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Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.

Publication ,  Journal Article
Walsh, CE; Yang, YC; Oi, K; Aiello, A; Belsky, D; Harris, KM; Plassman, BL
Published in: J Gerontol B Psychol Sci Soc Sci
October 6, 2022

OBJECTIVES: To better understand the temporal dynamics of progression from cognitive decline to onset of dementia in the dementia-free older population in the United States. METHODS: We used longitudinal data from a diverse national population-based sample of older adults (N = 531) in the Aging, Demographics, and Memory Study from the Health and Retirement Study with repeated measures of cognitive function and dementia diagnosis during 12 years of follow-up from 1996 to 2009. We employed joint latent class mixed models to estimate the association between cognitive change and competing risks of dementia and nondementia death and identify heterogeneity in the age profiles of such association adjusting for baseline characteristics. RESULTS: Our analyses found 3 latent classes with distinct age profiles of cognitive decline and associated risk of dementia and mortality: "Rapid Cognitive Decline" (19.6%), "Moderate Progression" (44.6%), and "Optimal Cognitive Aging" (35.8%). When simultaneously accounting for cognitive trajectories and time-to-dementia/death, we also found associations of baseline covariates with slope of cognitive decline (e.g., steeper decline among non-Hispanic Blacks and more educated) and risk of dementia (e.g., greater risk for females and apolipoprotein E-4 carriers, but no difference by education level) that differ substantially from those in separate longitudinal mixed models or survival models. DISCUSSION: The differential age patterns of cognitive decline predicting dementia incidences identified in this study suggest variation in the course of cognitive aging in older adults that may inform future etiological and intervention studies.

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Published In

J Gerontol B Psychol Sci Soc Sci

DOI

EISSN

1758-5368

Publication Date

October 6, 2022

Volume

77

Issue

10

Start / End Page

1880 / 1891

Location

United States

Related Subject Headings

  • United States
  • Population Dynamics
  • Longitudinal Studies
  • Humans
  • Gerontology
  • Female
  • Cognitive Dysfunction
  • Cognition
  • Apolipoprotein E4
  • Aging
 

Citation

APA
Chicago
ICMJE
MLA
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Walsh, C. E., Yang, Y. C., Oi, K., Aiello, A., Belsky, D., Harris, K. M., & Plassman, B. L. (2022). Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study. J Gerontol B Psychol Sci Soc Sci, 77(10), 1880–1891. https://doi.org/10.1093/geronb/gbac038
Walsh, Christine E., Yang C. Yang, Katsuya Oi, Allison Aiello, Daniel Belsky, Kathleen Mullan Harris, and Brenda L. Plassman. “Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.J Gerontol B Psychol Sci Soc Sci 77, no. 10 (October 6, 2022): 1880–91. https://doi.org/10.1093/geronb/gbac038.
Walsh CE, Yang YC, Oi K, Aiello A, Belsky D, Harris KM, et al. Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study. J Gerontol B Psychol Sci Soc Sci. 2022 Oct 6;77(10):1880–91.
Walsh, Christine E., et al. “Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study.J Gerontol B Psychol Sci Soc Sci, vol. 77, no. 10, Oct. 2022, pp. 1880–91. Pubmed, doi:10.1093/geronb/gbac038.
Walsh CE, Yang YC, Oi K, Aiello A, Belsky D, Harris KM, Plassman BL. Age Profiles of Cognitive Decline and Dementia in Late Life in the Aging, Demographics, and Memory Study. J Gerontol B Psychol Sci Soc Sci. 2022 Oct 6;77(10):1880–1891.
Journal cover image

Published In

J Gerontol B Psychol Sci Soc Sci

DOI

EISSN

1758-5368

Publication Date

October 6, 2022

Volume

77

Issue

10

Start / End Page

1880 / 1891

Location

United States

Related Subject Headings

  • United States
  • Population Dynamics
  • Longitudinal Studies
  • Humans
  • Gerontology
  • Female
  • Cognitive Dysfunction
  • Cognition
  • Apolipoprotein E4
  • Aging