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A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.

Publication ,  Journal Article
McArdle, JJ; Plassman, BL
Published in: Behav Genet
September 2009

Previous research has shown cognitive abilities to have different biometric patterns of age-changes. We examined the variation in episodic memory (word recall task) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed up to three more times over 12 years. In cross-sectional analyses, variation in the number of words recalled independent of age was explained largely by non-shared influences (65-72%), with clear additive genetic influences (12-32%), and marginal shared family influences (1-18%). The longitudinal phenotypic analysis of the word recall task showed systematic linear declines over age, but several nonlinear models with more dramatic changes at later ages, improved the overall fit. A two-part spline model for the longitudinal twin data with an optimal turning point at age 74 led to: (a) a separation of non-shared environmental influences and transient measurement error (~50%); (b) strong additive genetic components of this latent curve (~44% at age 60) with increases (over 50%) up to age 74, but with no additional genetic variation after age 74; (c) the smaller influences of shared family environment (~15% at age 74) were constant over all ages; (d) non-shared effects play an important role over most of the life-span but diminish after age 74.

Duke Scholars

Published In

Behav Genet

DOI

EISSN

1573-3297

Publication Date

September 2009

Volume

39

Issue

5

Start / End Page

472 / 495

Location

United States

Related Subject Headings

  • Twins
  • Time Factors
  • Registries
  • Phenotype
  • Multivariate Analysis
  • Models, Genetic
  • Middle Aged
  • Memory Disorders
  • Male
  • Humans
 

Citation

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MLA
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McArdle, J. J., & Plassman, B. L. (2009). A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry. Behav Genet, 39(5), 472–495. https://doi.org/10.1007/s10519-009-9272-1
McArdle, John J., and Brenda L. Plassman. “A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.Behav Genet 39, no. 5 (September 2009): 472–95. https://doi.org/10.1007/s10519-009-9272-1.
McArdle JJ, Plassman BL. A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry. Behav Genet. 2009 Sep;39(5):472–95.
McArdle, John J., and Brenda L. Plassman. “A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.Behav Genet, vol. 39, no. 5, Sept. 2009, pp. 472–95. Pubmed, doi:10.1007/s10519-009-9272-1.
McArdle JJ, Plassman BL. A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry. Behav Genet. 2009 Sep;39(5):472–495.
Journal cover image

Published In

Behav Genet

DOI

EISSN

1573-3297

Publication Date

September 2009

Volume

39

Issue

5

Start / End Page

472 / 495

Location

United States

Related Subject Headings

  • Twins
  • Time Factors
  • Registries
  • Phenotype
  • Multivariate Analysis
  • Models, Genetic
  • Middle Aged
  • Memory Disorders
  • Male
  • Humans