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Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol.

Publication ,  Journal Article
Lawrence, KA; Pachner, TM; Long, MM; Henderson, S; Schuman, DL; Plassman, BL
Published in: BMJ Open
June 3, 2020

INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia. Individual epidemiological studies have controlled for several confounders of the relationship between PTSD and increased dementia risk, yet particular risk factors underlying this relationship have not been determined. This systematic review protocol aims to identify risk and protective factors of dementia among adults with PTSD. METHODS AND ANALYSIS: We will conduct an electronic search of the databases: PubMed, CINAHL, PsychINFO, The Cochrane Library, Scopus and ProQuest Dissertation and Theses Global. After screening the studies, quantitative synthesis will be performed, if possible. Otherwise, a narrative synthesis will be performed. We will include randomised controlled trials and other types of research evidence including longitudinal cohort studies. Strength of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations method. Examples of variables that will be extracted are: year of PTSD diagnosis, comorbid conditions, health behaviours, pharmacological treatments and year of mild cognitive impairment or dementia diagnosis. We developed this systematic review protocol according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement. ETHICS AND DISSEMINATION: The proposed study will not collect individual-level data and, therefore, does not require ethical approval. Results of this study will provide current evidence on risk and protective factors of dementia in adults with PTSD. Findings will be disseminated in peer-reviewed publications and conference presentations. PROSPERO REGISTRATION NUMBER: CRD42019128553.

Duke Scholars

Published In

BMJ Open

DOI

EISSN

2044-6055

Publication Date

June 3, 2020

Volume

10

Issue

6

Start / End Page

e035517

Location

England

Related Subject Headings

  • Systematic Reviews as Topic
  • Stress Disorders, Post-Traumatic
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Protective Factors
  • Longitudinal Studies
  • Humans
  • Dementia
  • Cohort Studies
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
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Lawrence, K. A., Pachner, T. M., Long, M. M., Henderson, S., Schuman, D. L., & Plassman, B. L. (2020). Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol. BMJ Open, 10(6), e035517. https://doi.org/10.1136/bmjopen-2019-035517
Lawrence, Karen A., Theresia M. Pachner, Molly M. Long, Stephanie Henderson, Donna L. Schuman, and Brenda L. Plassman. “Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol.BMJ Open 10, no. 6 (June 3, 2020): e035517. https://doi.org/10.1136/bmjopen-2019-035517.
Lawrence KA, Pachner TM, Long MM, Henderson S, Schuman DL, Plassman BL. Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol. BMJ Open. 2020 Jun 3;10(6):e035517.
Lawrence, Karen A., et al. “Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol.BMJ Open, vol. 10, no. 6, June 2020, p. e035517. Pubmed, doi:10.1136/bmjopen-2019-035517.
Lawrence KA, Pachner TM, Long MM, Henderson S, Schuman DL, Plassman BL. Risk and protective factors of dementia among adults with post-traumatic stress disorder: a systematic review protocol. BMJ Open. 2020 Jun 3;10(6):e035517.

Published In

BMJ Open

DOI

EISSN

2044-6055

Publication Date

June 3, 2020

Volume

10

Issue

6

Start / End Page

e035517

Location

England

Related Subject Headings

  • Systematic Reviews as Topic
  • Stress Disorders, Post-Traumatic
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Protective Factors
  • Longitudinal Studies
  • Humans
  • Dementia
  • Cohort Studies
  • Adult