Brenda Lee Plassman

Journal Article J Appl Gerontol · November 2024 BACKGROUND AND OBJECTIVES: Mild cognitive impairment (MCI) affects up to 22% of US older adults aged 65 and older. Research suggests that physicians may recommend less cardiovascular disease (CVD) treatment for older adults with MCI due to assumptions abou ... Full text Link to item Cite

Beta amyloid PET scans for dementia diagnoses: Practice and research implications from CARE-IDEAS.

Journal Article J Am Geriatr Soc · October 2024 Beta amyloid PET scans are a minimally invasive biomarker that may inform Alzheimer's disease (AD) diagnosis. The Caregiver's Reactions and Experience (CARE) study, an IDEAS supplement, aimed to understand experiences of PET scan recipients and their care ... Full text Link to item Cite

Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer's disease.

Journal Article Sci Rep · July 29, 2024 Inflammation is an important factor in Alzheimer's disease (AD). An NMR measurement in plasma, glycoprotein acetyls (GlycA), captures the overall level of protein production and glycosylation implicated in systemic inflammation. With its additional advanta ... Full text Link to item Cite

Age and Sex Differences in the Genetic Architecture of Measures of Subjective Health: Relationships With Physical Health, Depressive Symptoms, and Episodic Memory.

Journal Article J Gerontol B Psychol Sci Soc Sci · June 1, 2024 OBJECTIVES: Subjective health (SH) is not just an indicator of physical health, but also reflects active cognitive processing of information about one's own health and has been associated with emotional health measures, such as neuroticism and depression. ... Full text Link to item Cite

Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.

Conference Anesthesiology · May 1, 2024 BACKGROUND: Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer's disease-related biomarker and cognitive traje ... Full text Link to item Cite

An Early and Unequal Decline: Life Course Trajectories of Cognitive Aging in the United States.

Journal Article J Aging Health · March 2024 Objectives: Cognitive aging is a lifelong process with implications for Alzheimer's disease and dementia. This study aims to fill major gaps in research on the natural history of and social disparities in aging-related cognitive decline over the life span. ... Full text Link to item Cite

Association between results of an amyloid PET scan and healthcare utilization in individuals with cognitive impairment.

Journal Article J Am Geriatr Soc · March 2024 BACKGROUND: The Imaging Dementia Evidence for Amyloid Scanning (IDEAS) study reports that amyloid PET scans help providers diagnose and manage Alzheimer's disease and related dementias (ADRD). Using CARE-IDEAS, an IDEAS supplemental study, we examined the ... Full text Link to item Cite

Preventing cognitive decline by reducing BP target (PCOT): A randomized, pragmatic, multi-health systems clinical trial.

Journal Article Contemp Clin Trials · March 2024 BACKGROUND: Growing evidence suggests that intensive lowering of systolic blood pressure (BP) may prevent mild cognitive impairment (MCI) and dementia. However, current guidelines provide inconsistent recommendations regarding optimal BP targets, citing sa ... Full text Link to item Cite

Care partners experience of an oral health intervention for individuals with mild cognitive impairment and mild dementia using behavior change technique: A qualitative study.

Journal Article Geriatr Nurs · 2024 Oral health declines in older adults with cognitive impairment. We aimed to improve oral hygiene outcomes for individuals with mild cognitive impairment (MCI) or mild dementia (MD) by fostering behavior changes among carepartners assisting them. We used qu ... Full text Link to item Cite

Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI ... Full text Link to item Cite

Patient Cognitive Status and Physician Recommendations for Cardiovascular Disease Treatment: Results of Two Nationwide, Randomized Survey Studies.

Journal Article Journal of general internal medicine · November 2023 BackgroundClinical guidelines recommend that older patients (65+) with mild cognitive impairment (MCI) and early-stage dementia receive similar guideline-concordant care after cardiovascular disease (CVD) events as those with normal cognition (NC) ... Full text Cite

Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

Journal Article EBioMedicine · November 2023 BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. T ... Full text Link to item Cite

Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study.

Journal Article Neurology · October 31, 2023 BACKGROUND AND OBJECTIVES: Traumatic brain injuries (TBIs) are associated with increased risk of dementia, but whether lifetime TBI influences cognitive trajectories in later life is less clear. Cognitive interventions after TBI may improve cognitive traje ... Full text Link to item Cite

Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment.

Journal Article J Affect Disord · August 1, 2023 BACKGROUND: Depression and cognitive impairment commonly co-occur, and it has been hypothesized that the two share pathological processes. Our objective for this study was to determine the relationship between elevated β-amyloid level and the prevalence an ... Full text Link to item Cite

Diabetes, Edentulism, and Cognitive Decline: A 12-Year Prospective Analysis.

Journal Article J Dent Res · July 2023 Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is associated with cognitive impairment and dementia. However, the effect of the co-occurrence of DM and edentulism on cognitive decline is under ... Full text Link to item Cite

Influence of mild cognitive impairment on patient and care partner decision-making for acute ischemic stroke.

Journal Article J Stroke Cerebrovasc Dis · June 2023 GOALS: Evidence suggests that patients with mild cognitive impairment (MCI) receive fewer treatments for acute ischemic stroke and other cardiovascular diseases than patients with normal cognition. Little is known about how patient and care partner prefere ... Full text Link to item Cite

Systematic Review, Meta-Analysis, and Population Attributable Risk of Dementia Associated with Traumatic Brain Injury in Civilians and Veterans.

Journal Article J Neurotrauma · April 2023 Traumatic brain injury (TBI) is an established risk factor for dementia. However, the magnitude of risk is highly variable across studies. Identification of sub-populations at highest risk, with careful consideration of potential sources of bias, is urgent ... Full text Link to item Cite

Remember This: Age Moderation of Genetic and Environmental Contributions to Verbal Episodic Memory from Midlife through Late Adulthood.

Journal Article Intelligence · 2023 It is well documented that memory is heritable and that older adults tend to have poorer memory performance than younger adults. However, whether the magnitudes of genetic and environmental contributions to late-life verbal episodic memory ability differ f ... Full text Link to item Cite

Genotypic Effects of the TOMM40'523 Variant and APOE on Longitudinal Cognitive Change over 4 Years: The TOMMORROW Study.

Journal Article J Prev Alzheimers Dis · 2023 BACKGROUND: The 523 poly-T length polymorphism (rs10524523) in TOMM40 has been reported to influence longitudinal cognitive test performance within APOE ε3/3 carriers. The results from prior studies are inconsistent. It is also unclear whether specific APO ... Full text Open Access Link to item Cite

Comparing the Experiences of Participants With Mild Cognitive Impairment and Mild Dementia During an Oral Health Intervention.

Journal Article Innov Aging · 2023 BACKGROUND AND OBJECTIVES: Cognitive impairment is associated with poor oral health outcomes. Oral hygiene tasks are an essential target of interventions aiming to improve oral health for older adults with cognitive impairment. We aimed to examine whether ... Full text Link to item Cite

The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

Journal Article Contemp Clin Trials · December 2022 BACKGROUND: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially av ... Full text Link to item Cite

Advance directives among cognitively impaired persons who had an amyloid PET scan and their care partners: a mixed-methods study.

Journal Article BMC Palliat Care · November 6, 2022 BACKGROUND: Little research exists on the role of β-amyloid PET scans as part of Alzheimer's diagnostic tests and documentation of end-of-life preferences for persons with cognitive impairment. The study objectives were to examine the association of amyloi ... Full text Link to item Cite

Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.

Journal Article Alzheimers Dement · November 2022 INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-Nat ... Full text Link to item Cite

Lifecourse Traumatic Events and Cognitive Aging in the Health and Retirement Study.

Journal Article Am J Prev Med · November 2022 INTRODUCTION: Much of the heterogeneity in the rate of cognitive decline and the age of dementia onset remains unexplained, and there is compelling data supporting psychosocial stressors as important risk factors. However, the literature has yet to come to ... Full text Link to item Cite

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.

Journal Article Commun Biol · October 8, 2022 Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzhe ... Full text Link to item Cite

Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · October 6, 2022 OBJECTIVES: To better understand the temporal dynamics of progression from cognitive decline to onset of dementia in the dementia-free older population in the United States. METHODS: We used longitudinal data from a diverse national population-based sample ... Full text Link to item Cite

"Now at least we have something to call it": Patient and care partner experiences receiving an amyloid PET scan.

Journal Article J Am Geriatr Soc · October 2022 BACKGROUND: The primary objective of this paper was to examine perspectives and experiences of individuals with cognitive impairment who received an amyloid PET scan and their care partners, with regard to the process, logistics, and decision-making associ ... Full text Link to item Cite

Sex Differences in the Association Between Metabolic Dysregulation and Cognitive Aging: The Health and Retirement Study.

Journal Article J Gerontol A Biol Sci Med Sci · September 1, 2022 BACKGROUND: Dysregulation of some metabolic factors increases the risk of dementia. It remains unclear if overall metabolic dysregulation, or only certain components, contribute to cognitive aging and if these associations are sex specific. METHODS: Data f ... Full text Link to item Cite

Oral Health, Diabetes, and Inflammation: Effects of Oral Hygiene Behaviour.

Journal Article Int Dent J · August 2022 INTRODUCTION: The aim of this research was to assess the association between inflammation and oral health and diabetes, as well as the mediating role of oral hygiene practice in this association. METHODS: Data were from the 2009-2010 National Health and Nu ... Full text Link to item Cite

Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.

Journal Article Ophthalmol Retina · July 2022 PURPOSE: To assess the baseline differences and longitudinal rate of change in retinal and choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and noncarriers with normal cognition. DESIGN: Prospective study. SUBJECTS: Four hundred th ... Full text Link to item Cite

Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group.

Journal Article Lancet Healthy Longev · July 2022 Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted ... Full text Link to item Cite

Study protocol for a randomised controlled trial of a care partner assisted intervention to improve oral health of individuals with mild dementia.

Journal Article BMJ Open · June 22, 2022 INTRODUCTION: Individuals with mild dementia are at high risk of poor oral health outcomes. To address this issue, we describe an intervention to teach care partners skills to guide individuals with mild dementia in proper oral hygiene techniques and provi ... Full text Link to item Cite

The Association Between Mild Cognitive Impairment Diagnosis and Patient Treatment Preferences: a Survey of Older Adults.

Journal Article J Gen Intern Med · June 2022 BACKGROUND: Older patients (65+) with mild cognitive impairment (MCI) receive less guideline-concordant care for cardiovascular disease (CVD) and other conditions than patients with normal cognition (NC). One potential explanation is that patients with MCI ... Full text Link to item Cite

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.

Journal Article Mov Disord · May 2022 BACKGROUND: Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological ... Full text Link to item Cite

Occupational cognitive stimulation, socioeconomic status, and cognitive functioning in young adulthood.

Journal Article SSM Popul Health · March 2022 BACKGROUND: Occupational characteristics are associated with late-life cognition. However, little is known about the association between occupational factors and cognition in early adulthood, especially when controlling for early life socioeconomic status ... Full text Link to item Cite

A Mixed-Methods Study of the Impact of Mild Cognitive Impairment Diagnosis on Patient and Care Partner Perception of Health Risks.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Older patients (≥65 years) with mild cognitive impairment (MCI) are undertreated for cardiovascular disease (CVD). One reason for this disparity could be that patients with MCI might underestimate the chances of CVD and overestimate dementia. O ... Full text Link to item Cite

Raising Awareness of Alzheimer's Disease and Dementia in Native Americans in North Carolina.

Journal Article N C Med J · 2022 Full text Link to item Cite

Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Diagnostic tests, such as amyloid-β positron emission tomography (PET) scans, can increase appropriate therapeutic management for the underlying causes of cognitive decline. To evaluate the full utility of this diagnostic tool, information is n ... Full text Link to item Cite

Sensory impairment and cognitive decline among older adults: An analysis of mediation and moderation effects of loneliness.

Journal Article Frontiers in neuroscience · January 2022 BackgroundMultiple studies have reported that hearing and vision impairment are linked to cognitive decline. Yet little is known about factors that may influence the association between sensory impairment and cognitive decline. This study examined ... Full text Cite

Analysis of pleiotropic genetic effects on cognitive decline and systemic inflammation in the Women's Health Initiative Memory Study

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2021 BACKGROUND: SNPs associated with C-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease (AD) risk SNPs. Previously, we reported pleiotropic effects between SNPs associated with cognitive impairment ... Full text Cite

Immune function, cortisol, and cognitive decline & dementia in an aging latino population.

Journal Article Psychoneuroendocrinology · November 2021 BACKGROUND: The etiology of dementias and cognitive decline remain largely unknown. It is widely accepted that inflammation in the central nervous system plays a critical role in the pathogenesis of dementia. However, less is known about the role of the pe ... Full text Link to item Cite

Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.

Journal Article J Am Med Dir Assoc · October 2021 OBJECTIVES: To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia. DESIGN: Longitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 ... Full text Link to item Cite

Care partner-assisted intervention to improve oral health for older adults with cognitive impairment: A feasibility study.

Journal Article Gerodontology · September 2021 BACKGROUND AND OBJECTIVES: Older adults with cognitive impairment often experience poor oral health outcomes due to inadequate oral hygiene practices. This pilot study aimed to evaluate the feasibility of a care partner-assisted intervention to improve the ... Full text Link to item Cite

Safety and efficacy of pioglitazone for the delay of cognitive impairment in people at risk of Alzheimer's disease (TOMMORROW): a prognostic biomarker study and a phase 3, randomised, double-blind, placebo-controlled trial.

Journal Article Lancet Neurol · July 2021 BACKGROUND: The identification of people at risk of cognitive impairment is essential for improving recruitment in secondary prevention trials of Alzheimer's disease. We aimed to test and qualify a biomarker risk assignment algorithm (BRAA) to identify par ... Full text Link to item Cite

Drivers of Long-Term Care Considerations by Persons With Cognitive Impairment.

Journal Article J Appl Gerontol · June 2021 Consideration of place of care is the first step in long-term care (LTC) planning and is critical for patients diagnosed with Alzheimer's disease; yet, drivers of consideration of place of care are unknown. We apply machine learning algorithms to cross-sec ... Full text Link to item Cite

Longitudinal Association Between Hearing Loss, Vision Loss, Dual Sensory Loss, and Cognitive Decline.

Journal Article J Am Geriatr Soc · March 2021 BACKGROUND/OBJECTIVES: To better understand the role of sensory loss as a potentially modifiable risk factor for cognitive decline, this study examined cognitive decline in relation to single modality hearing or vision loss and dual sensory loss. DESIGN: L ... Full text Link to item Cite

Video-Enhanced Care Management for Medically Complex Older Adults with Cognitive Impairment.

Journal Article J Am Geriatr Soc · January 2021 OBJECTIVE: This pilot study assessed feasibility of video-enhanced care management for complex older veterans with suspected mild cognitive impairment (CI) and their care partners, compared with telephone delivery. DESIGN: Pilot randomized controlled trial ... Full text Link to item Cite

Effects of the Co-occurrence of Diabetes Mellitus and Tooth Loss on Cognitive Function.

Journal Article Curr Alzheimer Res · 2021 OBJECTIVE: Both diabetes mellitus (DM) and poor oral health are common chronic conditions and risk factors of Alzheimer's disease and related dementia among older adults. This study assessed the effects of DM and complete tooth loss (TL) on cognitive funct ... Full text Link to item Cite

Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults.

Journal Article J Vitreoretin Dis · 2021 PURPOSE: This work assesses the intrasession repeatability of capillary perfusion density (CPD) and capillary flux index (CFI) measurements on peripapillary optical coherence tomography angiography (OCTA) in healthy eyes of older adults. METHODS: In this c ... Full text Link to item Cite

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease.

Journal Article Cell Rep Med · November 17, 2020 Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism. We analyze 2,114 post-mortem brain transcriptomes and identify genes in the alternative bile ... Full text Link to item Cite

Sex, race, and risk of dementia diagnosis after traumatic brain injury among older veterans.

Journal Article Neurology · September 29, 2020 OBJECTIVE: To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS: Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with ... Full text Link to item Cite

The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS).

Journal Article Aging Ment Health · September 2020 Background: A small but growing body of evidence supports a relationship between neighborhood socioeconomic status (NSES) and cognitive decline. Additional work is needed to characterize this relationship controlling for risk factors such as cardiovascular ... Full text Link to item Cite

Measurement Properties of the CAPACITY Instrument to Assess Perceived Communication With the Health Care Team Among Care Partners of Patients With Cognitive Impairment.

Journal Article Med Care · September 2020 BACKGROUND: The CAregiver Perceptions About CommunIcaTion with Clinical Team members (CAPACITY) instrument measures how care partners perceive themselves to be supported by the patient's health care team and their experiences communicating with the team. O ... Full text Link to item Cite

Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies.

Journal Article Alzheimers Dement · August 2020 INTRODUCTION: The Alzheimer's Disease Prevention Registry (ADPR) of the Joseph and Kathleen Bryan Alzheimer's Disease Research Center at Duke University has been successful in achieving a racially diverse and "research ready" cohort of cognitively healthy ... Full text Link to item Cite

Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol.

Journal Article BMJ Open · June 3, 2020 INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia. Individual epidemiological studies have controlled for several confounders of the relationship between PTSD and increased dementia risk, yet particular ri ... Full text Link to item Cite

Investigating Predictors of Cognitive Decline Using Machine Learning.

Journal Article J Gerontol B Psychol Sci Soc Sci · March 9, 2020 OBJECTIVES: Genetic risks for cognitive decline are not modifiable; however their relative importance compared to modifiable factors is unclear. We used machine learning to evaluate modifiable and genetic risk factors for Alzheimer's disease (AD), to predi ... Full text Link to item Cite

Willingness to Undergo a Risky Treatment to Improve Cognition Among Persons With Cognitive Impairment Who Received an Amyloid PET Scan.

Journal Article Alzheimer Dis Assoc Disord · 2020 OBJECTIVE: To evaluate determinants of willingness to accept a treatment to return memory to normal among persons with cognitive impairment who received an amyloid positron emission tomography (PET) scan and their care partner and discordance in risk takin ... Full text Link to item Cite

How Accurately Do Patients and Their Care Partners Report Results of Amyloid-β PET Scans for Alzheimer's Disease Assessment?

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Amyloid-β PET scans will likely become an integral part of the diagnostic evaluation for Alzheimer's disease if Medicare approves reimbursement for the scans. However, little is known about patients' and their care partners' interpretation of s ... Full text Link to item Cite

Remember this: harmonization of episodic memory measures across twin studies of aging

Conference BEHAVIOR GENETICS · 2020 Cite

Repeatability, Interocular Symmetry, and Correlation with Age of Peripapillary Optical Coherence Tomography Angiography Parameters in Healthy Eyes

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2020 Cite

The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update.

Journal Article Twin Res Hum Genet · December 2019 The National Academy of Sciences-National Research Council (NAS-NRC) Twin Registry is one of the oldest, national population-based twin registries in the USA. It comprises 15,924 White male twin pairs born in the years 1917-1927 (N = 31.848), both of whom ... Full text Link to item Cite

Validating Silicone Wristbands to Measure Pesticide Exposures Among Older Adults -- Proof-of-Concept Study

Conference · November 8, 2019 Silicone wristbands have been used to measure exposure to pesticides and other chemicals among children and younger farm workers, but not in older adults. Thus, we aimed to examine exposure to pesticides using silicone wristbands in a small cohort of older ... Full text Link to item Cite

Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study.

Journal Article Neurobiol Aging · August 2019 Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease risk variants. We examined pleiotropic genetic effects on cognitive impairment conditioned on genetic va ... Full text Link to item Cite

A blood-based signature of cerebrospinal fluid Aβ1-42 status.

Journal Article Sci Rep · March 11, 2019 It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of ... Full text Link to item Cite

Reasons Pre-Existing Mild Cognitive Impairment May Influence Physician Recommendations for Stroke and Heart Attack Treatments

Conference STROKE · February 1, 2019 Link to item Cite

Working together to learn new oral hygiene techniques: Pilot of a carepartner-assisted intervention for persons with cognitive impairment.

Journal Article Geriatr Nurs · 2019 We pilot tested a carepartner-assisted intervention to improve oral hygiene in persons with cognitive impairment (participants) and help carepartners become leaders who can adapt approaches that foster participants' ability to develop new skills for oral h ... Full text Link to item Cite

Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults.

Journal Article Alzheimers Dement (N Y) · 2019 INTRODUCTION: Mitochondrial dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). Accordingly, drugs that positively influence mitochondrial function are being evaluated in delay-of-onset clinical trials with at-risk individuals. Su ... Full text Link to item Cite

The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.

Journal Article Alzheimers Dement (N Y) · 2019 INTRODUCTION: Alzheimer's disease (AD) is a continuum with neuropathologies manifesting years before clinical symptoms; thus, AD research is attempting to identify more disease-modifying approaches to test treatments administered before full disease expres ... Full text Link to item Cite

Short-Term Changes in the Prevalence of Probable Dementia: An Analysis of the 2011-2015 National Health and Aging Trends Study.

Journal Article J Gerontol B Psychol Sci Soc Sci · April 16, 2018 OBJECTIVES: Studies have reported decreasing dementia prevalence in recent decades in the United States. We explore with a new national data source whether declines have occurred since 2011, whether trends are attributable to shifts in dementia incidence o ... Full text Link to item Cite

Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?

Journal Article Alzheimers Dement · April 2018 INTRODUCTION: We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. METHODS: Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multi ... Full text Link to item Cite

Dual-Task Gait and Alzheimer's Disease Genetic Risk in Cognitively Normal Adults: A Pilot Study.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Dual-task paradigms, in which an individual performs tasks separately and then concurrently, often demonstrate that people with neurodegenerative disorders experience more dual-task interference, defined as worse performance in the dual-task co ... Full text Link to item Cite

TOMMORROW neuropsychological battery: German language validation and normative study.

Journal Article Alzheimers Dement (N Y) · 2018 INTRODUCTION: Assessment of preclinical Alzheimer's disease (AD) requires reliable and validated methods to detect subtle cognitive changes. The battery of standardized cognitive assessments that is used for diagnostic criteria for mild cognitive impairmen ... Full text Link to item Cite

Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).

Journal Article J Prev Alzheimers Dis · 2018 BACKGROUND: Continuing advances in the understanding of Alzheimer's disease progression have inspired development of disease-modifying therapeutics intended for use in preclinical populations. However, identification of clinically meaningful cognitive and ... Full text Link to item Cite

Trends in decayed teeth among middle-aged and older adults in the United States: socioeconomic disparities persist over time.

Journal Article J Public Health Dent · September 2016 OBJECTIVES: While trends in tooth loss among older adults have been well documented and show a decline over the last few decades, little is known about trends in tooth decay which may lead to tooth loss. The study aim was to examine trends in tooth decay a ... Full text Link to item Cite

Association Between Oral Health and Cognitive Status: A Systematic Review.

Journal Article J Am Geriatr Soc · August 2016 Full text Link to item Cite

Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline.

Journal Article Hypertension (Dallas, Tex. : 1979) · July 2016 The association between visit-to-visit variability of blood pressure (BP) and cognitive decline over time remains incompletely understood in a general population of older adults. We assessed the hypothesis that higher visit-to-visit variability in BP, but ... Full text Cite

Mediation Effect of Oral Hygiene on the Relationship Between Cognitive Function and Oral Health in Older Adults.

Journal Article J Gerontol Nurs · May 1, 2016 Poor oral health is a common problem among older adults in general and particularly among those with cognitive impairment. The current study was conducted to (a) explore direct and indirect relationships between cognitive function and oral health outcomes ... Full text Link to item Cite

Epigenetic assimilation in the aging human brain.

Journal Article Genome Biol · April 28, 2016 BACKGROUND: Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages ... Full text Link to item Cite

Association Between Oral Health and Cognitive Status: A Systematic Review.

Journal Article J Am Geriatr Soc · April 2016 OBJECTIVES: To systematically review longitudinal studies examining the association between oral health and cognitive decline. DESIGN: Studies published between January 1993 and March 2013 were identified by search of English language publications in PubMe ... Full text Link to item Cite

Authors' Response to Kaufman and Muntaner.

Journal Article Int J Epidemiol · April 2016 Full text Link to item Cite

The association between intelligence and lifespan is mostly genetic.

Journal Article Int J Epidemiol · February 2016 BACKGROUND: Several studies in the new field of cognitive epidemiology have shown that higher intelligence predicts longer lifespan. This positive correlation might arise from socioeconomic status influencing both intelligence and health; intelligence lead ... Full text Link to item Cite

Trajectories of depressive symptoms and oral health outcomes in a community sample of older adults.

Journal Article Int J Geriatr Psychiatry · January 2016 OBJECTIVE: Adverse outcomes associated with chronic depressive symptoms are of clinical importance. The objective was to identify subgroups of older adults based on their trajectories of depressive symptoms over a 10-year period and determine if these subg ... Full text Link to item Cite

TRENDS IN NUMBER OF FILLED TEETH AMONG MIDDLE-AGED AND OLDER AMERICANS

Conference The Gerontologist · November 2015 Full text Cite

Heritability of Health and Aging Limitations on Personally Desired Activities.

Journal Article Health Psychol Res · September 30, 2015 The aim of this study is to estimate heritability of incident limitations on personally desired activities within the eighth decade of life. We measured self-rated ability to perform ten personally desired activities in 1606 male veteran twin pairs at base ... Full text Link to item Cite

Dietary Patterns and Cognitive Decline Among Chinese Older Adults.

Journal Article Epidemiology · September 2015 BACKGROUND: Prospective evidence of associations of dietary patterns with cognitive decline is limited and inconsistent. We examined how cognitive changes among Chinese older adults relate to either an adapted Mediterranean diet score or factor analysis-de ... Full text Link to item Cite

Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.

Journal Article J Am Geriatr Soc · June 2015 OBJECTIVES: To describe the stability of cognitive impairment, not dementia (CIND) in a longitudinal cohort of primary care veterans. To examine the association between baseline brief cognitive screening tests, demographic and clinical characteristics, and ... Full text Link to item Cite

Dental care utilization among older adults with cognitive impairment in the USA.

Journal Article Geriatr Gerontol Int · March 2015 AIM: We examined the relationship between cognitive impairment and dental care utilization among older adults in the USA. METHODS: A total of 329 older adults aged 70 years and older in West Virginia, USA, were included in the present analyses. We carried ... Full text Link to item Cite

Factors associated with cognitive evaluations in the United States.

Journal Article Neurology · January 6, 2015 OBJECTIVE: We aimed to explore factors associated with clinical evaluations for cognitive impairment among older residents of the United States. METHODS: Two hundred ninety-seven of 845 subjects in the Aging, Demographics, and Memory Study (ADAMS), a natio ... Full text Link to item Cite

Traumatic brain injury and late-life dementia.

Journal Article Handb Clin Neurol · 2015 Little is known of the impact of traumatic brain injury (TBI) on outcomes decades later when the effects of the injury interact with the aging brain. Some, but not all, epidemiologic studies have reported an association between TBI and increased risk of Al ... Full text Link to item Cite

Effect of APOE and CD33 on Cognitive Decline.

Journal Article PLoS One · 2015 OBJECTIVE: An Alzheimer's disease (AD) diagnosis is preceded by a long period of cognitive decline. We previously demonstrated increased risk of decline among individuals possessing one or more APOE ε4 alleles together with a family history of AD. The obje ... Full text Link to item Cite

Correction: Effect of APOE and CD33 on Cognitive Decline.

Journal Article PLoS One · 2015 Full text Link to item Cite

Social stratification and tooth loss among middle-aged and older Americans from 1988 to 2004.

Journal Article Community Dent Oral Epidemiol · December 2014 OBJECTIVES: Tooth retention has improved over the past few decades, but it is not known whether these trends have been observed across all demographic/socioeconomic subgroups. We examined number of missing teeth among dentate individuals (n = 9,113) as wel ... Full text Link to item Cite

A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.

Journal Article Alzheimers Dement · November 2014 BACKGROUND: Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials. METHODS: Data from Durham and Cabarrus Counties in North Carolina, USA and Tomsk, Russia (n = 2972) we ... Full text Link to item Cite

Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

Journal Article Neurobiol Aging · November 2014 Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal co ... Full text Link to item Cite

Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.

Journal Article Am J Geriatr Psychiatry · November 2014 BACKGROUND: Cognitive profiles for pre-clinical Alzheimer disease (AD) can be used to identify groups of individuals at risk for disease and better characterize pre-clinical disease. Profiles or patterns of performance as pre-clinical phenotypes may be mor ... Full text Link to item Cite

Fish intake is associated with slower cognitive decline in Chinese older adults.

Journal Article J Nutr · October 2014 Modifiable lifestyle changes, including dietary changes, could translate into a great reduction in the global burden of cognitive impairment and dementia. Few studies evaluated the benefits of fish intake for delaying cognitive decline, and no studies were ... Full text Link to item Cite

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

Journal Article Alzheimers Dement · October 2014 With increasing numbers of people with Alzheimer's and other dementias across the globe, many countries have developed national plans to deal with the resulting challenges. In the United States, the National Alzheimer's Project Act, signed into law in 2011 ... Full text Link to item Cite

Social stratification, oral hygiene, and trajectories of dental caries among old Americans.

Journal Article J Aging Health · September 2014 OBJECTIVE: This study analyzed how oral hygiene (i.e., brushing, rinsing, and flossing) influences the trajectories of dental caries (i.e., numbers of decayed, missing, and filled teeth) among older Americans within the context of social stratification. ME ... Full text Link to item Cite

Community engagement in diverse populations for Alzheimer disease prevention trials.

Journal Article Alzheimer Dis Assoc Disord · 2014 The recruitment of asymptomatic volunteers has been identified as a critical factor that is delaying the development and validation of preventive therapies for Alzheimer disease (AD). Typical recruitment strategies involve the use of convenience samples or ... Full text Link to item Cite

Racial disparities in trajectories of dental caries experience.

Journal Article Community Dent Oral Epidemiol · December 2013 OBJECTIVES: This study charted the trajectories of dental caries, including decayed teeth, missing teeth and filled teeth among older Americans over a 5-year period. In particular, it focused on racial differences in the levels of and rates of change in de ... Full text Link to item Cite