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Community engagement in diverse populations for Alzheimer disease prevention trials.

Publication ,  Journal Article
Romero, HR; Welsh-Bohmer, KA; Gwyther, LP; Edmonds, HL; Plassman, BL; Germain, CM; McCart, M; Hayden, KM; Pieper, C; Roses, AD
Published in: Alzheimer Dis Assoc Disord
2014

The recruitment of asymptomatic volunteers has been identified as a critical factor that is delaying the development and validation of preventive therapies for Alzheimer disease (AD). Typical recruitment strategies involve the use of convenience samples or soliciting participation of older adults with a family history of AD from clinics and outreach efforts. However, high-risk groups, such as ethnic/racial minorities, are traditionally less likely to be recruited for AD prevention studies, thus limiting the ability to generalize findings for a significant proportion of the aging population. A community-engagement approach was used to create a registry of 2311 research-ready, healthy adult volunteers who reflect the ethnically diverse local community. Furthermore, the registry's actual commitment to research was examined, through demonstrated participation rates in a clinical study. The approach had varying levels of success in establishing a large, diverse pool of individuals who are interested in participating in pharmacological prevention trials and meet the criteria for primary prevention research trials designed to delay the onset of AD. Our efforts suggest that entry criteria for the clinical trials need to be carefully considered to be inclusive of African Americans, and that sustained effort is needed to engage African Americans in pharmacological prevention approaches.

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Published In

Alzheimer Dis Assoc Disord

DOI

EISSN

1546-4156

Publication Date

2014

Volume

28

Issue

3

Start / End Page

269 / 274

Location

United States

Related Subject Headings

  • Residence Characteristics
  • Registries
  • Patient Selection
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Female
  • Alzheimer Disease
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Romero, H. R., Welsh-Bohmer, K. A., Gwyther, L. P., Edmonds, H. L., Plassman, B. L., Germain, C. M., … Roses, A. D. (2014). Community engagement in diverse populations for Alzheimer disease prevention trials. Alzheimer Dis Assoc Disord, 28(3), 269–274. https://doi.org/10.1097/WAD.0000000000000029
Romero, Heather R., Kathleen A. Welsh-Bohmer, Lisa P. Gwyther, Henry L. Edmonds, Brenda L. Plassman, Cassandra M. Germain, Michelle McCart, Kathleen M. Hayden, Carl Pieper, and Allen D. Roses. “Community engagement in diverse populations for Alzheimer disease prevention trials.Alzheimer Dis Assoc Disord 28, no. 3 (2014): 269–74. https://doi.org/10.1097/WAD.0000000000000029.
Romero HR, Welsh-Bohmer KA, Gwyther LP, Edmonds HL, Plassman BL, Germain CM, et al. Community engagement in diverse populations for Alzheimer disease prevention trials. Alzheimer Dis Assoc Disord. 2014;28(3):269–74.
Romero, Heather R., et al. “Community engagement in diverse populations for Alzheimer disease prevention trials.Alzheimer Dis Assoc Disord, vol. 28, no. 3, 2014, pp. 269–74. Pubmed, doi:10.1097/WAD.0000000000000029.
Romero HR, Welsh-Bohmer KA, Gwyther LP, Edmonds HL, Plassman BL, Germain CM, McCart M, Hayden KM, Pieper C, Roses AD. Community engagement in diverse populations for Alzheimer disease prevention trials. Alzheimer Dis Assoc Disord. 2014;28(3):269–274.

Published In

Alzheimer Dis Assoc Disord

DOI

EISSN

1546-4156

Publication Date

2014

Volume

28

Issue

3

Start / End Page

269 / 274

Location

United States

Related Subject Headings

  • Residence Characteristics
  • Registries
  • Patient Selection
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Female
  • Alzheimer Disease
  • Aged