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Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis.

Publication ,  Journal Article
Tate, DF; Neeley, ES; Norton, MC; Tschanz, JT; Miller, MJ; Wolfson, L; Hulette, C; Leslie, C; Welsh-Bohmer, KA; Plassman, B; Bigler, ED
Published in: Brain Res
April 18, 2011

The brain reserve hypothesis has been posited as being one important mediating factor for developing dementia, especially Alzheimer's disease (AD). Evidence for this hypothesis is mixed though different methodologies have made these findings difficult to interpret. We examined imaging data from a large cohort (N=194) of mixed dementia patients and controls, 65years old and older from the Cache County, Utah Study of Memory and Aging for evidence of the brain reserve hypothesis using total intracranial volume (TICV) as a quantitative measure of pre-morbid brain size and a vicarious indicator of reserve. A broader spectrum of non-demented elderly control subjects from previous studies was also included for comparison (N=423). In addition, non-parametric Classification and Regression Tree (CART) analyses were performed to model group heterogeneity and identify any subgroups of patients where TICV might be an important predictor of dementia. Parametrically, no main effect was found for TICV when predicting a dementia diagnosis; however, the CART analysis did reveal important TICV subgroups, including a sex differential wherein ε4 APOE allele presence in males and low TICV predicted AD classification. TICV, APOE, and other potential mediator/moderator variables are discussed in the context of the brain reserve hypothesis.

Duke Scholars

Published In

Brain Res

DOI

EISSN

1872-6240

Publication Date

April 18, 2011

Volume

1385

Start / End Page

151 / 162

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Sex Characteristics
  • Organ Size
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dementia
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tate, D. F., Neeley, E. S., Norton, M. C., Tschanz, J. T., Miller, M. J., Wolfson, L., … Bigler, E. D. (2011). Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. Brain Res, 1385, 151–162. https://doi.org/10.1016/j.brainres.2010.12.038
Tate, D. F., E. S. Neeley, M. C. Norton, J. T. Tschanz, M. J. Miller, L. Wolfson, C. Hulette, et al. “Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis.Brain Res 1385 (April 18, 2011): 151–62. https://doi.org/10.1016/j.brainres.2010.12.038.
Tate DF, Neeley ES, Norton MC, Tschanz JT, Miller MJ, Wolfson L, et al. Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. Brain Res. 2011 Apr 18;1385:151–62.
Tate, D. F., et al. “Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis.Brain Res, vol. 1385, Apr. 2011, pp. 151–62. Pubmed, doi:10.1016/j.brainres.2010.12.038.
Tate DF, Neeley ES, Norton MC, Tschanz JT, Miller MJ, Wolfson L, Hulette C, Leslie C, Welsh-Bohmer KA, Plassman B, Bigler ED. Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. Brain Res. 2011 Apr 18;1385:151–162.
Journal cover image

Published In

Brain Res

DOI

EISSN

1872-6240

Publication Date

April 18, 2011

Volume

1385

Start / End Page

151 / 162

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Sex Characteristics
  • Organ Size
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dementia
  • Cohort Studies