Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.

Publication ,  Journal Article
Brainerd, CJ; Reyna, VF; Petersen, RC; Smith, GE; Kenney, AE; Gross, CJ; Taub, ES; Plassman, BL; Fisher, GG
Published in: Neuropsychology
January 2013

OBJECTIVE: The ε4 allele of the apolipoprotein E (APOE) genotype is the most widely accepted genetic risk factor for Alzheimer's dementia (AD), but findings on whether it is a risk factor for the AD prodrome, mild cognitive impairment (MCI), have been inconsistent. In a prospective longitudinal design, we investigated (a) whether transitions to MCI and other forms of neurocognitive impairment without dementia (CIND) are more frequent among normal ε4 carriers than among noncarriers and (b) whether subsequent transitions to AD from MCI and from other forms of CIND are more frequent among ε4 carriers than among noncarriers. METHOD: The frequency of the ε4 allele was studied in older adults (mean age > 70), who had participated in two or more waves of neuropsychological testing and diagnosis in the Aging, Demographics, and Memory Study (ADAMS) of the United States Department of Health and Human Services, National Institutes of Health, National Institute on Aging's Health and Retirement Study, conducted by the University of Michigan. The association between ε4 and longitudinal transitions to specific types of CIND and dementia can be determined with this data set. RESULTS: Epsilon 4 increased the rate of progression from normal functioning to MCI (58% of new diagnoses were carriers) but not to other forms of CIND. The rate of progression to AD from MCI or from other forms of CIND was not increased by ε4. CONCLUSIONS: The results support the hypothesis that ε4 is a risk factor for transitions from normal functioning to MCI but not for subsequent transitions to AD. In the ADAMS sample, the reason ε4 is elevated in AD individuals is because it is already elevated in MCI individuals, who are the primary source of new AD diagnoses.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuropsychology

DOI

EISSN

1931-1559

Publication Date

January 2013

Volume

27

Issue

1

Start / End Page

86 / 94

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Neuropsychological Tests
  • National Institutes of Health (U.S.)
  • Male
  • Longitudinal Studies
  • Logistic Models
  • Humans
  • Genotype
  • Genetic Testing
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brainerd, C. J., Reyna, V. F., Petersen, R. C., Smith, G. E., Kenney, A. E., Gross, C. J., … Fisher, G. G. (2013). The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study. Neuropsychology, 27(1), 86–94. https://doi.org/10.1037/a0030855
Brainerd, C. J., V. F. Reyna, R. C. Petersen, G. E. Smith, A. E. Kenney, C. J. Gross, E. S. Taub, B. L. Plassman, and G. G. Fisher. “The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.Neuropsychology 27, no. 1 (January 2013): 86–94. https://doi.org/10.1037/a0030855.
Brainerd, C. J., et al. “The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.Neuropsychology, vol. 27, no. 1, Jan. 2013, pp. 86–94. Pubmed, doi:10.1037/a0030855.
Brainerd CJ, Reyna VF, Petersen RC, Smith GE, Kenney AE, Gross CJ, Taub ES, Plassman BL, Fisher GG. The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study. Neuropsychology. 2013 Jan;27(1):86–94.

Published In

Neuropsychology

DOI

EISSN

1931-1559

Publication Date

January 2013

Volume

27

Issue

1

Start / End Page

86 / 94

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Neuropsychological Tests
  • National Institutes of Health (U.S.)
  • Male
  • Longitudinal Studies
  • Logistic Models
  • Humans
  • Genotype
  • Genetic Testing