of activation of the diaphragm, intercostal-accessory muscles and abdominal muscles during postural t ... Full text Link to item Cite

Perceptual cues used to reproduce an inspired lung volume.

Journal Article J Appl Physiol (1985) · September 1990 The perceptual cues used to reproduce a specific lung volume were studied in five healthy males. Performance was examined under three conditions that were designed progressively to remove the reliability of cues that a subject might use to duplicate a spec ... Full text Link to item Cite

High-voltage stimulation over the human spinal cord: sources of latency variation.

Journal Article J Neurol Neurosurg Psychiatry · February 1989 Percutaneous electrical stimuli (up to 600 V) were applied over the cervical spinal cord to evoke responses in the biceps brachii and thenar muscles. Cathodal stimulation over the C7 spinous process was more effective than anodal stimulation or stimulation ... Full text Link to item Cite

Comparison of human motor cortical projections to abdominal muscles and intrinsic muscles of the hand.

Journal Article Exp Brain Res · 1989 Percutaneous electrical stimulation of the motor cortex was used to activate rapidly conducting corticofugal pathways to human abdominal muscles. Following cortical stimulation the response latencies for the abdominal muscles were similar to those for limb ... Full text Link to item Cite

Abdominal muscle activity during speech production.

Journal Article J Appl Physiol (1985) · December 1988 Abdominal muscle activity was investigated during resting tidal breathing and speech production in upright and supine body positions in five male and five female young adult subjects. Results showed that patterns of abdominal electromyographic (EMG) activi ... Full text Link to item Cite

Responses in human intercostal and truncal muscles to motor cortical and spinal stimulation.

Journal Article Respir Physiol · September 1988 Percutaneous electrical stimulation of the human motor cortex (up to 750 V) has been used to study the cortical projections to intercostal and truncal muscles. The latencies of electromyographic (EMG) responses were measured to motor cortical stimuli and a ... Full text Link to item Cite

Maximal activation of the human diaphragm but not inspiratory intercostal muscles during static inspiratory efforts.

Journal Article Neurosci Lett · June 17, 1988 It is widely held that transdiaphragmatic pressure is a reliable index of the extent of central activation of the diaphragm but the maximal voluntary transdiaphragmatic pressure is lower during inspiratory than expulsive efforts. To determine whether the d ... Full text Link to item Cite

Inspiratory muscle responses to airway occlusion during learned breathing movements.

Journal Article J Neurophysiol · January 1987 Respiratory muscle responses to sudden obstruction of learned breathing movements were studied in seven normal adults. Subjects were trained to inspire at a constant rate (0.4 liters/s), or maintain a static inspiratory effort(-10 cmH2O). On each trial the ... Full text Link to item Cite

TBI and Increased Risk of Non-Alzheimer’s disease dementia in older male twins

Conference Background: Several studies have reported an association between traumatic brain injury(TBI) and increased risk of Alzheimer’s disease(AD) and all cause dementia. Considering the heterogeneous genetic and environmental factors that may contribute to develo ... Full text Link to item Cite