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Epigenetic assimilation in the aging human brain.

Publication ,  Journal Article
Oh, G; Ebrahimi, S; Wang, S-C; Cortese, R; Kaminsky, ZA; Gottesman, II; Burke, JR; Plassman, BL; Petronis, A
Published in: Genome Biol
April 28, 2016

BACKGROUND: Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages of human life. RESULTS: We find that brain tissues of older individuals (>75 years) become more similar to each other, both epigenetically and transcriptionally, compared with younger individuals. Inter-individual epigenetic assimilation is concurrent with increasing similarity between the cerebral cortex and the cerebellum, which points to potential brain cell dedifferentiation. DNA modification analysis of twins affected with Alzheimer's disease reveals a potential for accelerated epigenetic assimilation in neurodegenerative disease. We also observe loss of boundaries and merging of neighboring DNA modification and transcriptomic domains over time. CONCLUSIONS: Age-dependent epigenetic divergence, paradoxically, changes to convergence in the later stages of life. The newly described phenomena of epigenetic assimilation and tissue dedifferentiation may help us better understand the molecular mechanisms of aging and the origins of diseases for which age is a risk factor.

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Published In

Genome Biol

DOI

EISSN

1474-760X

Publication Date

April 28, 2016

Volume

17

Start / End Page

76

Location

England

Related Subject Headings

  • Twins
  • Middle Aged
  • Male
  • Humans
  • Frontal Lobe
  • Female
  • Epigenesis, Genetic
  • DNA Methylation
  • Bioinformatics
  • Alzheimer Disease
 

Citation

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Chicago
ICMJE
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Oh, G., Ebrahimi, S., Wang, S.-C., Cortese, R., Kaminsky, Z. A., Gottesman, I. I., … Petronis, A. (2016). Epigenetic assimilation in the aging human brain. Genome Biol, 17, 76. https://doi.org/10.1186/s13059-016-0946-8
Oh, Gabriel, Sasha Ebrahimi, Sun-Chong Wang, Rene Cortese, Zachary A. Kaminsky, Irving I. Gottesman, James R. Burke, Brenda L. Plassman, and Art Petronis. “Epigenetic assimilation in the aging human brain.Genome Biol 17 (April 28, 2016): 76. https://doi.org/10.1186/s13059-016-0946-8.
Oh G, Ebrahimi S, Wang S-C, Cortese R, Kaminsky ZA, Gottesman II, et al. Epigenetic assimilation in the aging human brain. Genome Biol. 2016 Apr 28;17:76.
Oh, Gabriel, et al. “Epigenetic assimilation in the aging human brain.Genome Biol, vol. 17, Apr. 2016, p. 76. Pubmed, doi:10.1186/s13059-016-0946-8.
Oh G, Ebrahimi S, Wang S-C, Cortese R, Kaminsky ZA, Gottesman II, Burke JR, Plassman BL, Petronis A. Epigenetic assimilation in the aging human brain. Genome Biol. 2016 Apr 28;17:76.

Published In

Genome Biol

DOI

EISSN

1474-760X

Publication Date

April 28, 2016

Volume

17

Start / End Page

76

Location

England

Related Subject Headings

  • Twins
  • Middle Aged
  • Male
  • Humans
  • Frontal Lobe
  • Female
  • Epigenesis, Genetic
  • DNA Methylation
  • Bioinformatics
  • Alzheimer Disease