Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction.

Publication ,  Journal Article
Gorman, RB; McKenzie, DK; Gandevia, SC; Plassman, BL
Published in: Thorax
November 1992

BACKGROUND: This study investigated whether the inspiratory muscles are susceptible to fatigue during acute airway narrowing because of increased airway resistance and hyperinflation. METHODS: Asthmatic subjects performed up to four series (on separate days) of 18 maximal static inspiratory efforts of 10 seconds' duration with 10 second rest intervals (50% duty cycle; total duration six minutes): at functional residual capacity (FRC) (control); after histamine induced bronchoconstriction, which decreased forced expiratory volume in one second (FEV1) to a mean of 55% (SD 11%) of the initial value; at a voluntarily increased lung volume (initial volume held at 140% control); and after inhalation of histamine at a voluntarily increased lung volume. RESULTS: For the group of subjects the mean (SD) maximal inspiratory pressure (MIP) in the control experiments was 114 (22) cmH2O and the initial volume was 3.5 (1.2) 1. After histamine inhalation the initial lung volume for contractions increased to 118% (5%) of the control volume. In the high lung volume experiments initial volumes were 140% (12%) of the control (volume without histamine) and 140% (15%) (with histamine). The relation between MIP and initial absolute lung volume was determined for each subject before fatigue developed. When the inspiratory pressures for each contraction in the endurance test were normalised to the pressure expected for that lung volume, no significant differences were found between the four experimental conditions for MIP, or between pressures sustained over the 18 contractions. CONCLUSIONS: Histamine induced bronchoconstriction and hyperinflation had no detectable effect on inspiratory muscle strength or endurance in these asthmatic subjects.

Duke Scholars

Published In

Thorax

DOI

ISSN

0040-6376

Publication Date

November 1992

Volume

47

Issue

11

Start / End Page

922 / 927

Location

England

Related Subject Headings

  • Vital Capacity
  • Respiratory System
  • Respiratory Muscles
  • Respiration
  • Physical Endurance
  • Male
  • Lung
  • Humans
  • Histamine
  • Functional Residual Capacity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gorman, R. B., McKenzie, D. K., Gandevia, S. C., & Plassman, B. L. (1992). Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction. Thorax, 47(11), 922–927. https://doi.org/10.1136/thx.47.11.922
Gorman, R. B., D. K. McKenzie, S. C. Gandevia, and B. L. Plassman. “Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction.Thorax 47, no. 11 (November 1992): 922–27. https://doi.org/10.1136/thx.47.11.922.
Gorman RB, McKenzie DK, Gandevia SC, Plassman BL. Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction. Thorax. 1992 Nov;47(11):922–7.
Gorman, R. B., et al. “Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction.Thorax, vol. 47, no. 11, Nov. 1992, pp. 922–27. Pubmed, doi:10.1136/thx.47.11.922.
Gorman RB, McKenzie DK, Gandevia SC, Plassman BL. Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction. Thorax. 1992 Nov;47(11):922–927.

Published In

Thorax

DOI

ISSN

0040-6376

Publication Date

November 1992

Volume

47

Issue

11

Start / End Page

922 / 927

Location

England

Related Subject Headings

  • Vital Capacity
  • Respiratory System
  • Respiratory Muscles
  • Respiration
  • Physical Endurance
  • Male
  • Lung
  • Humans
  • Histamine
  • Functional Residual Capacity