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Differences in functional impairment across subtypes of dementia.

Publication ,  Journal Article
Gure, TR; Kabeto, MU; Plassman, BL; Piette, JD; Langa, KM
Published in: J Gerontol A Biol Sci Med Sci
April 2010

BACKGROUND: Dementia is a cause of disability in later life. Despite the importance of functional status to the diagnosis of dementia, limited information exists on differences in functional limitations by dementia subtype. We conducted a cross-sectional analysis using the Aging, Demographics, and Memory Study (ADAMS) to determine the extent of functional impairment among older adults with dementia due to different etiologies. METHODS: The ADAMS sample consisted of 856 individuals aged 71 years and older originally surveyed as part of the Health and Retirement Study. Based on a comprehensive in-person cognitive evaluation, respondents were assigned to diagnostic categories of normal cognition, cognitive impairment not demented, and demented. Dementia subtypes were grouped into three categories: vascular dementia (VaD), Alzheimer's dementia (AD), and dementia due to other etiologies. For 744 of the 856 respondents, a proxy informant completed a questionnaire asking whether the respondent had difficulty completing instrumental activities of daily living and activities of daily living (ADLs). RESULTS: Of 744 ADAMS participants, 263 had dementia: 199 (70.5%) with AD, 42 (16.9%) with VaD, and 22 (12.6%) were demented due to other etiologies. After adjustment for demographics, chronic illnesses, and dementia severity, participants with VaD (odds ratio [OR] 5.74; 95% confidence interval [CI] 2.60-12.69) and other etiologies of dementia (OR 21.23; 95% CI 7.25-62.16) were more likely to have greater than or equal to four ADL limitations compared with those with AD. CONCLUSIONS: VaD is associated with significantly more ADL limitations than AD. These physical limitations should be considered when designing adult day care programs, which adequately accommodate the needs of non-AD patients.

Duke Scholars

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

April 2010

Volume

65

Issue

4

Start / End Page

434 / 441

Location

United States

Related Subject Headings

  • Humans
  • Gerontology
  • Dementia, Vascular
  • Dementia
  • Alzheimer Disease
  • Aged
  • Activities of Daily Living
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gure, T. R., Kabeto, M. U., Plassman, B. L., Piette, J. D., & Langa, K. M. (2010). Differences in functional impairment across subtypes of dementia. J Gerontol A Biol Sci Med Sci, 65(4), 434–441. https://doi.org/10.1093/gerona/glp197
Gure, Tanya Ruff, Mohammed U. Kabeto, Brenda L. Plassman, John D. Piette, and Kenneth M. Langa. “Differences in functional impairment across subtypes of dementia.J Gerontol A Biol Sci Med Sci 65, no. 4 (April 2010): 434–41. https://doi.org/10.1093/gerona/glp197.
Gure TR, Kabeto MU, Plassman BL, Piette JD, Langa KM. Differences in functional impairment across subtypes of dementia. J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):434–41.
Gure, Tanya Ruff, et al. “Differences in functional impairment across subtypes of dementia.J Gerontol A Biol Sci Med Sci, vol. 65, no. 4, Apr. 2010, pp. 434–41. Pubmed, doi:10.1093/gerona/glp197.
Gure TR, Kabeto MU, Plassman BL, Piette JD, Langa KM. Differences in functional impairment across subtypes of dementia. J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):434–441.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

April 2010

Volume

65

Issue

4

Start / End Page

434 / 441

Location

United States

Related Subject Headings

  • Humans
  • Gerontology
  • Dementia, Vascular
  • Dementia
  • Alzheimer Disease
  • Aged
  • Activities of Daily Living
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 1103 Clinical Sciences