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High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.

Publication ,  Journal Article
Yuan, Y; Shrestha, S; Luo, Z; Li, C; Plassman, BL; Parks, CG; Hofmann, JN; Beane Freeman, LE; Sandler, DP; Chen, H
Published in: Mov Disord
May 2022

BACKGROUND: Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological evidence is limited. OBJECTIVES: To examine high pesticide exposure events in relation to dream-enacting behaviors among farmers in the Agricultural Health Study. METHODS: We conducted multivariable logistic regression analyses to examine high pesticide exposure events reported from 1993 to 1997 in relation to dream-enacting behaviors assessed from 2013 to 2015 among 11,248 farmers (age 47 ± 11 years). RESULTS: A history of dream-enacting behaviors was reported by 939 (8.3%) farmers. Compared with farmers who did not report any high pesticide exposure event, those who reported were more likely to endorse dream-enacting behaviors 2 decades later (odds ratio = 1.75; 95% confidence interval [CI], 1.49-2.05). The association appeared stronger when there was a long delay in washing with soap and water after the event (2.63 [95% CI, 1.62-4.27] for waiting >6 hours vs. 1.71 [95% CI, 1.36-2.15] for washing within 30 minutes) and when the exposure involved the respiratory or digestive tract (2.04 [95% CI, 1.62-2.57] vs. 1.58 [95% CI, 1.29-1.93] for dermal contact only). In the analyses of specific pesticides involved, we found positive associations with two organochlorine insecticides (dichlorodiphenyltrichloroethane and lindane), four organophosphate insecticides (phorate, ethoprop, terbufos, and parathion), two herbicides (alachlor and paraquat), and fungicides as a group. CONCLUSIONS: This study provides the first epidemiological evidence that high pesticide exposures may be associated with a higher risk of dream-enacting behaviors. © 2022 International Parkinson and Movement Disorder Society.

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Published In

Mov Disord

DOI

EISSN

1531-8257

Publication Date

May 2022

Volume

37

Issue

5

Start / End Page

962 / 971

Location

United States

Related Subject Headings

  • Pesticides
  • Occupational Exposure
  • Neurology & Neurosurgery
  • Middle Aged
  • Insecticides
  • Humans
  • Farmers
  • Agriculture
  • Adult
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
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Yuan, Y., Shrestha, S., Luo, Z., Li, C., Plassman, B. L., Parks, C. G., … Chen, H. (2022). High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers. Mov Disord, 37(5), 962–971. https://doi.org/10.1002/mds.28960
Yuan, Yaqun, Srishti Shrestha, Zhehui Luo, Chenxi Li, Brenda L. Plassman, Christine G. Parks, Jonathan N. Hofmann, Laura E. Beane Freeman, Dale P. Sandler, and Honglei Chen. “High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.Mov Disord 37, no. 5 (May 2022): 962–71. https://doi.org/10.1002/mds.28960.
Yuan Y, Shrestha S, Luo Z, Li C, Plassman BL, Parks CG, et al. High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers. Mov Disord. 2022 May;37(5):962–71.
Yuan, Yaqun, et al. “High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers.Mov Disord, vol. 37, no. 5, May 2022, pp. 962–71. Pubmed, doi:10.1002/mds.28960.
Yuan Y, Shrestha S, Luo Z, Li C, Plassman BL, Parks CG, Hofmann JN, Beane Freeman LE, Sandler DP, Chen H. High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers. Mov Disord. 2022 May;37(5):962–971.
Journal cover image

Published In

Mov Disord

DOI

EISSN

1531-8257

Publication Date

May 2022

Volume

37

Issue

5

Start / End Page

962 / 971

Location

United States

Related Subject Headings

  • Pesticides
  • Occupational Exposure
  • Neurology & Neurosurgery
  • Middle Aged
  • Insecticides
  • Humans
  • Farmers
  • Agriculture
  • Adult
  • 3209 Neurosciences