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Job demands and dementia risk among male twin pairs.

Publication ,  Journal Article
Potter, GG; Helms, MJ; Burke, JR; Steffens, DC; Plassman, BL
Published in: Alzheimers Dement
July 2007

BACKGROUND: Job characteristics may influence dementia risk, but some types of job complexity remain to be examined. Twin studies provide a useful methodology to examine job differences between pairs who share many environmental and genetic influences. METHODS: Members of the NAS-NRC Twins Registry of World War II Veterans received a clinical evaluation for dementia and had job ratings from the Dictionary of Occupational Titles. RESULTS: Cotwin-control models (n = 220 pairs) indicated lower dementia risk with greater job demands of reasoning, mathematics, language, and vocational training, with comparable results in case-control models (n=425 cases). These effects were significant among twin pairs discordant for 6 or more years, but not among those discordant between 3-5 years. Results were similar for Alzheimer's disease, and main effects were not further explained by zygosity or apolipoprotein E genotype. CONCLUSIONS: Jobs that utilize data, academic skills, and extensive vocational training may protect against dementia; however, in twin pairs these effects only emerged among individuals who remained free of dementia several years after onset in their sibling.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

July 2007

Volume

3

Issue

3

Start / End Page

192 / 199

Location

United States

Related Subject Headings

  • Geriatrics
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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Chicago
ICMJE
MLA
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Potter, G. G., Helms, M. J., Burke, J. R., Steffens, D. C., & Plassman, B. L. (2007). Job demands and dementia risk among male twin pairs. Alzheimers Dement, 3(3), 192–199. https://doi.org/10.1016/j.jalz.2007.04.377
Potter, Guy G., Michael J. Helms, James R. Burke, David C. Steffens, and Brenda L. Plassman. “Job demands and dementia risk among male twin pairs.Alzheimers Dement 3, no. 3 (July 2007): 192–99. https://doi.org/10.1016/j.jalz.2007.04.377.
Potter GG, Helms MJ, Burke JR, Steffens DC, Plassman BL. Job demands and dementia risk among male twin pairs. Alzheimers Dement. 2007 Jul;3(3):192–9.
Potter, Guy G., et al. “Job demands and dementia risk among male twin pairs.Alzheimers Dement, vol. 3, no. 3, July 2007, pp. 192–99. Pubmed, doi:10.1016/j.jalz.2007.04.377.
Potter GG, Helms MJ, Burke JR, Steffens DC, Plassman BL. Job demands and dementia risk among male twin pairs. Alzheimers Dement. 2007 Jul;3(3):192–199.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

July 2007

Volume

3

Issue

3

Start / End Page

192 / 199

Location

United States

Related Subject Headings

  • Geriatrics
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences