Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

Publication ,  Journal Article
Breitner, JC; Gau, BA; Welsh, KA; Plassman, BL; McDonald, WM; Helms, MJ; Anthony, JC
Published in: Neurology
February 1994

We conducted a co-twin control study among 50 elderly twin pairs with onsets of Alzheimer's disease (AD) separated by 3 or more years. Twenty-three male pairs (46%) were screened from the (U.S.) National Academy of Sciences-National Research Council Registry (NAS-NRC Registry) of World War II veteran twins; others (mostly women) had responded to advertisements or were referred from AD clinics. Twenty-six pairs (52%) were monozygous. The onset of AD was inversely associated with prior use of corticosteroids or ACTH (odds ratio [OR], 0.25; 95% confidence interval [CI], 0.06 to 0.95; p = 0.04). Similar but weaker trends were present among pairs discordant for history of arthritis or for prior daily use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin. The association was strongest when we combined use of steroids/ACTH or NSAIDs post hoc into a single variable of anti-inflammatory drugs (AIs) (OR, 0.24; CI, 0.07 to 0.74; p = 0.01). The inverse relation was strong in female (volunteer) twin pairs but was not present in the younger men from the NAS-NRC Registry. AIs had typically been taken for arthritis or related conditions, but a similar result was apparent after controlling statistically for the arthritis variable (OR, 0.08; CI, 0.01 to 0.69; p = 0.02). AIs have been proposed as a means of retarding the progression of AD symptoms, and these data suggest that AIs may also prevent or delay the initial onset of AD symptoms. Because of limitations in the case-control method, our results require corroboration with hypothesis-driven research designed to control bias and confounding.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

February 1994

Volume

44

Issue

2

Start / End Page

227 / 232

Location

United States

Related Subject Headings

  • United States
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Sex Factors
  • Risk Factors
  • Registries
  • Odds Ratio
  • Neurology & Neurosurgery
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Breitner, J. C., Gau, B. A., Welsh, K. A., Plassman, B. L., McDonald, W. M., Helms, M. J., & Anthony, J. C. (1994). Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology, 44(2), 227–232. https://doi.org/10.1212/wnl.44.2.227
Breitner, J. C., B. A. Gau, K. A. Welsh, B. L. Plassman, W. M. McDonald, M. J. Helms, and J. C. Anthony. “Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.Neurology 44, no. 2 (February 1994): 227–32. https://doi.org/10.1212/wnl.44.2.227.
Breitner JC, Gau BA, Welsh KA, Plassman BL, McDonald WM, Helms MJ, et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology. 1994 Feb;44(2):227–32.
Breitner, J. C., et al. “Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.Neurology, vol. 44, no. 2, Feb. 1994, pp. 227–32. Pubmed, doi:10.1212/wnl.44.2.227.
Breitner JC, Gau BA, Welsh KA, Plassman BL, McDonald WM, Helms MJ, Anthony JC. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology. 1994 Feb;44(2):227–232.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

February 1994

Volume

44

Issue

2

Start / End Page

227 / 232

Location

United States

Related Subject Headings

  • United States
  • Twins, Monozygotic
  • Twins, Dizygotic
  • Sex Factors
  • Risk Factors
  • Registries
  • Odds Ratio
  • Neurology & Neurosurgery
  • Male
  • Humans