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Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease

Publication ,  Journal Article
Welsh-Bohmer, KA; Plassman, BL; Hayden, KM
Published in: Annual Review of Gerontology and Geriatrics
January 1, 2010

Inheritance appears to play a strong role in terms of human longevity and also in risk for chronic neurodegenerative diseases of late life such as Alzheimer's disease (AD). Understanding the role of genes in normal biological aging of the nervous system and in the expression of AD pathological changes is important for developing useful disease targets for clinical intervention and treatment. The extent to which gene expression can be altered through environmental exposures may also provide important clues for disease prevention. In this chapter, we consider the role of genetic and environmental factors in AD risk and in age-related cognitive decline. We focus, in particular, on targets that are potentially modifiable with respect to exerting positive effects on cognition and AD risk. In this context, we conclude the chapter by considering lifestyle approaches to disease prevention and enhancement of successful cognitive aging that extend from the current state of evidence and discuss areas for future research development. © 2010 Springer Publishing Company.

Duke Scholars

Published In

Annual Review of Gerontology and Geriatrics

DOI

ISSN

0198-8794

Publication Date

January 1, 2010

Volume

30

Issue

1

Start / End Page

81 / 114
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Welsh-Bohmer, K. A., Plassman, B. L., & Hayden, K. M. (2010). Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease. Annual Review of Gerontology and Geriatrics, 30(1), 81–114. https://doi.org/10.1891/0198-8794.30.81
Welsh-Bohmer, K. A., B. L. Plassman, and K. M. Hayden. “Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease.” Annual Review of Gerontology and Geriatrics 30, no. 1 (January 1, 2010): 81–114. https://doi.org/10.1891/0198-8794.30.81.
Welsh-Bohmer KA, Plassman BL, Hayden KM. Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease. Annual Review of Gerontology and Geriatrics. 2010 Jan 1;30(1):81–114.
Welsh-Bohmer, K. A., et al. “Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease.” Annual Review of Gerontology and Geriatrics, vol. 30, no. 1, Jan. 2010, pp. 81–114. Scopus, doi:10.1891/0198-8794.30.81.
Welsh-Bohmer KA, Plassman BL, Hayden KM. Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease. Annual Review of Gerontology and Geriatrics. 2010 Jan 1;30(1):81–114.

Published In

Annual Review of Gerontology and Geriatrics

DOI

ISSN

0198-8794

Publication Date

January 1, 2010

Volume

30

Issue

1

Start / End Page

81 / 114