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Risk factors and preventive interventions for Alzheimer disease: state of the science.

Publication ,  Journal Article
Daviglus, ML; Plassman, BL; Pirzada, A; Bell, CC; Bowen, PE; Burke, JR; Connolly, ES; Dunbar-Jacob, JM; Granieri, EC; McGarry, K; Patel, D ...
Published in: Arch Neurol
September 2011

BACKGROUND: Numerous studies have investigated risk factors for Alzheimer disease (AD). However, at a recent National Institutes of Health State-of-the-Science Conference, an independent panel found insufficient evidence to support the association of any modifiable factor with risk of cognitive decline or AD. OBJECTIVE: To present key findings for selected factors and AD risk that led the panel to their conclusion. DATA SOURCES: An evidence report was commissioned by the Agency for Healthcare Research and Quality. It included English-language publications in MEDLINE and the Cochrane Database of Systematic Reviews from 1984 through October 27, 2009. Expert presentations and public discussions were considered. STUDY SELECTION: Study inclusion criteria for the evidence report were participants aged 50 years and older from general populations in developed countries; minimum sample sizes of 300 for cohort studies and 50 for randomized controlled trials; at least 2 years between exposure and outcome assessment; and use of well-accepted diagnostic criteria for AD. DATA EXTRACTION: Included studies were evaluated for eligibility and data were abstracted. Quality of overall evidence for each factor was summarized as low, moderate, or high. DATA SYNTHESIS: Diabetes mellitus, hyperlipidemia in midlife, and current tobacco use were associated with increased risk of AD, and Mediterranean-type diet, folic acid intake, low or moderate alcohol intake, cognitive activities, and physical activity were associated with decreased risk. The quality of evidence was low for all of these associations. CONCLUSION: Currently, insufficient evidence exists to draw firm conclusions on the association of any modifiable factors with risk of AD.

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Published In

Arch Neurol

DOI

EISSN

1538-3687

Publication Date

September 2011

Volume

68

Issue

9

Start / End Page

1185 / 1190

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Neurology & Neurosurgery
  • Motor Activity
  • Hypertension
  • Hypercholesterolemia
  • Humans
  • Diabetes Complications
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
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Daviglus, M. L., Plassman, B. L., Pirzada, A., Bell, C. C., Bowen, P. E., Burke, J. R., … Williams, J. W. (2011). Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol, 68(9), 1185–1190. https://doi.org/10.1001/archneurol.2011.100
Daviglus, Martha L., Brenda L. Plassman, Amber Pirzada, Carl C. Bell, Phyllis E. Bowen, James R. Burke, E Sander Connolly, et al. “Risk factors and preventive interventions for Alzheimer disease: state of the science.Arch Neurol 68, no. 9 (September 2011): 1185–90. https://doi.org/10.1001/archneurol.2011.100.
Daviglus ML, Plassman BL, Pirzada A, Bell CC, Bowen PE, Burke JR, et al. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol. 2011 Sep;68(9):1185–90.
Daviglus, Martha L., et al. “Risk factors and preventive interventions for Alzheimer disease: state of the science.Arch Neurol, vol. 68, no. 9, Sept. 2011, pp. 1185–90. Pubmed, doi:10.1001/archneurol.2011.100.
Daviglus ML, Plassman BL, Pirzada A, Bell CC, Bowen PE, Burke JR, Connolly ES, Dunbar-Jacob JM, Granieri EC, McGarry K, Patel D, Trevisan M, Williams JW. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol. 2011 Sep;68(9):1185–1190.

Published In

Arch Neurol

DOI

EISSN

1538-3687

Publication Date

September 2011

Volume

68

Issue

9

Start / End Page

1185 / 1190

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Neurology & Neurosurgery
  • Motor Activity
  • Hypertension
  • Hypercholesterolemia
  • Humans
  • Diabetes Complications
  • Cohort Studies