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Traumatic brain injury and late-life dementia.

Publication ,  Journal Article
Plassman, BL; Grafman, J
Published in: Handb Clin Neurol
2015

Little is known of the impact of traumatic brain injury (TBI) on outcomes decades later when the effects of the injury interact with the aging brain. Some, but not all, epidemiologic studies have reported an association between TBI and increased risk of Alzheimer's disease (AD) and other neurodegenerative disorders years after the injury. There is evidence that this association has a dose-response pattern such that risk of dementia progressively increases as the number and severity of head injuries increase. Some studies have shown that one of the mechanisms underlying the association is that TBI may contribute to earlier onset of dementia. The APOE ϵ4 allele has been proposed as a biological link between TBI and AD because individuals with an APOE ϵ4 allele show typical AD pathology within a short period postinjury and are at increased risk of poorer cognitive outcomes. There are also likely other, yet to be identified factors that interact with the postinjury damage and aging-related brain changes leading to exacerbated cognitive decline and dementia. Given the large number of young individuals with military, sports-related, and other causes of head injuries, there is a window of opportunity and an urgency to understand the link between TBI and dementia before these TBI survivors reach the age of risk for dementia.

Duke Scholars

Published In

Handb Clin Neurol

DOI

ISSN

0072-9752

Publication Date

2015

Volume

128

Start / End Page

711 / 722

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Neurology & Neurosurgery
  • Humans
  • Disease Progression
  • Dementia
  • Brain Injuries
  • Aging
  • 3209 Neurosciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Plassman, B. L., & Grafman, J. (2015). Traumatic brain injury and late-life dementia. Handb Clin Neurol, 128, 711–722. https://doi.org/10.1016/B978-0-444-63521-1.00044-3
Plassman, Brenda L., and Jordan Grafman. “Traumatic brain injury and late-life dementia.Handb Clin Neurol 128 (2015): 711–22. https://doi.org/10.1016/B978-0-444-63521-1.00044-3.
Plassman BL, Grafman J. Traumatic brain injury and late-life dementia. Handb Clin Neurol. 2015;128:711–22.
Plassman, Brenda L., and Jordan Grafman. “Traumatic brain injury and late-life dementia.Handb Clin Neurol, vol. 128, 2015, pp. 711–22. Pubmed, doi:10.1016/B978-0-444-63521-1.00044-3.
Plassman BL, Grafman J. Traumatic brain injury and late-life dementia. Handb Clin Neurol. 2015;128:711–722.
Journal cover image

Published In

Handb Clin Neurol

DOI

ISSN

0072-9752

Publication Date

2015

Volume

128

Start / End Page

711 / 722

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Neurology & Neurosurgery
  • Humans
  • Disease Progression
  • Dementia
  • Brain Injuries
  • Aging
  • 3209 Neurosciences