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Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline.

Publication ,  Journal Article
Qin, B; Viera, AJ; Muntner, P; Plassman, BL; Edwards, LJ; Adair, LS; Popkin, BM; Mendez, MA
Published in: Hypertension
July 2016

The association between visit-to-visit variability of blood pressure (BP) and cognitive decline over time remains incompletely understood in a general population of older adults. We assessed the hypothesis that higher visit-to-visit variability in BP, but not mean BP, would be associated with faster decline in cognitive function among community-dwelling older adults. This prospective cohort study comprised 976 adults who had 3 or 4 visits with BP measurements as part of the China Health and Nutrition Survey from 1991, up to their first cognitive tests, and completed cognitive screening tests at ≥2 visits in 1997, 2000, or 2004. Visit-to-visit BP variability was expressed as the SD, coefficient of variation, or as the variation independent of mean BP across visits conducted at a mean interval of 3.2 years. Mean (SD) age at the first cognitive test was 64 (6) years. Using multivariable-adjusted linear mixed-effects models, we found higher visit-to-visit variability in systolic BP, but not mean systolic BP, was associated with a faster decline of cognitive function (adjusted mean difference [95% confidence interval] for high versus low tertile of SD variability: standardized composite scores -0.038 standard units (SU)/y [-0.066 to -0.009] and verbal memory -0.041 SU/y [-0.075 to -0.008]). Higher visit-to-visit variability in diastolic BP was associated with a faster decline of cognitive function, independent of mean diastolic BP, among adults aged 55 to 64 years but not those ≥65 years. Our results suggest that higher long-term BP visit-to-visit variability is associated with a faster rate of cognitive decline among older adults.

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Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

July 2016

Volume

68

Issue

1

Start / End Page

106 / 113

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Risk Assessment
  • Prognosis
  • Office Visits
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Linear Models
  • Independent Living
  • Hypertension
 

Citation

APA
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ICMJE
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Qin, B., Viera, A. J., Muntner, P., Plassman, B. L., Edwards, L. J., Adair, L. S., … Mendez, M. A. (2016). Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline. Hypertension, 68(1), 106–113. https://doi.org/10.1161/HYPERTENSIONAHA.116.07494
Qin, Bo, Anthony J. Viera, Paul Muntner, Brenda L. Plassman, Lloyd J. Edwards, Linda S. Adair, Barry M. Popkin, and Michelle A. Mendez. “Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline.Hypertension 68, no. 1 (July 2016): 106–13. https://doi.org/10.1161/HYPERTENSIONAHA.116.07494.
Qin B, Viera AJ, Muntner P, Plassman BL, Edwards LJ, Adair LS, et al. Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline. Hypertension. 2016 Jul;68(1):106–13.
Qin, Bo, et al. “Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline.Hypertension, vol. 68, no. 1, July 2016, pp. 106–13. Pubmed, doi:10.1161/HYPERTENSIONAHA.116.07494.
Qin B, Viera AJ, Muntner P, Plassman BL, Edwards LJ, Adair LS, Popkin BM, Mendez MA. Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline. Hypertension. 2016 Jul;68(1):106–113.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

July 2016

Volume

68

Issue

1

Start / End Page

106 / 113

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Risk Assessment
  • Prognosis
  • Office Visits
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Linear Models
  • Independent Living
  • Hypertension