Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.H.S., Duke University 2000
  • M.D., University of Texas at Dallas 1988
• 

  Previous Appointments & Affiliations

  • Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2012
  • Chief, Division of Geriatric Psychiatry, Psychiatry & Behavioral Sciences, Clinical Science Departments 2000 - 2012
  • Professor of Medicine, Medicine, General Internal Medicine, Medicine 2006 - 2012
  • Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2006 - 2012
  • Associate Professor of Medicine, Medicine, General Internal Medicine, Medicine 2002 - 2006
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2004 - 2006
  • Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2001 - 2003
  • Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 1997 - 2001
  • Clinical Associate in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 1994 - 1997
• Research
• 

  Selected Grants

  • Anhedonia, Aging, and the Neural Correlates of Attentional Control in Depression awarded by National Institutes of Health 2010 - 2015
  • Emotion Regulation in Late-Life Depression: Effectiveness and Neural Mechanisms awarded by National Institutes of Health 2009 - 2015
  • Cognitive Endophenotypes for Genetic Studies of Alzheimer's Disease awarded by National Institutes of Health 2007 - 2012
  • Geriatric Depression: Risk Factors for Adverse Outcomes awarded by National Institutes of Health 1995 - 2012
  • FMRI: Prediction of Mild Cognitive Impairment in Geriatric Depression awarded by National Institutes of Health 2008 - 2012
  • Midcareer Investigator Award in Geriatric Depression awarded by National Institutes of Health 2004 - 2012
  • Subtypes and Trajectories of Depression in Older Adults awarded by National Institutes of Health 2007 - 2012
  • Recovery Act Funds for Administrative Supplements for Conte Center grant programs awarded by National Institutes of Health 2010 - 2011
  • Training in Psychological Intervention Research awarded by National Institutes of Health 2006 - 2011
  • Epidemiology of Dementia in Cache County, Utah awarded by National Institutes of Health 1994 - 2011
  • Adapting Marital Therapy in Older Adults with Depression awarded by National Institutes of Health 2006 - 2010
  • PREMIER Mental Health Interventions Training Program awarded by National Institutes of Health 2002 - 2010
  • Tryptophan Metabolism, Genes, and Major Depression awarded by National Institutes of Health 2006 - 2008
  • Same awarded by National Institutes of Health 1989 - 2008
  • Geriatric Training Regarding Physicians and Dentists awarded by Department of Health and Human Services 1998 - 2007
  • Testing for Cytochrome P450 Polymorphisms in Adults with non-Psychotic Depression Prior to Treatment with SSRIs awarded by Agency for Healthcare Research and Quality 2005 - 2006
  • Conte Center for the Neuroscience of Depression awarded by National Institutes of Health 2001 - 2006
  • Geriatric Depression: Risk Factors For Adverse Outcomes awarded by National Institutes of Health 1995 - 2002
  • Geriatric Depression - Apolipoprotein E and Dementia Risk awarded by National Institutes of Health 1997 - 2002
  • Study Of Depression awarded by National Institutes of Health 1994 - 2000
  • Epidemiology Of Alzheimer'S Dementia In Cache County Utah awarded by National Institutes of Health 1994 - 1999
  • Geratric Depression: Risk Factors For Adverse Outcome awarded by National Institutes of Health 1995 - 1999
  • Geriatric Depression: Apolipoprotein E And Dementia Risk awarded by National Institutes of Health 1997 - 1999
  • Genetic Epidemiolgy Of Alzheimer Disease In Twins awarded by National Institutes of Health 1996 - 1998
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Adams, Kathryn Betts, Rupal Parekh, Rebecca L. Mauldin, Richard H. Fortinsky, and David C. Steffens. “The Risk for Loneliness and Major Depression among Solo Agers.” J Appl Gerontol 42, no. 5 (May 2023): 962–71. https://doi.org/10.1177/07334648221146770.
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    • Steffens, David C. “Applying the construct of social determinants of health to imaging-based brain changes.” Int Psychogeriatr, April 11, 2023, 1–9. https://doi.org/10.1017/S1041610223000339.
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    • Barry, Lisa C., David C. Steffens, Kenneth E. Covinsky, Yeates Conwell, John Boscardin, Yixia Li, and Amy L. Byers. “High Risk of Substance Use Disorder-Related Outcomes in Veterans Released from Correctional Facilities in Mid to Late Life.” J Gen Intern Med 38, no. 5 (April 2023): 1109–18. https://doi.org/10.1007/s11606-023-08057-y.
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    • Fortinsky, Richard H., Julie Robison, David C. Steffens, James Grady, Deborah Migneault, and Dorothy Wakefield. “Association of Race, Ethnicity, Education, and Neighborhood Context With Dementia Prevalence and Cognitive Impairment Severity Among Older Adults Receiving Medicaid-Funded Home and Community-Based Services.” Am J Geriatr Psychiatry 31, no. 4 (April 2023): 241–51. https://doi.org/10.1016/j.jagp.2022.12.001.
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    • Steffens, David C., Kevin J. Manning, Rong Wu, and James J. Grady. “Effects of Longitudinal Changes in Neuroticism and Stress on Cognitive Decline.” Am J Geriatr Psychiatry 31, no. 3 (March 2023): 171–79. https://doi.org/10.1016/j.jagp.2022.10.005.
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    • Manning, Kevin J., Rong Wu, Douglas R. McQuoid, David C. Steffens, and Guy G. Potter. “Reliable Cognitive Decline in Late-Life Major Depression.” Arch Clin Neuropsychol 38, no. 2 (February 18, 2023): 247–57. https://doi.org/10.1093/arclin/acac083.
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    • Steffens, David C., Mario Fahed, Kevin J. Manning, and Lihong Wang. “The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research.” Transl Psychiatry 12, no. 1 (December 26, 2022): 525. https://doi.org/10.1038/s41398-022-02292-3.
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    • Tao, Q., S. C. Akhter-Khan, T. F. A. Ang, C. DeCarli, M. L. Alosco, J. Mez, R. Killiany, et al. “Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study.” Eclinicalmedicine 53 (November 1, 2022). https://doi.org/10.1016/j.eclinm.2022.101643.
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    • Steffens, David C. “Risk Prediction in Late Life Depression: A Screening Tool, a Teaching Tool.” Am J Geriatr Psychiatry 30, no. 9 (September 2022): 961–63. https://doi.org/10.1016/j.jagp.2022.06.004.
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    • Steffens, David C., Kevin J. Manning, Rong Wu, and James J. Grady. “Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.” Int Psychogeriatr 34, no. 7 (July 2022): 645–50. https://doi.org/10.1017/S1041610222000084.
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    • Ochs-Ross, Rachel, Ewa Wajs, Ella J. Daly, Yun Zhang, Rosanne Lane, Pilar Lim, Wayne C. Drevets, et al. “Comparison of Long-Term Efficacy and Safety of Esketamine Nasal Spray Plus Oral Antidepressant in Younger Versus Older Patients With Treatment-Resistant Depression: Post-Hoc Analysis of SUSTAIN-2, a Long-Term Open-Label Phase 3 Safety and Efficacy Study.” Am J Geriatr Psychiatry 30, no. 5 (May 2022): 541–56. https://doi.org/10.1016/j.jagp.2021.09.014.
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    • Akhter-Khan, Samia C., Qiushan Tao, Ting Fang Alvin Ang, Indira Swetha Itchapurapu, Michael L. Alosco, Jesse Mez, Ryan J. Piers, David C. Steffens, Rhoda Au, and Wei Qiao Qiu. “Associations of loneliness with risk of Alzheimer's disease dementia in the Framingham Heart Study.” Alzheimers Dement 17, no. 10 (October 2021): 1619–27. https://doi.org/10.1002/alz.12327.
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    • Steffens, David C. “Depression and Dementia Risk: Research Findings That Are Shovel-Ready for Clinicians.” Am J Geriatr Psychiatry 29, no. 9 (September 2021): 927–29. https://doi.org/10.1016/j.jagp.2021.01.001.
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    • Ji, Lanxin, David C. Steffens, and Lihong Wang. “Effects of physical exercise on the aging brain across imaging modalities: A meta-analysis of neuroimaging studies in randomized controlled trials.” Int J Geriatr Psychiatry 36, no. 8 (August 2021): 1148–57. https://doi.org/10.1002/gps.5510.
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    • Fahed, M., and D. C. Steffens. “Apathy: Neurobiology, assessment and treatment.” Clinical Psychopharmacology and Neuroscience 19, no. 2 (May 1, 2021): 181–89. https://doi.org/10.9758/cpn.2021.19.2.181.
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    • Manning, Kevin J., Joshua Preciado-Pina, Lihong Wang, Kimberly Fitzgibbon, Grace Chan, and David C. Steffens. “Cognitive variability, brain aging, and cognitive decline in late-life major depression.” Int J Geriatr Psychiatry 36, no. 5 (May 2021): 665–76. https://doi.org/10.1002/gps.5465.
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    • Joseph, Chinaka, Lihong Wang, Rong Wu, Kevin J. Manning, and David C. Steffens. “Structural brain changes and neuroticism in late-life depression: a neural basis for depression subtypes.” Int Psychogeriatr 33, no. 5 (May 2021): 515–20. https://doi.org/10.1017/S1041610221000284.
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    • Levine, Allison M. P., Erin E. Emonds, Marie A. Smith, Nathaniel M. Rickles, George A. Kuchel, David C. Steffens, Alis Ohlheiser, and Richard H. Fortinsky. “Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team.” Drugs Aging 38, no. 2 (February 2021): 157–68. https://doi.org/10.1007/s40266-020-00821-7.
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    • Atkins, Janice L., Luke C. Pilling, Christine J. Heales, Sharon Savage, Chia-Ling Kuo, George A. Kuchel, David C. Steffens, and David Melzer. “Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.” J Alzheimers Dis 79, no. 3 (2021): 1203–11. https://doi.org/10.3233/JAD-201080.
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    • Manning, Kevin J., Grace Chan, David C. Steffens, Cortnee W. Pierce, and Guy G. Potter. “The Interaction of Personality and Social Support on Prospective Suicidal Ideation in Men and Women With Late-Life Depression.” Am J Geriatr Psychiatry 29, no. 1 (January 2021): 66–77. https://doi.org/10.1016/j.jagp.2020.03.018.
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    • Rhee, Taeho Greg, Samuel T. Wilkinson, David C. Steffens, Robert A. Rosenheck, and Mark Olfson. “Prevalence of Treatment for Depression Among US Adults Who Screen Positive for Depression, 2007-2016.” Jama Psychiatry 77, no. 11 (November 1, 2020): 1193–95. https://doi.org/10.1001/jamapsychiatry.2020.1818.
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    • Rhee, Taeho Greg, and David C. Steffens. “Major depressive disorder and impaired health-related quality of life among US older adults.” Int J Geriatr Psychiatry 35, no. 10 (October 2020): 1189–97. https://doi.org/10.1002/gps.5356.
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    • Manning, Kevin J., and David C. Steffens. “Blue Genes, Exercise, and Cognition in Late-Life Depression: A Lot of Moving Parts.” Am J Geriatr Psychiatry 28, no. 9 (September 2020): 968–70. https://doi.org/10.1016/j.jagp.2020.05.027.
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    • Fahed, Mario, Gregory C. Barron, and David C. Steffens. “Ethical and Logistical Considerations of Caring for Older Adults on Inpatient Psychiatry During the COVID-19 Pandemic.” Am J Geriatr Psychiatry 28, no. 8 (August 2020): 829–34. https://doi.org/10.1016/j.jagp.2020.04.027.
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    • Vahia, Ipsit V., Dan G. Blazer, Gwenn S. Smith, Jordan F. Karp, David C. Steffens, Brent P. Forester, Rajesh Tampi, Marc Agronin, Dilip V. Jeste, and Charles F. Reynolds. “COVID-19, Mental Health and Aging: A Need for New Knowledge to Bridge Science and Service.” Am J Geriatr Psychiatry 28, no. 7 (July 2020): 695–97. https://doi.org/10.1016/j.jagp.2020.03.007.
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    • Fortinsky, Richard H., George A. Kuchel, David C. Steffens, James Grady, Marie Smith, and Julie T. Robison. “Clinical trial testing in-home multidisciplinary care management for older adults with cognitive vulnerability: Rationale and study design.” Contemp Clin Trials 92 (May 2020): 105992. https://doi.org/10.1016/j.cct.2020.105992.
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    • Barry, Lisa C., Emil Coman, Dorothy Wakefield, Robert L. Trestman, Yeates Conwell, and David C. Steffens. “Functional disability, depression, and suicidal ideation in older prisoners.” J Affect Disord 266 (April 1, 2020): 366–73. https://doi.org/10.1016/j.jad.2020.01.156.
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    • Ochs-Ross, Rachel, Ella J. Daly, Yun Zhang, Rosanne Lane, Pilar Lim, Randall L. Morrison, David Hough, et al. “Efficacy and Safety of Esketamine Nasal Spray Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression-TRANSFORM-3.” Am J Geriatr Psychiatry 28, no. 2 (February 2020): 121–41. https://doi.org/10.1016/j.jagp.2019.10.008.
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    • Steffens, David C., Lihong Wang, and Godfrey D. Pearlson. “Functional connectivity predictors of acute depression treatment outcome.” Int Psychogeriatr 31, no. 12 (December 2019): 1831–35. https://doi.org/10.1017/S1041610218002260.
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    • Zhang, Xue, Xuesong Li, David C. Steffens, Hua Guo, and Lihong Wang. “Dynamic changes in thalamic connectivity following stress and its association with future depression severity.” Brain Behav 9, no. 12 (December 2019): e01445. https://doi.org/10.1002/brb3.1445.
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    • Fahed, Mario, and David C. Steffens. “Is it time to do away with disorders in the very old?” Int Psychogeriatr 31, no. 11 (November 2019): 1535–37. https://doi.org/10.1017/S1041610219001765.
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    • Rhee, Taeho Greg, Lisa C. Barry, George A. Kuchel, David C. Steffens, and Samuel T. Wilkinson. “Associations of Adverse Childhood Experiences with Past-Year DSM-5 Psychiatric and Substance Use Disorders in Older Adults.” J Am Geriatr Soc 67, no. 10 (October 2019): 2085–93. https://doi.org/10.1111/jgs.16032.
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    • Sobieraj, Diana M., Brandon K. Martinez, Adrian V. Hernandez, Craig I. Coleman, Joseph S. Ross, Karina M. Berg, David C. Steffens, and William L. Baker. “Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults.” J Am Geriatr Soc 67, no. 8 (August 2019): 1571–81. https://doi.org/10.1111/jgs.15966.
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    • Manning, Kevin J., Faith M. Gunning, Howard J. Aizenstein, and David C. Steffens. “Training the Next Generation of Geriatric-Focused Clinical Neuroscientists.” Am J Geriatr Psychiatry 27, no. 7 (July 2019): 720–27. https://doi.org/10.1016/j.jagp.2019.03.006.
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    • Emam, Hadeer, David C. Steffens, Godfrey D. Pearlson, and Lihong Wang. “Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late-life depression.” Int J Geriatr Psychiatry 34, no. 5 (May 2019): 730–37. https://doi.org/10.1002/gps.5079.
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    • Reynolds, Charles F., Stephan Arndt, Dan G. Blazer, Jordan Karp, Helen Lavretsky, Gwenn Smith, David Steffens, and Ipsit Vahia. “Perspectives: Measuring the Impact of Articles Published in The American Journal of Geriatric Psychiatry, July 1, 2017, to June 30, 2018.” Am J Geriatr Psychiatry 27, no. 4 (April 2019): 337–45. https://doi.org/10.1016/j.jagp.2019.01.014.
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    • Steffens, David C. “Vascular Depression: Is an Old Research Construct Finally Ready for Clinical Prime Time?” Biol Psychiatry 85, no. 6 (March 15, 2019): 441–42. https://doi.org/10.1016/j.biopsych.2019.01.007.
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    • Manning, Kevin, Lihong Wang, and David Steffens. “Recent advances in the use of imaging in psychiatry: functional magnetic resonance imaging of large-scale brain networks in late-life depression.” F1000res 8 (2019). https://doi.org/10.12688/f1000research.17399.1.
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    • Shin, Cheolmin, Byung-Joo Ham, Young-Hoon Ko, Chi-Un Pae, Moon Ho Park, David C. Steffens, Ashwin A. Patkar, and Changsu Han. “Increased plasma complement factor H is associated with geriatric depression.” Int Psychogeriatr 31, no. 1 (January 2019): 101–8. https://doi.org/10.1017/S1041610218000558.
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    • Taylor, Warren D., Susan K. Schultz, Vanessa Panaite, and David C. Steffens. “Perspectives on the Management of Vascular Depression.” Am J Psychiatry 175, no. 12 (December 1, 2018): 1169–75. https://doi.org/10.1176/appi.ajp.2018.18050568.
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    • Barry, Lisa C., David C. Steffens, Kenneth E. Covinsky, Yeates Conwell, Yixia Li, and Amy L. Byers. “Increased Risk of Suicide Attempts and Unintended Death Among Those Transitioning From Prison to Community in Later Life.” Am J Geriatr Psychiatry 26, no. 11 (November 2018): 1165–74. https://doi.org/10.1016/j.jagp.2018.07.004.
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    • Ji, Lanxin, Godfrey D. Pearlson, Xue Zhang, David C. Steffens, Xiaoqing Ji, Hua Guo, and Lihong Wang. “Physical exercise increases involvement of motor networks as a compensatory mechanism during a cognitively challenging task.” Int J Geriatr Psychiatry 33, no. 8 (August 2018): 1153–59. https://doi.org/10.1002/gps.4909.
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    • Steffens, David C., Rong Wu, James J. Grady, and Kevin J. Manning. “Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study.” Int Psychogeriatr 30, no. 7 (July 2018): 1069–74. https://doi.org/10.1017/S1041610217002551.
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    • Deng, Yi, Douglas R. McQuoid, Guy G. Potter, David C. Steffens, Kimberly Albert, Meghan Riddle, John L. Beyer, and Warren D. Taylor. “Predictors of recurrence in remitted late-life depression.” Depress Anxiety 35, no. 7 (July 2018): 658–67. https://doi.org/10.1002/da.22772.
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    • Manning, Kevin J., and David C. Steffens. “Can Addressing Personality Change Enhance Cognitive Functioning and Delay Development of Mild Cognitive Impairment?” J Am Geriatr Soc 66, no. 4 (April 2018): 650–51. https://doi.org/10.1111/jgs.15252.
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    • Manning, Kevin J., and David C. Steffens. “State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.” J Am Geriatr Soc 66 Suppl 1, no. Suppl 1 (April 2018): S17–23. https://doi.org/10.1111/jgs.15353.
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    • Ji, L., G. D. Pearlson, K. A. Hawkins, D. C. Steffens, H. Guo, and L. Wang. “A new measure for neural compensation is positively correlated with working memory and gait speed.” Frontiers in Aging Neuroscience 10, no. MAR (March 19, 2018). https://doi.org/10.3389/fnagi.2018.00071.
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    • Steffens, David C. “A Geriatrics Perspective on Dementia Prevention and Treatment.” Am J Psychiatry 175, no. 3 (March 1, 2018): 199–201. https://doi.org/10.1176/appi.ajp.2017.17101155.
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    • Sachs-Ericsson, Natalie J., Greg Hajcak, Julia L. Sheffler, Ian H. Stanley, Edward A. Selby, Guy G. Potter, and David C. Steffens. “Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age.” J Geriatr Psychiatry Neurol 31, no. 1 (January 2018): 39–49. https://doi.org/10.1177/0891988717747049.
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    • Johnson, Anne D., Douglas R. McQuoid, David C. Steffens, Martha E. Payne, John L. Beyer, and Warren D. Taylor. “Effects of stressful life events on cerebral white matter hyperintensity progression.” Int J Geriatr Psychiatry 32, no. 12 (December 2017): e10–17. https://doi.org/10.1002/gps.4644.
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    • Riddle, Meghan, Guy G. Potter, Douglas R. McQuoid, David C. Steffens, John L. Beyer, and Warren D. Taylor. “Longitudinal Cognitive Outcomes of Clinical Phenotypes of Late-Life Depression.” Am J Geriatr Psychiatry 25, no. 10 (October 2017): 1123–34. https://doi.org/10.1016/j.jagp.2017.03.016.
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    • Steffens, David C., Lihong Wang, Kevin J. Manning, and Godfrey D. Pearlson. “Negative Affectivity, Aging, and Depression: Results From the Neurobiology of Late-Life Depression (NBOLD) Study.” Am J Geriatr Psychiatry 25, no. 10 (October 2017): 1135–49. https://doi.org/10.1016/j.jagp.2017.03.017.
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    • Rajkowska, Grazyna, Gouri Mahajan, Beata Legutko, Lavanya Challagundla, Michael Griswold, Paul R. Albert, Mireille Daigle, et al. “Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression.” Neuroscience 359 (September 17, 2017): 30–39. https://doi.org/10.1016/j.neuroscience.2017.07.006.
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    • Lanctôt, K. L., J. Amatniek, S. Ancoli-Israel, S. E. Arnold, C. Ballard, J. Cohen-Mansfield, Z. Ismail, et al. “Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms.” Alzheimer’S and Dementia: Translational Research and Clinical Interventions 3, no. 3 (September 1, 2017): 440–49. https://doi.org/10.1016/j.trci.2017.07.001.
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    • Springate, Beth A., and David C. Steffens. “Editorial Comment: Is It Time to Take the "Sub" Out of Subsyndromal Depression?” Am J Geriatr Psychiatry 25, no. 9 (September 2017): 992–93. https://doi.org/10.1016/j.jagp.2017.05.010.
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    • Steffens, David Carl. “Late-Life Depression and the Prodromes of Dementia.” Jama Psychiatry 74, no. 7 (July 1, 2017): 673–74. https://doi.org/10.1001/jamapsychiatry.2017.0658.
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    • Manning, Kevin J., Grace Chan, and David C. Steffens. “Neuroticism Traits Selectively Impact Long Term Illness Course and Cognitive Decline in Late-Life Depression.” Am J Geriatr Psychiatry 25, no. 3 (March 2017): 220–29. https://doi.org/10.1016/j.jagp.2016.10.006.
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    • Li, Xuesong, David C. Steffens, Guy G. Potter, Hua Guo, Sen Song, and Lihong Wang. “Decreased between-hemisphere connectivity strength and network efficiency in geriatric depression.” Hum Brain Mapp 38, no. 1 (January 2017): 53–67. https://doi.org/10.1002/hbm.23343.
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    • Ji, Lanxin, Han Zhang, Guy G. Potter, Yu-Feng Zang, David C. Steffens, Hua Guo, and Lihong Wang. “Multiple Neuroimaging Measures for Examining Exercise-induced Neuroplasticity in Older Adults: A Quasi-experimental Study.” Front Aging Neurosci 9 (2017): 102. https://doi.org/10.3389/fnagi.2017.00102.
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    • Tascone, Lyssandra Dos Santos, Martha E. Payne, James MacFall, Dionísio Azevedo, Claudio Campi de Castro, David C. Steffens, Geraldo F. Busatto, and Cássio M. C. Bottino. “Cortical brain volume abnormalities associated with few or multiple neuropsychiatric symptoms in Alzheimer's disease.” Plos One 12, no. 5 (2017): e0177169. https://doi.org/10.1371/journal.pone.0177169.
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    • Aizenstein, Howard J., Andrius Baskys, Maura Boldrini, Meryl A. Butters, Breno S. Diniz, Manoj Kumar Jaiswal, Kurt A. Jellinger, et al. “Vascular depression consensus report - a critical update.” Bmc Med 14, no. 1 (November 3, 2016): 161. https://doi.org/10.1186/s12916-016-0720-5.
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    • Kellner, Charles H., Mustafa M. Husain, Rebecca G. Knapp, W Vaughn McCall, Georgios Petrides, Matthew V. Rudorfer, Robert C. Young, et al. “A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study.” Am J Psychiatry 173, no. 11 (November 1, 2016): 1110–18. https://doi.org/10.1176/appi.ajp.2016.16010118.
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    • Kellner, Charles H., Mustafa M. Husain, Rebecca G. Knapp, W Vaughn McCall, Georgios Petrides, Matthew V. Rudorfer, Robert C. Young, et al. “Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.” Am J Psychiatry 173, no. 11 (November 1, 2016): 1101–9. https://doi.org/10.1176/appi.ajp.2016.15081101.
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    • Saha, Sayoni, Daniel J. Hatch, Kathleen M. Hayden, David C. Steffens, and Guy G. Potter. “Appetite and Weight Loss Symptoms in Late-Life Depression Predict Dementia Outcomes.” Am J Geriatr Psychiatry 24, no. 10 (October 2016): 870–78. https://doi.org/10.1016/j.jagp.2016.05.004.
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    • Steffens, Eleanor Bastian, and David C. Steffens. “Getting on Message: Preventing Alzheimer Disease Through Diet and Exercise.” Am J Geriatr Psychiatry 24, no. 9 (September 2016): 738–39. https://doi.org/10.1016/j.jagp.2016.06.002.
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    • Steffens, David C. “J'accuse! depression as a likely culprit in cases of AD.” Int Psychogeriatr 28, no. 9 (September 2016): 1407–8. https://doi.org/10.1017/S1041610216000855.
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    • Dong, Hyun-Seok, Changsu Han, Sang Won Jeon, Seoyoung Yoon, Hyun-Ghang Jeong, Yu Jeong Huh, Chi-Un Pae, Ashwin A. Patkar, and David C. Steffens. “Characteristics of neurocognitive functions in mild cognitive impairment with depression.” Int Psychogeriatr 28, no. 7 (July 2016): 1181–90. https://doi.org/10.1017/S1041610216000314.
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    • Hybels, Celia F., Carl F. Pieper, Dan G. Blazer, and David C. Steffens. “Heterogeneity in the three-year course of major depression among older adults.” Int J Geriatr Psychiatry 31, no. 7 (July 2016): 775–82. https://doi.org/10.1002/gps.4391.
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    • Potter, Guy G., Douglas R. McQuoid, Heather E. Whitson, and David C. Steffens. “Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.” Int J Geriatr Psychiatry 31, no. 5 (May 2016): 466–74. https://doi.org/10.1002/gps.4351.
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    • Qiu, Wei Qiao, Haihao Zhu, Michael Dean, Zhiheng Liu, Linh Vu, Guanguang Fan, Huajie Li, Mkaya Mwamburi, David C. Steffens, and Rhoda Au. “Amyloid-associated depression and ApoE4 allele: longitudinal follow-up for the development of Alzheimer's disease.” Int J Geriatr Psychiatry 31, no. 3 (March 2016): 316–22. https://doi.org/10.1002/gps.4339.
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    • Kirwin, Paul, Michelle Conroy, Constantine Lyketsos, Blaine Greenwald, Brent Forester, Christine deVries, Iqbal Ike Ahmed, et al. “A Call to Restructure Psychiatry General and Subspecialty Training.” Acad Psychiatry 40, no. 1 (February 2016): 145–48. https://doi.org/10.1007/s40596-014-0144-5.
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    • Rubinow, Marisa J., Gouri Mahajan, Warren May, James C. Overholser, George J. Jurjus, Lesa Dieter, Nicole Herbst, et al. “Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study.” Brain Struct Funct 221, no. 1 (January 2016): 171–84. https://doi.org/10.1007/s00429-014-0900-z.
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    • Zdanys, Kristina F., André F. Carvalho, Rajesh R. Tampi, and David C. Steffens. “The Treatment of Behavioral and Psychological Symptoms of Dementia: Weighing Benefits and Risks.” Curr Alzheimer Res 13, no. 10 (2016): 1124–33. https://doi.org/10.2174/1567205013666160510121633.
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    • Hybels, Celia F., Carl F. Pieper, Martha E. Payne, and David C. Steffens. “Late-life Depression Modifies the Association Between Cerebral White Matter Hyperintensities and Functional Decline Among Older Adults.” Am J Geriatr Psychiatry 24, no. 1 (January 2016): 42–49. https://doi.org/10.1016/j.jagp.2015.03.001.
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    • Jeon, Sang Won, Changsu Han, Jongha Lee, JaeHyoung Lim, Hyun-Ghang Jeong, Moon Ho Park, Young-Hoon Ko, et al. “Perspectives on the Happiness of Community-Dwelling Elderly in Korea.” Psychiatry Investig 13, no. 1 (January 2016): 50–57. https://doi.org/10.4306/pi.2016.13.1.50.
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    • Zdanys, Kristina F., and David C. Steffens. “Sleep Disturbances in the Elderly.” Psychiatr Clin North Am 38, no. 4 (December 2015): 723–41. https://doi.org/10.1016/j.psc.2015.07.010.
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    • Steffens, David C., Kevin J. Manning, Rong Wu, James J. Grady, Richard H. Fortinsky, and Howard A. Tennen. “Methodology and preliminary results from the neurobiology of late-life depression study.” Int Psychogeriatr 27, no. 12 (December 2015): 1987–97. https://doi.org/10.1017/S1041610215001386.
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    • Dzierzewski, Joseph M., Guy G. Potter, Richard N. Jones, Ola S. Rostant, Brian Ayotte, Frances M. Yang, Bonnie C. Sachs, Betsy J. Feldman, and David C. Steffens. “Cognitive functioning throughout the treatment history of clinical late-life depression.” Int J Geriatr Psychiatry 30, no. 10 (October 2015): 1076–84. https://doi.org/10.1002/gps.4264.
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    • Xiong, Glen L., Kevin Prybol, Stephen H. Boyle, Russell Hall, Robert D. Streilein, David C. Steffens, Ranga Krishnan, et al. “Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure: Results From the Sertraline Against Depression and Heart Disease in Chronic Heart Failure Study.” Psychosom Med 77, no. 7 (September 2015): 808–15. https://doi.org/10.1097/PSY.0000000000000216.
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    • Potter, Guy G., Douglas R. McQuoid, and David C. Steffens. “Appetite loss and neurocognitive deficits in late-life depression.” Int J Geriatr Psychiatry 30, no. 6 (June 2015): 647–54. https://doi.org/10.1002/gps.4196.
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    • Mah, Linda, Malcolm A. Binns, David C. Steffens, and David C. Alzheimer’s Disease Neuroimaging Initiative. “Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease.” Am J Geriatr Psychiatry 23, no. 5 (May 2015): 466–76. https://doi.org/10.1016/j.jagp.2014.10.005.
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    • Riddle, Meghan, Douglas R. McQuoid, Guy G. Potter, David C. Steffens, and Warren D. Taylor. “Disability but not social support predicts cognitive deterioration in late-life depression.” Int Psychogeriatr 27, no. 5 (May 2015): 707–14. https://doi.org/10.1017/S1041610214002543.
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    • Reuben, David B., Anika A. H. Alvanzo, Takamaru Ashikaga, G Anne Bogat, Christopher M. Callahan, Victoria Ruffing, and David C. Steffens. “National Institutes of Health Pathways to Prevention Workshop: the role of opioids in the treatment of chronic pain.” Ann Intern Med 162, no. 4 (February 17, 2015): 295–300. https://doi.org/10.7326/M14-2775.
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    • Kotagal, Vikas, Kenneth M. Langa, Brenda L. Plassman, Gwenith G. Fisher, Bruno J. Giordani, Robert B. Wallace, James R. Burke, et al. “Factors associated with cognitive evaluations in the United States.” Neurology 84, no. 1 (January 6, 2015): 64–71. https://doi.org/10.1212/WNL.0000000000001096.
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    • Cummings, Jeffrey, Jacobo Mintzer, Henry Brodaty, Mary Sano, Sube Banerjee, D. P. Devanand, Serge Gauthier, et al. “Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition.” Int Psychogeriatr 27, no. 1 (January 2015): 7–17. https://doi.org/10.1017/S1041610214001963.
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    • Wang, Lihong, Ying-Hui Chou, Guy G. Potter, and David C. Steffens. “Altered Synchronizations among Neural Networks in Geriatric Depression.” Biomed Res Int 2015 (2015): 343720. https://doi.org/10.1155/2015/343720.
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    • Taylor, Warren D., Douglas R. McQuoid, Martha E. Payne, Anthony S. Zannas, James R. MacFall, and David C. Steffens. “Hippocampus atrophy and the longitudinal course of late-life depression.” Am J Geriatr Psychiatry 22, no. 12 (December 2014): 1504–12. https://doi.org/10.1016/j.jagp.2013.11.004.
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    • Wen, Ming-Ching, David C. Steffens, Mei-Kuang Chen, and Nur Hani Zainal. “Diffusion tensor imaging studies in late-life depression: systematic review and meta-analysis.” Int J Geriatr Psychiatry 29, no. 12 (December 2014): 1173–84. https://doi.org/10.1002/gps.4129.
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    • Yoon, Seoyoung, Yunhwan Lee, Changsu Han, Chi-Un Pae, Ho-Kyoung Yoon, Ashwin A. Patkar, David C. Steffens, and Yong-Ku Kim. “Usefulness of the Patient Health Questionnaire-9 for Korean medical students.” Acad Psychiatry 38, no. 6 (December 2014): 661–67. https://doi.org/10.1007/s40596-014-0140-9.
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    • Steffens, David C., Douglas R. McQuoid, and Guy G. Potter. “Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression.” Int Psychogeriatr 26, no. 12 (December 2014): 2029–36. https://doi.org/10.1017/S1041610214001446.
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    • Zannas, Anthony S., Douglas R. McQuoid, Martha E. Payne, James R. MacFall, Allison Ashley-Koch, David C. Steffens, Guy G. Potter, and Warren D. Taylor. “Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age.” Am J Psychiatry 171, no. 11 (November 1, 2014): 1214–21. https://doi.org/10.1176/appi.ajp.2014.13111543.
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    • Chuang, Yi-Fang, John C. S. Breitner, Yen-Ling Chiu, Ara Khachaturian, Kathleen Hayden, Chris Corcoran, JoAnn Tschanz, et al. “Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.” Neurobiol Aging 35, no. 11 (November 2014): 2429–35. https://doi.org/10.1016/j.neurobiolaging.2014.05.002.
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    • Jeong, Hyun-Ghang, Changsu Han, Moon Ho Park, Seung-Ho Ryu, Chi-Un Pae, Jun Young Lee, Seung Hyun Kim, and David C. Steffens. “Influence of the number and severity of somatic symptoms on the severity of depression and suicidality in community-dwelling elders.” Asia Pac Psychiatry 6, no. 3 (September 2014): 274–83. https://doi.org/10.1111/appy.12138.
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    • Sachs-Ericsson, Natalie, Jerad H. Moxley, Elizabeth Corsentino, Nicole Collins Rushing, Julia Sheffler, Edward A. Selby, Ian Gotlib, and David C. Steffens. “Melancholia in later life: late and early onset differences in presentation, course, and dementia risk.” Int J Geriatr Psychiatry 29, no. 9 (September 2014): 943–51. https://doi.org/10.1002/gps.4083.
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    • Smoski, Moria J., Kevin S. LaBar, and David C. Steffens. “Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression.” Am J Geriatr Psychiatry 22, no. 9 (September 2014): 898–907. https://doi.org/10.1016/j.jagp.2013.01.070.
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    • Payne, Martha E., Douglas R. McQuoid, David C. Steffens, and John J. B. Anderson. “Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study.” Br J Nutr 112, no. 2 (July 28, 2014): 220–27. https://doi.org/10.1017/S0007114514000828.
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    • Taylor, Warren D., Kamil Kudra, Zheen Zhao, David C. Steffens, and James R. MacFall. “Cingulum bundle white matter lesions influence antidepressant response in late-life depression: a pilot study.” J Affect Disord 162 (June 2014): 8–11. https://doi.org/10.1016/j.jad.2014.03.031.
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    • Hybels, Celia F., Carl F. Pieper, Lawrence R. Landerman, Martha E. Payne, and David C. Steffens. “Vascular lesions and functional limitations among older adults: does depression make a difference?” Int Psychogeriatr, May 9, 2014, 1–9. https://doi.org/10.1017/S1041610214000829.
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    • Qiu, Wendy Wei Qiao, Angela Lai, Timothy Mon, Mkaya Mwamburi, Warren Taylor, James Rosenzweig, Neil Kowall, Robert Stern, Haihao Zhu, and David C. Steffens. “Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele.” Am J Geriatr Psychiatry 22, no. 2 (February 2014): 177–85. https://doi.org/10.1016/j.jagp.2012.08.017.
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    • Rushing, Nicole C., Natalie Sachs-Ericsson, and David C. Steffens. “Neuropsychological indicators of preclinical Alzheimer's disease among depressed older adults.” Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 21, no. 1 (2014): 99–128. https://doi.org/10.1080/13825585.2013.795514.
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    • Sachs-Ericsson, Natalie, Jennifer L. Hames, Thomas E. Joiner, Elizabeth Corsentino, Nicole C. Rushing, Emily Palmer, Ian H. Gotlib, Edward A. Selby, Steven Zarit, and David C. Steffens. “Differences between suicide attempters and nonattempters in depressed older patients: depression severity, white-matter lesions, and cognitive functioning.” Am J Geriatr Psychiatry 22, no. 1 (January 2014): 75–85. https://doi.org/10.1016/j.jagp.2013.01.063.
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    • Aziz, Rehan, and David C. Steffens. “What are the causes of late-life depression?” Psychiatr Clin North Am 36, no. 4 (December 2013): 497–516. https://doi.org/10.1016/j.psc.2013.08.001.
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    • Fortinsky, R. H., H. Tennen, and D. C. Steffens. “Resilience in the face of chronic illness and family caregiving in middle and later life.” Psychiatric Annals 43, no. 12 (December 1, 2013): 549–54. https://doi.org/10.3928/00485713-20131206-07.
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    • Steffens, David C., Douglas R. McQuoid, Moria J. Smoski, and Guy G. Potter. “Clinical outcomes of older depressed patients with and without comorbid neuroticism.” Int Psychogeriatr 25, no. 12 (December 2013): 1985–90. https://doi.org/10.1017/S1041610213001324.
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    • Barcelos-Ferreira, Ricardo, Eduardo Yoshio Nakano, David C. Steffens, and Cassio M. C. Bottino. “Quality of life and physical activity associated to lower prevalence of depression in community-dwelling elderly subjects from Sao Paulo.” J Affect Disord 150, no. 2 (September 5, 2013): 616–22. https://doi.org/10.1016/j.jad.2013.02.024.
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    • Jamerson, Brenda D., Martha E. Payne, Melanie E. Garrett, Allison E. Ashley-Koch, Marcy C. Speer, and David C. Steffens. “Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression.” Int J Geriatr Psychiatry 28, no. 9 (September 2013): 925–32. https://doi.org/10.1002/gps.3899.
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    • Lim, JaeHyoung, In Kyung Oh, Changsu Han, Yu Jeong Huh, In-Kwa Jung, Ashwin A. Patkar, David C. Steffens, and Bo-Hyoung Jang. “Sensitivity of cognitive tests in four cognitive domains in discriminating MDD patients from healthy controls: a meta-analysis.” Int Psychogeriatr 25, no. 9 (September 2013): 1543–57. https://doi.org/10.1017/S1041610213000689.
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    • Miguel-Hidalgo, Jose Javier, Wei Jiang, Lisa Konick, James C. Overholser, George J. Jurjus, Craig A. Stockmeier, David C. Steffens, K Ranga R. Krishnan, and Grazyna Rajkowska. “Morphometric analysis of vascular pathology in the orbitofrontal cortex of older subjects with major depression.” Int J Geriatr Psychiatry 28, no. 9 (September 2013): 959–70. https://doi.org/10.1002/gps.3911.
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    • Tschanz, Joann T., Roxane Pfister, Joseph Wanzek, Chris Corcoran, Ken Smith, Brian T. Tschanz, David C. Steffens, Truls Østbye, Kathleen A. Welsh-Bohmer, and Maria C. Norton. “Stressful life events and cognitive decline in late life: moderation by education and age. The Cache County Study.” Int J Geriatr Psychiatry 28, no. 8 (August 2013): 821–30. https://doi.org/10.1002/gps.3888.
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    • Steffens, David C. “Exercise for late-life depression? It depends.” Lancet 382, no. 9886 (July 6, 2013): 4–5. https://doi.org/10.1016/S0140-6736(13)60860-0.
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    • Steffens, David C. “In our hands: responding to the IOM report on workforce needs for older adults with mental health and substance use disorders.” Int Psychogeriatr 25, no. 7 (July 2013): 1039–40. https://doi.org/10.1017/S1041610213000641.
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    • Payne, Martha E., Cortnee W. Pierce, Douglas R. McQuoid, David C. Steffens, and John J. B. Anderson. “Serum ionized calcium may be related to white matter lesion volumes in older adults: a pilot study.” Nutrients 5, no. 6 (June 18, 2013): 2192–2205. https://doi.org/10.3390/nu5062192.
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    • Banga, Alok, Tsewang Gyurmey, David Matuskey, Daniel F. Connor, Richard F. Kaplan, and David C. Steffens. “Late-life onset bipolar disorder presenting as a case of pseudo-dementia: a case discussion and review of literature.” Yale J Biol Med 86, no. 2 (June 2013): 235–44.
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    • Zannas, Anthony S., Douglas R. McQuoid, Martha E. Payne, David C. Steffens, James R. MacFall, Allison Ashley-Koch, and Warren D. Taylor. “Negative life stress and longitudinal hippocampal volume changes in older adults with and without depression.” J Psychiatr Res 47, no. 6 (June 2013): 829–34. https://doi.org/10.1016/j.jpsychires.2013.02.008.
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    • Ribeiz, Salma R. I., Renata Ávila, Camila B. Martins, Marco A. A. Moscoso, David C. Steffens, and Cássio M. C. Bottino. “Validation of a treatment algorithm for major depression in an older Brazilian sample.” Int J Geriatr Psychiatry 28, no. 6 (June 2013): 647–53. https://doi.org/10.1002/gps.3876.
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    • Potter, Guy G., H Ryan Wagner, James R. Burke, Brenda L. Plassman, Kathleen A. Welsh-Bohmer, and David C. Steffens. “Neuropsychological predictors of dementia in late-life major depressive disorder.” Am J Geriatr Psychiatry 21, no. 3 (March 2013): 297–306. https://doi.org/10.1016/j.jagp.2012.12.009.
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    • Taylor, Warren D., Zheen Zhao, Allison Ashley-Koch, Martha E. Payne, David C. Steffens, Ranga R. Krishnan, Elizabeth Hauser, and James R. MacFall. “Fiber tract-specific white matter lesion severity Findings in late-life depression and by AGTR1 A1166C genotype.” Hum Brain Mapp 34, no. 2 (February 2013): 295–303. https://doi.org/10.1002/hbm.21445.
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    • Hayward, R David, Warren D. Taylor, Moria J. Smoski, David C. Steffens, and Martha E. Payne. “Association of five-factor model personality domains and facets with presence, onset, and treatment outcomes of major depression in older adults.” Am J Geriatr Psychiatry 21, no. 1 (January 2013): 88–96. https://doi.org/10.1016/j.jagp.2012.11.012.
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    • Ribeiz, Salma R. I., Fabio Duran, Melaine C. Oliveira, Diana Bezerra, Claudio Campi Castro, David C. Steffens, Geraldo Busatto Filho, and Cássio M. C. Bottino. “Structural brain changes as biomarkers and outcome predictors in patients with late-life depression: a cross-sectional and prospective study.” Plos One 8, no. 11 (2013): e80049. https://doi.org/10.1371/journal.pone.0080049.
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    • Rushing, Nicole C., Elizabeth Corsentino, Jennifer L. Hames, Natalie Sachs-Ericsson, and David C. Steffens. “The relationship of religious involvement indicators and social support to current and past suicidality among depressed older adults.” Aging Ment Health 17, no. 3 (2013): 366–74. https://doi.org/10.1080/13607863.2012.738414.
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    • Sachs-Ericsson, Natalie, Elizabeth Corsentino, Jerad Moxley, Jennifer L. Hames, Nicole C. Rushing, Kathryn Sawyer, Thomas Joiner, et al. “A longitudinal study of differences in late- and early-onset geriatric depression: depressive symptoms and psychosocial, cognitive, and neurological functioning.” Aging Ment Health 17, no. 1 (2013): 1–11. https://doi.org/10.1080/13607863.2012.717253.
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    • Potter, Guy G., David J. Madden, Mathew C. Costello, and David C. Steffens. “Reduced comparison speed during visual search in late life depression.” J Clin Exp Neuropsychol 35, no. 10 (2013): 1060–70. https://doi.org/10.1080/13803395.2013.856381.
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    • Hayward, R. D., A. D. Owen, H. G. Koenig, D. C. Steffens, and M. E. Payne. “Longitudinal relationships of religion with posttreatment depression severity in older psychiatric patients: Evidence of direct and indirect effects.” Depression Research and Treatment 2012 (December 1, 2012). https://doi.org/10.1155/2012/745970.
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    • Payne, Martha E., Susan E. Steck, Rebecca R. George, and David C. Steffens. “Fruit, vegetable, and antioxidant intakes are lower in older adults with depression.” J Acad Nutr Diet 112, no. 12 (December 2012): 2022–27. https://doi.org/10.1016/j.jand.2012.08.026.
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    • Potter, Guy G., Douglas R. McQuoid, Martha E. Payne, Warren D. Taylor, and David C. Steffens. “Association of attentional shift and reversal learning to functional deficits in geriatric depression.” Int J Geriatr Psychiatry 27, no. 11 (November 2012): 1172–79. https://doi.org/10.1002/gps.3764.
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    • Sheline, Yvette I., Brianne M. Disabato, Jennifer Hranilovich, Carrie Morris, Gina D’Angelo, Carl Pieper, Tommaso Toffanin, et al. “Treatment course with antidepressant therapy in late-life depression.” Am J Psychiatry 169, no. 11 (November 2012): 1185–93. https://doi.org/10.1176/appi.ajp.2012.12010122.
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    • Whitson, Heather E., Diane Whitaker, Linda L. Sanders, Guy G. Potter, Scott W. Cousins, Deidra Ansah, Eleanor McConnell, et al. “Memory deficit associated with worse functional trajectories in older adults in low-vision rehabilitation for macular disease.” J Am Geriatr Soc 60, no. 11 (November 2012): 2087–92. https://doi.org/10.1111/j.1532-5415.2012.04194.x.
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    • Lee, Chien-Ti, Jeannie-Marie Leoutsakos, Constantine G. Lyketsos, David C. Steffens, John C. S. Breitner, and Maria C. Norton. “Latent class-derived subgroups of depressive symptoms in a community sample of older adults: the Cache County Study.” Int J Geriatr Psychiatry 27, no. 10 (October 2012): 1061–69. https://doi.org/10.1002/gps.2824.
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    • Barcelos-Ferreira, Ricardo, Marcos A. Lopes, Eduardo Yoshio Nakano, David C. Steffens, and Cássio M. C. Bottino. “Clinical and sociodemographic factors in a sample of older subjects experiencing depressive symptoms.” Int J Geriatr Psychiatry 27, no. 9 (September 2012): 924–30. https://doi.org/10.1002/gps.2803.
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    • Chiu, Pai-Yi, David Steffens, Ping-Kun Chen, Ya-Chen Hsu, Hsiu-Tzu Huang, and Te-Jen Lai. “Depression in Taiwanese patients with Alzheimer's disease determined by the National Institutes of Mental Health Provisional Criteria.” Int Psychogeriatr 24, no. 8 (August 2012): 1299–1305. https://doi.org/10.1017/S1041610211002262.
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    • Wang, Lihong, Guy G. Potter, RK Ranga Krishnan, Florin Dolcos, Gwenn S. Smith, and David C. Steffens. “Neural correlates associated with cognitive decline in late-life depression.” Am J Geriatr Psychiatry 20, no. 8 (August 2012): 653–63. https://doi.org/10.1097/JGP.0b013e31823e2cc7.
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    • Sachs-Ericsson, Natalie, Edward Selby, Elizabeth Corsentino, Nicole Collins, Kathryn Sawyer, Jennifer Hames, Darleine Arce, Thomas Joiner, and David C. Steffens. “Depressed older patients with the atypical features of interpersonal rejection sensitivity and reversed-vegetative symptoms are similar to younger atypical patients.” Am J Geriatr Psychiatry 20, no. 7 (July 2012): 622–34. https://doi.org/10.1097/JGP.0b013e31822cccff.
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    • Zannas, Anthony S., Douglas R. McQuoid, David C. Steffens, George P. Chrousos, and Warren D. Taylor. “Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.” Stress 15, no. 4 (July 2012): 425–34. https://doi.org/10.3109/10253890.2011.634263.
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    • Steffens, David C. “Depressive symptoms and mild cognitive impairment in the elderly: an ominous combination.” Biol Psychiatry 71, no. 9 (May 1, 2012): 762–64. https://doi.org/10.1016/j.biopsych.2012.02.002.
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    • Wang, L., A. Ashley-Koch, D. C. Steffens, K. R. R. Krishnan, and W. D. Taylor. “Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.” Genes Brain Behav 11, no. 3 (April 2012): 352–59. https://doi.org/10.1111/j.1601-183X.2012.00764.x.
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    • Hayward, R. D., W. D. Taylor, M. J. Smoski, D. C. Steffens, and M. E. Payne. “Association of Five-Factor Model Personality Domains and Facets with Presence, Onset, and Treatment Outcomes of Major Depression in Older Adults.” Am J Geriatr Psychiatry, March 15, 2012. https://doi.org/10.1097/JGP.0b013e3182436200.
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    • Potter, G. G., H. R. Wagner, J. R. Burke, B. L. Plassman, K. A. Welsh-Bohmer, and D. C. Steffens. “Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.” Am J Geriatr Psychiatry, March 11, 2012. https://doi.org/10.1097/JGP.0b013e318248764e.
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    • Hayward, R David, Amy D. Owen, Harold G. Koenig, David C. Steffens, and Martha E. Payne. “Religion and the presence and severity of depression in older adults.” Am J Geriatr Psychiatry 20, no. 2 (February 2012): 188–92. https://doi.org/10.1097/JGP.0b013e31822ccd51.
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    • Jiang, Wei, Harry Oken, Mona Fiuzat, Linda K. Shaw, Carolyn Martsberger, Maragatha Kuchibhatla, Rima Kaddurah-Daouk, et al. “Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder.” J Cardiovasc Transl Res 5, no. 1 (February 2012): 92–99. https://doi.org/10.1007/s12265-011-9325-8.
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    • Hybels, C. F., D. G. Blazer, L. R. Landerman, and D. C. Steffens. “Erratum: Heterogeneity in symptom profiles among older adults diagnosed with major depression (International Psychogeriatrics (2011) 23:5 (906-922) DOI: 10.1017/S1041610210002346).” International Psychogeriatrics 24, no. 1 (January 1, 2012): 170. https://doi.org/10.1017/S1041610211002304.
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    • Sawyer, Kathryn, Elizabeth Corsentino, Natalie Sachs-Ericsson, and David C. Steffens. “Depression, hippocampal volume changes, and cognitive decline in a clinical sample of older depressed outpatients and non-depressed controls.” Aging Ment Health 16, no. 6 (2012): 753–62. https://doi.org/10.1080/13607863.2012.678478.
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    • Zhang, X., P. J. Nicholls, G. Laje, T. D. Sotnikova, R. R. Gainetdinov, P. R. Albert, G. Rajkowska, et al. “A functional alternative splicing mutation in human tryptophan hydroxylase-2.” Mol Psychiatry 16, no. 12 (December 2011): 1169–76. https://doi.org/10.1038/mp.2010.99.
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    • Dickinson, Whitney J., Guy G. Potter, Celia F. Hybels, Douglas R. McQuoid, and David C. Steffens. “Change in stress and social support as predictors of cognitive decline in older adults with and without depression.” Int J Geriatr Psychiatry 26, no. 12 (December 2011): 1267–74. https://doi.org/10.1002/gps.2676.
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    • Culang-Reinlieb, Michelle E., Lauren C. Johnert, Adam M. Brickman, David C. Steffens, Ernst Garcon, and Joel R. Sneed. “MRI-defined vascular depression: a review of the construct.” Int J Geriatr Psychiatry 26, no. 11 (November 2011): 1101–8. https://doi.org/10.1002/gps.2668.
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    • Norton, Maria C., Ken R. Smith, Truls Østbye, JoAnn T. Tschanz, Sarah Schwartz, Chris Corcoran, John C. S. Breitner, et al. “Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study.” Am J Geriatr Psychiatry 19, no. 9 (September 2011): 814–24. https://doi.org/10.1097/JGP.0b013e3182011b38.
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    • Burke, Julie, Douglas R. McQuoid, Martha E. Payne, David C. Steffens, Ranga R. Krishnan, and Warren D. Taylor. “Amygdala volume in late-life depression: relationship with age of onset.” Am J Geriatr Psychiatry 19, no. 9 (September 2011): 771–76. https://doi.org/10.1097/JGP.0b013e318211069a.
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    • Plassman, Brenda L., Kenneth M. Langa, Ryan J. McCammon, Gwenith G. Fisher, Guy G. Potter, James R. Burke, David C. Steffens, et al. “Incidence of dementia and cognitive impairment, not dementia in the United States.” Ann Neurol 70, no. 3 (September 2011): 418–26. https://doi.org/10.1002/ana.22362.
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    • Hybels, Celia F., Dan G. Blazer, Lawrence R. Landerman, and David C. Steffens. “Heterogeneity in symptom profiles among older adults diagnosed with major depression.” Int Psychogeriatr 23, no. 6 (August 2011): 906–22. https://doi.org/10.1017/S1041610210002346.
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    • Chang, Cheng-Chen, Shun-Chieh Yu, Douglas R. McQuoid, Denise F. Messer, Warren D. Taylor, Kulpreet Singh, Brian D. Boyd, et al. “Reduction of dorsolateral prefrontal cortex gray matter in late-life depression.” Psychiatry Res 193, no. 1 (July 30, 2011): 1–6. https://doi.org/10.1016/j.pscychresns.2011.01.003.
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    • Benjamin, Sophiya, and David C. Steffens. “Structural neuroimaging of geriatric depression.” Psychiatr Clin North Am 34, no. 2 (June 2011): 423–ix. https://doi.org/10.1016/j.psc.2011.02.001.
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    • Steffens, David C., J Craig Nelson, James M. Eudicone, Candace Andersson, Huyuan Yang, Quynh-Van Tran, Robert A. Forbes, Berit X. Carlson, and Robert M. Berman. “Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysis.” Int J Geriatr Psychiatry 26, no. 6 (June 2011): 564–72. https://doi.org/10.1002/gps.2564.
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    • Taylor, W. D., D. R. McQuoid, A. Ashley-Koch, J. R. MacFall, J. Bridgers, R. R. Krishnan, and D. C. Steffens. “BDNF Val66Met genotype and 6-month remission rates in late-life depression.” Pharmacogenomics J 11, no. 2 (April 2011): 146–54. https://doi.org/10.1038/tpj.2010.12.
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    • Owen, Amy D., R David Hayward, Harold G. Koenig, David C. Steffens, and Martha E. Payne. “Religious factors and hippocampal atrophy in late life.” Plos One 6, no. 3 (March 30, 2011): e17006. https://doi.org/10.1371/journal.pone.0017006.
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    • Okura, Toru, Brenda L. Plassman, David C. Steffens, David J. Llewellyn, Guy G. Potter, and Kenneth M. Langa. “Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study.” J Am Geriatr Soc 59, no. 3 (March 2011): 473–81. https://doi.org/10.1111/j.1532-5415.2011.03314.x.
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    • Oddone, Cameron G., Celia F. Hybels, Douglas R. McQuoid, and David C. Steffens. “Social support modifies the relationship between personality and depressive symptoms in older adults.” Am J Geriatr Psychiatry 19, no. 2 (February 2011): 123–31. https://doi.org/10.1097/jgp.0b013e3181f7d89a.
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    • Alalade, Emmanuel, Kevin Denny, Guy Potter, David Steffens, and Lihong Wang. “Altered cerebellar-cerebral functional connectivity in geriatric depression.” Plos One 6, no. 5 (2011): e20035. https://doi.org/10.1371/journal.pone.0020035.
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    • Hayward, R David, Amy D. Owen, Harold G. Koenig, David C. Steffens, and Martha E. Payne. “Associations of religious behavior and experiences with extent of regional atrophy in the orbitofrontal cortex during older adulthood.” Religion Brain Behav 1, no. 2 (2011): 103–18. https://doi.org/10.1080/2153599X.2011.598328.
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    • Sachs-Erisson, Natalie, Kathryn Sawyer, Elizabeth Corsentino, Nicole Collins, and David C. Steffens. “The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients.” Am J Geriatr Psychiatry 19, no. 1 (January 2011): 23–32. https://doi.org/10.1097/jgp.0b013e3181f61ae8.
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    • Steffens, David C., Douglas R. McQuoid, Martha E. Payne, and Guy G. Potter. “Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study.” Am J Geriatr Psychiatry 19, no. 1 (January 2011): 4–12. https://doi.org/10.1097/JGP.0b013e3181d6c245.
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    • Steffens, David C., Warren D. Taylor, Kevin L. Denny, Sara R. Bergman, and Lihong Wang. “Structural integrity of the uncinate fasciculus and resting state functional connectivity of the ventral prefrontal cortex in late life depression.” Plos One 6, no. 7 (2011): e22697. https://doi.org/10.1371/journal.pone.0022697.
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    • Lee, Jung Jae, Ki Woong Kim, Tae Hui Kim, Joon Hyuk Park, Seok Bum Lee, Jin Woo Park, Douglas R. McQuoid, and David C. Steffens. “Cross-cultural considerations in administering the center for epidemiologic studies depression scale.” Gerontology 57, no. 5 (2011): 455–61. https://doi.org/10.1159/000318030.
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    • Whitson, Heather E., Deidra Ansah, Linda L. Sanders, Diane Whitaker, Guy G. Potter, Scott W. Cousins, David C. Steffens, Lawrence R. Landerman, Carl F. Pieper, and Harvey Jay Cohen. “Comorbid cognitive impairment and functional trajectories in low vision rehabilitation for macular disease.” Aging Clin Exp Res 23, no. 5–6 (2011): 343–50. https://doi.org/10.1007/BF03325233.
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    • Isamah, Nneka, Warachal Faison, Martha E. Payne, James MacFall, David C. Steffens, John L. Beyer, K Ranga Krishnan, and Warren D. Taylor. “Variability in frontotemporal brain structure: the importance of recruitment of African Americans in neuroscience research.” Plos One 5, no. 10 (October 26, 2010): e13642. https://doi.org/10.1371/journal.pone.0013642.
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    • Wee, C. Y., P. T. Yap, J. N. Brownyke, G. G. Potter, D. C. Steffens, K. Welsh-Bohmer, L. Wang, and D. Shen. “Accurate identification of MCI patients via enriched white-matter connectivity network.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6357 LNCS (October 25, 2010): 140–47. https://doi.org/10.1007/978-3-642-15948-0_18.
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    • Pae, Chi-Un, Manmohandeep Singh Sohi, Ho-Jun Seo, Alessandro Serretti, Ashwin A. Patkar, David C. Steffens, and Prakash S. Masand. “Quetiapine XR: current status for the treatment of major depressive disorder.” Prog Neuropsychopharmacol Biol Psychiatry 34, no. 7 (October 1, 2010): 1165–73. https://doi.org/10.1016/j.pnpbp.2010.03.023.
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    • Calakos, Nicole, Viren D. Patel, Melissa Gottron, Gaofeng Wang, Khan-Nhat Tran-Viet, Danielle Brewington, John L. Beyer, David C. Steffens, Ranga R. Krishnan, and Stephan Züchner. “Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia.” J Med Genet 47, no. 9 (September 2010): 646–50. https://doi.org/10.1136/jmg.2009.072082.
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    • Smith, Patrick J., James A. Blumenthal, Michael A. Babyak, Lana L. Watkins, Alan Hinderliter, Benson M. Hoffman, David C. Steffens, Andrew Sherwood, and P Murali Doraiswamy. “Cerebrovascular risk factors and cerebral hyperintensities among middle-aged and older adults with major depression.” Am J Geriatr Psychiatry 18, no. 9 (September 2010): 848–52. https://doi.org/10.1097/JGP.0b013e3181dba0fa.
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    • Marquine, María J., Deborah K. Attix, Larry B. Goldstein, Gregory P. Samsa, Martha E. Payne, Gordon J. Chelune, and David C. Steffens. “Differential patterns of cognitive decline in anterior and posterior white matter hyperintensity progression.” Stroke 41, no. 9 (September 2010): 1946–50. https://doi.org/10.1161/STROKEAHA.110.587717.
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    • Barcelos-Ferreira, Ricardo, Rafael Izbicki, David C. Steffens, and Cássio M. C. Bottino. “Depressive morbidity and gender in community-dwelling Brazilian elderly: systematic review and meta-analysis.” Int Psychogeriatr 22, no. 5 (August 2010): 712–26. https://doi.org/10.1017/S1041610210000463.
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    • Naylor, Jennifer C., Jason D. Kilts, Christine M. Hulette, David C. Steffens, Dan G. Blazer, John F. Ervin, Jennifer L. Strauss, et al. “Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.” Biochim Biophys Acta 1801, no. 8 (August 2010): 951–59. https://doi.org/10.1016/j.bbalip.2010.05.006.
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    • Taylor, W. D., D. C. Steffens, A. Ashley-Koch, M. E. Payne, J. R. MacFall, C. F. Potocky, and K. R. R. Krishnan. “Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men.” Mol Psychiatry 15, no. 8 (August 2010): 816–22. https://doi.org/10.1038/mp.2009.26.
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    • Grangeon, Maria Conceição, Camila Seixas, Lucas C. Quarantini, Angela Miranda-Scippa, Maurizio Pompili, David C. Steffens, Amy Wenzel, Acioly L. T. Lacerda, and Irismar Reis de Oliveira. “White matter hyperintensities and their association with suicidality in major affective disorders: a meta-analysis of magnetic resonance imaging studies.” Cns Spectr 15, no. 6 (June 2010): 375–81. https://doi.org/10.1017/s1092852900029242.
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    • Steffens, David C., David C. Wei Jiang, K Ranga R. Krishnan, Edward D. Karoly, Matthew W. Mitchell, Christopher M. O’Connor, and Rima Kaddurah-Daouk. “Metabolomic differences in heart failure patients with and without major depression.” J Geriatr Psychiatry Neurol 23, no. 2 (June 2010): 138–46. https://doi.org/10.1177/0891988709358592.
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    • Norton, Maria C., Ken R. Smith, Truls Østbye, JoAnn T. Tschanz, Chris Corcoran, Sarah Schwartz, Kathleen W. Piercy, et al. “Greater risk of dementia when spouse has dementia? The Cache County study.” J Am Geriatr Soc 58, no. 5 (May 2010): 895–900. https://doi.org/10.1111/j.1532-5415.2010.02806.x.
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    • Benjamin, Sophiya, Douglas R. McQuoid, Guy G. Potter, Martha E. Payne, James R. MacFall, David C. Steffens, and Warren D. Taylor. “The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.” Am J Geriatr Psychiatry 18, no. 4 (April 2010): 323–31. https://doi.org/10.1097/JGP.0b013e3181cabd2b.
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    • Ribeiz, Salma R. I., Débora P. Bassitt, Jony A. Arrais, Renata Avila, David C. Steffens, and Cássio M. C. Bottino. “Cholinesterase inhibitors as adjunctive therapy in patients with schizophrenia and schizoaffective disorder: a review and meta-analysis of the literature.” Cns Drugs 24, no. 4 (April 2010): 303–17. https://doi.org/10.2165/11530260-000000000-00000.
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    • Sheline, Yvette I., Carl F. Pieper, Deanna M. Barch, Kathleen Welsh-Bohmer, Robert C. McKinstry, James R. MacFall, Gina D’Angelo, et al. “Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.” Arch Gen Psychiatry 67, no. 3 (March 2010): 277–85. https://doi.org/10.1001/archgenpsychiatry.2009.204.
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    • Okura, Toru, Brenda L. Plassman, David C. Steffens, David J. Llewellyn, Guy G. Potter, and Kenneth M. Langa. “Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.” J Am Geriatr Soc 58, no. 2 (February 2010): 330–37. https://doi.org/10.1111/j.1532-5415.2009.02680.x.
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    • Blazer, D. G., and D. C. Steffens. “Geriatric Psychiatry.” Psychiatric Annals 40, no. 1 (January 1, 2010): 7–8. https://doi.org/10.3928/00485718-20100105-02.
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    • Steffens, David C. “Imaging and genetics advances in understanding geriatric depression.” Neuropsychopharmacology 35, no. 1 (January 2010): 349–50. https://doi.org/10.1038/npp.2009.135.
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    • Walker, E. M., and D. C. Steffens. “Understanding depression and cognitive impairment in the elderly.” Psychiatric Annals 40, no. 1 (January 1, 2010): 29–40. https://doi.org/10.3928/00485718-20091229-03.
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    • Hybels, Celia F., Carl F. Pieper, Dan G. Blazer, Gerda G. Fillenbaum, and David C. Steffens. “Trajectories of mobility and IADL function in older patients diagnosed with major depression.” Int J Geriatr Psychiatry 25, no. 1 (January 2010): 74–81. https://doi.org/10.1002/gps.2300.
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    • Whitson, Heather E., Deidra Ansah, Diane Whitaker, Guy Potter, Scott W. Cousins, Heather MacDonald, Carl F. Pieper, Lawrence Landerman, David C. Steffens, and Harvey J. Cohen. “Prevalence and patterns of comorbid cognitive impairment in low vision rehabilitation for macular disease.” Arch Gerontol Geriatr 50, no. 2 (2010): 209–12. https://doi.org/10.1016/j.archger.2009.03.010.
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    • Steffens, David C. “A multiplicity of approaches to characterize geriatric depression and its outcomes.” Curr Opin Psychiatry 22, no. 6 (November 2009): 522–26. https://doi.org/10.1097/YCO.0b013e32832fcd93.
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    • Potter, Guy G., Brenda L. Plassman, James R. Burke, Mohammed U. Kabeto, Kenneth M. Langa, David J. Llewellyn, Mary A. M. Rogers, and David C. Steffens. “Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.” Alzheimers Dement 5, no. 6 (November 2009): 445–53. https://doi.org/10.1016/j.jalz.2009.04.1234.
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    • Hong, Edmund D., Warren D. Taylor, Douglas R. McQuoid, Guy G. Potter, Martha E. Payne, Allison Ashley-Koch, and David C. Steffens. “Influence of the MTHFR C677T polymorphism on magnetic resonance imaging hyperintensity volume and cognition in geriatric depression.” Am J Geriatr Psychiatry 17, no. 10 (October 2009): 847–55. https://doi.org/10.1097/JGP.0b013e3181aad5b2.
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    • Payne, Martha E., Brenda D. Jamerson, Christopher F. Potocky, Allison E. Ashley-Koch, Marcy C. Speer, and David C. Steffens. “Natural food folate and late-life depression.” J Nutr Elder 28, no. 4 (October 2009): 348–58. https://doi.org/10.1080/01639360903417181.
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    • Potter, G. G., W. D. Taylor, D. R. McQuoid, D. C. Steffens, K. A. Welsh-Bohmer, and K. R. R. Krishnan. “The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults.” Int J Geriatr Psychiatry 24, no. 10 (October 2009): 1127–33. https://doi.org/10.1002/gps.2235.
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    • Steffens, David C., Gwenith G. Fisher, Kenneth M. Langa, Guy G. Potter, and Brenda L. Plassman. “Prevalence of depression among older Americans: the Aging, Demographics and Memory Study.” Int Psychogeriatr 21, no. 5 (October 2009): 879–88. https://doi.org/10.1017/S1041610209990044.
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    • Ayotte, Brian J., Guy G. Potter, Heather T. Williams, David C. Steffens, and Hayden B. Bosworth. “The moderating role of personality factors in the relationship between depression and neuropsychological functioning among older adults.” Int J Geriatr Psychiatry 24, no. 9 (September 2009): 1010–19. https://doi.org/10.1002/gps.2213.
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    • Pan, Chih-Chuan, Douglas R. McQuoid, Warren D. Taylor, Martha E. Payne, Allison Ashley-Koch, and David C. Steffens. “Association analysis of the COMT/MTHFR genes and geriatric depression: an MRI study of the putamen.” Int J Geriatr Psychiatry 24, no. 8 (August 2009): 847–55. https://doi.org/10.1002/gps.2206.
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    • Van Otterloo, Eric, Gillian O’Dwyer, Craig A. Stockmeier, David C. Steffens, Ranga R. Krishnan, and Grazyna Rajkowska. “Reductions in neuronal density in elderly depressed are region specific.” Int J Geriatr Psychiatry 24, no. 8 (August 2009): 856–64. https://doi.org/10.1002/gps.2281.
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    • Barcelos-Ferreira, Ricardo, Jony Arrais Pinto, Eduardo Yoshio Nakano, David C. Steffens, Júlio Litvoc, and Cássio M. C. Bottino. “Clinically significant depressive symptoms and associated factors in community elderly subjects from Sao Paulo, Brazil.” Am J Geriatr Psychiatry 17, no. 7 (July 2009): 582–90. https://doi.org/10.1097/JGP.0b013e3181a76ddc.
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    • Pae, Chi-Un, Laura Mandelli, Changsu Han, Byung-Joo Ham, Prakash S. Masand, Ashwin A. Patkar, David C. Steffens, Diana De Ronchi, and Alessandro Serretti. “Thyroid hormones affect recovery from depression during antidepressant treatment.” Psychiatry Clin Neurosci 63, no. 3 (June 2009): 305–13. https://doi.org/10.1111/j.1440-1819.2009.01938.x.
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    • Hybels, Celia F., Dan G. Blazer, Carl F. Pieper, Lawrence R. Landerman, and David C. Steffens. “Profiles of depressive symptoms in older adults diagnosed with major depression: latent cluster analysis.” Am J Geriatr Psychiatry 17, no. 5 (May 2009): 387–96. https://doi.org/10.1097/JGP.0b013e31819431ff.
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    • Wang, C Sheei-Meei, J. R. Burke, D. C. Steffens, C. M. Hulette, J. C. S. Breitner, and B. L. Plassman. “Twin pairs discordant for neuropathologically confirmed Lewy body dementia.” J Neurol Neurosurg Psychiatry 80, no. 5 (May 2009): 562–65. https://doi.org/10.1136/jnnp.2008.151654.
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    • Venkatraman, Talaignair N., Ranga R. Krishnan, David C. Steffens, Allen W. Song, and Warren D. Taylor. “Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.” Psychiatry Res 172, no. 1 (April 30, 2009): 49–54. https://doi.org/10.1016/j.pscychresns.2008.07.001.
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    • Steffens, David C., Douglas R. McQuoid, and Guy G. Potter. “Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study.” J Geriatr Psychiatry Neurol 22, no. 1 (March 2009): 52–61. https://doi.org/10.1177/0891988708328213.
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    • Pae, Chi-Un, Laura Mandelli, Tae-Suk Kim, Changsu Han, Prakash S. Masand, David M. Marks, Ashwin A. Patkar, David C. Steffens, Diana De Ronchi, and Alessandro Serretti. “Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects.” Biomed Pharmacother 63, no. 3 (March 2009): 228–35. https://doi.org/10.1016/j.biopha.2008.03.010.
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    • Potter, G. G., D. R. McQuoid, D. C. Steffens, K. A. Welsh-Bohmer, and K. R. R. Krishnan. “Neuropsychological correlates of magnetic resonance imaging-defined subcortical ischemic depression.” Int J Geriatr Psychiatry 24, no. 3 (March 2009): 219–25. https://doi.org/10.1002/gps.2093.
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    • Qiu, Anqi, Warren D. Taylor, Zheen Zhao, James R. MacFall, Michael I. Miller, Cynthia R. Key, Martha E. Payne, David C. Steffens, and K Ranga R. Krishnan. “APOE related hippocampal shape alteration in geriatric depression.” Neuroimage 44, no. 3 (February 1, 2009): 620–26. https://doi.org/10.1016/j.neuroimage.2008.10.010.
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    • Cukrowicz, Kelly C., Paul R. Duberstein, Steven D. Vannoy, Thomas R. Lynch, Douglas R. McQuoid, and David C. Steffens. “Course of suicide ideation and predictors of change in depressed older adults.” J Affect Disord 113, no. 1–2 (February 2009): 30–36. https://doi.org/10.1016/j.jad.2008.05.012.
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    • Trone, R. J., K. G. Weaver, D. C. Steffens, and M. E. Payne. “Glycemic index and glycemic load are not associated with brain lesions in the elderly.” J Nutr Health Aging 13, no. 2 (February 2009): 117–20. https://doi.org/10.1007/s12603-009-0017-x.
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    • Züchner, S., J. R. Wendland, A. E. Ashley-Koch, A. L. Collins, K. N. Tran-Viet, K. Quinn, K. C. Timpano, et al. “Multiple rare SAPAP3 missense variants in trichotillomania and OCD.” Mol Psychiatry 14, no. 1 (January 2009): 6–9. https://doi.org/10.1038/mp.2008.83.
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    • Cannell, John J. “Discovering the obvious, damaging the defenseless.” Nutr Res 28, no. 11 (November 2008): 809. https://doi.org/10.1016/j.nutres.2008.09.008.
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    • Pae, Chi-Un, David M. Marks, Changsu Han, Ashwin A. Patkar, and David Steffens. “Does neurotropin-3 have a therapeutic implication in major depression?” Int J Neurosci 118, no. 11 (November 2008): 1515–22. https://doi.org/10.1080/00207450802174589.
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    • Taylor, Warren D., Stephan Züchner, Douglas R. McQuoid, David C. Steffens, Dan G. Blazer, and K Ranga R. Krishnan. “Social support in older individuals: the role of the BDNF Val66Met polymorphism.” Am J Med Genet B Neuropsychiatr Genet 147B, no. 7 (October 5, 2008): 1205–12. https://doi.org/10.1002/ajmg.b.30754.
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    • Sneed, Joel R., David Rindskopf, David C. Steffens, K Ranga Rama Krishnan, and Steven P. Roose. “The vascular depression subtype: evidence of internal validity.” Biol Psychiatry 64, no. 6 (September 15, 2008): 491–97. https://doi.org/10.1016/j.biopsych.2008.03.032.
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    • Carlson, Michelle C., Michael J. Helms, David C. Steffens, James R. Burke, Guy G. Potter, and Brenda L. Plassman. “Midlife activity predicts risk of dementia in older male twin pairs.” Alzheimers Dement 4, no. 5 (September 2008): 324–31. https://doi.org/10.1016/j.jalz.2008.07.002.
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    • Story, Tyler J., Guy G. Potter, Deborah K. Attix, Kathleen A. Welsh-Bohmer, and David C. Steffens. “Neurocognitive correlates of response to treatment in late-life depression.” Am J Geriatr Psychiatry 16, no. 9 (September 2008): 752–59. https://doi.org/10.1097/JGP.0b013e31817e739a.
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    • Naylor, Jennifer C., Christine M. Hulette, David C. Steffens, Lawrence J. Shampine, John F. Ervin, Victoria M. Payne, Mark W. Massing, et al. “Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.” J Clin Endocrinol Metab 93, no. 8 (August 2008): 3173–78. https://doi.org/10.1210/jc.2007-1229.
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    • Pae, Chi-Un, Laura Mandelli, Changsu Han, Byung-Joo Ham, Prakash S. Masand, Ashwin A. Patkar, David C. Steffens, Diana De Ronchi, and Alessandro Serretti. “Do estradiol levels influence on the cognitive function during antidepressant treatments in post-menopausal women with major depressive disorder? A comparison with pre-menopausal women.” Neuro Endocrinol Lett 29, no. 4 (August 2008): 500–506.
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    • Steffens, David C. “Separating mood disturbance from mild cognitive impairment in geriatric depression.” Int Rev Psychiatry 20, no. 4 (August 2008): 374–81. https://doi.org/10.1080/09540260802094589.
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    • Greenberg, Daniel L., Martha E. Payne, James R. MacFall, David C. Steffens, and Ranga R. Krishnan. “Hippocampal volumes and depression subtypes.” Psychiatry Res 163, no. 2 (July 15, 2008): 126–32. https://doi.org/10.1016/j.pscychresns.2007.12.009.
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    • Wang, Lihong, K Ranga Krishnan, David C. Steffens, Guy G. Potter, Florin Dolcos, and Gregory McCarthy. “Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression.” Am J Psychiatry 165, no. 7 (July 2008): 863–71. https://doi.org/10.1176/appi.ajp.2008.07101590.
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    • Doty, Tracy J., Martha E. Payne, David C. Steffens, John L. Beyer, K Ranga R. Krishnan, and Kevin S. LaBar. “Age-dependent reduction of amygdala volume in bipolar disorder.” Psychiatry Res 163, no. 1 (May 30, 2008): 84–94. https://doi.org/10.1016/j.pscychresns.2007.08.003.
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    • Norton, Maria C., Archana Singh, Ingmar Skoog, Christopher Corcoran, Joann T. Tschanz, Peter P. Zandi, John C. S. Breitner, Kathleen A. Welsh-Bohmer, David C. Steffens, and David C. Cache County Investigators. “Church attendance and new episodes of major depression in a community study of older adults: the Cache County Study.” J Gerontol B Psychol Sci Soc Sci 63, no. 3 (May 2008): P129–37. https://doi.org/10.1093/geronb/63.3.p129.
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    • Payne, Martha E., John J. B. Anderson, and David C. Steffens. “Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders.” Nutr Res 28, no. 5 (May 2008): 285–92. https://doi.org/10.1016/j.nutres.2008.02.013.
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    • Sun, Xiaoyan, David C. Steffens, Rhoda Au, Marshal Folstein, Paul Summergrad, Jacqueline Yee, Irwin Rosenberg, D Mkaya Mwamburi, and Wei Qiao Qiu. “Amyloid-associated depression: a prodromal depression of Alzheimer disease?” Arch Gen Psychiatry 65, no. 5 (May 2008): 542–50. https://doi.org/10.1001/archpsyc.65.5.542.
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    • Hybels, Celia F., Carl F. Pieper, Dan G. Blazer, and David C. Steffens. “The course of depressive symptoms in older adults with comorbid major depression and dysthymia.” Am J Geriatr Psychiatry 16, no. 4 (April 2008): 300–309. https://doi.org/10.1097/JGP.0b013e318162f15f.
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    • Taylor, Warren D., Stephan Züchner, Douglas R. McQuoid, Martha E. Payne, James R. MacFall, David C. Steffens, Marcy C. Speer, and K Ranga R. Krishnan. “The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.” Am J Geriatr Psychiatry 16, no. 4 (April 2008): 263–71. https://doi.org/10.1097/JGP.0b013e3181591c30.
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    • Zhao, Zheen, Warren D. Taylor, Martin Styner, David C. Steffens, K Ranga R. Krishnan, and James R. MacFall. “Hippocampus shape analysis and late-life depression.” Plos One 3, no. 3 (March 19, 2008): e1837. https://doi.org/10.1371/journal.pone.0001837.
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    • Plassman, Brenda L., Kenneth M. Langa, Gwenith G. Fisher, Steven G. Heeringa, David R. Weir, Mary Beth Ofstedal, James R. Burke, et al. “Prevalence of cognitive impairment without dementia in the United States.” Ann Intern Med 148, no. 6 (March 18, 2008): 427–34. https://doi.org/10.7326/0003-4819-148-6-200803180-00005.
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    • Steffens, David C., Hyoju Chung, K Ranga R. Krishnan, W. T. Longstreth, Michelle Carlson, and Gregory L. Burke. “Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study.” Stroke 39, no. 3 (March 2008): 857–62. https://doi.org/10.1161/STROKEAHA.107.498097.
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    • Steffens, David C., Warren D. Taylor, Douglas R. McQuoid, and K Ranga R. Krishnan. “Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.” Int J Geriatr Psychiatry 23, no. 3 (March 2008): 244–48. https://doi.org/10.1002/gps.1869.
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    • Kim, Jung-Jin, Laura Mandelli, Chi-Un Pae, Diana De Ronchi, Tae-Youn Jun, Chul Lee, In-Ho Paik, et al. “Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder.” Prog Neuropsychopharmacol Biol Psychiatry 32, no. 2 (February 15, 2008): 375–79. https://doi.org/10.1016/j.pnpbp.2007.09.002.
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    • Steffens, D. C., and G. G. Potter. “Geriatric depression and cognitive impairment.” Psychol Med 38, no. 2 (February 2008): 163–75. https://doi.org/10.1017/S003329170700102X.
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    • Bosworth, Hayden B., Corrine I. Voils, Guy G. Potter, and David C. Steffens. “The effects of antidepressant medication adherence as well as psychosocial and clinical factors on depression outcome among older adults.” Int J Geriatr Psychiatry 23, no. 2 (February 2008): 129–34. https://doi.org/10.1002/gps.1852.
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    • Greenberg, Daniel L., Denise F. Messer, Martha E. Payne, James R. Macfall, James M. Provenzale, David C. Steffens, and Ranga R. Krishnan. “Aging, gender, and the elderly adult brain: an examination of analytical strategies.” Neurobiol Aging 29, no. 2 (February 2008): 290–302. https://doi.org/10.1016/j.neurobiolaging.2006.09.016.
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    • Steinberg, Martin, Huibo Shao, Peter Zandi, Constantine G. Lyketsos, Kathleen A. Welsh-Bohmer, Maria C. Norton, John C. S. Breitner, David C. Steffens, Joann T. Tschanz, and Joann T. Cache County Investigators. “Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.” Int J Geriatr Psychiatry 23, no. 2 (February 2008): 170–77. https://doi.org/10.1002/gps.1858.
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    • Han, Changsu, Sangmee Ahn Jo, Ji-Hyun Kwak, Chi-Un Pae, David Steffens, Inho Jo, and Moon Ho Park. “Validation of the Patient Health Questionnaire-9 Korean version in the elderly population: the Ansan Geriatric study.” Compr Psychiatry 49, no. 2 (2008): 218–23. https://doi.org/10.1016/j.comppsych.2007.08.006.
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    • Taylor, Warren D., James R. Macfall, Martha E. Payne, Douglas R. McQuoid, David C. Steffens, James M. Provenzale, and K Ranga R. Krishnan. “Orbitofrontal cortex volume in late life depression: influence of hyperintense lesions and genetic polymorphisms.” Psychol Med 37, no. 12 (December 2007): 1763–73. https://doi.org/10.1017/S0033291707000128.
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    • Voils, Corrine I., Jason C. Allaire, Maren K. Olsen, David C. Steffens, Rick H. Hoyle, and Hayden B. Bosworth. “Five-year trajectories of social networks and social support in older adults with major depression.” Int Psychogeriatr 19, no. 6 (December 2007): 1110–24. https://doi.org/10.1017/S1041610207005303.
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    • Thakur, Mugdha, Iris Grossman, Douglas C. McCrory, Lori A. Orlando, David C. Steffens, Kathryn E. Cline, Rebecca N. Gray, et al. “Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors.” Genet Med 9, no. 12 (December 2007): 826–35. https://doi.org/10.1097/gim.0b013e31815bf98f.
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    • Potter, G. G., and D. C. Steffens. “Depression and cognitive impairment in older adults.” Psychiatric Times 24, no. 13 (November 1, 2007).
    • Pae, Chi-Un, Hyun-Kook Lim, Changsu Han, Ashwin A. Patkar, David C. Steffens, Prakash S. Masand, and Chul Lee. “Fatigue as a core symptom in major depressive disorder: overview and the role of bupropion.” Expert Rev Neurother 7, no. 10 (October 2007): 1251–63. https://doi.org/10.1586/14737175.7.10.1251.
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    • Potter, Guy G., Andrew D. Blackwell, Douglas R. McQuoid, Martha E. Payne, David C. Steffens, Barbara J. Sahakian, Kathleen A. Welsh-Bohmer, and KR Ranga Krishnan. “Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.” Neuropsychopharmacology 32, no. 10 (October 2007): 2135–42. https://doi.org/10.1038/sj.npp.1301339.
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    • Taylor, Warren D., Stephan Züchner, Douglas R. McQuoid, David C. Steffens, Marcy C. Speer, and K Ranga R. Krishnan. “Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.” Am J Geriatr Psychiatry 15, no. 10 (October 2007): 850–57. https://doi.org/10.1097/JGP.0b013e318050c9d5.
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    • Steffens, David C., Guy G. Potter, Douglas R. McQuoid, James R. MacFall, Martha E. Payne, James R. Burke, Brenda L. Plassman, and Kathleen A. Welsh-Bohmer. “Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.” Am J Geriatr Psychiatry 15, no. 10 (October 2007): 839–49. https://doi.org/10.1097/JGP.0b013e318048a1a0.
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    • Steffens, David C. “Spiritual considerations in suicide and depression among the elderly.” South Med J 100, no. 7 (July 2007): 748–49. https://doi.org/10.1097/SMJ.0b013e318073c7c6.
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    • Steffens, David C., Karen M. Stechuchak, and Eugene Z. Oddone. “How asymptomatic is asymptomatic carotid stenosis?” Radiology 244, no. 1 (July 2007): 317–18. https://doi.org/10.1148/radiol.2441061336.
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    • Fearing, Michael A., Erin D. Bigler, Maria Norton, Jo Ann Tschanz, Christine Hulette, Carol Leslie, Kathleen Welsh-Bohmer, and Kathleen Cache County Investigators. “Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.” J Clin Exp Neuropsychol 29, no. 5 (July 2007): 553–60. https://doi.org/10.1080/13803390600826579.
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    • Kondo, Douglas G., Marcy C. Speer, K Ranga Krishnan, Douglas R. McQuoid, Susan H. Slifer, Carl F. Pieper, Ashley V. Billups, and David C. Steffens. “Association of AGTR1 with 18-month treatment outcome in late-life depression.” Am J Geriatr Psychiatry 15, no. 7 (July 2007): 564–72. https://doi.org/10.1097/JGP.0b013e31805470a4.
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    • Potter, Guy G., Michael J. Helms, James R. Burke, David C. Steffens, and Brenda L. Plassman. “Job demands and dementia risk among male twin pairs.” Alzheimers Dement 3, no. 3 (July 2007): 192–99. https://doi.org/10.1016/j.jalz.2007.04.377.
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    • Taylor, Warren D., Jae Nam Bae, James R. MacFall, Martha E. Payne, James M. Provenzale, David C. Steffens, and K Ranga R. Krishnan. “Widespread effects of hyperintense lesions on cerebral white matter structure.” Ajr Am J Roentgenol 188, no. 6 (June 2007): 1695–1704. https://doi.org/10.2214/AJR.06.1163.
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    • Plassman, B. L., G. L. Xiong, M. J. Helms, and D. C. Steffens. “Reply from the authors [5].” Neurology 68, no. 21 (May 1, 2007): 1871. https://doi.org/10.1212/01.wnl.0000265355.98285.65.
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    • Potter, Guy G., and David C. Steffens. “Contribution of depression to cognitive impairment and dementia in older adults.” Neurologist 13, no. 3 (May 2007): 105–17. https://doi.org/10.1097/01.nrl.0000252947.15389.a9.
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    • Paige, Lisa A., Matthew W. Mitchell, K Ranga R. Krishnan, Rima Kaddurah-Daouk, and David C. Steffens. “A preliminary metabolomic analysis of older adults with and without depression.” Int J Geriatr Psychiatry 22, no. 5 (May 2007): 418–23. https://doi.org/10.1002/gps.1690.
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    • Payne, Martha E., Pamela S. Haines, Lloyd E. Chambless, John J. B. Anderson, and David C. Steffens. “Food group intake and brain lesions in late-life vascular depression.” Int Psychogeriatr 19, no. 2 (April 2007): 295–305. https://doi.org/10.1017/S1041610206004431.
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    • Sun, Cong, Gabriella Tikellis, Ronald Klein, David C. Steffens, Emily K Marino Larsen, David S. Siscovick, Barbara E. K. Klein, and Tien Y. Wong. “Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study.” Am J Geriatr Psychiatry 15, no. 4 (April 2007): 335–43. https://doi.org/10.1097/01.JGP.0000247161.98311.0f.
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    • Lee, Jung Sik, Guy G. Potter, H Ryan Wagner, Kathleen A. Welsh-Bohmer, and David C. Steffens. “Persistent mild cognitive impairment in geriatric depression.” Int Psychogeriatr 19, no. 1 (February 2007): 125–35. https://doi.org/10.1017/S1041610206003607.
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    • Saur, C. D., D. C. Steffens, L. H. Harpole, M. Y. Fan, E. Z. Oddone, and J. Unützer. “Satisfaction and outcomes of depressed older adults with psychiatric clinical nurse specialists in primary care.” Journal of the American Psychiatric Nurses Association 13, no. 1 (February 1, 2007): 62–70. https://doi.org/10.1177/1078390307301938.
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    • Gopal, S., J. L. Beyer, D. C. Steffens, and M. L. Kramer. “Symptomatic Remission in Patients with Bipolar Mania: Results from a Double-Blind, Placebo-Controlled Trial of Risperidone Monotherapy.” Progress in Neurotherapeutics and Neuropsychopharmacology 2, no. 1 (January 1, 2007): 213–24. https://doi.org/10.1017/S1748232106000152.
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    • Matchar, David B., Mugdha E. Thakur, Iris Grossman, Douglas C. McCrory, Lori A. Orlando, David C. Steffens, David B. Goldstein, Kathryn E. Cline, and Rebecca N. Gray. “Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs).” Evid Rep Technol Assess (Full Rep), no. 146 (January 2007): 1–77.
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    • Plassman, B. L., K. M. Langa, G. G. Fisher, S. G. Heeringa, D. R. Weir, M. B. Ofstedal, J. R. Burke, et al. “Prevalence of dementia in the United States: the aging, demographics, and memory study.” Neuroepidemiology 29, no. 1–2 (2007): 125–32. https://doi.org/10.1159/000109998.
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    • Sun, Cong, Gabriella Tikellis, Ronald Klein, David C. Steffens, Emily K Marino Larsen, and Tien Y. Wong. “Depressive symptoms and age-related macular degeneration in older people: the cardiovascular health study.” Ophthalmic Epidemiol 14, no. 3 (2007): 127–33. https://doi.org/10.1080/09286580601186742.
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    • Young, A Joyce, Stephanie Johnson, David C. Steffens, and P Murali Doraiswamy. “Coenzyme Q10: a review of its promise as a neuroprotectant.” Cns Spectr 12, no. 1 (January 2007): 62–68. https://doi.org/10.1017/s1092852900020538.
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    • Bae, Jae Nam, James R. MacFall, K Ranga R. Krishnan, Martha E. Payne, David C. Steffens, and Warren D. Taylor. “Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression.” Biol Psychiatry 60, no. 12 (December 15, 2006): 1356–63. https://doi.org/10.1016/j.biopsych.2006.03.052.
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    • Marx, Christine E., William T. Trost, Lawrence J. Shampine, Robert D. Stevens, Christine M. Hulette, David C. Steffens, John F. Ervin, et al. “The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.” Biol Psychiatry 60, no. 12 (December 15, 2006): 1287–94. https://doi.org/10.1016/j.biopsych.2006.06.017.
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    • Taylor, Warren D., David C. Steffens, and K Ranga Krishnan. “Psychiatric disease in the twenty-first century: The case for subcortical ischemic depression.” Biol Psychiatry 60, no. 12 (December 15, 2006): 1299–1303. https://doi.org/10.1016/j.biopsych.2006.05.028.
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    • Hannestad, Jonas, Warren D. Taylor, Douglas R. McQuoid, Martha E. Payne, K Ranga R. Krishnan, David C. Steffens, and James R. Macfall. “White matter lesion volumes and caudate volumes in late-life depression.” Int J Geriatr Psychiatry 21, no. 12 (December 2006): 1193–98. https://doi.org/10.1002/gps.1640.
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    • Plassman, Brenda L., David C. Steffens, James R. Burke, Kathleen A. Welsh-Bohmer, Tiffany N. Newman, Deborah Drosdick, Michael J. Helms, Guy G. Potter, and John C. S. Breitner. “Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.” Twin Res Hum Genet 9, no. 6 (December 2006): 950–57. https://doi.org/10.1375/183242706779462381.
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    • Xiong, Glen L., Brenda L. Plassman, Michael J. Helms, and David C. Steffens. “Vascular risk factors and cognitive decline among elderly male twins.” Neurology 67, no. 9 (November 14, 2006): 1586–91. https://doi.org/10.1212/01.wnl.0000242730.44003.1d.
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    • Greenberg, Daniel L., Martha E. Payne, James R. MacFall, James M. Provenzale, David C. Steffens, and Ranga R. Krishnan. “Differences in brain volumes among males and female hormone-therapy users and nonusers.” Psychiatry Res 147, no. 2–3 (October 30, 2006): 127–34. https://doi.org/10.1016/j.pscychresns.2006.01.001.
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    • Unützer, Jürgen, Lingqi Tang, Sabine Oishi, Wayne Katon, John W. Williams, Enid Hunkeler, Hugh Hendrie, et al. “Reducing suicidal ideation in depressed older primary care patients.” J Am Geriatr Soc 54, no. 10 (October 2006): 1550–56. https://doi.org/10.1111/j.1532-5415.2006.00882.x.
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    • Chen, Po See, Douglas R. McQuoid, Martha E. Payne, and David C. Steffens. “White matter and subcortical gray matter lesion volume changes and late-life depression outcome: a 4-year magnetic resonance imaging study.” Int Psychogeriatr 18, no. 3 (September 2006): 445–56. https://doi.org/10.1017/S1041610205002796.
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    • Payne, Martha E., Celia F. Hybels, Connie W. Bales, and David C. Steffens. “Vascular nutritional correlates of late-life depression.” Am J Geriatr Psychiatry 14, no. 9 (September 2006): 787–95. https://doi.org/10.1097/01.JGP.0000203168.28872.21.
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    • Steinberg, M., C. Corcoran, J. T. Tschanz, C. Huber, K. Welsh-Bohmer, M. C. Norton, P. Zandi, J. C. S. Breitner, D. C. Steffens, and C. G. Lyketsos. “Risk factors for neuropsychiatric symptoms in dementia: the Cache County Study.” Int J Geriatr Psychiatry 21, no. 9 (September 2006): 824–30. https://doi.org/10.1002/gps.1567.
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    • MacFall, James R., Warren D. Taylor, David E. Rex, Steve Pieper, Martha E. Payne, Douglas R. McQuoid, David C. Steffens, Ron Kikinis, Arthur W. Toga, and K Ranga Rama Krishnan. “Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN).” Neuropsychopharmacology 31, no. 7 (July 2006): 1500–1507. https://doi.org/10.1038/sj.npp.1300986.
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    • Sheline, Yvette I., Deanna M. Barch, Keith Garcia, Kenneth Gersing, Carl Pieper, Kathleen Welsh-Bohmer, David C. Steffens, and P Murali Doraiswamy. “Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed.” Biol Psychiatry 60, no. 1 (July 1, 2006): 58–65. https://doi.org/10.1016/j.biopsych.2005.09.019.
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    • Yaffe, Kristine, and David Steffens. “Epidemiology of mental health: a keystone of geriatric psychiatry.” Am J Geriatr Psychiatry 14, no. 6 (June 2006): 477–79. https://doi.org/10.1097/01.JGP.0000222934.91587.86.
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    • Lyketsos, Constantine G., Leslie Toone, Joann Tschanz, Christopher Corcoran, Maria Norton, Peter Zandi, Ron Munger, John C. S. Breitner, Kathleen Welsh-Bohmer, and Kathleen Cache County Study Group. “A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: the Cache County study.” Int J Geriatr Psychiatry 21, no. 6 (June 2006): 509–18. https://doi.org/10.1002/gps.1502.
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    • Norton, Maria C., Ingmar Skoog, Lynn M. Franklin, Christopher Corcoran, JoAnn T. Tschanz, Peter P. Zandi, John C. S. Breitner, Kathleen A. Welsh-Bohmer, David C. Steffens, and David C. Cache County Investigators. “Gender differences in the association between religious involvement and depression: the Cache County (Utah) study.” J Gerontol B Psychol Sci Soc Sci 61, no. 3 (May 2006): P129–36. https://doi.org/10.1093/geronb/61.3.p129.
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    • Steffens, David C., Mark Snowden, Ming-Yu Fan, Hugh Hendrie, Wayne J. Katon, Jürgen Unützer, and Jürgen IMPACT Investigators. “Cognitive impairment and depression outcomes in the IMPACT study.” Am J Geriatr Psychiatry 14, no. 5 (May 2006): 401–9. https://doi.org/10.1097/01.JGP.0000194646.65031.3f.
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    • Hybels, Celia F., Dan G. Blazer, and David C. Steffens. “Partial remission. A common outcome in older adults treated for major depression.” Geriatrics 61, no. 4 (April 2006): 22–26.
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    • Lekwauwa, Ruby, Douglas McQuoid, and David C. Steffens. “Hippocampal volume is associated with physician-reported acute cognitive deficits after electroconvulsive therapy.” J Geriatr Psychiatry Neurol 19, no. 1 (March 2006): 21–25. https://doi.org/10.1177/0891988705284724.
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    • Norton, Maria C., Ingmar Skoog, Leslie Toone, Christopher Corcoran, Joann T. Tschanz, Robert D. Lisota, Andrea D. Hart, et al. “Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study.” Am J Geriatr Psychiatry 14, no. 3 (March 2006): 237–45. https://doi.org/10.1097/01.JGP.0000196626.34881.42.
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    • Gum, Amber M., Patricia A. Areán, Enid Hunkeler, Lingqi Tang, Wayne Katon, Polly Hitchcock, David C. Steffens, Jeanne Dickens, and Jürgen Unützer. “Depression treatment preferences in older primary care patients.” Gerontologist 46, no. 1 (February 2006): 14–22. https://doi.org/10.1093/geront/46.1.14.
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    • Steffens, David C., Emeline Otey, George S. Alexopoulos, Meryl A. Butters, Bruce Cuthbert, Mary Ganguli, Yonas E. Geda, et al. “Perspectives on depression, mild cognitive impairment, and cognitive decline.” Arch Gen Psychiatry 63, no. 2 (February 2006): 130–38. https://doi.org/10.1001/archpsyc.63.2.130.
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    • Jeste, Neelum D., Judith C. Hays, and David C. Steffens. “Clinical correlates of anxious depression among elderly patients with depression.” J Affect Disord 90, no. 1 (January 2006): 37–41. https://doi.org/10.1016/j.jad.2005.10.007.
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    • Roose, S. P., A. Glassman, S. J. Mathew, D. Musselman, J. C. Nelson, and D. C. Steffens. “Managing patients with vascular disease and depression.” Journal of Clinical Psychiatry 67, no. 10 (January 1, 2006): 1633–44. https://doi.org/10.4088/JCP.v67n1021.
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    • Sair, Haris I., Kathleen A. Welsh-Bohmer, H Ryan Wagner, and David C. Steffens. “Ascending digits task as a measure of executive function in geriatric depression.” J Neuropsychiatry Clin Neurosci 18, no. 1 (2006): 117–20. https://doi.org/10.1176/jnp.18.1.117.
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    • Plassman, Brenda L., Ara S. Khachaturian, Jeannette J. Townsend, Melvyn J. Ball, David C. Steffens, Carol E. Leslie, JoAnn T. Tschanz, et al. “Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.” Alzheimers Dement 2, no. 1 (January 2006): 2–11. https://doi.org/10.1016/j.jalz.2005.11.001.
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    • Hybels, Celia F., David C. Steffens, Douglas R. McQuoid, and K Ranga Rama Krishnan. “Residual symptoms in older patients treated for major depression.” Int J Geriatr Psychiatry 20, no. 12 (December 2005): 1196–1202. https://doi.org/10.1002/gps.1418.
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    • Lekwauwa, Ruby E., Douglas R. McQuoid, and David C. Steffens. “Hippocampal volume as a predictor of short-term ECT outcomes in older patients with depression.” Am J Geriatr Psychiatry 13, no. 10 (October 2005): 910–13. https://doi.org/10.1176/appi.ajgp.13.10.910.
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    • Steffens, David C. “Research in geriatric depression: a model for mental health research in the 21st century?” Am J Geriatr Psychiatry 13, no. 10 (October 2005): 829–33. https://doi.org/10.1176/appi.ajgp.13.10.829.
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    • Gopal, Srihari, David C. Steffens, Michelle L. Kramer, and Maren K. Olsen. “Symptomatic remission in patients with bipolar mania: results from a double-blind, placebo-controlled trial of risperidone monotherapy.” J Clin Psychiatry 66, no. 8 (August 2005): 1016–20. https://doi.org/10.4088/jcp.v66n0809.
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    • Hybels, Celia F., Dan G. Blazer, and David C. Steffens. “Predictors of partial remission in older patients treated for major depression: the role of comorbid dysthymia.” Am J Geriatr Psychiatry 13, no. 8 (August 2005): 713–21. https://doi.org/10.1176/appi.ajgp.13.8.713.
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    • Goldstein, Karen M., Linda H. Harpole, Karen M. Stechuchak, Cynthia J. Coffman, Hayden B. Bosworth, David C. Steffens, and Lori A. Bastian. “Hormone therapy does not affect depression severity in older women.” Am J Geriatr Psychiatry 13, no. 7 (July 2005): 616–23. https://doi.org/10.1176/appi.ajgp.13.7.616.
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    • Taylor, Warren D., James R. MacFall, Martha E. Payne, Douglas R. McQuoid, David C. Steffens, James M. Provenzale, and Ranga Rama Krishnan. “Greater MRI lesion volumes in elderly depressed subjects than in control subjects.” Psychiatry Res 139, no. 1 (May 30, 2005): 1–7. https://doi.org/10.1016/j.pscychresns.2004.08.004.
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    • Taylor, Warren D., David C. Steffens, Martha E. Payne, James R. MacFall, Douglas A. Marchuk, Ingrid K. Svenson, and K Ranga R. Krishnan. “Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression.” Arch Gen Psychiatry 62, no. 5 (May 2005): 537–44. https://doi.org/10.1001/archpsyc.62.5.537.
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    • Steffens, David C., Carl F. Pieper, Hayden B. Bosworth, James R. MacFall, James M. Provenzale, Martha E. Payne, Bernard J. Carroll, Linda K. George, and K Ranga R. Krishnan. “Biological and social predictors of long-term geriatric depression outcome.” Int Psychogeriatr 17, no. 1 (March 2005): 41–56. https://doi.org/10.1017/s1041610205000979.
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    • Voils, Corrine I., David C. Steffens, Elizabeth P. Flint, and Hayden B. Bosworth. “Social support and locus of control as predictors of adherence to antidepressant medication in an elderly population.” Am J Geriatr Psychiatry 13, no. 2 (February 2005): 157–65. https://doi.org/10.1176/appi.ajgp.13.2.157.
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    • Langa, Kenneth M., Brenda L. Plassman, Robert B. Wallace, A Regula Herzog, Steven G. Heeringa, Mary Beth Ofstedal, James R. Burke, et al. “The Aging, Demographics, and Memory Study: study design and methods.” Neuroepidemiology 25, no. 4 (2005): 181–91. https://doi.org/10.1159/000087448.
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    • Steffens, David C., Margaret Maytan, Michael J. Helms, and Brenda L. Plassman. “Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.” Am J Alzheimers Dis Other Demen 20, no. 6 (2005): 367–73. https://doi.org/10.1177/153331750502000611.
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    • Steffens, David C., and Douglas R. McQuoid. “Impact of symptoms of generalized anxiety disorder on the course of late-life depression.” Am J Geriatr Psychiatry 13, no. 1 (January 2005): 40–47. https://doi.org/10.1176/appi.ajgp.13.1.40.
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    • Tschanz, Joann T., Katherine Treiber, Maria C. Norton, Kathleen A. Welsh-Bohmer, Leslie Toone, Peter P. Zandi, Christine A. Szekely, Constantine Lyketsos, John C. S. Breitner, and John C. S. Cache County Study Group. “A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.” Care Manag J 6, no. 2 (2005): 107–14. https://doi.org/10.1891/cmaj.6.2.107.
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    • Potter, G. G., B. L. Plassman, M. J. Helms, D. C. Steffens, and K. A. Welsh-Bohmer. “Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.” Neurology 63, no. 12 (December 28, 2004): 2245–49. https://doi.org/10.1212/01.wnl.0000147291.49404.0a.
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    • Potter, Guy G., Joshua D. Kittinger, H Ryan Wagner, David C. Steffens, and K Ranga Rama Krishnan. “Prefrontal neuropsychological predictors of treatment remission in late-life depression.” Neuropsychopharmacology 29, no. 12 (December 2004): 2266–71. https://doi.org/10.1038/sj.npp.1300551.
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    • Taylor, Warren D., Douglas R. McQuoid, David C. Steffens, and K Ranga Rama Krishnan. “Is there a definition of remission in late-life depression that predicts later relapse?” Neuropsychopharmacology 29, no. 12 (December 2004): 2272–77. https://doi.org/10.1038/sj.npp.1300549.
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    • Steffens, David C., Kathleen A. Welsh-Bohmer, James R. Burke, Brenda L. Plassman, John L. Beyer, Kenneth R. Gersing, and Guy G. Potter. “Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.” J Geriatr Psychiatry Neurol 17, no. 4 (December 2004): 202–11. https://doi.org/10.1177/0891988704269819.
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    • Steffens, David C. “Establishing diagnostic criteria for vascular depression.” J Neurol Sci 226, no. 1–2 (November 15, 2004): 59–62. https://doi.org/10.1016/j.jns.2004.09.013.
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    • Taylor, Warren D., James R. MacFall, Martha E. Payne, Douglas R. McQuoid, James M. Provenzale, David C. Steffens, and K Ranga Rama Krishnan. “Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter.” Am J Psychiatry 161, no. 7 (July 2004): 1293–96. https://doi.org/10.1176/appi.ajp.161.7.1293.
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    • Steffens, D. C. “Depression in the elderly: A timely update.” Primary Psychiatry 11, no. 5 (May 1, 2004): 30.
    • Douris, P., A. Chinan, M. Gomez, A. Aw, D. Steffens, and S. Weiss. “Fitness levels of middle aged martial art practitioners.” Br J Sports Med 38, no. 2 (April 2004): 143–47. https://doi.org/10.1136/bjsm.2002.001768.
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    • Krishnan, K Ranga Rama, Warren D. Taylor, Douglas R. McQuoid, James R. MacFall, Martha E. Payne, James M. Provenzale, and David C. Steffens. “Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression.” Biol Psychiatry 55, no. 4 (February 15, 2004): 390–97. https://doi.org/10.1016/j.biopsych.2003.08.014.
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    • Doraiswamy, P Murali, David C. Steffens, and Douglas R. McQuoid. “Statin use and hippocampal volumes in elderly subjects at risk for Alzheimer's disease: a pilot observational study.” Am J Alzheimers Dis Other Demen 19, no. 5 (2004): 275–78. https://doi.org/10.1177/153331750401900506.
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    • Steinberg, Martin, JoAnn T. Tschanz, Christopher Corcoran, David C. Steffens, Maria C. Norton, Constantine G. Lyketsos, and John C. S. Breitner. “The persistence of neuropsychiatric symptoms in dementia: the Cache County Study.” Int J Geriatr Psychiatry 19, no. 1 (January 2004): 19–26. https://doi.org/10.1002/gps.1025.
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    • Olin, J. T., L. S. Schneider, I. R. Katz, B. S. Meyers, G. S. Alexopoulos, J. C. Breitner, M. L. Bruce, et al. “Diagnostic criteria for Depression of Alzheimer disease (DAD).” Research and Practice in Alzheimer’S Disease 7 (December 1, 2003): 174–79.
    • Steffens, David C., Douglas R. McQuoid, Kathleen A. Welsh-Bohmer, and K Ranga Rama Krishnan. “Left orbital frontal cortex volume and performance on the benton visual retention test in older depressives and controls.” Neuropsychopharmacology 28, no. 12 (December 2003): 2179–83. https://doi.org/10.1038/sj.npp.1300285.
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    • Bosworth, Hayden B., Rachel M. Bartash, Maren K. Olsen, and David C. Steffens. “The association of psychosocial factors and depression with hypertension among older adults.” Int J Geriatr Psychiatry 18, no. 12 (December 2003): 1142–48. https://doi.org/10.1002/gps.1026.
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    • Taylor, Warren D., David C. Steffens, James R. MacFall, Douglas R. McQuoid, Martha E. Payne, James M. Provenzale, and K Ranga Rama Krishnan. “White matter hyperintensity progression and late-life depression outcomes.” Arch Gen Psychiatry 60, no. 11 (November 2003): 1090–96. https://doi.org/10.1001/archpsyc.60.11.1090.
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    • Steffens, David C., Warren D. Taylor, and K Ranga Rama Krishnan. “Progression of subcortical ischemic disease from vascular depression to vascular dementia.” Am J Psychiatry 160, no. 10 (October 2003): 1751–56. https://doi.org/10.1176/appi.ajp.160.10.1751.
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    • Steffens, David C., William T. Trost, Martha E. Payne, Celia F. Hybels, and James R. MacFall. “Apolipoprotein E genotype and subcortical vascular lesions in older depressed patients and control subjects.” Biol Psychiatry 54, no. 7 (October 1, 2003): 674–81. https://doi.org/10.1016/s0006-3223(02)01782-1.
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    • Bosworth, Hayden B., Kwang-Soo Park, Douglas R. McQuoid, Judith C. Hays, and David C. Steffens. “The impact of religious practice and religious coping on geriatric depression.” Int J Geriatr Psychiatry 18, no. 10 (October 2003): 905–14. https://doi.org/10.1002/gps.945.
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    • Lee, Shwu-Hua, Martha E. Payne, David C. Steffens, Douglas R. McQuoid, Te-Jen Lai, James M. Provenzale, and K Ranga Rama Krishnan. “Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression.” Biol Psychiatry 54, no. 5 (September 1, 2003): 529–33. https://doi.org/10.1016/s0006-3223(03)00063-5.
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    • Taylor, Warren D., James R. MacFall, James M. Provenzale, Martha E. Payne, Douglas R. McQuoid, David C. Steffens, and K Ranga Rama Krishnan. “Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors.” Ajr Am J Roentgenol 181, no. 2 (August 2003): 571–76. https://doi.org/10.2214/ajr.181.2.1810571.
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    • Taylor, Warren D., James R. MacFall, David C. Steffens, Martha E. Payne, James M. Provenzale, and K Ranga Rama Krishnan. “Localization of age-associated white matter hyperintensities in late-life depression.” Prog Neuropsychopharmacol Biol Psychiatry 27, no. 3 (May 2003): 539–44. https://doi.org/10.1016/S0278-5846(02)00358-5.
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    • Steffens, D. C., M. C. Norton, A. D. Hart, I. Skoog, C. Corcoran, J. C. S. Breitner, and J. C. S. Cache County Study Group. “Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study.” Psychol Med 33, no. 3 (April 2003): 541–47. https://doi.org/10.1017/s0033291702007201.
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    • Brummett, Beverly H., Ilene C. Siegler, Douglas R. McQuoid, Ingrid K. Svenson, Douglas A. Marchuk, and David C. Steffens. “Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender.” Psychiatr Genet 13, no. 1 (March 2003): 13–18. https://doi.org/10.1097/00041444-200303000-00002.
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    • Taylor, Warren D., David C. Steffens, Douglas R. McQuoid, Martha E. Payne, Shwu-Hua Lee, Te-Jen Lai, and K Ranga Rama Krishnan. “Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.” Biol Psychiatry 53, no. 2 (January 15, 2003): 144–49. https://doi.org/10.1016/s0006-3223(02)01490-7.
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    • Olin, Jason T., Lon S. Schneider, Ira R. Katz, Barnett S. Meyers, George S. Alexopoulos, John C. Breitner, Martha L. Bruce, et al. “Provisional diagnostic criteria for depression of Alzheimer's disease: description and review.” Expert Rev Neurother 3, no. 1 (January 2003): 99–106. https://doi.org/10.1586/14737175.3.1.99.
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    • Steinberg, Martin, Jeannie-Marie Sheppard, JoAnn T. Tschanz, Maria C. Norton, David C. Steffens, John C. S. Breitner, and Constantine G. Lyketsos. “The incidence of mental and behavioral disturbances in dementia: the cache county study.” J Neuropsychiatry Clin Neurosci 15, no. 3 (2003): 340–45. https://doi.org/10.1176/jnp.15.3.340.
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    • Harpole, Linda H., Karen M. Stechuchak, Carol D. Saur, David C. Steffens, Jürgen Unützer, and Eugene Oddone. “Implementing a disease management intervention for depression in primary care: a random work sampling study.” Gen Hosp Psychiatry 25, no. 4 (2003): 238–45. https://doi.org/10.1016/s0163-8343(03)00023-9.
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    • Levy, Robert M., David C. Steffens, Douglas R. McQuoid, James M. Provenzale, James R. MacFall, and K Ranga Rama Krishnan. “MRI lesion severity and mortality in geriatric depression.” Am J Geriatr Psychiatry 11, no. 6 (2003): 678–82. https://doi.org/10.1176/appi.ajgp.11.6.678.
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    • Parker, R. D., Elizabeth P. Flint, Hayden B. Bosworth, Carl F. Pieper, and David C. Steffens. “A three-factor analytic model of the MADRS in geriatric depression.” Int J Geriatr Psychiatry 18, no. 1 (January 2003): 73–77. https://doi.org/10.1002/gps.776.
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    • Steffens, David C., Douglas R. McQuoid, and K Ranga Rama Krishnan. “Partial response as a predictor of outcome in geriatric depression.” Am J Geriatr Psychiatry 11, no. 3 (2003): 340–48.
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    • Steffens, David C., Douglas R. McQuoid, and K Ranga Rama Krishnan. “Cholesterol-lowering medication and relapse of depression.” Psychopharmacol Bull 37, no. 4 (2003): 92–98.
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    • Zandi, Peter P., Michelle C. Carlson, Brenda L. Plassman, Kathleen A. Welsh-Bohmer, Lawrence S. Mayer, David C. Steffens, John C. S. Breitner, and John C. S. Cache County Memory Study Investigators. “Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.” Jama 288, no. 17 (November 6, 2002): 2123–29. https://doi.org/10.1001/jama.288.17.2123.
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    • Ahearn, Eileen P., Marcy C. Speer, Y. T. Chen, David C. Steffens, Frederick Cassidy, Susan Van Meter, James M. Provenzale, Richard H. Weisler, and K Ranga Rama Krishnan. “Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype.” Am J Med Genet 114, no. 6 (August 8, 2002): 652–58. https://doi.org/10.1002/ajmg.10512.
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    • Tupler, Larry A., K Ranga R. Krishnan, William M. McDonald, Carrie B. Dombeck, Sean D’Souza, and David C. Steffens. “Anatomic location and laterality of MRI signal hyperintensities in late-life depression.” J Psychosom Res 53, no. 2 (August 2002): 665–76. https://doi.org/10.1016/s0022-3999(02)00425-7.
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    • Siegler, Ilene C., Lori A. Bastian, David C. Steffens, Hayden B. Bosworth, and Paul T. Costa. “Behavioral medicine and aging.” J Consult Clin Psychol 70, no. 3 (June 2002): 843–51. https://doi.org/10.1037//0022-006x.70.3.843.
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    • Steffens, David C., K Ranga Rama Krishnan, Casey Crump, and Gregory L. Burke. “Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study.” Stroke 33, no. 6 (June 2002): 1636–44. https://doi.org/10.1161/01.str.0000018405.59799.d5.
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    • Hsieh, Ming-Hong, Douglas R. McQuoid, Robert M. Levy, Martha E. Payne, James R. MacFall, and David C. Steffens. “Hippocampal volume and antidepressant response in geriatric depression.” Int J Geriatr Psychiatry 17, no. 6 (June 2002): 519–25. https://doi.org/10.1002/gps.611.
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    • Kim, Do Hoon, Martha E. Payne, Robert M. Levy, James R. MacFall, and David C. Steffens. “APOE genotype and hippocampal volume change in geriatric depression.” Biol Psychiatry 51, no. 5 (March 1, 2002): 426–29. https://doi.org/10.1016/s0006-3223(01)01272-0.
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    • Bosworth, Hayden B., Judith C. Hays, Linda K. George, and David C. Steffens. “Psychosocial and clinical predictors of unipolar depression outcome in older adults.” Int J Geriatr Psychiatry 17, no. 3 (March 2002): 238–46. https://doi.org/10.1002/gps.590.
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    • Tschanz, JoAnn T., Kathleen A. Welsh-Bohmer, Brenda L. Plassman, Maria C. Norton, Bonita W. Wyse, John C. S. Breitner, and John C. S. Cache County Study Group. “An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study.” Neuropsychiatry Neuropsychol Behav Neurol 15, no. 1 (March 2002): 28–38.
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    • Saur, C. D., L. H. Harpole, D. C. Steffens, C. D. Fulcher, Y. Porterfield, R. Haverkamp, D. Kivett, and J. Unützer. “Treating depression in primary care: An innovative role for mental health nurses.” Journal of the American Psychiatric Nurses Association 8, no. 5 (January 1, 2002): 159–67. https://doi.org/10.1067/mpn.2002.128680.
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    • Bosworth, Hayden B., Douglas R. McQuoid, Linda K. George, and David C. Steffens. “Time-to-remission from geriatric depression: psychosocial and clinical factors.” Am J Geriatr Psychiatry 10, no. 5 (2002): 551–59.
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    • Holsinger, Tracey, David C. Steffens, Caroline Phillips, Michael J. Helms, Richard J. Havlik, John C. S. Breitner, Jack M. Guralnik, and Brenda L. Plassman. “Head injury in early adulthood and the lifetime risk of depression.” Arch Gen Psychiatry 59, no. 1 (January 2002): 17–22. https://doi.org/10.1001/archpsyc.59.1.17.
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    • Olin, Jason T., Lon S. Schneider, Ira R. Katz, Barnett S. Meyers, George S. Alexopoulos, John C. Breitner, Martha L. Bruce, et al. “Provisional diagnostic criteria for depression of Alzheimer disease.” Am J Geriatr Psychiatry 10, no. 2 (2002): 125–28.
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    • Steffens, David C., Douglas R. McQuoid, and K Ranga Rama Krishnan. “The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach.” Psychopharmacol Bull 36, no. 2 (2002): 58–68.
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    • Steffens, David C., Hayden B. Bosworth, James M. Provenzale, and James R. MacFall. “Subcortical white matter lesions and functional impairment in geriatric depression.” Depress Anxiety 15, no. 1 (2002): 23–28. https://doi.org/10.1002/da.1081.
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    • Steffens, David C., Ingrid Svenson, Douglas A. Marchuk, Robert M. Levy, Judith C. Hays, Elizabeth P. Flint, K Ranga Rama Krishnan, and Ilene C. Siegler. “Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression.” Am J Geriatr Psychiatry 10, no. 2 (2002): 185–91.
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    • Steffens, David C., Martha E. Payne, Daniel L. Greenberg, Christopher E. Byrum, Kathleen A. Welsh-Bohmer, H Ryan Wagner, and James R. MacFall. “Hippocampal volume and incident dementia in geriatric depression.” Am J Geriatr Psychiatry 10, no. 1 (2002): 62–71.
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    • Steffens, David C., Robert M. Levy, Ryan Wagner, Douglas R. McQuoid, K Ranga Rama Krishnan, and Bernard J. Carroll. “Sociodemographic and clinical predictors of mortality in geriatric depression.” Am J Geriatr Psychiatry 10, no. 5 (2002): 531–40.
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    • Taylor, Warren D., H Ryan Wagner, and David C. Steffens. “Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects.” Am J Geriatr Psychiatry 10, no. 5 (2002): 632–35.
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    • Carlson, M. C., P. P. Zandi, B. L. Plassman, J. T. Tschanz, K. A. Welsh-Bohmer, D. C. Steffens, L. A. Bastian, K. M. Mehta, J. C. Breitner, and J. C. Cache County Study Group. “Hormone replacement therapy and reduced cognitive decline in older women: the Cache County Study.” Neurology 57, no. 12 (December 26, 2001): 2210–16. https://doi.org/10.1212/wnl.57.12.2210.
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    • Hays, J. C., D. C. Steffens, E. P. Flint, H. B. Bosworth, and L. K. George. “Does social support buffer functional decline in elderly patients with unipolar depression?” Am J Psychiatry 158, no. 11 (November 2001): 1850–55. https://doi.org/10.1176/appi.ajp.158.11.1850.
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    • Lyketsos, C. G., J. M. Sheppard, M. Steinberg, J. A. Tschanz, M. C. Norton, D. C. Steffens, and J. C. Breitner. “Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study.” Int J Geriatr Psychiatry 16, no. 11 (November 2001): 1043–53. https://doi.org/10.1002/gps.448.
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    • Steffens, D. C., H. R. Wagner, R. M. Levy, K. A. Horn, and K. R. Krishnan. “Performance feedback deficit in geriatric depression.” Biol Psychiatry 50, no. 5 (September 1, 2001): 358–63. https://doi.org/10.1016/s0006-3223(01)01165-9.
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    • Steffens, D. C., P. M. Doraiswamy, and D. R. McQuoid. “Bupropion SR in the naturalistic treatment of elderly patients with major depression.” Int J Geriatr Psychiatry 16, no. 9 (September 2001): 862–65. https://doi.org/10.1002/gps.424.
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    • Faison, W. E., and D. C. Steffens. “Diagnosis, epidemiology, and clinical course of geriatric depression.” Economics of Neuroscience 3, no. 7 (August 25, 2001): 40–43.
    • Ahearn, E. P., K. R. Jamison, D. C. Steffens, F. Cassidy, J. M. Provenzale, A. Lehman, R. H. Weisler, B. J. Carroll, and K. R. Krishnan. “MRI correlates of suicide attempt history in unipolar depression.” Biol Psychiatry 50, no. 4 (August 15, 2001): 266–70. https://doi.org/10.1016/s0006-3223(01)01098-8.
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    • Taylor, W. D., M. E. Payne, K. R. Krishnan, H. R. Wagner, J. M. Provenzale, D. C. Steffens, and J. R. MacFall. “Evidence of white matter tract disruption in MRI hyperintensities.” Biol Psychiatry 50, no. 3 (August 1, 2001): 179–83. https://doi.org/10.1016/s0006-3223(01)01160-x.
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    • Steffens, D. C., C. R. Conway, C. B. Dombeck, H. R. Wagner, L. A. Tupler, and R. D. Weiner. “Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression.” J Ect 17, no. 1 (March 2001): 45–49. https://doi.org/10.1097/00124509-200103000-00009.
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    • Bosworth, H. B., L. A. Bastian, M. N. Kuchibhatla, D. C. Steffens, C. M. McBride, C. S. Skinner, B. K. Rimer, and I. C. Siegler. “Depressive symptoms, menopausal status, and climacteric symptoms in women at midlife.” Psychosom Med 63, no. 4 (2001): 603–8. https://doi.org/10.1097/00006842-200107000-00013.
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    • Brummett, B. H., J. C. Barefoot, I. C. Siegler, and D. C. Steffens. “Relation of subjective and received social support to clinical and self-report assessments of depressive symptoms in an elderly population.” J Affect Disord 61, no. 1–2 (December 2000): 41–50. https://doi.org/10.1016/s0165-0327(99)00191-3.
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    • Lai, T., M. E. Payne, C. E. Byrum, D. C. Steffens, and K. R. Krishnan. “Reduction of orbital frontal cortex volume in geriatric depression.” Biol Psychiatry 48, no. 10 (November 15, 2000): 971–75. https://doi.org/10.1016/s0006-3223(00)01042-8.
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    • Steffens, D. C., J. R. MacFall, M. E. Payne, K. A. Welsh-Bohmer, and K. R. Krishnan. “Grey-matter lesions and dementia.” Lancet 356, no. 9242 (November 11, 2000): 1686–87. https://doi.org/10.1016/S0140-6736(05)70393-7.
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    • Plassman, B. L., R. J. Havlik, D. C. Steffens, M. J. Helms, T. N. Newman, D. Drosdick, C. Phillips, et al. “Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias.” Neurology 55, no. 8 (October 24, 2000): 1158–66. https://doi.org/10.1212/wnl.55.8.1158.
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    • Steffens, D. C., C. E. Byrum, D. R. McQuoid, D. L. Greenberg, M. E. Payne, T. F. Blitchington, J. R. MacFall, and K. R. Krishnan. “Hippocampal volume in geriatric depression.” Biol Psychiatry 48, no. 4 (August 15, 2000): 301–9. https://doi.org/10.1016/s0006-3223(00)00829-5.
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    • Steffens, D. C., I. Skoog, M. C. Norton, A. D. Hart, J. T. Tschanz, B. L. Plassman, B. W. Wyse, K. A. Welsh-Bohmer, and J. C. Breitner. “Prevalence of depression and its treatment in an elderly population: the Cache County study.” Arch Gen Psychiatry 57, no. 6 (June 2000): 601–7. https://doi.org/10.1001/archpsyc.57.6.601.
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    • Lyketsos, C. G., M. Steinberg, J. T. Tschanz, M. C. Norton, D. C. Steffens, and J. C. Breitner. “Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging.” Am J Psychiatry 157, no. 5 (May 2000): 708–14. https://doi.org/10.1176/appi.ajp.157.5.708.
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    • Steffens, D. C., B. L. Plassman, M. J. Helms, K. A. Welsh-Bohmer, T. T. Newman, and J. C. Breitner. “APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives.” Neurology 54, no. 3 (February 8, 2000): 593–98. https://doi.org/10.1212/wnl.54.3.593.
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    • Garside, S., P. I. Rosebush, A. J. Levinson, and M. F. Mazurek. “Magnetic resonance imaging abnormalities and psychiatric illness.” Am J Psychiatry 157, no. 2 (February 2000): 306–7. https://doi.org/10.1176/appi.ajp.157.2.306-b.
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    • Bosworth, H. B., D. C. Steffens, M. N. Kuchibhatla, W. J. Jiang, R. M. Arias, C. M. O’Connor, and K. R. R. Krishnan. “The relationship of social support, social networks and negative events with depression in patients with coronary artery disease.” Aging and Mental Health 4, no. 3 (January 1, 2000): 253–58. https://doi.org/10.1080/713649927.
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    • Conway, C. R., and D. C. Steffens. “Geriatric depression: Further evidence for the 'vascular depression' hypothesis.” Current Opinion in Psychiatry 12, no. 4 (November 17, 1999): 463–70. https://doi.org/10.1097/00001504-199907000-00015.
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    • Steffens, D. C., and J. C. Morgenlander. “Initial evaluation of suspected dementia. Asking the right questions.” Postgrad Med 106, no. 5 (October 15, 1999): 72–83. https://doi.org/10.3810/pgm.1999.10.15.745.
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    • Steffens, D. C., M. C. Norton, B. L. Plassman, J. T. Tschanz, B. W. Wyse, K. A. Welsh-Bohmer, J. C. Anthony, and J. C. Breitner. “Enhanced cognitive performance with estrogen use in nondemented community-dwelling older women.” J Am Geriatr Soc 47, no. 10 (October 1999): 1171–75. https://doi.org/10.1111/j.1532-5415.1999.tb05195.x.
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    • Steffens, D. C., M. J. Helms, K. R. Krishnan, and G. L. Burke. “Cerebrovascular disease and depression symptoms in the cardiovascular health study.” Stroke 30, no. 10 (October 1999): 2159–66. https://doi.org/10.1161/01.str.30.10.2159.
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    • Breitner, J. C., B. W. Wyse, J. C. Anthony, K. A. Welsh-Bohmer, D. C. Steffens, M. C. Norton, J. T. Tschanz, et al. “APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.” Neurology 53, no. 2 (July 22, 1999): 321–31. https://doi.org/10.1212/wnl.53.2.321.
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    • Steffens, D. C., C. M. O’Connor, W. J. Jiang, C. F. Pieper, M. N. Kuchibhatla, R. M. Arias, A. Look, C. Davenport, M. B. Gonzalez, and K. R. Krishnan. “The effect of major depression on functional status in patients with coronary artery disease.” J Am Geriatr Soc 47, no. 3 (March 1999): 319–22. https://doi.org/10.1111/j.1532-5415.1999.tb02995.x.
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    • Steffens, D. C., J. C. Hays, and K. R. Krishnan. “Disability in geriatric depression.” Am J Geriatr Psychiatry 7, no. 1 (1999): 34–40.
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    • Ahearn, E. P., D. C. Steffens, F. Cassidy, S. A. Van Meter, J. M. Provenzale, M. F. Seldin, R. H. Weisler, and K. R. Krishnan. “Familial leukoencephalopathy in bipolar disorder.” Am J Psychiatry 155, no. 11 (November 1998): 1605–7. https://doi.org/10.1176/ajp.155.11.1605.
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    • Doraiswamy, P. M., and D. C. Steffens. “Combination therapy for early Alzheimer's disease: what are we waiting for?” J Am Geriatr Soc 46, no. 10 (October 1998): 1322–24. https://doi.org/10.1111/j.1532-5415.1998.tb04556.x.
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    • Steffens, D. C., L. A. Tupler, K. Ranga, and R. Krishnan. “Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients.” Psychiatry Res 83, no. 2 (August 26, 1998): 95–103. https://doi.org/10.1016/s0925-4927(98)00032-8.
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    • Meyer, M. R., J. T. Tschanz, M. C. Norton, K. A. Welsh-Bohmer, D. C. Steffens, B. W. Wyse, and J. C. Breitner. “APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease.” Nat Genet 19, no. 4 (August 1998): 321–22. https://doi.org/10.1038/1206.
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    • Steffens, D. C., and K. R. Krishnan. “Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions.” Biol Psychiatry 43, no. 10 (May 15, 1998): 705–12. https://doi.org/10.1016/s0006-3223(98)00084-5.
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    • Krystal, A. D., B. V. Watts, R. D. Weiner, S. Moore, D. C. Steffens, and V. Lindahl. “The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient.” J Ect 14, no. 1 (March 1998): 5–14.
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    • Steffens, D. C., and K. R. Rama Krishnan. “Psychotherapeutic agents in older adults. Metabolism, bioavailability, and drug interactions.” Clin Geriatr Med 14, no. 1 (February 1998): 17–31.
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    • Doraiswamy, P. M., D. C. Steffens, S. Pitchumoni, and S. Tabrizi. “Early recognition of Alzheimer's disease: what is consensual? What is controversial? What is practical?” J Clin Psychiatry 59 Suppl 13 (1998): 6–18.
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    • Steffens, D. C., D. L. Artigues, K. A. Ornstein, and K. R. Krishnan. “A review of racial differences in geriatric depression: implications for care and clinical research.” J Natl Med Assoc 89, no. 11 (November 1997): 731–36.
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    • Steffens, D. C., B. L. Plassman, M. J. Helms, K. A. Welsh-Bohmer, A. M. Saunders, and J. C. Breitner. “A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease.” Biol Psychiatry 41, no. 8 (April 15, 1997): 851–56. https://doi.org/10.1016/S0006-3223(96)00247-8.
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    • Steffens, D. C., K. R. Krishnan, and M. J. Helms. “Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: a meta-analysis.” Depress Anxiety 6, no. 1 (1997): 10–18. https://doi.org/10.1002/(sici)1520-6394(1997)6:1<10::aid-da2>3.0.co;2-9.
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    • Steffens, D. C., W. M. McDonald, L. A. Tupler, O. B. Boyko, and K. R. Krishnan. “Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects.” Psychiatry Res 68, no. 1 (November 25, 1996): 55–61. https://doi.org/10.1016/0925-4927(96)02834-x.
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    • Steffens, D. C., J. C. Hays, L. K. George, K. R. Krishnan, and D. G. Blazer. “Sociodemographic and clinical correlates of number of previous depressive episodes in the depressed elderly.” J Affect Disord 39, no. 2 (July 8, 1996): 99–106. https://doi.org/10.1016/0165-0327(96)00019-5.
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    • Steffens, D. C., K. A. Welsh, J. R. Burke, M. J. Helms, M. F. Folstein, J. Brandt, W. M. McDonald, and J. C. S. Breitner. “Diagnosis of Alzheimer's disease in epidemiologic studies by staged review of clinical data.” Neuropsychiatry, Neuropsychology and Behavioral Neurology 9, no. 2 (April 1, 1996): 107–13.
    • Steffens, D. C., and K. R. Krishnan. “Decision model for the acute treatment of mania.” Depress Anxiety 4, no. 6 (1996): 289–93. https://doi.org/10.1002/(SICI)1520-6394(1996)4:6<289::AID-DA5>3.0.CO;2-7.
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    • Steffens, D. C., A. D. Krystal, T. E. Sibert, S. D. Moore, and R. D. Weiner. “Cost effectiveness of maintenance ECT.” Convuls Ther 11, no. 4 (December 1995): 283–84.
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    • Breitner, J. C., K. A. Welsh, B. A. Gau, W. M. McDonald, D. C. Steffens, A. M. Saunders, K. M. Magruder, M. J. Helms, B. L. Plassman, and M. F. Folstein. “Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance.” Arch Neurol 52, no. 8 (August 1995): 763–71. https://doi.org/10.1001/archneur.1995.00540320035011.
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    • Jerrett, J. G., and D. C. Steffens. “Carbon monoxide-related organic mood disorder successfully treated with ECT.” J Clin Psychiatry 56, no. 7 (July 1995): 332–33.
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    • Muly, E. C., W. McDonald, D. Steffens, and S. Book. “Serotonin syndrome produced by a combination of fluoxetine and lithium.” Am J Psychiatry 150, no. 10 (October 1993): 1565. https://doi.org/10.1176/ajp.150.10.1565.
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    • Steffens, D. C., L. A. Tupler, and K. R. R. Krishnan. “The neurostructural/neurofunctional basis of depression/mania.” Current Opinion in Psychiatry 6, no. 1 (January 1, 1993): 22–26. https://doi.org/10.1097/00001504-199302000-00005.
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  • Book Sections

    • Jain, N., and D. C. Steffens. “Neurobiology and risk factors of late-life depression.” In Understanding Depression, 1:279–95, 2018. https://doi.org/10.1007/978-981-10-6580-4_23.
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    • Manning, K. J., and D. C. Steffens. “Systems Neuroscience in Late-Life Depression.” In Systems Neuroscience in Depression, 325–40, 2016. https://doi.org/10.1016/B978-0-12-802456-0.00011-X.
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    • Gardner, V., and D. C. Steffens. “Acute Management of Late-Life Depression.” In Principles and Practice of Geriatric Psychiatry: Third Edition, 552–54, 2010. https://doi.org/10.1002/9780470669600.ch88.
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    • Saur, C. D., and D. C. Steffens. “Adherence to treatment for depression.” In Improving Patient Treatment Adherence: A Clinician’s Guide, 241–57, 2010. https://doi.org/10.1007/978-1-4419-5866-2_10.
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  • Conference Papers

    • Zhang, Lintao, Minhui Yu, Lihong Wang, David C. Steffens, Rong Wu, Guy G. Potter, and Mingxia Liu. “Understanding Clinical Progression of Late-Life Depression to Alzheimer's Disease Over 5 Years with Structural MRI.” In Mach Learn Med Imaging, 13583:259–68, 2022. https://doi.org/10.1007/978-3-031-21014-3_27.
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    • Yang, E., L. Wang, D. Steffens, G. Potter, and M. Liu. “Deep factor regression for computer-aided analysis of major depressive disorders with structural MRI data.” In Proceedings  International Symposium on Biomedical Imaging, 2021-April:208–11, 2021. https://doi.org/10.1109/ISBI48211.2021.9433817.
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